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MOUSE:HIG1A
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Higd1a (synonyms: Hig1) | |
| Protein Name(s) | HIG1 domain family member 1A, mitochondrial
Hypoxia-inducible gene 1 protein | |
| External Links | ||
| UniProt | Q9JLR9 | |
| EMBL | AF141312 AY028386 AK004166 AK008756 AK018360 BC021594 BC090259 | |
| CCDS | CCDS40812.1 | |
| RefSeq | NP_062788.1 XP_006512264.1 XP_006512265.1 | |
| UniGene | Mm.347915 | |
| ProteinModelPortal | Q9JLR9 | |
| SMR | Q9JLR9 | |
| BioGrid | 207883 | |
| PhosphoSite | Q9JLR9 | |
| MaxQB | Q9JLR9 | |
| PaxDb | Q9JLR9 | |
| PRIDE | Q9JLR9 | |
| Ensembl | ENSMUST00000060251 | |
| GeneID | 56295 | |
| KEGG | mmu:56295 | |
| UCSC | uc009seb.2 | |
| CTD | 25994 | |
| MGI | MGI:1930666 | |
| eggNOG | NOG323028 | |
| GeneTree | ENSGT00530000063398 | |
| HOGENOM | HOG000234513 | |
| HOVERGEN | HBG054361 | |
| InParanoid | Q9JLR9 | |
| OMA | GDTKMSV | |
| OrthoDB | EOG7GN2R1 | |
| PhylomeDB | Q9JLR9 | |
| TreeFam | TF314628 | |
| NextBio | 312212 | |
| PRO | PR:Q9JLR9 | |
| Proteomes | UP000000589 | |
| Bgee | Q9JLR9 | |
| CleanEx | MM_HIGD1A | |
| ExpressionAtlas | Q9JLR9 | |
| Genevestigator | Q9JLR9 | |
| GO | GO:0016021 GO:0016020 GO:0005743 GO:0005739 GO:0043234 GO:0070469 GO:0042149 GO:0071456 GO:0090201 GO:0055114 | |
| InterPro | IPR007667 | |
| Pfam | PF04588 | |
| PROSITE | PS51503 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0005634 |
nucleus |
ECO:0000314 |
C |
Figure 1E. |
complete | |||||
| GO:0005739 |
mitochondrion |
ECO:0000314 |
C |
Figure 1D. |
complete | |||||
| GO:0005515 |
protein binding |
ECO:0000314 |
F |
Figure 2Cii demonstrated protein interaction between the HIGD1A and AIF (uniprot ID: Q970X1). |
complete | |||||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005743 |
mitochondrial inner membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003674 |
molecular_function |
ECO:0000307 |
no biological data found used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0090201 |
negative regulation of release of cytochrome c from mitochondria |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0071902 |
positive regulation of protein serine/threonine kinase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0071456 |
cellular response to hypoxia |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0071456 |
cellular response to hypoxia |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0071456 |
cellular response to hypoxia |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0042149 |
cellular response to glucose starvation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0042149 |
cellular response to glucose starvation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Y241 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Y241 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Y241 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Y241 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005743 |
mitochondrial inner membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070469 |
respirasome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031966 |
mitochondrial membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Ameri, K et al. (2013) Nuclear localization of the mitochondrial factor HIGD1A during metabolic stress. PLoS ONE 8 e62758 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Wang, J et al. (2006) Pancreatic beta cells lack a low glucose and O2-inducible mitochondrial protein that augments cell survival. Proc. Natl. Acad. Sci. U.S.A. 103 10636-41 PubMed GONUTS page
- ↑ Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 An, HJ et al. (2011) The survival effect of mitochondrial Higd-1a is associated with suppression of cytochrome C release and prevention of caspase activation. Biochim. Biophys. Acta 1813 2088-98 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Ameri, K et al. (2015) HIGD1A Regulates Oxygen Consumption, ROS Production, and AMPK Activity during Glucose Deprivation to Modulate Cell Survival and Tumor Growth. Cell Rep PubMed GONUTS page
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