MOUSE:FOXO1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Foxo1 (synonyms: Fkhr, Foxo1a)
Protein Name(s)	Forkhead box protein O1 Forkhead box protein O1A Forkhead in rhabdomyosarcoma
External Links
UniProt	Q9R1E0
EMBL	AF126056 AJ252157 AK137629 AK154041 CH466530
CCDS	CCDS17343.1
RefSeq	NP_062713.2
UniGene	Mm.29891
ProteinModelPortal	Q9R1E0
SMR	Q9R1E0
BioGrid	207997
IntAct	Q9R1E0
MINT	MINT-5112421
STRING	10090.ENSMUSP00000055308
iPTMnet	Q9R1E0
PhosphoSitePlus	Q9R1E0
SwissPalm	Q9R1E0
EPD	Q9R1E0
MaxQB	Q9R1E0
PaxDb	Q9R1E0
PeptideAtlas	Q9R1E0
PRIDE	Q9R1E0
DNASU	56458
Ensembl	ENSMUST00000053764
GeneID	56458
KEGG	mmu:56458
UCSC	uc008pei.2
CTD	2308
MGI	MGI:1890077
eggNOG	KOG2294 COG5025
GeneTree	ENSGT00790000123003
HOGENOM	HOG000251635
HOVERGEN	HBG057789
InParanoid	Q9R1E0
KO	K07201
OMA	KWPGSPN
OrthoDB	EOG091G06K3
TreeFam	TF315583
Reactome	[www.reactome.org/content/detail/R-MMU-198693 R-MMU-198693] [www.reactome.org/content/detail/R-MMU-210745 R-MMU-210745] [www.reactome.org/content/detail/R-MMU-211163 R-MMU-211163] [www.reactome.org/content/detail/R-MMU-5687128 R-MMU-5687128]
PRO	PR:Q9R1E0
Proteomes	UP000000589
Bgee	ENSMUSG00000044167
CleanEx	MM_FOXO1
Genevisible	Q9R1E0
GO	GO:0005737 GO:0005829 GO:0005654 GO:0005634 GO:0008013 GO:0003677 GO:0051721 GO:0043565 GO:0003700 GO:0000989 GO:0008134 GO:0001078 GO:0001227 GO:0031625 GO:0006915 GO:0006914 GO:0001568 GO:0030154 GO:0071549 GO:0006974 GO:0070301 GO:0071455 GO:0032869 GO:0071732 GO:0034599 GO:0009267 GO:0070166 GO:0042593 GO:0008286 GO:0043066 GO:0090090 GO:0045599 GO:0032873 GO:0097150 GO:0043065 GO:0010508 GO:0045722 GO:0045732 GO:0045944 GO:0045893 GO:0042127 GO:0035947 GO:2000177 GO:2000377 GO:0006355 GO:1902617 GO:0006351
Gene3D	1.10.10.10
InterPro	IPR001766 IPR032067 IPR032068 IPR030456 IPR011991
Pfam	PF00250 PF16676 PF16675
PRINTS	PR00053
SMART	SM00339
SUPFAM	SSF46785
PROSITE	PS00658 PS50039

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005634	nucleus	PMID:28790135^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1903243	negative regulation of cardiac muscle hypertrophy in response to stress	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:G3V7R4	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18388859^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:18388859^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21317886^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21317886^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:17090532^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:17090532^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P53566	F		Seeded From UniProt	complete
involved_in	GO:0071732	cellular response to nitric oxide	PMID:21196578^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071455	cellular response to hyperoxia	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q12778	P		Seeded From UniProt	complete
enables	GO:0051721	protein phosphatase 2A binding	PMID:22417654^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q12778	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q12778	P		Seeded From UniProt	complete
involved_in	GO:0045732	positive regulation of protein catabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q12778	P		Seeded From UniProt	complete
involved_in	GO:0045599	negative regulation of fat cell differentiation	PMID:17681146^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045599	negative regulation of fat cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:A4L7N3	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q12778	F		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q12778	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q12778	P		Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	PMID:22417654^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	PMID:17681146^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010508	positive regulation of autophagy	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q12778	P		Seeded From UniProt	complete
involved_in	GO:0009267	cellular response to starvation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q12778	P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:21196578^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17681146^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19037106^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q12778	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17681146^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19037106^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q12778	C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0038197 MGI:MGI:1890077 MGI:MGI:1890081 PANTHER:PTN002908599 UniProtKB:O43524 UniProtKB:P98177 UniProtKB:Q12778 WB:WBGene00000912	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1890077 MGI:MGI:1890081 MGI:MGI:1891915 PANTHER:PTN002908599 RGD:620283 UniProtKB:O43524 UniProtKB:P98177 UniProtKB:Q12778 WB:WBGene00000912	F		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0038197 MGI:MGI:1890077 MGI:MGI:1890081 PANTHER:PTN002908599	P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1890077 PANTHER:PTN000215135 UniProtKB:A4L7N3 UniProtKB:P98177 WB:WBGene00000912	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1890077 PANTHER:PTN002908599 UniProtKB:P98177	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0038197 MGI:MGI:1890077 MGI:MGI:1890081 MGI:MGI:2676586 PANTHER:PTN002908599 RGD:1309196 RGD:1561201 RGD:620283 UniProtKB:A4L7N3 UniProtKB:F1NNE8 UniProtKB:F1RME6 UniProtKB:O43524 UniProtKB:P98177 UniProtKB:Q12778 WB:WBGene00000912	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0038197 MGI:MGI:1890077 MGI:MGI:1890081 MGI:MGI:2676586 PANTHER:PTN002908599 RGD:1309196 RGD:1561201 RGD:620283 UniProtKB:A4L7N3 UniProtKB:F1RME6 UniProtKB:O43524 UniProtKB:P98177 UniProtKB:Q12778 WB:WBGene00000912	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0038197 MGI:MGI:1890077 MGI:MGI:1890081 PANTHER:PTN002908599 RGD:620283 UniProtKB:O43524 UniProtKB:P98177 WB:WBGene00000912	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2676586 PANTHER:PTN002908599	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002908599 UniProtKB:O43524 WB:WBGene00000912 ZFIN:ZDB-GENE-990708-6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000377	regulation of reactive oxygen species metabolic process	PMID:19896444^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1890081	P	regulates_o_occurs_in:(CL:0000337) occurs_in:(CL:0000337)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000177	regulation of neural precursor cell proliferation	PMID:19896444^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1890081	P	regulates_o_occurs_in:(EMAPA:32804) occurs_in:(EMAPA:32804) occurs_in:(CL:0000337)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903243	negative regulation of cardiac muscle hypertrophy in response to stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620283	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097150	neuronal stem cell population maintenance	PMID:19896444^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1890081	P	occurs_in:(EMAPA:32804)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:19896444^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1890081 MGI:MGI:98956	P	occurs_in:(CL:0000337) regulates_o_occurs_in:(CL:0000337)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071455	cellular response to hyperoxia	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12778	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17550780^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2669849	P	has_regulation_target:(MGI:MGI:892013)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:12783775^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12778	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12778	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620283	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045732	positive regulation of protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12778	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045722	positive regulation of gluconeogenesis	PMID:12783775^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:11353388^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12778	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620283	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12778	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12778	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042593	glucose homeostasis	PMID:21317886^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042127	regulation of cell population proliferation	PMID:12488434^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2447732	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035947	regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter	PMID:18497885^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:16846)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032873	negative regulation of stress-activated MAPK cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12778	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12778	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010508	positive regulation of autophagy	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12778	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009267	cellular response to starvation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12778	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008286	insulin receptor signaling pathway	PMID:12488434^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2447732	P		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12778	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620283	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	PMID:12488434^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620283	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16027169^[16]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16846) part_of:(CL:0000115)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12857750^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12488434^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12778	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620283	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:23906066^[18]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17528) part_of:(CL:0000312)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21817126^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16027169^[16]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16846) part_of:(CL:0000115)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12857750^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12488434^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12778	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620283	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:12488434^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620283	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:12488434^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001568	blood vessel development	PMID:15184386^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3052743	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001568	blood vessel development	PMID:14978268^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2447732	P		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:19896444^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1890081	F		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:17950246^[22]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(EMAPA:35375) has_regulation_target:(MGI:MGI:2677164)	Seeded From UniProt	complete
enables	GO:0001223	transcription coactivator binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620283	F		Seeded From UniProt	complete
involved_in	GO:1903243	negative regulation of cardiac muscle hypertrophy in response to stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7R4 ensembl:ENSRNOP00000018244	P		Seeded From UniProt	complete
involved_in	GO:1902617	response to fluoride	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7R4 ensembl:ENSRNOP00000018244	P		Seeded From UniProt	complete
involved_in	GO:0071549	cellular response to dexamethasone stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7R4 ensembl:ENSRNOP00000018244	P		Seeded From UniProt	complete
involved_in	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7R4 ensembl:ENSRNOP00000018244	P		Seeded From UniProt	complete
involved_in	GO:0070166	enamel mineralization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7R4 ensembl:ENSRNOP00000018244	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7R4 ensembl:ENSRNOP00000018244	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7R4 ensembl:ENSRNOP00000018244	F		Seeded From UniProt	complete
involved_in	GO:0032868	response to insulin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7R4 ensembl:ENSRNOP00000018244	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7R4 ensembl:ENSRNOP00000018244	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7R4 ensembl:ENSRNOP00000018244	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7R4 ensembl:ENSRNOP00000018244	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7R4 ensembl:ENSRNOP00000018244	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7R4 ensembl:ENSRNOP00000018244	F		Seeded From UniProt	complete
enables	GO:0001223	transcription coactivator binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7R4 ensembl:ENSRNOP00000018244	F		Seeded From UniProt	complete
involved_in	GO:0071455	cellular response to hyperoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12778 ensembl:ENSP00000368880	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12778 ensembl:ENSP00000368880	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12778 ensembl:ENSP00000368880	P		Seeded From UniProt	complete
involved_in	GO:0045732	positive regulation of protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12778 ensembl:ENSP00000368880	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12778 ensembl:ENSP00000368880	F		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12778 ensembl:ENSP00000368880	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12778 ensembl:ENSP00000368880	P		Seeded From UniProt	complete
involved_in	GO:0032873	negative regulation of stress-activated MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12778 ensembl:ENSP00000368880	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12778 ensembl:ENSP00000368880	F		Seeded From UniProt	complete
involved_in	GO:0010508	positive regulation of autophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12778 ensembl:ENSP00000368880	P		Seeded From UniProt	complete
involved_in	GO:0009267	cellular response to starvation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12778 ensembl:ENSP00000368880	P		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12778 ensembl:ENSP00000368880	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12778 ensembl:ENSP00000368880	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12778 ensembl:ENSP00000368880	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR030456	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR030456	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR030456	F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-NUL-9626944 Reactome:R-MMU-9626966 Reactome:R-MMU-9625830 Reactome:R-MMU-9625700 Reactome:R-MMU-9625402 Reactome:R-MMU-9625109 Reactome:R-MMU-9623284 Reactome:R-MMU-9623232 Reactome:R-MMU-9623231 Reactome:R-MMU-9623061 Reactome:R-MMU-9623032	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0072	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Tong, X et al. (2017) DDB1-Mediated CRY1 Degradation Promotes FOXO1-Driven Gluconeogenesis in Liver. Diabetes 66 2571-2582 PubMed GONUTS page
↑ ^2.0 ^2.1 Fritzius, T & Moelling, K (2008) Akt- and Foxo1-interacting WD-repeat-FYVE protein promotes adipogenesis. EMBO J. 27 1399-410 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Zhou, Y et al. (2011) Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction. Nat. Med. 17 356-65 PubMed GONUTS page
↑ ^4.0 ^4.1 Qiao, L & Shao, J (2006) SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein alpha transcriptional complex. J. Biol. Chem. 281 39915-24 PubMed GONUTS page
↑ ^5.0 ^5.1 Hughes, KJ et al. (2011) FoxO1 and SIRT1 regulate beta-cell responses to nitric oxide. J. Biol. Chem. 286 8338-48 PubMed GONUTS page
↑ ^6.0 ^6.1 Yan, L et al. (2012) The B55α-containing PP2A holoenzyme dephosphorylates FOXO1 in islet β-cells under oxidative stress. Biochem. J. 444 239-47 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Jing, E et al. (2007) SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation. Cell Metab. 6 105-14 PubMed GONUTS page
↑ ^8.0 ^8.1 Wang, F & Tong, Q (2009) SIRT2 suppresses adipocyte differentiation by deacetylating FOXO1 and enhancing FOXO1's repressive interaction with PPARgamma. Mol. Biol. Cell 20 801-8 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 ^9.7 ^9.8 ^9.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 Paik, JH et al. (2009) FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell 5 540-53 PubMed GONUTS page
↑ Sakkou, M et al. (2007) A role for brain-specific homeobox factor Bsx in the control of hyperphagia and locomotory behavior. Cell Metab. 5 450-63 PubMed GONUTS page
↑ ^12.0 ^12.1 Altomonte, J et al. (2003) Inhibition of Foxo1 function is associated with improved fasting glycemia in diabetic mice. Am. J. Physiol. Endocrinol. Metab. 285 E718-28 PubMed GONUTS page
↑ Biggs, WH 3rd et al. (2001) Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse. Mamm. Genome 12 416-25 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 Kitamura, T et al. (2002) The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J. Clin. Invest. 110 1839-47 PubMed GONUTS page
↑ Kamagate, A et al. (2008) FoxO1 mediates insulin-dependent regulation of hepatic VLDL production in mice. J. Clin. Invest. 118 2347-64 PubMed GONUTS page
↑ ^16.0 ^16.1 Manning, BD et al. (2005) Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2. Genes Dev. 19 1773-8 PubMed GONUTS page
↑ ^17.0 ^17.1 Jacobs, FM et al. (2003) FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics. J. Biol. Chem. 278 35959-67 PubMed GONUTS page
↑ Günschmann, C et al. (2013) Insulin/IGF-1 controls epidermal morphogenesis via regulation of FoxO-mediated p63 inhibition. Dev. Cell 26 176-87 PubMed GONUTS page
↑ Alejandro, EU et al. (2011) Pancreatic β-cell Raf-1 is required for glucose tolerance, insulin secretion, and insulin 2 transcription. FASEB J. 25 3884-95 PubMed GONUTS page
↑ Furuyama, T et al. (2004) Abnormal angiogenesis in Foxo1 (Fkhr)-deficient mice. J. Biol. Chem. 279 34741-9 PubMed GONUTS page
↑ Hosaka, T et al. (2004) Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification. Proc. Natl. Acad. Sci. U.S.A. 101 2975-80 PubMed GONUTS page
↑ Yasui, A et al. (2007) Foxo1 represses expression of musclin, a skeletal muscle-derived secretory factor. Biochem. Biophys. Res. Commun. 364 358-65 PubMed GONUTS page

[PMID:28790135-1] Tong, X et al. (2017) DDB1-Mediated CRY1 Degradation Promotes FOXO1-Driven Gluconeogenesis in Liver. Diabetes 66 2571-2582 PubMed GONUTS page

[PMID:18388859-2] 2.0 ^2.1 Fritzius, T & Moelling, K (2008) Akt- and Foxo1-interacting WD-repeat-FYVE protein promotes adipogenesis. EMBO J. 27 1399-410 PubMed GONUTS page

[PMID:21317886-3] 3.0 ^3.1 ^3.2 Zhou, Y et al. (2011) Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction. Nat. Med. 17 356-65 PubMed GONUTS page

[PMID:17090532-4] 4.0 ^4.1 Qiao, L & Shao, J (2006) SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein alpha transcriptional complex. J. Biol. Chem. 281 39915-24 PubMed GONUTS page

[PMID:21196578-5] 5.0 ^5.1 Hughes, KJ et al. (2011) FoxO1 and SIRT1 regulate beta-cell responses to nitric oxide. J. Biol. Chem. 286 8338-48 PubMed GONUTS page

[PMID:22417654-6] 6.0 ^6.1 Yan, L et al. (2012) The B55α-containing PP2A holoenzyme dephosphorylates FOXO1 in islet β-cells under oxidative stress. Biochem. J. 444 239-47 PubMed GONUTS page

[PMID:17681146-7] 7.0 ^7.1 ^7.2 ^7.3 Jing, E et al. (2007) SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation. Cell Metab. 6 105-14 PubMed GONUTS page

[PMID:19037106-8] 8.0 ^8.1 Wang, F & Tong, Q (2009) SIRT2 suppresses adipocyte differentiation by deacetylating FOXO1 and enhancing FOXO1's repressive interaction with PPARgamma. Mol. Biol. Cell 20 801-8 PubMed GONUTS page

[PMID:21873635-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 ^9.7 ^9.8 ^9.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19896444-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 Paik, JH et al. (2009) FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell 5 540-53 PubMed GONUTS page

[PMID:17550780-11] Sakkou, M et al. (2007) A role for brain-specific homeobox factor Bsx in the control of hyperphagia and locomotory behavior. Cell Metab. 5 450-63 PubMed GONUTS page

[PMID:12783775-12] 12.0 ^12.1 Altomonte, J et al. (2003) Inhibition of Foxo1 function is associated with improved fasting glycemia in diabetic mice. Am. J. Physiol. Endocrinol. Metab. 285 E718-28 PubMed GONUTS page

[PMID:11353388-13] Biggs, WH 3rd et al. (2001) Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse. Mamm. Genome 12 416-25 PubMed GONUTS page

[PMID:12488434-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 Kitamura, T et al. (2002) The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J. Clin. Invest. 110 1839-47 PubMed GONUTS page

[PMID:18497885-15] Kamagate, A et al. (2008) FoxO1 mediates insulin-dependent regulation of hepatic VLDL production in mice. J. Clin. Invest. 118 2347-64 PubMed GONUTS page

[PMID:16027169-16] 16.0 ^16.1 Manning, BD et al. (2005) Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2. Genes Dev. 19 1773-8 PubMed GONUTS page

[PMID:12857750-17] 17.0 ^17.1 Jacobs, FM et al. (2003) FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics. J. Biol. Chem. 278 35959-67 PubMed GONUTS page

[PMID:23906066-18] Günschmann, C et al. (2013) Insulin/IGF-1 controls epidermal morphogenesis via regulation of FoxO-mediated p63 inhibition. Dev. Cell 26 176-87 PubMed GONUTS page

[PMID:21817126-19] Alejandro, EU et al. (2011) Pancreatic β-cell Raf-1 is required for glucose tolerance, insulin secretion, and insulin 2 transcription. FASEB J. 25 3884-95 PubMed GONUTS page

[PMID:15184386-20] Furuyama, T et al. (2004) Abnormal angiogenesis in Foxo1 (Fkhr)-deficient mice. J. Biol. Chem. 279 34741-9 PubMed GONUTS page

[PMID:14978268-21] Hosaka, T et al. (2004) Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification. Proc. Natl. Acad. Sci. U.S.A. 101 2975-80 PubMed GONUTS page

[PMID:17950246-22] Yasui, A et al. (2007) Foxo1 represses expression of musclin, a skeletal muscle-derived secretory factor. Biochem. Biophys. Res. Commun. 364 358-65 PubMed GONUTS page

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MOUSE:FOXO1

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