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MOUSE:FTO

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Fto (synonyms: Kiaa1752)
Protein Name(s) Alpha-ketoglutarate-dependent dioxygenase FTO

Fat mass and obesity-associated protein Protein fatso

External Links
UniProt Q8BGW1
EMBL AJ237917
AK129437
AK036677
AK040866
AK045465
AK049502
AK088881
AK161060
BC022222
BC057008
CCDS CCDS22521.1
RefSeq NP_036066.2
UniGene Mm.4375
ProteinModelPortal Q8BGW1
SMR Q8BGW1
BioGrid 204941
PhosphoSite Q8BGW1
MaxQB Q8BGW1
PaxDb Q8BGW1
PRIDE Q8BGW1
Ensembl ENSMUST00000069718
GeneID 26383
KEGG mmu:26383
UCSC uc009msq.2
uc009msr.2
uc009mss.2
uc009mst.2
CTD 79068
MGI MGI:1347093
eggNOG NOG45792
GeneTree ENSGT00390000017730
HOVERGEN HBG101847
InParanoid Q8BGW1
OMA AVYNYSC
OrthoDB EOG7CK36T
PhylomeDB Q8BGW1
TreeFam TF333296
ChiTaRS Fto
NextBio 304305
PRO PR:Q8BGW1
Proteomes UP000000589
Bgee Q8BGW1
CleanEx MM_FTO
ExpressionAtlas Q8BGW1
Genevestigator Q8BGW1
GO GO:0016607
GO:0005634
GO:0043734
GO:0008198
GO:0035516
GO:0035515
GO:0060612
GO:0006307
GO:0080111
GO:0070989
GO:0035552
GO:0035553
GO:0010883
GO:0040014
GO:0044065
GO:0070350
GO:0042245
GO:0001659
InterPro IPR024366
IPR024367
Pfam PF12934
PF12933

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005737

cytoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9C0B1

C

Seeded From UniProt

complete

enables

GO:1990984

tRNA demethylase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9C0B1

F

Seeded From UniProt

complete

involved_in

GO:0061157

mRNA destabilization

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9C0B1

P

Seeded From UniProt

complete

enables

GO:1990931

RNA N6-methyladenosine dioxygenase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9C0B1

F

Seeded From UniProt

complete

involved_in

GO:0080111

DNA demethylation

PMID:17991826[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0080111

DNA demethylation

PMID:18775698[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070989

oxidative demethylation

PMID:18775698[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042245

RNA repair

PMID:18775698[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035553

oxidative single-stranded RNA demethylation

PMID:18775698[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035552

oxidative single-stranded DNA demethylation

PMID:18775698[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0035516

oxidative DNA demethylase activity

PMID:18775698[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0035515

oxidative RNA demethylase activity

PMID:18775698[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006307

DNA dealkylation involved in DNA repair

PMID:18775698[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:17991826[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0070350

regulation of white fat cell proliferation

PMID:19234441[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060612

adipose tissue development

PMID:19234441[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0044065

regulation of respiratory system process

PMID:19234441[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0043734

DNA-N1-methyladenine dioxygenase activity

PMID:17991826[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0040014

regulation of multicellular organism growth

PMID:19234441[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0016607

nuclear speck

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9C0B1

C

Seeded From UniProt

complete

involved_in

GO:0010883

regulation of lipid storage

PMID:19234441[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008198

ferrous iron binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9C0B1

F

Seeded From UniProt

complete

involved_in

GO:0006307

DNA dealkylation involved in DNA repair

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9C0B1

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:19234441[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0001659

temperature homeostasis

PMID:19234441[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:1990984

tRNA demethylase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9C0B1

F

Seeded From UniProt

complete

enables

GO:1990931

RNA N6-methyladenosine dioxygenase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9C0B1

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0090335

regulation of brown fat cell differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9C0B1

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0080111

DNA demethylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9C0B1

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070989

oxidative demethylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9C0B1

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0061157

mRNA destabilization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9C0B1

P

Seeded From UniProt

complete

enables

GO:0043734

DNA-N1-methyladenine dioxygenase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9C0B1

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042245

RNA repair

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9C0B1

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035553

oxidative single-stranded RNA demethylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9C0B1

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035552

oxidative single-stranded DNA demethylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9C0B1

P

Seeded From UniProt

complete

enables

GO:0035516

oxidative DNA demethylase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9C0B1

F

Seeded From UniProt

complete

enables

GO:0035515

oxidative RNA demethylase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9C0B1

F

Seeded From UniProt

complete

part_of

GO:0016607

nuclear speck

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9C0B1

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010883

regulation of lipid storage

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9C0B1

P

Seeded From UniProt

complete

enables

GO:0008198

ferrous iron binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9C0B1

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006307

DNA dealkylation involved in DNA repair

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9C0B1

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9C0B1

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9C0B1

C

Seeded From UniProt

complete

enables

GO:1990984

tRNA demethylase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9C0B1
ensembl:ENSP00000418823

F

Seeded From UniProt

complete

enables

GO:1990931

RNA N6-methyladenosine dioxygenase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9C0B1
ensembl:ENSP00000418823

F

Seeded From UniProt

complete

involved_in

GO:0090335

regulation of brown fat cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9C0B1
ensembl:ENSP00000418823

P

Seeded From UniProt

complete

involved_in

GO:0080111

DNA demethylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9C0B1
ensembl:ENSP00000418823

P

Seeded From UniProt

complete

involved_in

GO:0070989

oxidative demethylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9C0B1
ensembl:ENSP00000418823

P

Seeded From UniProt

complete

involved_in

GO:0061157

mRNA destabilization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9C0B1
ensembl:ENSP00000418823

P

Seeded From UniProt

complete

enables

GO:0043734

DNA-N1-methyladenine dioxygenase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9C0B1
ensembl:ENSP00000418823

F

Seeded From UniProt

complete

involved_in

GO:0042245

RNA repair

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9C0B1
ensembl:ENSP00000418823

P

Seeded From UniProt

complete

involved_in

GO:0035553

oxidative single-stranded RNA demethylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9C0B1
ensembl:ENSP00000418823

P

Seeded From UniProt

complete

involved_in

GO:0035552

oxidative single-stranded DNA demethylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9C0B1
ensembl:ENSP00000418823

P

Seeded From UniProt

complete

enables

GO:0035516

oxidative DNA demethylase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9C0B1
ensembl:ENSP00000418823

F

Seeded From UniProt

complete

enables

GO:0035515

oxidative RNA demethylase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9C0B1
ensembl:ENSP00000418823

F

Seeded From UniProt

complete

part_of

GO:0016607

nuclear speck

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9C0B1
ensembl:ENSP00000418823

C

Seeded From UniProt

complete

involved_in

GO:0010883

regulation of lipid storage

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9C0B1
ensembl:ENSP00000418823

P

Seeded From UniProt

complete

enables

GO:0008198

ferrous iron binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9C0B1
ensembl:ENSP00000418823

F

Seeded From UniProt

complete

involved_in

GO:0006307

DNA dealkylation involved in DNA repair

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9C0B1
ensembl:ENSP00000418823

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9C0B1
ensembl:ENSP00000418823

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9C0B1
ensembl:ENSP00000418823

C

Seeded From UniProt

complete

involved_in

GO:0006307

DNA dealkylation involved in DNA repair

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR032868

P

Seeded From UniProt

complete

enables

GO:0035515

oxidative RNA demethylase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR032868

F

Seeded From UniProt

complete

enables

GO:0035516

oxidative DNA demethylase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR032868

F

Seeded From UniProt

complete

involved_in

GO:0035552

oxidative single-stranded DNA demethylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR032868

P

Seeded From UniProt

complete

involved_in

GO:0035553

oxidative single-stranded RNA demethylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR032868

P

Seeded From UniProt

complete

involved_in

GO:0040014

regulation of multicellular organism growth

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR032868

P

Seeded From UniProt

complete

involved_in

GO:0042245

RNA repair

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR032868

P

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

enables

GO:0051213

dioxygenase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0223

F

Seeded From UniProt

complete

part_of

GO:0016607

nuclear speck

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0186

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Gerken, T et al. (2007) The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science 318 1469-72 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Jia, G et al. (2008) Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO. FEBS Lett. 582 3313-9 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Fischer, J et al. (2009) Inactivation of the Fto gene protects from obesity. Nature 458 894-8 PubMed GONUTS page