GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PMID:12360192

From GONUTS
Jump to: navigation, search
Citation

Thomas, G (2002) Furin at the cutting edge: from protein traffic to embryogenesis and disease. Nat. Rev. Mol. Cell Biol. 3:753-66

Abstract

Furin catalyses a simple biochemical reaction--the proteolytic maturation of proprotein substrates in the secretory pathway. But the simplicity of this reaction belies furin's broad and important roles in homeostasis, as well as in diseases ranging from Alzheimer's disease and cancer to anthrax and Ebola fever. This review summarizes various features of furin--its structural and enzymatic properties, intracellular localization, trafficking, substrates, and roles in vivo.

Links

PubMed PMC1964754 Online version:10.1038/nrm934

Keywords

Amino Acid Sequence; Disease; Embryonic and Fetal Development/physiology; Endocytosis; Furin; Golgi Apparatus/enzymology; Homeostasis; Humans; Models, Biological; Molecular Sequence Data; Molecular Structure; Neoplasm Metastasis; Signal Transduction; Subtilisins/chemistry; Subtilisins/genetics; Subtilisins/physiology; Transforming Growth Factor beta/physiology; Tumor Necrosis Factor-alpha/physiology

Significance

Annotations

Gene product Qualifier GO ID GO term name Evidence Code with/from Aspect Notes Status


See also

References

See Help:References for how to manage references in GONUTS.