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MOUSE:GLP1R
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Glp1r | |
| Protein Name(s) | Glucagon-like peptide 1 receptor
GLP-1 receptor GLP-1-R GLP-1R | |
| External Links | ||
| UniProt | O35659 | |
| EMBL | AJ001692 DQ093397 AY293742 AC165951 BC139464 BC139466 | |
| CCDS | CCDS37542.1 | |
| RefSeq | NP_067307.2 | |
| UniGene | Mm.390969 | |
| ProteinModelPortal | O35659 | |
| SMR | O35659 | |
| ChEMBL | CHEMBL1075290 | |
| GuidetoPHARMACOLOGY | 249 | |
| PhosphoSite | O35659 | |
| PRIDE | O35659 | |
| Ensembl | ENSMUST00000114574 | |
| GeneID | 14652 | |
| KEGG | mmu:14652 | |
| UCSC | uc008bud.1 | |
| CTD | 2740 | |
| MGI | MGI:99571 | |
| eggNOG | NOG263329 | |
| GeneTree | ENSGT00760000118800 | |
| HOGENOM | HOG000008250 | |
| HOVERGEN | HBG008318 | |
| InParanoid | O35659 | |
| KO | K04581 | |
| OMA | CIVVSKL | |
| OrthoDB | EOG7TF78W | |
| TreeFam | TF315710 | |
| Reactome | REACT_231304 REACT_242871 REACT_248547 | |
| NextBio | 286510 | |
| PRO | PR:O35659 | |
| Proteomes | UP000000589 | |
| CleanEx | MM_GLP1R | |
| ExpressionAtlas | O35659 | |
| Genevestigator | O35659 | |
| GO | GO:0016021 GO:0005886 GO:0004967 GO:0004872 GO:0019933 GO:0007611 GO:0007218 GO:0007204 GO:0008016 GO:0006950 | |
| InterPro | IPR017981 IPR001879 IPR003290 IPR003292 IPR000832 IPR017983 | |
| Pfam | PF00002 PF02793 | |
| PRINTS | PR01353 PR01355 PR00249 | |
| SMART | SM00008 | |
| PROSITE | PS00649 PS00650 PS50227 PS50261 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0045777 |
positive regulation of blood pressure |
ECO:0000314 |
P |
Figure 1 |
complete | |||||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0044508 |
glucagon-like peptide 1 receptor activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007189 |
adenylate cyclase-activating G protein-coupled receptor signaling pathway |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045777 |
positive regulation of blood pressure |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008016 |
regulation of heart contraction |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007611 |
learning or memory |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1990911 |
response to psychosocial stress |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045777 |
positive regulation of blood pressure |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:99571 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0017046 |
peptide hormone binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95710 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008528 |
G protein-coupled peptide receptor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000244369 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0051924 |
regulation of calcium ion transport |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2703 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0051209 |
release of sequestered calcium ion into cytosol |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2703 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0046879 |
hormone secretion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2703 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2703 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0045823 |
positive regulation of heart contraction |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2703 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0045777 |
positive regulation of blood pressure |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2703 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0045597 |
positive regulation of cell differentiation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2703 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0044508 |
glucagon-like peptide 1 receptor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0043524 |
negative regulation of neuron apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2703 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2703 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0032024 |
positive regulation of insulin secretion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2703 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0030073 |
insulin secretion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2703 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0019933 |
cAMP-mediated signaling |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0019933 |
cAMP-mediated signaling |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2703 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0017046 |
peptide hormone binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2703 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0009749 |
response to glucose |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2703 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008528 |
G protein-coupled peptide receptor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2703 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0008306 |
associative learning |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2703 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2703 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0007631 |
feeding behavior |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2703 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0007613 |
memory |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2703 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0007611 |
learning or memory |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2703 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0007204 |
positive regulation of cytosolic calcium ion concentration |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007189 |
adenylate cyclase-activating G protein-coupled receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007189 |
adenylate cyclase-activating G protein-coupled receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2703 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2703 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2703 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0001653 |
peptide receptor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2703 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071377 |
cellular response to glucagon stimulus |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004967 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0044508 |
glucagon-like peptide 1 receptor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P43220 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0019933 |
cAMP-mediated signaling |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P43220 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007204 |
positive regulation of cytosolic calcium ion concentration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P43220 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007189 |
adenylate cyclase-activating G protein-coupled receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P43220 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P43220 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004888 |
transmembrane signaling receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000832 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004967 |
glucagon receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007166 |
cell surface receptor signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000832 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008528 |
G protein-coupled peptide receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001879 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0038023 |
signaling receptor activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007218 |
neuropeptide signaling pathway |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Cabou, C et al. (2011) Brain GLP-1 signaling regulates femoral artery blood flow and insulin sensitivity through hypothalamic PKC-δ. Diabetes 60 2245-56 PubMed GONUTS page
- ↑ Gros, R et al. (2003) Cardiac function in mice lacking the glucagon-like peptide-1 receptor. Endocrinology 144 2242-52 PubMed GONUTS page
- ↑ During, MJ et al. (2003) Glucagon-like peptide-1 receptor is involved in learning and neuroprotection. Nat. Med. 9 1173-9 PubMed GONUTS page
- ↑ MacLusky, NJ et al. (2000) Neuroendocrine function and response to stress in mice with complete disruption of glucagon-like peptide-1 receptor signaling. Endocrinology 141 752-62 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 6.0 6.1 Seeley, RJ et al. (2000) Targeted gene disruption in endocrine research--the case of glucagon-like peptide-1 and neuroendocrine function. Endocrinology 141 473-5 PubMed GONUTS page
a
c
g
i
m
n
p
- GO:0017046 ! peptide hormone binding
- GO:0001653 ! peptide receptor activity
- GO:0005886 ! plasma membrane
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:0045823 ! positive regulation of heart contraction
- GO:0045597 ! positive regulation of cell differentiation
- GO:0045777 ! positive regulation of blood pressure
- GO:0032024 ! positive regulation of insulin secretion
- GO:0008284 ! positive regulation of cell population proliferation
- GO:0007204 ! positive regulation of cytosolic calcium ion concentration
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