MOUSE:FOXH1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Foxh1 (synonyms: Fast1, Fast2)
Protein Name(s)	Forkhead box protein H1 Forkhead activin signal transducer 1 Fast-1 Forkhead activin signal transducer 2 Fast-2
External Links
UniProt	O88621
EMBL	AF069303 AF079514 AF177770 AF110506
CCDS	CCDS27584.1
RefSeq	NP_032015.1 XP_006520499.1
UniGene	Mm.42011
ProteinModelPortal	O88621
SMR	O88621
BioGrid	199598
IntAct	O88621
MINT	MINT-4998752
PRIDE	O88621
Ensembl	ENSMUST00000037824
GeneID	14106
KEGG	mmu:14106
UCSC	uc007wlm.1
CTD	8928
MGI	MGI:1347465
eggNOG	COG5025
HOGENOM	HOG000112630
HOVERGEN	HBG051647
InParanoid	O88621
KO	K09400
OMA	SERPLWP
OrthoDB	EOG76HQ1T
PhylomeDB	O88621
TreeFam	TF350620
Reactome	REACT_216258 REACT_220645
NextBio	285148
PRO	PR:O88621
Proteomes	UP000000589
Bgee	O88621
CleanEx	MM_FOXH1
ExpressionAtlas	O88621
Genevestigator	O88621
GO	GO:0032444 GO:0000790 GO:0005634 GO:0005667 GO:0003677 GO:0070412 GO:0001205 GO:0001104 GO:0001190 GO:0043565 GO:0003700 GO:0046332 GO:0044212 GO:0009952 GO:0035909 GO:0048318 GO:0003215 GO:0007368 GO:0035054 GO:0001947 GO:2000824 GO:0033147 GO:0000122 GO:0003151 GO:0045944 GO:0045893 GO:0006357 GO:0003139 GO:0006366 GO:0007179 GO:0003222
Gene3D	1.10.10.10
InterPro	IPR001766 IPR018122 IPR011991
Pfam	PF00250
PRINTS	PR00053
SMART	SM00339
PROSITE	PS00658 PS50039

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:15363409^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSMUSG00000079033)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15363409^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSMUSG00000005583) part_of:(GO:0007179)	Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:15363409^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070412	R-SMAD binding	PMID:9858566^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:9858566^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:9858566^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0035909	aorta morphogenesis	PMID:15363409^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032444	activin responsive factor complex	PMID:9858566^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:9858566^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003222	ventricular trabecula myocardium morphogenesis	PMID:15363409^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003215	cardiac right ventricle morphogenesis	PMID:15363409^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003151	outflow tract morphogenesis	PMID:15363409^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003139	secondary heart field specification	PMID:15363409^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	PMID:15363409^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:15363409^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	PMID:9702197^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q62432	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:10349617^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:10349617^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032444	activin responsive factor complex	PMID:10349617^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:10349617^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071345	cellular response to cytokine stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O75593	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071345	cellular response to cytokine stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75593	P		Seeded From UniProt	complete
enables	GO:0070412	R-SMAD binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75593	F		Seeded From UniProt	complete
enables	GO:0070410	co-SMAD binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75593	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060766	negative regulation of androgen receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75593	P		Seeded From UniProt	complete
enables	GO:0050681	androgen receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75593	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048318	axial mesoderm development	PMID:11358869^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2179442	P		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75593	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75593	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75593	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:17568773^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(MGI:MGI:1351322)	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75593	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043433	negative regulation of DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75593	P		Seeded From UniProt	complete
enables	GO:0043425	bHLH transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75593	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035054	embryonic heart tube anterior/posterior pattern specification	PMID:15363409^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2179442	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75593	P		Seeded From UniProt	complete
part_of	GO:0032444	activin responsive factor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75593	C		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75593	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009952	anterior/posterior pattern specification	PMID:11358868^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2387775	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007368	determination of left/right symmetry	PMID:12642485^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2387775	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006357	regulation of transcription by RNA polymerase II	PMID:9702197^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:9702197^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:17568773^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75593	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9702197^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75593	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:9702197^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75593	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:9702197^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:15363409^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0003677	DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75593	F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:18331719^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75593	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:17568773^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95841	P	has_regulation_target:(MGI:MGI:1351322)	Seeded From UniProt	complete
involved_in	GO:0071345	cellular response to cytokine stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75593 ensembl:ENSP00000366534	P		Seeded From UniProt	complete
enables	GO:0070412	R-SMAD binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75593 ensembl:ENSP00000366534	F		Seeded From UniProt	complete
enables	GO:0070410	co-SMAD binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75593 ensembl:ENSP00000366534	F		Seeded From UniProt	complete
involved_in	GO:0060766	negative regulation of androgen receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75593 ensembl:ENSP00000366534	P		Seeded From UniProt	complete
enables	GO:0050681	androgen receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75593 ensembl:ENSP00000366534	F		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75593 ensembl:ENSP00000366534	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75593 ensembl:ENSP00000366534	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75593 ensembl:ENSP00000366534	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75593 ensembl:ENSP00000366534	F		Seeded From UniProt	complete
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75593 ensembl:ENSP00000366534	P		Seeded From UniProt	complete
enables	GO:0043425	bHLH transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75593 ensembl:ENSP00000366534	F		Seeded From UniProt	complete
involved_in	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75593 ensembl:ENSP00000366534	P		Seeded From UniProt	complete
part_of	GO:0032444	activin responsive factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75593 ensembl:ENSP00000366534	C		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75593 ensembl:ENSP00000366534	F		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75593 ensembl:ENSP00000366534	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75593 ensembl:ENSP00000366534	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75593 ensembl:ENSP00000366534	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75593 ensembl:ENSP00000366534	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75593 ensembl:ENSP00000366534	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR030456	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR030456	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR030456	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 von Both, I et al. (2004) Foxh1 is essential for development of the anterior heart field. Dev. Cell 7 331-45 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Liu, B et al. (1999) FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals. Mol. Cell. Biol. 19 424-30 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Labbé, E et al. (1998) Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2. Mol. Cell 2 109-20 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Weisberg, E et al. (1998) A mouse homologue of FAST-1 transduces TGF beta superfamily signals and is expressed during early embryogenesis. Mech. Dev. 79 17-27 PubMed GONUTS page
↑ Hoodless, PA et al. (2001) FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse. Genes Dev. 15 1257-71 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Izzi, L et al. (2007) Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development. EMBO J. 26 3132-43 PubMed GONUTS page
↑ Yamamoto, M et al. (2001) The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouse. Genes Dev. 15 1242-56 PubMed GONUTS page
↑ Yamamoto, M et al. (2003) Nodal signaling induces the midline barrier by activating Nodal expression in the lateral plate. Development 130 1795-804 PubMed GONUTS page
↑ Silvestri, C et al. (2008) Genome-wide identification of Smad/Foxh1 targets reveals a role for Foxh1 in retinoic acid regulation and forebrain development. Dev. Cell 14 411-23 PubMed GONUTS page

[PMID:15363409-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 von Both, I et al. (2004) Foxh1 is essential for development of the anterior heart field. Dev. Cell 7 331-45 PubMed GONUTS page

[PMID:9858566-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Liu, B et al. (1999) FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals. Mol. Cell. Biol. 19 424-30 PubMed GONUTS page

[PMID:9702197-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Labbé, E et al. (1998) Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2. Mol. Cell 2 109-20 PubMed GONUTS page

[PMID:10349617-4] 4.0 ^4.1 ^4.2 ^4.3 Weisberg, E et al. (1998) A mouse homologue of FAST-1 transduces TGF beta superfamily signals and is expressed during early embryogenesis. Mech. Dev. 79 17-27 PubMed GONUTS page

[PMID:11358869-5] Hoodless, PA et al. (2001) FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse. Genes Dev. 15 1257-71 PubMed GONUTS page

[PMID:17568773-6] 6.0 ^6.1 ^6.2 Izzi, L et al. (2007) Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development. EMBO J. 26 3132-43 PubMed GONUTS page

[PMID:11358868-7] Yamamoto, M et al. (2001) The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouse. Genes Dev. 15 1242-56 PubMed GONUTS page

[PMID:12642485-8] Yamamoto, M et al. (2003) Nodal signaling induces the midline barrier by activating Nodal expression in the lateral plate. Development 130 1795-804 PubMed GONUTS page

[PMID:18331719-9] Silvestri, C et al. (2008) Genome-wide identification of Smad/Foxh1 targets reveals a role for Foxh1 in retinoic acid regulation and forebrain development. Dev. Cell 14 411-23 PubMed GONUTS page

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MOUSE:FOXH1

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