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MOUSE:FOXH1
Contents
Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
Gene Name(s) | Foxh1 (synonyms: Fast1, Fast2) | |
Protein Name(s) | Forkhead box protein H1
Forkhead activin signal transducer 1 Fast-1 Forkhead activin signal transducer 2 Fast-2 | |
External Links | ||
UniProt | O88621 | |
EMBL | AF069303 AF079514 AF177770 AF110506 | |
CCDS | CCDS27584.1 | |
RefSeq | NP_032015.1 XP_006520499.1 | |
UniGene | Mm.42011 | |
ProteinModelPortal | O88621 | |
SMR | O88621 | |
BioGrid | 199598 | |
IntAct | O88621 | |
MINT | MINT-4998752 | |
PRIDE | O88621 | |
Ensembl | ENSMUST00000037824 | |
GeneID | 14106 | |
KEGG | mmu:14106 | |
UCSC | uc007wlm.1 | |
CTD | 8928 | |
MGI | MGI:1347465 | |
eggNOG | COG5025 | |
HOGENOM | HOG000112630 | |
HOVERGEN | HBG051647 | |
InParanoid | O88621 | |
KO | K09400 | |
OMA | SERPLWP | |
OrthoDB | EOG76HQ1T | |
PhylomeDB | O88621 | |
TreeFam | TF350620 | |
Reactome | REACT_216258 REACT_220645 | |
NextBio | 285148 | |
PRO | PR:O88621 | |
Proteomes | UP000000589 | |
Bgee | O88621 | |
CleanEx | MM_FOXH1 | |
ExpressionAtlas | O88621 | |
Genevestigator | O88621 | |
GO | GO:0032444 GO:0000790 GO:0005634 GO:0005667 GO:0003677 GO:0070412 GO:0001205 GO:0001104 GO:0001190 GO:0043565 GO:0003700 GO:0046332 GO:0044212 GO:0009952 GO:0035909 GO:0048318 GO:0003215 GO:0007368 GO:0035054 GO:0001947 GO:2000824 GO:0033147 GO:0000122 GO:0003151 GO:0045944 GO:0045893 GO:0006357 GO:0003139 GO:0006366 GO:0007179 GO:0003222 | |
Gene3D | 1.10.10.10 | |
InterPro | IPR001766 IPR018122 IPR011991 | |
Pfam | PF00250 | |
PRINTS | PR00053 | |
SMART | SM00339 | |
PROSITE | PS00658 PS50039 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
regulates_transcription_of:(ENSEMBL:ENSMUSG00000079033) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0007179 |
transforming growth factor beta receptor signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0070412 |
R-SMAD binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0044212 |
transcription regulatory region DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0035909 |
aorta morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0032444 |
activin responsive factor complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007179 |
transforming growth factor beta receptor signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0003222 |
ventricular trabecula myocardium morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0003215 |
cardiac right ventricle morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0003151 |
outflow tract morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0003139 |
secondary heart field specification |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0001947 |
heart looping |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0001228 |
DNA-binding transcription activator activity, RNA polymerase II-specific |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0046332 |
SMAD binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0032444 |
activin responsive factor complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007179 |
transforming growth factor beta receptor signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071345 |
cellular response to cytokine stimulus |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0071345 |
cellular response to cytokine stimulus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0070412 |
R-SMAD binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0070410 |
co-SMAD binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0060766 |
negative regulation of androgen receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0050681 |
androgen receptor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0048318 |
axial mesoderm development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2179442 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0046332 |
SMAD binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_input:(MGI:MGI:1351322) |
Seeded From UniProt |
complete | ||
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0043433 |
negative regulation of DNA-binding transcription factor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0043425 |
bHLH transcription factor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0035054 |
embryonic heart tube anterior/posterior pattern specification |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2179442 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0033147 |
negative regulation of intracellular estrogen receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0032444 |
activin responsive factor complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0019904 |
protein domain specific binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0009952 |
anterior/posterior pattern specification |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2387775 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0007368 |
determination of left/right symmetry |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2387775 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0006357 |
regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005667 |
transcription factor complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005667 |
transcription factor complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005667 |
transcription factor complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
contributes_to |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
contributes_to |
GO:0003677 |
DNA binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0001228 |
DNA-binding transcription activator activity, RNA polymerase II-specific |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0000790 |
nuclear chromatin |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:95841 |
P |
has_regulation_target:(MGI:MGI:1351322) |
Seeded From UniProt |
complete | |
involved_in |
GO:0071345 |
cellular response to cytokine stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O75593 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0070412 |
R-SMAD binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O75593 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0070410 |
co-SMAD binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O75593 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060766 |
negative regulation of androgen receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O75593 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0050681 |
androgen receptor binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O75593 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0046332 |
SMAD binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O75593 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O75593 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O75593 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O75593 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043433 |
negative regulation of DNA-binding transcription factor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O75593 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0043425 |
bHLH transcription factor binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O75593 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0033147 |
negative regulation of intracellular estrogen receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O75593 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0032444 |
activin responsive factor complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O75593 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0019904 |
protein domain specific binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O75593 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0005667 |
transcription factor complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O75593 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O75593 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O75593 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0003677 |
DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O75593 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0000790 |
nuclear chromatin |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O75593 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 von Both, I et al. (2004) Foxh1 is essential for development of the anterior heart field. Dev. Cell 7 331-45 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Liu, B et al. (1999) FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals. Mol. Cell. Biol. 19 424-30 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Labbé, E et al. (1998) Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2. Mol. Cell 2 109-20 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Weisberg, E et al. (1998) A mouse homologue of FAST-1 transduces TGF beta superfamily signals and is expressed during early embryogenesis. Mech. Dev. 79 17-27 PubMed GONUTS page
- ↑ Hoodless, PA et al. (2001) FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse. Genes Dev. 15 1257-71 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Izzi, L et al. (2007) Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development. EMBO J. 26 3132-43 PubMed GONUTS page
- ↑ Yamamoto, M et al. (2001) The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouse. Genes Dev. 15 1242-56 PubMed GONUTS page
- ↑ Yamamoto, M et al. (2003) Nodal signaling induces the midline barrier by activating Nodal expression in the lateral plate. Development 130 1795-804 PubMed GONUTS page
- ↑ Silvestri, C et al. (2008) Genome-wide identification of Smad/Foxh1 targets reveals a role for Foxh1 in retinoic acid regulation and forebrain development. Dev. Cell 14 411-23 PubMed GONUTS page
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- GO:0000122 ! negative regulation of transcription by RNA polymerase II
- GO:0033147 ! negative regulation of intracellular estrogen receptor signaling pathway
- GO:0043433 ! negative regulation of DNA-binding transcription factor activity
- GO:0060766 ! negative regulation of androgen receptor signaling pathway
- GO:0050681 ! nuclear androgen receptor binding
- GO:0000790 ! nuclear chromatin
- GO:0005634 ! nucleus
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