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PMID:21810595
| Citation |
Cabou, C, Vachoux, C, Campistron, G, Drucker, DJ and Burcelin, R (2011) Brain GLP-1 signaling regulates femoral artery blood flow and insulin sensitivity through hypothalamic PKC-δ. Diabetes 60:2245-56 |
|---|---|
| Abstract |
Glucagon-like peptide 1 (GLP-1) is a gut-brain hormone that regulates food intake, energy metabolism, and cardiovascular functions. In the brain, through a currently unknown molecular mechanism, it simultaneously reduces femoral artery blood flow and muscle glucose uptake. By analogy to pancreatic β-cells where GLP-1 activates protein kinase C (PKC) to stimulate insulin secretion, we postulated that PKC enzymes would be molecular targets of brain GLP-1 signaling that regulate metabolic and vascular function. |
| Links |
PubMed PMC3161335 Online version:10.2337/db11-0464 |
| Keywords |
Animals; Brain/drug effects; Brain/metabolism; Femoral Artery/drug effects; Femoral Artery/physiology; Glucagon-Like Peptide 1/metabolism; Hypoglycemic Agents/pharmacology; Hypothalamus/drug effects; Hypothalamus/metabolism; Insulin/metabolism; Male; Mice; Mice, Knockout; Peptides/pharmacology; Protein Kinase C-delta/metabolism; Receptors, Glucagon/agonists; Receptors, Glucagon/genetics; Regional Blood Flow/drug effects; Regional Blood Flow/physiology; Signal Transduction/drug effects; Signal Transduction/physiology; Venoms/pharmacology |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0045777: positive regulation of blood pressure |
ECO:0000314: |
P |
Figure 1 |
complete | ||||
|
involved_in |
GO:0045777: positive regulation of blood pressure |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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