GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:10650957
| Citation |
MacLusky, NJ, Cook, S, Scrocchi, L, Shin, J, Kim, J, Vaccarino, F, Asa, SL and Drucker, DJ (2000) Neuroendocrine function and response to stress in mice with complete disruption of glucagon-like peptide-1 receptor signaling. Endocrinology 141:752-62 |
|---|---|
| Abstract |
Glucagon-like peptide-1 (GLP-1), a potent regulator of glucose homeostasis, is also produced in the central nervous system, where GLP-1 has been implicated in the neuroendocrine control of hypothalamic-pituitary function, food intake, and the response to stress. The finding that intracerebroventricular GLP-1 stimulates LH, TSH, corticosterone, and vasopressin secretion in rats prompted us to assess the neuroendocrine consequences of disrupting GLP-1 signaling in mice in vivo. Male GLP-1 receptor knockout (GLP-1R-/-) mice exhibit reduced gonadal weights, and females exhibit a slight delay in the onset of puberty; however, male and female GLP-1R-/- animals reproduce successfully and respond appropriately to fluid restriction. Although adrenal weights are reduced in GLP-1R-/- mice, hypothalamic CRH gene expression and circulating levels of corticosterone, thyroid hormone, testosterone, estradiol, and progesterone are normal in the absence of GLP-1R-/- signaling. Intriguingly, GLP-1R-/- mice exhibit paradoxically increased corticosterone responses to stress as well as abnormal responses to acoustic startle that are corrected by glucocorticoid treatment. These findings suggest that although GLP-1R signaling is not essential for development and basal function of the murine hypothalamic-pituitary-adrenal axis, abrogation of GLP-1 signaling is associated with impairment of the behavioral and neuroendocrine responses to stress. |
| Links | |
| Keywords |
Acoustic Stimulation; Adrenal Glands/growth & development; Aging/physiology; Animals; Body Weight; Corticosterone/blood; Corticotropin-Releasing Hormone/genetics; Estradiol/blood; Estrus; Female; Hypothalamus/metabolism; Male; Maze Learning/physiology; Mice; Mice, Knockout; Ovary/growth & development; Pituitary Gland/growth & development; Progesterone/blood; Rats; Receptors, Glucagon/deficiency; Receptors, Glucagon/genetics; Receptors, Glucagon/physiology; Sexual Maturation/physiology; Startle Reaction/physiology; Stress, Physiological/blood; Stress, Physiological/physiopathology; Testis/growth & development; Testosterone/blood; Thyroid Hormones/blood |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
