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MOUSE:HIG1A

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Higd1a (synonyms: Hig1)
Protein Name(s) HIG1 domain family member 1A, mitochondrial

Hypoxia-inducible gene 1 protein

External Links
UniProt Q9JLR9
EMBL AF141312
AY028386
AK004166
AK008756
AK018360
BC021594
BC090259
CCDS CCDS40812.1
RefSeq NP_062788.1
XP_006512264.1
XP_006512265.1
UniGene Mm.347915
ProteinModelPortal Q9JLR9
SMR Q9JLR9
BioGrid 207883
PhosphoSite Q9JLR9
MaxQB Q9JLR9
PaxDb Q9JLR9
PRIDE Q9JLR9
Ensembl ENSMUST00000060251
GeneID 56295
KEGG mmu:56295
UCSC uc009seb.2
CTD 25994
MGI MGI:1930666
eggNOG NOG323028
GeneTree ENSGT00530000063398
HOGENOM HOG000234513
HOVERGEN HBG054361
InParanoid Q9JLR9
OMA GDTKMSV
OrthoDB EOG7GN2R1
PhylomeDB Q9JLR9
TreeFam TF314628
NextBio 312212
PRO PR:Q9JLR9
Proteomes UP000000589
Bgee Q9JLR9
CleanEx MM_HIGD1A
ExpressionAtlas Q9JLR9
Genevestigator Q9JLR9
GO GO:0016021
GO:0016020
GO:0005743
GO:0005739
GO:0043234
GO:0070469
GO:0042149
GO:0071456
GO:0090201
GO:0055114
InterPro IPR007667
Pfam PF04588
PROSITE PS51503

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0005634

nucleus

PMID:23646141[1]

ECO:0000314

C

Figure 1E.

complete
CACAO 8249

GO:0005739

mitochondrion

PMID:23646141[1]

ECO:0000314

C

Figure 1D.

complete
CACAO 8250

GO:0005515

protein binding

PMID:23646141[1]

ECO:0000314

F

Figure 2Cii demonstrated protein interaction between the HIGD1A and AIF (uniprot ID: Q970X1).

complete
CACAO 8251

part_of

GO:0005739

mitochondrion

PMID:23646141[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:23646141[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y241

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:16815968[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005743

mitochondrial inner membrane

PMID:16815968[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:18614015[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:21856340[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y241

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y241

C

Seeded From UniProt

complete

enables

GO:0003674

molecular_function

GO_REF:0000015

ECO:0000307

no biological data found used in manual assertion

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0090201

negative regulation of release of cytochrome c from mitochondria

PMID:21856340[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071902

positive regulation of protein serine/threonine kinase activity

PMID:25683712[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071456

cellular response to hypoxia

PMID:25683712[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071456

cellular response to hypoxia

PMID:21856340[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071456

cellular response to hypoxia

PMID:16815968[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y241

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042149

cellular response to glucose starvation

PMID:25683712[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042149

cellular response to glucose starvation

PMID:16815968[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y241
ensembl:ENSP00000398064

P

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y241
ensembl:ENSP00000398064

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y241
ensembl:ENSP00000398064

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y241
ensembl:ENSP00000398064

C

Seeded From UniProt

complete

part_of

GO:0005743

mitochondrial inner membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0999
UniProtKB-SubCell:SL-0168

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496

C

Seeded From UniProt

complete

part_of

GO:0070469

respirasome

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0679

C

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0249

P

Seeded From UniProt

complete

part_of

GO:0031966

mitochondrial membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0171

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 Ameri, K et al. (2013) Nuclear localization of the mitochondrial factor HIGD1A during metabolic stress. PLoS ONE 8 e62758 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Wang, J et al. (2006) Pancreatic beta cells lack a low glucose and O2-inducible mitochondrial protein that augments cell survival. Proc. Natl. Acad. Sci. U.S.A. 103 10636-41 PubMed GONUTS page
  3. Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page
  4. 4.0 4.1 4.2 An, HJ et al. (2011) The survival effect of mitochondrial Higd-1a is associated with suppression of cytochrome C release and prevention of caspase activation. Biochim. Biophys. Acta 1813 2088-98 PubMed GONUTS page
  5. 5.0 5.1 5.2 Ameri, K et al. (2015) HIGD1A Regulates Oxygen Consumption, ROS Production, and AMPK Activity during Glucose Deprivation to Modulate Cell Survival and Tumor Growth. Cell Rep PubMed GONUTS page