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PMID:7508007
| Citation |
Fung, KM, Chikaraishi, DM, Suri, C, Theuring, F, Messing, A, Albert, DM, Lee, VM and Trojanowski, JQ (1994) Molecular phenotype of simian virus 40 large T antigen-induced primitive neuroectodermal tumors in four different lines of transgenic mice. Lab. Invest. 70:114-24 |
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| Abstract |
We compared the molecular phenotypes of central nervous system tumors arising in four different lines of transgenic mice (TGM) carrying the Simian virus 40 large T antigen driven by different promoters or enhancers. Two of the four lines developed primitive neuroectodermal tumors (PNETs) in the brain stem or pineal gland. A third TGM line developed retinoblastomas (a PNET-like tumor of the retina) as well as PNETs in the mesencephalon, while the fourth TGM developed retinoblastomas and adrenal pheochromocytomas. |
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| Keywords |
Adrenal Gland Neoplasms/chemistry; Adrenal Gland Neoplasms/etiology; Adrenal Gland Neoplasms/pathology; Animals; Antigens, Polyomavirus Transforming/analysis; Antigens, Polyomavirus Transforming/physiology; Blotting, Western; Central Nervous System Neoplasms/chemistry; Central Nervous System Neoplasms/etiology; Central Nervous System Neoplasms/pathology; Disease Models, Animal; Eye Neoplasms/chemistry; Eye Neoplasms/etiology; Eye Neoplasms/pathology; Glial Fibrillary Acidic Protein/analysis; Immunohistochemistry; Mice; Mice, Transgenic; Microscopy, Electron; Myelin Basic Proteins/analysis; Neuroectodermal Tumors, Primitive/chemistry; Neuroectodermal Tumors, Primitive/etiology; Neuroectodermal Tumors, Primitive/pathology; Neurofilament Proteins/analysis; Phenotype; Pheochromocytoma/chemistry; Pheochromocytoma/etiology; Pheochromocytoma/pathology; Promoter Regions, Genetic/physiology; Retinoblastoma/chemistry; Retinoblastoma/etiology; Retinoblastoma/pathology; Synaptophysin/analysis; Tumor Cells, Cultured |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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