Category:GO:0035516 ! broad specificity oxidative DNA demethylase activity

name: broad specificity oxidative DNA demethylase activity
namespace: molecular_function
alt_id: GO:0103051
alt_id: GO:0103052
alt_id: GO:0103053
def: "Catalysis of the reaction: a methylated nucleobase within DNA + 2-oxoglutarate + O2 = a nucleobase within DNA + formaldehyde + succinate + CO2. Catalyzes oxidative demethylation of the DNA base lesions N1- methyladenine, N3-methylcytosine, N1-methylguanine, and N3- methylthymine. Can also act of RNA." [PMID:12594517, PMID:16482161, PMID:18775698, PMID:19786499, RHEA:30299]
comment: This reaction directly reverses the alkylation on a nucleotide within DNA. Do not confuse with 5-methylcytosine dioxygenase activity ; GO:0070579, which removes the methyl group from position 5 of cytosine in DNA via oxidation of the 5-methylcytosine, followed by removal of the oxidated base by the base excision repair system.
synonym: "1-ethyladenine demethylase activity" NARROW []
synonym: "2-oxoglutarate-dependent DNA demethylase" EXACT [PMID:17991826]
synonym: "5-formylcytosine dioxygenase activity" NARROW []
synonym: "5-hydroxymethylcytosine dioxygenase activity" NARROW []
synonym: "5fC dioxygenase" NARROW []
synonym: "5hmC dioxygenase" NARROW []
synonym: "N1-methyladenine demethylase activity" NARROW []
synonym: "N3-methylcytosine demethylase activity" NARROW []
synonym: "oxidative DNA demethylase activity" BROAD []
xref: EC:1.14.11.33
xref: MetaCyc:RXN-12353
xref: RHEA:30299
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity
is_a: GO:0035514 ! DNA demethylase activity

AmiGO <GOterm>GO:0035516</GOterm>
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