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PMID:11358868
| Citation |
Yamamoto, M, Meno, C, Sakai, Y, Shiratori, H, Mochida, K, Ikawa, Y, Saijoh, Y and Hamada, H (2001) The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouse. Genes Dev. 15:1242-56 |
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| Abstract |
FoxH1 (FAST) is a transcription factor that mediates signaling by transforming growth factor-beta, Activin, and Nodal. The role of FoxH1 in development has now been investigated by the generation and analysis of FoxH1-deficient (FoxH1(-/-)) mice. The FoxH1(-/-) embryos showed various patterning defects that recapitulate most of the defects induced by the loss of Nodal signaling. A substantial proportion of FoxH1(-/-) embryos failed to orient the anterior-posterior (A-P) axis correctly, as do mice lacking Cripto, a coreceptor for Nodal. In less severely affected FoxH1(-/-) embryos, A-P polarity was established, but the primitive streak failed to elongate, resulting in the lack of a definitive node and its derivatives. Heterozygosity for nodal renders the FoxH1(-/-) phenotype more severe, indicative of a genetic interaction between FoxH1 and nodal. The expression of FoxH1 in the primitive endoderm rescued the A-P patterning defects, but not the midline defects, of FoxH1(-/-) mice. These results indicate that a Nodal-FoxH1 signaling pathway plays a central role in A-P patterning and node formation in the mouse. |
| Links |
PubMed PMC313795 Online version:883901 10.1101/gad. 883901 |
| Keywords |
Animals; Body Patterning; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Embryonic and Fetal Development; Epidermal Growth Factor; Forkhead Transcription Factors; Gene Expression Regulation, Developmental; Membrane Glycoproteins; Mice; Mice, Knockout; Mutation; Neoplasm Proteins/genetics; Nodal Protein; Phenotype; Polymerase Chain Reaction; Signal Transduction; Transcription Factors/genetics; Transcription Factors/metabolism; Transforming Growth Factor beta/genetics; Transforming Growth Factor beta/metabolism |
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Significance
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| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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