MOUSE:FURIN

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Furin (synonyms: Fur, Pcsk3)
Protein Name(s)	Furin Dibasic-processing enzyme Paired basic amino acid residue-cleaving enzyme PACE Prohormone convertase 3
External Links
UniProt	P23188
EMBL	X54056 L26489 CH466543 BC048234
CCDS	CCDS21397.1
PIR	A23679
RefSeq	NP_001074923.1 NP_035176.1
UniGene	Mm.5241
PDB	1P8J
PDBsum	1P8J
ProteinModelPortal	P23188
SMR	P23188
STRING	10090.ENSMUSP00000102985
MEROPS	S08.071
PhosphoSite	P23188
EPD	P23188
MaxQB	P23188
PaxDb	P23188
PRIDE	P23188
Ensembl	ENSMUST00000107362 ENSMUST00000120753 ENSMUST00000122232
GeneID	18550
KEGG	mmu:18550
UCSC	uc009iau.1
CTD	5045
MGI	MGI:97513
eggNOG	KOG3525 COG1404 COG4935
GeneTree	ENSGT00750000117358
HOGENOM	HOG000192536
HOVERGEN	HBG008705
InParanoid	P23188
KO	K01349
OMA	ESIGCKT
OrthoDB	EOG7BW0JD
TreeFam	TF314277
Reactome	R-MMU-1442490 R-MMU-1566948 R-MMU-1592389 R-MMU-159782 R-MMU-167060 R-MMU-186797 R-MMU-1912420 R-MMU-2173789
EvolutionaryTrace	P23188
NextBio	294346
PMAP-CutDB	Q6GTN6
PRO	PR:P23188
Proteomes	UP000000589
Bgee	P23188
CleanEx	MM_FURIN
ExpressionAtlas	P23188
Genevisible	P23188
GO	GO:0009986 GO:0005769 GO:0005783 GO:0005788 GO:0005789 GO:0070062 GO:0005576 GO:0005615 GO:0031985 GO:0016021 GO:0016020 GO:0045121 GO:0005886 GO:0005802 GO:0030140 GO:0012510 GO:0004175 GO:0046872 GO:0048406 GO:0008233 GO:0042277 GO:0002020 GO:0004252 GO:0004867 GO:0007568 GO:0008283 GO:0010951 GO:0032804 GO:0032911 GO:0032902 GO:0043043 GO:0016486 GO:0030335 GO:0030511 GO:0016485 GO:0052548 GO:0045714 GO:0042176 GO:0009966 GO:0032940 GO:0006465 GO:0019058
Gene3D	2.60.120.260 3.30.70.850 3.40.50.200
InterPro	IPR006212 IPR008979 IPR009030 IPR000209 IPR023827 IPR022398 IPR023828 IPR015500 IPR009020 IPR002884 IPR032815
PANTHER	PTHR10795
Pfam	PF01483 PF00082 PF16470
PRINTS	PR00723
SMART	SM00261
SUPFAM	SSF49785 SSF52743 SSF54897 SSF57184
PROSITE	PS00136 PS00137 PS00138

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0001825	blastocyst formation	PMID:26416966^[1]	ECO:0000316		UniProtKB:Q61139	P		In figure 1b, blastocyst is not properly forming in the furin and PC7 double mutant.	complete CACAO 11724
involved_in	GO:1901394	positive regulation of transforming growth factor beta1 activation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P09958	P		Seeded From UniProt	complete
enables	GO:0004252	serine-type endopeptidase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P09958	F		Seeded From UniProt	complete
part_of	GO:0030173	integral component of Golgi membrane	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000082856 UniProtKB:Q16549	C		Seeded From UniProt	complete
involved_in	GO:0016486	peptide hormone processing	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97515 PANTHER:PTN000082901 RGD:3246 UniProtKB:P09958 UniProtKB:P29122 UniProtKB:Q92824 WB:WBGene00002232	P		Seeded From UniProt	complete
involved_in	GO:0016485	protein processing	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023179 MGI:MGI:102897 MGI:MGI:97511 MGI:MGI:97512 MGI:MGI:97513 MGI:MGI:97515 PANTHER:PTN002451026 PomBase:SPAC22E12.09c RGD:3246 RGD:3272 RGD:3273 RGD:3274 UniProtKB:A0A1D8PEG3 UniProtKB:G5EB75 UniProtKB:P09958 UniProtKB:P16519 UniProtKB:P29122 UniProtKB:Q16549 UniProtKB:Q6UW60 UniProtKB:Q92824 WB:WBGene00000088 WB:WBGene00001172 WB:WBGene00002232	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004509 MGI:MGI:97514 PANTHER:PTN002451026 PomBase:SPAC22E12.09c RGD:3274 RGD:620326 UniProtKB:O05458 UniProtKB:O05461 UniProtKB:O53695 UniProtKB:P09958 UniProtKB:P16519 UniProtKB:Q16549 UniProtKB:Q8IHZ5	C		Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000082856 RGD:3272 RGD:620326 SGD:S000005182 UniProtKB:P09958	C		Seeded From UniProt	complete
enables	GO:0004252	serine-type endopeptidase activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004509 FB:FBgn0004598 MGI:MGI:97511 MGI:MGI:97512 MGI:MGI:97513 MGI:MGI:97515 PANTHER:PTN002451026 PomBase:SPAC22E12.09c RGD:3272 RGD:3273 RGD:3274 SGD:S000005182 UniProtKB:A0A1D8PEG3 UniProtKB:G5EB75 UniProtKB:O05461 UniProtKB:P09958 UniProtKB:P16519 UniProtKB:P29122 UniProtKB:Q92824 WB:WBGene00000088 WB:WBGene00001172 WB:WBGene00002232	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901394	positive regulation of transforming growth factor beta1 activation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09958	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090472	dibasic protein processing	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09958	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0052548	regulation of endopeptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09958	P		Seeded From UniProt	complete
enables	GO:0048406	nerve growth factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09958	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045714	regulation of low-density lipoprotein particle receptor biosynthetic process	PMID:21147780^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3700008	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09958	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043043	peptide biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09958	P		Seeded From UniProt	complete
enables	GO:0042277	peptide binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09958	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042176	regulation of protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09958	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032940	secretion by cell	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09958	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032911	negative regulation of transforming growth factor beta1 production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09958	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032902	nerve growth factor production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09958	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032804	negative regulation of low-density lipoprotein particle receptor catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09958	P		Seeded From UniProt	complete
part_of	GO:0031985	Golgi cisterna	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3274	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031638	zymogen activation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09958	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3274	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030335	positive regulation of cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3274	P		Seeded From UniProt	complete
part_of	GO:0030140	trans-Golgi network transport vesicle	PMID:15078902^[4]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09958	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016486	peptide hormone processing	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09958	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016485	protein processing	PMID:23918928^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3700008	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016485	protein processing	PMID:21147780^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3700008	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016485	protein processing	PMID:20530870^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	has_participant:(MGI:MGI:97513)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016485	protein processing	PMID:15606899^[7]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09958	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016485	protein processing	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09958	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016485	protein processing	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3274	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09958	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009966	regulation of signal transduction	PMID:17936261^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	PMID:15606899^[7]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09958	F		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	PMID:15082773^[9]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09958	F		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09958	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006465	signal peptide processing	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09958	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3274	C		Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09958	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3274	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09958	C		Seeded From UniProt	complete
enables	GO:0004867	serine-type endopeptidase inhibitor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09958	F		Seeded From UniProt	complete
enables	GO:0004252	serine-type endopeptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09958	F		Seeded From UniProt	complete
enables	GO:0004252	serine-type endopeptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3274	F		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09958	F		Seeded From UniProt	complete
enables	GO:0002020	protease binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09958	F		Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09958	C		Seeded From UniProt	complete
involved_in	GO:0010951	negative regulation of endopeptidase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004867	P		Seeded From UniProt	complete
involved_in	GO:0010951	negative regulation of endopeptidase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004867	P		Seeded From UniProt	complete
involved_in	GO:1901394	positive regulation of transforming growth factor beta1 activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	P		Seeded From UniProt	complete
involved_in	GO:0090472	dibasic protein processing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	P		Seeded From UniProt	complete
involved_in	GO:0052548	regulation of endopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	P		Seeded From UniProt	complete
enables	GO:0048406	nerve growth factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	F		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	C		Seeded From UniProt	complete
involved_in	GO:0043043	peptide biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	P		Seeded From UniProt	complete
enables	GO:0042277	peptide binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	F		Seeded From UniProt	complete
involved_in	GO:0042176	regulation of protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	P		Seeded From UniProt	complete
involved_in	GO:0032940	secretion by cell	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	P		Seeded From UniProt	complete
involved_in	GO:0032911	negative regulation of transforming growth factor beta1 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	P		Seeded From UniProt	complete
involved_in	GO:0032902	nerve growth factor production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	P		Seeded From UniProt	complete
involved_in	GO:0032804	negative regulation of low-density lipoprotein particle receptor catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	P		Seeded From UniProt	complete
involved_in	GO:0031638	zymogen activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	P		Seeded From UniProt	complete
part_of	GO:0030140	trans-Golgi network transport vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	C		Seeded From UniProt	complete
involved_in	GO:0019058	viral life cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	P		Seeded From UniProt	complete
involved_in	GO:0016486	peptide hormone processing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	P		Seeded From UniProt	complete
involved_in	GO:0016485	protein processing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	C		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	F		Seeded From UniProt	complete
involved_in	GO:0006465	signal peptide processing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	P		Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	C		Seeded From UniProt	complete
enables	GO:0004867	serine-type endopeptidase inhibitor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	F		Seeded From UniProt	complete
enables	GO:0004252	serine-type endopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	F		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	F		Seeded From UniProt	complete
enables	GO:0002020	protease binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	F		Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	C		Seeded From UniProt	complete
enables	GO:0004252	serine-type endopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000209 InterPro:IPR002884 InterPro:IPR036852	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000209 InterPro:IPR002884 InterPro:IPR036852	P		Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	Reactome:R-MMU-181788	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-MMU-2484926 Reactome:R-MMU-1181148	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004252	serine-type endopeptidase activity	Reactome:R-MMU-2484926	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:12360192^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0012510	trans-Golgi network transport vesicle membrane	PMID:12360192^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:12360192^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0008236	serine-type peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0720	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333 UniProtKB-SubCell:SL-0132	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0010008	endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0100	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Bessonnard, S et al. (2015) PC7 and the related proteases Furin and Pace4 regulate E-cadherin function during blastocyst formation. J. Cell Biol. 210 1185-97 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^3.0 ^3.1 Essalmani, R et al. (2011) In vivo evidence that furin from hepatocytes inactivates PCSK9. J. Biol. Chem. 286 4257-63 PubMed GONUTS page
↑ Seaman, MN (2004) Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer. J. Cell Biol. 165 111-22 PubMed GONUTS page
↑ Essalmani, R et al. (2013) Furin is the primary in vivo convertase of angiopoietin-like 3 and endothelial lipase in hepatocytes. J. Biol. Chem. 288 26410-8 PubMed GONUTS page
↑ Yang, T et al. (2010) E-selectin ligand-1 regulates growth plate homeostasis in mice by inhibiting the intracellular processing and secretion of mature TGF-beta. J. Clin. Invest. 120 2474-85 PubMed GONUTS page
↑ ^7.0 ^7.1 Wickham, L et al. (2005) Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin. J. Neurochem. 92 93-102 PubMed GONUTS page
↑ Andersson, O et al. (2007) Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development. Dev. Biol. 311 500-11 PubMed GONUTS page
↑ Marschang, P et al. (2004) Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1. Mol. Cell. Biol. 24 3782-93 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Thomas, G (2002) Furin at the cutting edge: from protein traffic to embryogenesis and disease. Nat. Rev. Mol. Cell Biol. 3 753-66 PubMed GONUTS page

[PMID:26416966-1] Bessonnard, S et al. (2015) PC7 and the related proteases Furin and Pace4 regulate E-cadherin function during blastocyst formation. J. Cell Biol. 210 1185-97 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21147780-3] 3.0 ^3.1 Essalmani, R et al. (2011) In vivo evidence that furin from hepatocytes inactivates PCSK9. J. Biol. Chem. 286 4257-63 PubMed GONUTS page

[PMID:15078902-4] Seaman, MN (2004) Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer. J. Cell Biol. 165 111-22 PubMed GONUTS page

[PMID:23918928-5] Essalmani, R et al. (2013) Furin is the primary in vivo convertase of angiopoietin-like 3 and endothelial lipase in hepatocytes. J. Biol. Chem. 288 26410-8 PubMed GONUTS page

[PMID:20530870-6] Yang, T et al. (2010) E-selectin ligand-1 regulates growth plate homeostasis in mice by inhibiting the intracellular processing and secretion of mature TGF-beta. J. Clin. Invest. 120 2474-85 PubMed GONUTS page

[PMID:15606899-7] 7.0 ^7.1 Wickham, L et al. (2005) Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin. J. Neurochem. 92 93-102 PubMed GONUTS page

[PMID:17936261-8] Andersson, O et al. (2007) Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development. Dev. Biol. 311 500-11 PubMed GONUTS page

[PMID:15082773-9] Marschang, P et al. (2004) Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1. Mol. Cell. Biol. 24 3782-93 PubMed GONUTS page

[PMID:12360192-10] 10.0 ^10.1 ^10.2 Thomas, G (2002) Furin at the cutting edge: from protein traffic to embryogenesis and disease. Nat. Rev. Mol. Cell Biol. 3 753-66 PubMed GONUTS page

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MOUSE:FURIN

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