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MOUSE:FOXH1

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Foxh1 (synonyms: Fast1, Fast2)
Protein Name(s) Forkhead box protein H1

Forkhead activin signal transducer 1 Fast-1 Forkhead activin signal transducer 2 Fast-2

External Links
UniProt O88621
EMBL AF069303
AF079514
AF177770
AF110506
CCDS CCDS27584.1
RefSeq NP_032015.1
XP_006520499.1
UniGene Mm.42011
ProteinModelPortal O88621
SMR O88621
BioGrid 199598
IntAct O88621
MINT MINT-4998752
PRIDE O88621
Ensembl ENSMUST00000037824
GeneID 14106
KEGG mmu:14106
UCSC uc007wlm.1
CTD 8928
MGI MGI:1347465
eggNOG COG5025
HOGENOM HOG000112630
HOVERGEN HBG051647
InParanoid O88621
KO K09400
OMA SERPLWP
OrthoDB EOG76HQ1T
PhylomeDB O88621
TreeFam TF350620
Reactome REACT_216258
REACT_220645
NextBio 285148
PRO PR:O88621
Proteomes UP000000589
Bgee O88621
CleanEx MM_FOXH1
ExpressionAtlas O88621
Genevestigator O88621
GO GO:0032444
GO:0000790
GO:0005634
GO:0005667
GO:0003677
GO:0070412
GO:0001205
GO:0001104
GO:0001190
GO:0043565
GO:0003700
GO:0046332
GO:0044212
GO:0009952
GO:0035909
GO:0048318
GO:0003215
GO:0007368
GO:0035054
GO:0001947
GO:2000824
GO:0033147
GO:0000122
GO:0003151
GO:0045944
GO:0045893
GO:0006357
GO:0003139
GO:0006366
GO:0007179
GO:0003222
Gene3D 1.10.10.10
InterPro IPR001766
IPR018122
IPR011991
Pfam PF00250
PRINTS PR00053
SMART SM00339
PROSITE PS00658
PS50039

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:15363409[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

regulates_transcription_of:(ENSEMBL:ENSMUSG00000079033)

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:15363409[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • regulates_transcription_of:(ENSEMBL:ENSMUSG00000005583)
  • part_of:(GO:0007179)

Seeded From UniProt

complete

involved_in

GO:0007179

transforming growth factor beta receptor signaling pathway

PMID:15363409[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0070412

R-SMAD binding

PMID:9858566[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:9858566[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0044212

transcription regulatory region DNA binding

PMID:9858566[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0035909

aorta morphogenesis

PMID:15363409[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0032444

activin responsive factor complex

PMID:9858566[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007179

transforming growth factor beta receptor signaling pathway

PMID:9858566[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0003222

ventricular trabecula myocardium morphogenesis

PMID:15363409[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0003215

cardiac right ventricle morphogenesis

PMID:15363409[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0003151

outflow tract morphogenesis

PMID:15363409[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0003139

secondary heart field specification

PMID:15363409[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001947

heart looping

PMID:15363409[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

PMID:15363409[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0046332

SMAD binding

PMID:9702197[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q62432

F

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:10349617[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:10349617[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0032444

activin responsive factor complex

PMID:10349617[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007179

transforming growth factor beta receptor signaling pathway

PMID:10349617[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0071345

cellular response to cytokine stimulus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O75593

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071345

cellular response to cytokine stimulus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75593

P

Seeded From UniProt

complete

enables

GO:0070412

R-SMAD binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75593

F

Seeded From UniProt

complete

enables

GO:0070410

co-SMAD binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75593

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060766

negative regulation of androgen receptor signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75593

P

Seeded From UniProt

complete

enables

GO:0050681

androgen receptor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75593

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048318

axial mesoderm development

PMID:11358869[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2179442

P

Seeded From UniProt

complete

enables

GO:0046332

SMAD binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75593

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75593

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75593

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

PMID:17568773[6]

ECO:0000314

direct assay evidence used in manual assertion

F

has_input:(MGI:MGI:1351322)

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75593

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043433

negative regulation of DNA-binding transcription factor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75593

P

Seeded From UniProt

complete

enables

GO:0043425

bHLH transcription factor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75593

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035054

embryonic heart tube anterior/posterior pattern specification

PMID:15363409[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2179442

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0033147

negative regulation of intracellular estrogen receptor signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75593

P

Seeded From UniProt

complete

part_of

GO:0032444

activin responsive factor complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75593

C

Seeded From UniProt

complete

enables

GO:0019904

protein domain specific binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75593

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009952

anterior/posterior pattern specification

PMID:11358868[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2387775

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007368

determination of left/right symmetry

PMID:12642485[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2387775

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006357

regulation of transcription by RNA polymerase II

PMID:9702197[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005667

transcription factor complex

PMID:9702197[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005667

transcription factor complex

PMID:17568773[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005667

transcription factor complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75593

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:9702197[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75593

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:9702197[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

contributes_to

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75593

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:9702197[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:15363409[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

contributes_to

GO:0003677

DNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75593

F

Seeded From UniProt

complete

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

PMID:18331719[9]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0000790

nuclear chromatin

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75593

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:17568773[6]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:95841

P

has_regulation_target:(MGI:MGI:1351322)

Seeded From UniProt

complete

involved_in

GO:0071345

cellular response to cytokine stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O75593
ensembl:ENSP00000366534

P

Seeded From UniProt

complete

enables

GO:0070412

R-SMAD binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O75593
ensembl:ENSP00000366534

F

Seeded From UniProt

complete

enables

GO:0070410

co-SMAD binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O75593
ensembl:ENSP00000366534

F

Seeded From UniProt

complete

involved_in

GO:0060766

negative regulation of androgen receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O75593
ensembl:ENSP00000366534

P

Seeded From UniProt

complete

enables

GO:0050681

androgen receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O75593
ensembl:ENSP00000366534

F

Seeded From UniProt

complete

enables

GO:0046332

SMAD binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O75593
ensembl:ENSP00000366534

F

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O75593
ensembl:ENSP00000366534

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O75593
ensembl:ENSP00000366534

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O75593
ensembl:ENSP00000366534

F

Seeded From UniProt

complete

involved_in

GO:0043433

negative regulation of DNA-binding transcription factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O75593
ensembl:ENSP00000366534

P

Seeded From UniProt

complete

enables

GO:0043425

bHLH transcription factor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O75593
ensembl:ENSP00000366534

F

Seeded From UniProt

complete

involved_in

GO:0033147

negative regulation of intracellular estrogen receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O75593
ensembl:ENSP00000366534

P

Seeded From UniProt

complete

part_of

GO:0032444

activin responsive factor complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O75593
ensembl:ENSP00000366534

C

Seeded From UniProt

complete

enables

GO:0019904

protein domain specific binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O75593
ensembl:ENSP00000366534

F

Seeded From UniProt

complete

part_of

GO:0005667

transcription factor complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O75593
ensembl:ENSP00000366534

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O75593
ensembl:ENSP00000366534

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O75593
ensembl:ENSP00000366534

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O75593
ensembl:ENSP00000366534

F

Seeded From UniProt

complete

part_of

GO:0000790

nuclear chromatin

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O75593
ensembl:ENSP00000366534

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001766
InterPro:IPR030456

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001766
InterPro:IPR030456

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001766
InterPro:IPR030456

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 von Both, I et al. (2004) Foxh1 is essential for development of the anterior heart field. Dev. Cell 7 331-45 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 Liu, B et al. (1999) FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals. Mol. Cell. Biol. 19 424-30 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 Labbé, E et al. (1998) Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2. Mol. Cell 2 109-20 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 Weisberg, E et al. (1998) A mouse homologue of FAST-1 transduces TGF beta superfamily signals and is expressed during early embryogenesis. Mech. Dev. 79 17-27 PubMed GONUTS page
  5. Hoodless, PA et al. (2001) FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse. Genes Dev. 15 1257-71 PubMed GONUTS page
  6. 6.0 6.1 6.2 Izzi, L et al. (2007) Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development. EMBO J. 26 3132-43 PubMed GONUTS page
  7. Yamamoto, M et al. (2001) The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouse. Genes Dev. 15 1242-56 PubMed GONUTS page
  8. Yamamoto, M et al. (2003) Nodal signaling induces the midline barrier by activating Nodal expression in the lateral plate. Development 130 1795-804 PubMed GONUTS page
  9. Silvestri, C et al. (2008) Genome-wide identification of Smad/Foxh1 targets reveals a role for Foxh1 in retinoic acid regulation and forebrain development. Dev. Cell 14 411-23 PubMed GONUTS page