MOUSE:FOXF1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Foxf1 (synonyms: Fkhl5, Foxf1a, Freac1, Hfh8)
Protein Name(s)	Forkhead box protein F1 Forkhead-related protein FKHL5 Forkhead-related transcription factor 1 FREAC-1 Hepatocyte nuclear factor 3 forkhead homolog 8 HFH-8
External Links
UniProt	Q61080
EMBL	L35949 AF346834 BC138805 BC138806 U42556
CCDS	CCDS22722.2
PIR	I49735
RefSeq	NP_034556.2
UniGene	Mm.33897
ProteinModelPortal	Q61080
SMR	Q61080
STRING	10090.ENSMUSP00000057481
PhosphoSite	Q61080
PRIDE	Q61080
Ensembl	ENSMUST00000181504
GeneID	15227
KEGG	mmu:15227
UCSC	uc009nrn.1
CTD	2294
MGI	MGI:1347470
eggNOG	COG5025
GeneTree	ENSGT00760000118794
HOGENOM	HOG000060124
HOVERGEN	HBG051644
InParanoid	Q61080
KO	K09399
OMA	MTAEVQQ
OrthoDB	EOG7D59PX
PhylomeDB	Q61080
TreeFam	TF351598
NextBio	287815
PRO	PR:Q61080
Proteomes	UP000000589
Bgee	Q61080
CleanEx	MM_FOXF1A
Genevestigator	Q61080
GO	GO:0005634 GO:0003677 GO:0000977 GO:0001228 GO:0044212 GO:0003214 GO:0071345 GO:0071407 GO:0014822 GO:0007368 GO:0097070 GO:0048566 GO:0048613 GO:0048617 GO:0003197 GO:0061030 GO:0060441 GO:0045198 GO:0030198 GO:0001701 GO:0048371 GO:0048286 GO:0030324 GO:0060463 GO:0060425 GO:0060426 GO:0090131 GO:0007498 GO:0007494 GO:0050728 GO:0043305 GO:0000122 GO:0009887 GO:0031016 GO:0030335 GO:0010811 GO:0002053 GO:0045944 GO:0051150 GO:0060461 GO:0016337 GO:0051145 GO:0007224 GO:0001756 GO:0060438 GO:0072189 GO:0001570 GO:0060841
Gene3D	1.10.10.10
InterPro	IPR001766 IPR018122 IPR011991
Pfam	PF00250
PRINTS	PR00053
SMART	SM00339
PROSITE	PS00657 PS00658 PS50039

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0010843	promoter binding	PMID:18579532^[1]	ECO:0000314			F		Supplamentary Figures 1: Foxc1 induces the mRNA levels of Itgb3, Itgb5 and FN.	complete
	GO:0010843	promoter binding	PMID:18579532^[1]	ECO:0000314			F		Supplamentary Figure 3: Foxf1 activates the Itbg3 promoter and regulates its expression.	complete
acts_upstream_of_or_within	GO:0098609	cell-cell adhesion	PMID:11124112^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1929432	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097070	ductus arteriosus closure	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12946	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090131	mesenchyme migration	PMID:17261592^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2179135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072189	ureter development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12946	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072001	renal system development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12946	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071407	cellular response to organic cyclic compound	PMID:18421012^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2179135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071345	cellular response to cytokine stimulus	PMID:9486531^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development	PMID:16691571^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96432	P	occurs_in:(EMAPA:19186)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060841	venous blood vessel development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12946	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060463	lung lobe morphogenesis	PMID:11493558^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1929432	P	has_participant:(EMAPA:17661)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060461	right lung morphogenesis	PMID:11493558^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1929432	P	has_participant:(EMAPA:17661)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060441	epithelial tube branching involved in lung morphogenesis	PMID:11493558^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1929432	P	occurs_in:(EMAPA:17661)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060438	trachea development	PMID:11493558^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1929432	P	results_in_development_of:(EMAPA:16853)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060438	trachea development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12946	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060426	lung vasculature development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12946	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060425	lung morphogenesis	PMID:11493558^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1929432	P	has_participant:(EMAPA:16728)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051150	regulation of smooth muscle cell differentiation	PMID:17881493^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88180	P	regulates_o_results_in_acquisition_of_features_of:(CL:0000222)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051150	regulation of smooth muscle cell differentiation	PMID:17881493^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1929432	P	regulates_o_results_in_acquisition_of_features_of:(CL:0000222)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051145	smooth muscle cell differentiation	PMID:11493558^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1929432	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050728	negative regulation of inflammatory response	PMID:18421012^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2179135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048617	embryonic foregut morphogenesis	PMID:11493558^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1929432	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048613	embryonic ectodermal digestive tract morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12946	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048566	embryonic digestive tract development	PMID:16439479^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1347479	P	results_in_development_of:(EMAPA:16247)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048565	digestive tract development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12946	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048557	embryonic digestive tract morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12946	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048371	lateral mesodermal cell differentiation	PMID:11124112^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1929432	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048286	lung alveolus development	PMID:11493558^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1929432	P	results_in_development_of:(EMAPA:19001)\|results_in_development_of:(EMAPA:19005)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17261592^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2179135	P	has_regulation_target:(MGI:MGI:96612)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:9486531^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:7958446^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17261592^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:96612)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12946	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12946	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045198	establishment of epithelial cell apical/basal polarity	PMID:16439479^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1347479	P	occurs_in:(EMAPA:18941) occurs_in:(CL:0000131)	Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:7958446^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:17261592^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	has_participant:(MGI:MGI:96612)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043305	negative regulation of mast cell degranulation	PMID:18421012^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2179135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031016	pancreas development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12946	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030335	positive regulation of cell migration	PMID:17261592^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2179135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030324	lung development	PMID:11493558^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1929432	P	results_in_development_of:(EMAPA:16728)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030324	lung development	PMID:11437453^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2179135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030324	lung development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12946	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030323	respiratory tube development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12946	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030198	extracellular matrix organization	PMID:16439479^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1347479	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014822	detection of wounding	PMID:12500195^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2179135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010811	positive regulation of cell-substrate adhesion	PMID:17261592^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2179135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009887	animal organ morphogenesis	PMID:11809759^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2179135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12946	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007498	mesoderm development	PMID:11124112^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1197522	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007498	mesoderm development	PMID:11493558^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1929432	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007494	midgut development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12946	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007368	determination of left/right symmetry	PMID:11493558^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_participant:(EMAPA:16039)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007224	smoothened signaling pathway	PMID:11493558^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:16728)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17261592^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:15987774^[14]	ECO:0000314	direct assay evidence used in manual assertion		F	has_participant:(MGI:MGI:95664)	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12946	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003214	cardiac left ventricle morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12946	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003197	endocardial cushion development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12946	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002053	positive regulation of mesenchymal cell proliferation	PMID:11124112^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1929432	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001763	morphogenesis of a branching structure	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12946	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001756	somitogenesis	PMID:11124112^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1929432	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:11493558^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1929432	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:11124112^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1929432	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12946	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001570	vasculogenesis	PMID:17881493^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1929432	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001570	vasculogenesis	PMID:11437453^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2179135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001570	vasculogenesis	PMID:11124112^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1929432	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001568	blood vessel development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12946	P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12946	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12946	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:18421012^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2179135	P	has_regulation_target:(MGI:MGI:103556)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:11124112^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1929432	P	has_regulation_target:(MGI:MGI:1197522)\|has_regulation_target:(MGI:MGI:98926)	Seeded From UniProt	complete
involved_in	GO:0097070	ductus arteriosus closure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12946 ensembl:ENSP00000262426	P		Seeded From UniProt	complete
involved_in	GO:0072189	ureter development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12946 ensembl:ENSP00000262426	P		Seeded From UniProt	complete
involved_in	GO:0072001	renal system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12946 ensembl:ENSP00000262426	P		Seeded From UniProt	complete
involved_in	GO:0060841	venous blood vessel development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12946 ensembl:ENSP00000262426	P		Seeded From UniProt	complete
involved_in	GO:0060438	trachea development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12946 ensembl:ENSP00000262426	P		Seeded From UniProt	complete
involved_in	GO:0060426	lung vasculature development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12946 ensembl:ENSP00000262426	P		Seeded From UniProt	complete
involved_in	GO:0048613	embryonic ectodermal digestive tract morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12946 ensembl:ENSP00000262426	P		Seeded From UniProt	complete
involved_in	GO:0048565	digestive tract development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12946 ensembl:ENSP00000262426	P		Seeded From UniProt	complete
involved_in	GO:0048557	embryonic digestive tract morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12946 ensembl:ENSP00000262426	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12946 ensembl:ENSP00000262426	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12946 ensembl:ENSP00000262426	P		Seeded From UniProt	complete
involved_in	GO:0031016	pancreas development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12946 ensembl:ENSP00000262426	P		Seeded From UniProt	complete
involved_in	GO:0030324	lung development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12946 ensembl:ENSP00000262426	P		Seeded From UniProt	complete
involved_in	GO:0030323	respiratory tube development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12946 ensembl:ENSP00000262426	P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12946 ensembl:ENSP00000262426	P		Seeded From UniProt	complete
involved_in	GO:0007494	midgut development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12946 ensembl:ENSP00000262426	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12946 ensembl:ENSP00000262426	F		Seeded From UniProt	complete
involved_in	GO:0003214	cardiac left ventricle morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12946 ensembl:ENSP00000262426	P		Seeded From UniProt	complete
involved_in	GO:0003197	endocardial cushion development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12946 ensembl:ENSP00000262426	P		Seeded From UniProt	complete
involved_in	GO:0001763	morphogenesis of a branching structure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12946 ensembl:ENSP00000262426	P		Seeded From UniProt	complete
involved_in	GO:0001701	in utero embryonic development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12946 ensembl:ENSP00000262426	P		Seeded From UniProt	complete
involved_in	GO:0001568	blood vessel development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12946 ensembl:ENSP00000262426	P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12946 ensembl:ENSP00000262426	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12946 ensembl:ENSP00000262426	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR018122 InterPro:IPR030456	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR018122 InterPro:IPR030456	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR018122 InterPro:IPR030456	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Hayashi, H et al. (2008) The Foxc2 transcription factor regulates angiogenesis via induction of integrin beta3 expression. J. Biol. Chem. 283 23791-800 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Mahlapuu, M et al. (2001) The forkhead transcription factor Foxf1 is required for differentiation of extra-embryonic and lateral plate mesoderm. Development 128 155-66 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Malin, D et al. (2007) Forkhead box F1 is essential for migration of mesenchymal cells and directly induces integrin-beta3 expression. Mol. Cell. Biol. 27 2486-98 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Kalin, TV et al. (2008) Pulmonary mastocytosis and enhanced lung inflammation in mice heterozygous null for the Foxf1 gene. Am. J. Respir. Cell Mol. Biol. 39 390-9 PubMed GONUTS page
↑ ^5.0 ^5.1 Peterson, RS et al. (1997) The winged helix transcriptional activator HFH-8 is expressed in the mesoderm of the primitive streak stage of mouse embryos and its cellular derivatives. Mech. Dev. 69 53-69 PubMed GONUTS page
↑ Moreno-Barriuso, N et al. (2006) Alterations in alveolar epithelium differentiation and vasculogenesis in lungs of LIF/IGF-I double deficient embryos. Dev. Dyn. 235 2040-50 PubMed GONUTS page
↑ ^7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 ^7.11 ^7.12 Mahlapuu, M et al. (2001) Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations. Development 128 2397-406 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Astorga, J & Carlsson, P (2007) Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4. Development 134 3753-61 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Ormestad, M et al. (2006) Foxf1 and Foxf2 control murine gut development by limiting mesenchymal Wnt signaling and promoting extracellular matrix production. Development 133 833-43 PubMed GONUTS page
↑ ^10.0 ^10.1 Clevidence, DE et al. (1994) Members of the HNF-3/forkhead family of transcription factors exhibit distinct cellular expression patterns in lung and regulate the surfactant protein B promoter. Dev. Biol. 166 195-209 PubMed GONUTS page
↑ ^11.0 ^11.1 Kalinichenko, VV et al. (2001) Defects in pulmonary vasculature and perinatal lung hemorrhage in mice heterozygous null for the Forkhead Box f1 transcription factor. Dev. Biol. 235 489-506 PubMed GONUTS page
↑ Kalinichenko, VV et al. (2003) Foxf1 +/- mice exhibit defective stellate cell activation and abnormal liver regeneration following CCl4 injury. Hepatology 37 107-17 PubMed GONUTS page
↑ Kalinichenko, VV et al. (2002) Haploinsufficiency of the mouse Forkhead Box f1 gene causes defects in gall bladder development. J. Biol. Chem. 277 12369-74 PubMed GONUTS page
↑ Rojas, A et al. (2005) Gata4 expression in lateral mesoderm is downstream of BMP4 and is activated directly by Forkhead and GATA transcription factors through a distal enhancer element. Development 132 3405-17 PubMed GONUTS page

[PMID:18579532-1] 1.0 ^1.1 Hayashi, H et al. (2008) The Foxc2 transcription factor regulates angiogenesis via induction of integrin beta3 expression. J. Biol. Chem. 283 23791-800 PubMed GONUTS page

[PMID:11124112-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Mahlapuu, M et al. (2001) The forkhead transcription factor Foxf1 is required for differentiation of extra-embryonic and lateral plate mesoderm. Development 128 155-66 PubMed GONUTS page

[PMID:17261592-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Malin, D et al. (2007) Forkhead box F1 is essential for migration of mesenchymal cells and directly induces integrin-beta3 expression. Mol. Cell. Biol. 27 2486-98 PubMed GONUTS page

[PMID:18421012-4] 4.0 ^4.1 ^4.2 ^4.3 Kalin, TV et al. (2008) Pulmonary mastocytosis and enhanced lung inflammation in mice heterozygous null for the Foxf1 gene. Am. J. Respir. Cell Mol. Biol. 39 390-9 PubMed GONUTS page

[PMID:9486531-5] 5.0 ^5.1 Peterson, RS et al. (1997) The winged helix transcriptional activator HFH-8 is expressed in the mesoderm of the primitive streak stage of mouse embryos and its cellular derivatives. Mech. Dev. 69 53-69 PubMed GONUTS page

[PMID:16691571-6] Moreno-Barriuso, N et al. (2006) Alterations in alveolar epithelium differentiation and vasculogenesis in lungs of LIF/IGF-I double deficient embryos. Dev. Dyn. 235 2040-50 PubMed GONUTS page

[PMID:11493558-7] 7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 ^7.11 ^7.12 Mahlapuu, M et al. (2001) Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations. Development 128 2397-406 PubMed GONUTS page

[PMID:17881493-8] 8.0 ^8.1 ^8.2 Astorga, J & Carlsson, P (2007) Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4. Development 134 3753-61 PubMed GONUTS page

[PMID:16439479-9] 9.0 ^9.1 ^9.2 Ormestad, M et al. (2006) Foxf1 and Foxf2 control murine gut development by limiting mesenchymal Wnt signaling and promoting extracellular matrix production. Development 133 833-43 PubMed GONUTS page

[PMID:7958446-10] 10.0 ^10.1 Clevidence, DE et al. (1994) Members of the HNF-3/forkhead family of transcription factors exhibit distinct cellular expression patterns in lung and regulate the surfactant protein B promoter. Dev. Biol. 166 195-209 PubMed GONUTS page

[PMID:11437453-11] 11.0 ^11.1 Kalinichenko, VV et al. (2001) Defects in pulmonary vasculature and perinatal lung hemorrhage in mice heterozygous null for the Forkhead Box f1 transcription factor. Dev. Biol. 235 489-506 PubMed GONUTS page

[PMID:12500195-12] Kalinichenko, VV et al. (2003) Foxf1 +/- mice exhibit defective stellate cell activation and abnormal liver regeneration following CCl4 injury. Hepatology 37 107-17 PubMed GONUTS page

[PMID:11809759-13] Kalinichenko, VV et al. (2002) Haploinsufficiency of the mouse Forkhead Box f1 gene causes defects in gall bladder development. J. Biol. Chem. 277 12369-74 PubMed GONUTS page

[PMID:15987774-14] Rojas, A et al. (2005) Gata4 expression in lateral mesoderm is downstream of BMP4 and is activated directly by Forkhead and GATA transcription factors through a distal enhancer element. Development 132 3405-17 PubMed GONUTS page

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