MOUSE:HDAC6

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Hdac6
Protein Name(s)	Histone deacetylase 6 HD6 Histone deacetylase mHDA2
External Links
UniProt	Q9Z2V5
EMBL	AF006603 AL670169
CCDS	CCDS40845.1
PIR	T13964
RefSeq	NP_001123888.1 NP_034543.3 XP_006527630.1 XP_017173877.1 XP_017173878.1
UniGene	Mm.29854
ProteinModelPortal	Q9Z2V5
SMR	Q9Z2V5
BioGrid	200263
DIP	DIP-36461N
IntAct	Q9Z2V5
MINT	MINT-220628
STRING	10090.ENSMUSP00000033501
BindingDB	Q9Z2V5
ChEMBL	CHEMBL2878
iPTMnet	Q9Z2V5
PhosphoSitePlus	Q9Z2V5
EPD	Q9Z2V5
MaxQB	Q9Z2V5
PaxDb	Q9Z2V5
PeptideAtlas	Q9Z2V5
PRIDE	Q9Z2V5
Ensembl	ENSMUST00000033501 ENSMUST00000115642
GeneID	15185
KEGG	mmu:15185
UCSC	uc009snh.2
CTD	10013
MGI	MGI:1333752
eggNOG	KOG1343 COG0123
GeneTree	ENSGT00530000062809
HOGENOM	HOG000004769
HOVERGEN	HBG051894
InParanoid	Q9Z2V5
KO	K11407
OMA	QPHGFCI
OrthoDB	EOG091G0210
TreeFam	TF106173
BRENDA	3.5.1.98
Reactome	[www.reactome.org/content/detail/R-MMU-3371511 R-MMU-3371511] [www.reactome.org/content/detail/R-MMU-5617833 R-MMU-5617833]
PRO	PR:Q9Z2V5
Proteomes	UP000000589
Bgee	ENSMUSG00000031161
CleanEx	MM_HDAC6
ExpressionAtlas	Q9Z2V5
Genevisible	Q9Z2V5
GO	GO:0016235 GO:0030424 GO:0005901 GO:0044297 GO:0031252 GO:0005737 GO:0005829 GO:0030425 GO:0030286 GO:0000118 GO:0016234 GO:0005874 GO:0005875 GO:0043005 GO:0005654 GO:0005634 GO:0043204 GO:0048471 GO:0043234 GO:0003779 GO:0043014 GO:0008013 GO:0048487 GO:0001047 GO:0070840 GO:0004407 GO:0042826 GO:0051879 GO:0008017 GO:0051787 GO:0032041 GO:0031593 GO:0048156 GO:0042903 GO:0043130 GO:0031625 GO:0008270 GO:0070842 GO:0070301 GO:0071218 GO:0035967 GO:0048668 GO:0060997 GO:0016575 GO:0070846 GO:0006886 GO:0032418 GO:0051646 GO:0007026 GO:0043242 GO:0045861 GO:0061734 GO:0034983 GO:0070845 GO:0090035 GO:0010634 GO:1901300 GO:0098779 GO:0010870 GO:0009967 GO:0043241 GO:0006476 GO:0000209 GO:0006515 GO:0070201 GO:0045598 GO:0040029 GO:0016241 GO:0031647 GO:0010469 GO:0006355 GO:0070848 GO:0051788 GO:0010033 GO:0009636 GO:0006351 GO:0090042 GO:0006511 GO:0043162
Gene3D	3.30.40.10 3.40.800.20
InterPro	IPR000286 IPR023801 IPR037138 IPR023696 IPR013083 IPR001607
PANTHER	PTHR10625
Pfam	PF00850 PF02148
PRINTS	PR01270
SMART	SM00290
SUPFAM	SSF52768
PROSITE	PS50271

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0031648	protein destabilization	PMID:24882211^[1]	ECO:0000315			P		The organism is H. Sapiens and the protein is HDAC6 or (Histone deacetylase 6) Figure 3C shows that knockdown of HDAC6 lowers the half life of MSH2 (MutS protein homolog 2) and “As shown in Figure 3C, wild-type HDAC6 (F-HD6, lanes 17–20), not the catalytically dead mutant of HDAC6 (F-HD6DM, lanes 13–16) or the DAC1-deficient mutant of HDAC6 (F-HD6[439–1215], lanes 21–24), could reduce the half-life of MSH2. “ Thus HDAC6 destabilizes MSH2	complete CACAO 13035
	GO:0000209	protein polyubiquitination	PMID:24882211^[1]	ECO:0000315			P		The Organism is Mus Musculus and the protein is HDAC6. Figure 4B shows that knocking out HDAC6 stops polyubiquitination and reintroducing wild type HDAC6 restores polyubiquitination of protein MSH2	complete CACAO 13048
	GO:0016575	histone deacetylation	PMID:24882211^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Mouse; HDAC6 According to Figure 5C, HDAC6 is involved in core histone deacetylation.	complete CACAO 13049
	GO:0004407	histone deacetylase activity	PMID:24882211^[1]	ECO:0000315			F		Mouse; HDAC6 According to Figure 5C, HDAC6 is involved in core histone deacetylation.	complete CACAO 13050
enables	GO:0042903	tubulin deacetylase activity	PMID:19457097^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_in:(CL:0000540)	Seeded From UniProt	complete
enables	GO:0048156	tau protein binding	PMID:19457097^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P10637	F	occurs_in:(UBERON:0000955)	Seeded From UniProt	complete
NOT\|enables	GO:0047611	acetylspermidine deacetylase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBN7	F		Seeded From UniProt	complete
NOT\|involved_in	GO:0106048	spermidine deacetylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBN7	P		Seeded From UniProt	complete
NOT\|involved_in	GO:0106047	polyamine deacetylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBN7	P		Seeded From UniProt	complete
enables	GO:0042903	tubulin deacetylase activity	PMID:27430620^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q5EG47,UniProtKB:Q8BRK8	F		Seeded From UniProt	complete
involved_in	GO:0034983	peptidyl-lysine deacetylation	PMID:23962722^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:P10637)	Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	PMID:23962722^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P10637)	Seeded From UniProt	complete
involved_in	GO:0051646	mitochondrion localization	PMID:20457763^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0098779	positive regulation of mitophagy in response to mitochondrial depolarization	PMID:20457763^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9JK66	P		Seeded From UniProt	complete
involved_in	GO:0090042	tubulin deacetylation	PMID:19893491^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	PMID:16933150^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042903	tubulin deacetylase activity	PMID:19893491^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:16933150^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:16933150^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	PMID:19893491^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:19893491^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19893491^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901300	positive regulation of hydrogen peroxide-mediated programmed cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090042	tubulin deacetylation	PMID:17785525^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3776868	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090042	tubulin deacetylation	PMID:16810319^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3776868	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090042	tubulin deacetylation	PMID:12606581^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090042	tubulin deacetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090035	positive regulation of chaperone-mediated protein complex assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071218	cellular response to misfolded protein	PMID:17785525^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3776868	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070848	response to growth factor	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070846	Hsp90 deacetylation	PMID:17785525^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3776868	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070846	Hsp90 deacetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070845	polyubiquitinated misfolded protein transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070842	aggresome assembly	PMID:16810319^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99919	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070842	aggresome assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	P		Seeded From UniProt	complete
enables	GO:0070840	dynein complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070201	regulation of establishment of protein localization	PMID:22792322^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061734	parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060997	dendritic spine morphogenesis	PMID:24113571^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0010012)	Seeded From UniProt	complete
enables	GO:0051879	Hsp90 protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051788	response to misfolded protein	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	P		Seeded From UniProt	complete
enables	GO:0051787	misfolded protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048668	collateral sprouting	PMID:24113571^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0010012)	Seeded From UniProt	complete
enables	GO:0048487	beta-tubulin binding	PMID:12606581^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	C		Seeded From UniProt	complete
enables	GO:0048156	tau protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045861	negative regulation of proteolysis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045598	regulation of fat cell differentiation	PMID:23126280^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0044297	cell body	PMID:24113571^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0010012)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043242	negative regulation of protein complex disassembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	PMID:17785525^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3776868	P		Seeded From UniProt	complete
enables	GO:0043130	ubiquitin binding	PMID:16810319^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043014	alpha-tubulin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	F		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:24113571^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0010012)	Seeded From UniProt	complete
enables	GO:0042903	tubulin deacetylase activity	PMID:12606581^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042903	tubulin deacetylase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	F		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0040029	regulation of gene expression, epigenetic	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035967	cellular response to topologically incorrect protein	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034983	peptidyl-lysine deacetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	P		Seeded From UniProt	complete
enables	GO:0033558	protein deacetylase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:17785525^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P38532 UniProtKB:Q01853	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032984	protein-containing complex disassembly	PMID:17785525^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96238 MGI:MGI:99919	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032461	positive regulation of protein oligomerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032418	lysosome localization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031647	regulation of protein stability	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	F		Seeded From UniProt	complete
enables	GO:0031593	polyubiquitin modification-dependent protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	F		Seeded From UniProt	complete
part_of	GO:0031252	cell leading edge	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619981	C		Seeded From UniProt	complete
colocalizes_with	GO:0030286	dynein complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	C		Seeded From UniProt	complete
enables	GO:0019213	deacetylase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619981	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016575	histone deacetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016241	regulation of macroautophagy	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	P		Seeded From UniProt	complete
part_of	GO:0016235	aggresome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	C		Seeded From UniProt	complete
part_of	GO:0016234	inclusion body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010870	positive regulation of receptor biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010634	positive regulation of epithelial cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010469	regulation of signaling receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010033	response to organic substance	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009967	positive regulation of signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009636	response to toxic substance	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	P		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	F		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007026	negative regulation of microtubule depolymerization	PMID:12486003^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006886	intracellular protein transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:16810319^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99919	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:16810319^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3776868	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006476	protein deacetylation	PMID:12486003^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006476	protein deacetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	P		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	C		Seeded From UniProt	complete
colocalizes_with	GO:0005881	cytoplasmic microtubule	PMID:12606581^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005875	microtubule associated complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	C		Seeded From UniProt	complete
part_of	GO:0005874	microtubule	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619981	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11689694^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	C		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	PMID:9891014^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	PMID:11689694^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000209	protein polyubiquitination	PMID:11689694^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0000118	histone deacetylase complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN7	C		Seeded From UniProt	complete
involved_in	GO:0070932	histone H3 deacetylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0032041	P		Seeded From UniProt	complete
involved_in	GO:1901300	positive regulation of hydrogen peroxide-mediated programmed cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	P		Seeded From UniProt	complete
involved_in	GO:0090042	tubulin deacetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	P		Seeded From UniProt	complete
involved_in	GO:0090035	positive regulation of chaperone-mediated protein complex assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	P		Seeded From UniProt	complete
involved_in	GO:0070848	response to growth factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	P		Seeded From UniProt	complete
involved_in	GO:0070846	Hsp90 deacetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	P		Seeded From UniProt	complete
involved_in	GO:0070845	polyubiquitinated misfolded protein transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	P		Seeded From UniProt	complete
involved_in	GO:0070842	aggresome assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	P		Seeded From UniProt	complete
enables	GO:0070840	dynein complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	F		Seeded From UniProt	complete
involved_in	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	P		Seeded From UniProt	complete
involved_in	GO:0061734	parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	P		Seeded From UniProt	complete
enables	GO:0051879	Hsp90 protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	F		Seeded From UniProt	complete
involved_in	GO:0051788	response to misfolded protein	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	C		Seeded From UniProt	complete
enables	GO:0048156	tau protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	F		Seeded From UniProt	complete
involved_in	GO:0045861	negative regulation of proteolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	P		Seeded From UniProt	complete
involved_in	GO:0043242	negative regulation of protein complex disassembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	P		Seeded From UniProt	complete
enables	GO:0043014	alpha-tubulin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	F		Seeded From UniProt	complete
enables	GO:0042903	tubulin deacetylase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	F		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	F		Seeded From UniProt	complete
involved_in	GO:0040029	regulation of gene expression, epigenetic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	P		Seeded From UniProt	complete
involved_in	GO:0035967	cellular response to topologically incorrect protein	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	P		Seeded From UniProt	complete
involved_in	GO:0034983	peptidyl-lysine deacetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	P		Seeded From UniProt	complete
enables	GO:0033558	protein deacetylase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	F		Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	P		Seeded From UniProt	complete
involved_in	GO:0032461	positive regulation of protein oligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	P		Seeded From UniProt	complete
involved_in	GO:0032418	lysosome localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	P		Seeded From UniProt	complete
involved_in	GO:0031647	regulation of protein stability	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	F		Seeded From UniProt	complete
enables	GO:0031593	polyubiquitin modification-dependent protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	F		Seeded From UniProt	complete
part_of	GO:0031252	cell leading edge	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	C		Seeded From UniProt	complete
part_of	GO:0030286	dynein complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	C		Seeded From UniProt	complete
involved_in	GO:0016575	histone deacetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	P		Seeded From UniProt	complete
involved_in	GO:0016241	regulation of macroautophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	P		Seeded From UniProt	complete
part_of	GO:0016235	aggresome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	C		Seeded From UniProt	complete
part_of	GO:0016234	inclusion body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	C		Seeded From UniProt	complete
involved_in	GO:0010870	positive regulation of receptor biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	P		Seeded From UniProt	complete
involved_in	GO:0010634	positive regulation of epithelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	P		Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	P		Seeded From UniProt	complete
involved_in	GO:0009967	positive regulation of signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	P		Seeded From UniProt	complete
involved_in	GO:0009636	response to toxic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	P		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	F		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	F		Seeded From UniProt	complete
involved_in	GO:0006886	intracellular protein transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	P		Seeded From UniProt	complete
involved_in	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	P		Seeded From UniProt	complete
involved_in	GO:0006476	protein deacetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	P		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	C		Seeded From UniProt	complete
part_of	GO:0005875	microtubule associated complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	C		Seeded From UniProt	complete
part_of	GO:0005874	microtubule	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	C		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	F		Seeded From UniProt	complete
part_of	GO:0000118	histone deacetylase complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN7 ensembl:ENSP00000334061	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A024QZ26 ensembl:ENSP00000334061	C		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001607	F		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.5.1.98	F		Seeded From UniProt	complete
enables	GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.5.1.98	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12486003^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0009	F		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0283	C		Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0197	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0279	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Zhang, M et al. (2014) HDAC6 deacetylates and ubiquitinates MSH2 to maintain proper levels of MutSα. Mol. Cell 55 31-46 PubMed GONUTS page
↑ ^2.0 ^2.1 Perez, M et al. (2009) Tau--an inhibitor of deacetylase HDAC6 function. J. Neurochem. 109 1756-66 PubMed GONUTS page
↑ Mahboubi, H et al. (2016) AMP Kinase Activation Alters Oxidant-Induced Stress Granule Assembly by Modulating Cell Signaling and Microtubule Organization. Mol. Pharmacol. 90 460-8 PubMed GONUTS page
↑ ^4.0 ^4.1 Cook, C et al. (2014) Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance. Hum. Mol. Genet. 23 104-16 PubMed GONUTS page
↑ ^5.0 ^5.1 Lee, JY et al. (2010) Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy. J. Cell Biol. 189 671-9 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Wickström, SA et al. (2010) CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin. EMBO J. 29 131-44 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Southwood, CM et al. (2007) Microtubule deacetylases, SirT2 and HDAC6, in the nervous system. Neurochem. Res. 32 187-95 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Boyault, C et al. (2007) HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. Genes Dev. 21 2172-81 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 Boyault, C et al. (2006) HDAC6-p97/VCP controlled polyubiquitin chain turnover. EMBO J. 25 3357-66 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Zhang, Y et al. (2003) HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo. EMBO J. 22 1168-79 PubMed GONUTS page
↑ Fusco, C et al. (2012) The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome. PLoS ONE 7 e40440 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Ageta-Ishihara, N et al. (2013) Septins promote dendrite and axon development by negatively regulating microtubule stability via HDAC6-mediated deacetylation. Nat Commun 4 2532 PubMed GONUTS page
↑ Yang, W et al. (2013) Regulation of adipogenesis by cytoskeleton remodelling is facilitated by acetyltransferase MEC-17-dependent acetylation of α-tubulin. Biochem. J. 449 605-12 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Matsuyama, A et al. (2002) In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation. EMBO J. 21 6820-31 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Seigneurin-Berny, D et al. (2001) Identification of components of the murine histone deacetylase 6 complex: link between acetylation and ubiquitination signaling pathways. Mol. Cell. Biol. 21 8035-44 PubMed GONUTS page
↑ Verdel, A & Khochbin, S (1999) Identification of a new family of higher eukaryotic histone deacetylases. Coordinate expression of differentiation-dependent chromatin modifiers. J. Biol. Chem. 274 2440-5 PubMed GONUTS page

[PMID:24882211-1] 1.0 ^1.1 ^1.2 ^1.3 Zhang, M et al. (2014) HDAC6 deacetylates and ubiquitinates MSH2 to maintain proper levels of MutSα. Mol. Cell 55 31-46 PubMed GONUTS page

[PMID:19457097-2] 2.0 ^2.1 Perez, M et al. (2009) Tau--an inhibitor of deacetylase HDAC6 function. J. Neurochem. 109 1756-66 PubMed GONUTS page

[PMID:27430620-3] Mahboubi, H et al. (2016) AMP Kinase Activation Alters Oxidant-Induced Stress Granule Assembly by Modulating Cell Signaling and Microtubule Organization. Mol. Pharmacol. 90 460-8 PubMed GONUTS page

[PMID:23962722-4] 4.0 ^4.1 Cook, C et al. (2014) Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance. Hum. Mol. Genet. 23 104-16 PubMed GONUTS page

[PMID:20457763-5] 5.0 ^5.1 Lee, JY et al. (2010) Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy. J. Cell Biol. 189 671-9 PubMed GONUTS page

[PMID:19893491-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Wickström, SA et al. (2010) CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin. EMBO J. 29 131-44 PubMed GONUTS page

[PMID:16933150-7] 7.0 ^7.1 ^7.2 Southwood, CM et al. (2007) Microtubule deacetylases, SirT2 and HDAC6, in the nervous system. Neurochem. Res. 32 187-95 PubMed GONUTS page

[PMID:17785525-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Boyault, C et al. (2007) HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. Genes Dev. 21 2172-81 PubMed GONUTS page

[PMID:16810319-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 Boyault, C et al. (2006) HDAC6-p97/VCP controlled polyubiquitin chain turnover. EMBO J. 25 3357-66 PubMed GONUTS page

[PMID:12606581-10] 10.0 ^10.1 ^10.2 ^10.3 Zhang, Y et al. (2003) HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo. EMBO J. 22 1168-79 PubMed GONUTS page

[PMID:22792322-11] Fusco, C et al. (2012) The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome. PLoS ONE 7 e40440 PubMed GONUTS page

[PMID:24113571-12] 12.0 ^12.1 ^12.2 ^12.3 Ageta-Ishihara, N et al. (2013) Septins promote dendrite and axon development by negatively regulating microtubule stability via HDAC6-mediated deacetylation. Nat Commun 4 2532 PubMed GONUTS page

[PMID:23126280-13] Yang, W et al. (2013) Regulation of adipogenesis by cytoskeleton remodelling is facilitated by acetyltransferase MEC-17-dependent acetylation of α-tubulin. Biochem. J. 449 605-12 PubMed GONUTS page

[PMID:12486003-14] 14.0 ^14.1 ^14.2 Matsuyama, A et al. (2002) In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation. EMBO J. 21 6820-31 PubMed GONUTS page

[PMID:11689694-15] 15.0 ^15.1 ^15.2 Seigneurin-Berny, D et al. (2001) Identification of components of the murine histone deacetylase 6 complex: link between acetylation and ubiquitination signaling pathways. Mol. Cell. Biol. 21 8035-44 PubMed GONUTS page

[PMID:9891014-16] Verdel, A & Khochbin, S (1999) Identification of a new family of higher eukaryotic histone deacetylases. Coordinate expression of differentiation-dependent chromatin modifiers. J. Biol. Chem. 274 2440-5 PubMed GONUTS page

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