MOUSE:FMR1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Fmr1 (synonyms: Fmr-1)
Protein Name(s)	Fragile X mental retardation protein 1 homolog FMRP Protein FMR-1 mFmr1p
External Links
UniProt	P35922
EMBL	L23971
CCDS	CCDS30171.1 CCDS72385.1
PIR	S36173
UniGene	Mm.3451
ProteinModelPortal	P35922
SMR	P35922
IntAct	P35922
MINT	MINT-111096
PhosphoSite	P35922
MaxQB	P35922
PaxDb	P35922
PRIDE	P35922
UCSC	uc009tiu.1 uc009tiv.1 uc009tiy.1
MGI	MGI:95564
eggNOG	NOG75351
HOGENOM	HOG000293377
HOVERGEN	HBG005739
InParanoid	P35922
PhylomeDB	P35922
ChiTaRS	Fmr1
PRO	PR:P35922
Proteomes	UP000000589
CleanEx	MM_FMR1
Genevestigator	P35922
GO	GO:0044297 GO:0010494 GO:0005845 GO:0071598 GO:0005730 GO:0005634 GO:0008017 GO:0003723 GO:0007417 GO:0051028 GO:0045947
Gene3D	3.30.1370.10
InterPro	IPR008395 IPR022034 IPR004087 IPR004088
Pfam	PF05641 PF12235 PF00013
SMART	SM00322
SUPFAM	SSF54791
PROSITE	PS51641 PS50084

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0045727	positive regulation of translation	PMID:19166269^[1]	ECO:0000315			P		Fig. 6: Sod1 expression reduced in Fmr1-mutant cells	complete CACAO 6772
	GO:0017148	negative regulation of translation	PMID:27666021^[2]	ECO:0000315			P		Figure 3 (c-g) shows that in mutant mice cells with no FMRP protein production, there was an increased expression of GABAbR1 and GABAbR2 proteins. This means that in the presence of FMRP, translation of GABAbR1 and GABAbR2 is repressed. This shows FMRP negatively regulates the expression of these proteins.	complete CACAO 12183
part_of	GO:0005844	polysome	PMID:15805463^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0060998	regulation of dendritic spine development	PMID:16631377^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051489	regulation of filopodium assembly	PMID:16631377^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032433	filopodium tip	PMID:16631377^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:16631377^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:16631377^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:1990812	growth cone filopodium	PMID:16631377^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1902416	positive regulation of mRNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06787	P		Seeded From UniProt	complete
enables	GO:0003730	mRNA 3'-UTR binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06787	F		Seeded From UniProt	complete
involved_in	GO:0043488	regulation of mRNA stability	PMID:17417632^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007215	glutamate receptor signaling pathway	PMID:17417632^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:1902737	dendritic filopodium	PMID:16631377^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:16631377^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	PMID:16631377^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1900453	negative regulation of long-term synaptic depression	PMID:11438589^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007215	glutamate receptor signaling pathway	PMID:11438589^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:1902737	dendritic filopodium	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q80WE1	C		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q80WE1	C		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06787	C		Seeded From UniProt	complete
part_of	GO:0043679	axon terminus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q80WE1	C		Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q80WE1	C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q80WE1	C		Seeded From UniProt	complete
enables	GO:0035198	miRNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06787	F		Seeded From UniProt	complete
enables	GO:0035197	siRNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06787	F		Seeded From UniProt	complete
enables	GO:0033592	RNA strand annealing activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06787	F		Seeded From UniProt	complete
involved_in	GO:2000637	positive regulation of gene silencing by miRNA	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06787	P		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q80WE1	C		Seeded From UniProt	complete
part_of	GO:0005844	polysome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q80WE1	C		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:23235829^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q16637	C		Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	PMID:17254795^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002608) part_of:(GO:0043197)	Seeded From UniProt	complete
involved_in	GO:0098908	regulation of neuronal action potential	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06787	P		Seeded From UniProt	complete
colocalizes_with	GO:0032797	SMN complex	PMID:18093976^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06787	C		Seeded From UniProt	complete
involved_in	GO:0002092	positive regulation of receptor internalization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06787	P		Seeded From UniProt	complete
enables	GO:0002151	G-quadruplex RNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06787	F		Seeded From UniProt	complete
involved_in	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	PMID:18653529^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1905244	regulation of modification of synaptic structure	PMID:16055059^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000121)	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:16790844^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16790844^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06787	F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06787	F		Seeded From UniProt	complete
involved_in	GO:0007215	glutamate receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q80WE1	P		Seeded From UniProt	complete
enables	GO:0035064	methylated histone binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06787	F		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	PMID:24813610^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0010369	chromocenter	PMID:24813610^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:24813610^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0033129	positive regulation of histone phosphorylation	PMID:24813610^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2001022	positive regulation of response to DNA damage stimulus	PMID:24813610^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034644	cellular response to UV	PMID:24813610^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072711	cellular response to hydroxyurea	PMID:24813610^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:24813610^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008089	anterograde axonal transport	PMID:26586091^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000121) regulates:(GO:0007268) transports_or_maintains_localization_of:(GO:1990904)	Seeded From UniProt	complete
enables	GO:0034046	poly(G) binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06787	F		Seeded From UniProt	complete
enables	GO:0008266	poly(U) RNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06787	F		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06787	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06787	C		Seeded From UniProt	complete
enables	GO:0003729	mRNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06787	F		Seeded From UniProt	complete
involved_in	GO:0099578	regulation of translation at postsynapse, modulating synaptic transmission	PMID:18614030^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002608) regulates_translation_of:(ENSEMBL:ENSMUSG00000022602)	Seeded From UniProt	complete
part_of	GO:0097386	glial cell projection	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q80WE1	C		Seeded From UniProt	complete
enables	GO:0003730	mRNA 3'-UTR binding	PMID:14613971^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003729	mRNA binding	PMID:14613971^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0017148	negative regulation of translation	PMID:14613971^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005844	polysome	PMID:14613971^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	PMID:14613971^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:1902737	dendritic filopodium	PMID:18539120^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	PMID:18539120^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:18539120^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051028	mRNA transport	PMID:18539120^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0036464	cytoplasmic ribonucleoprotein granule	PMID:18539120^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0071598	neuronal ribonucleoprotein granule	PMID:18539120^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007215	glutamate receptor signaling pathway	PMID:18539120^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	PMID:18539120^[17]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0070840	dynein complex binding	PMID:18539120^[17]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051491	positive regulation of filopodium assembly	PMID:18539120^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060999	positive regulation of dendritic spine development	PMID:18539120^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0048027	mRNA 5'-UTR binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06787	F		Seeded From UniProt	complete
enables	GO:0035613	RNA stem-loop binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06787	F		Seeded From UniProt	complete
involved_in	GO:0045727	positive regulation of translation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06787	P		Seeded From UniProt	complete
enables	GO:0003730	mRNA 3'-UTR binding	PMID:11376146^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:2000766	negative regulation of cytoplasmic translation	PMID:11376146^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0030371	translation repressor activity	PMID:11376146^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0098793	presynapse	PMID:19193898^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	PMID:19193898^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:19193898^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:19193898^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	PMID:19193898^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000301	negative regulation of synaptic vesicle exocytosis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q80WE1	P		Seeded From UniProt	complete
involved_in	GO:1901386	negative regulation of voltage-gated calcium channel activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q80WE1	P		Seeded From UniProt	complete
involved_in	GO:0046928	regulation of neurotransmitter secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q80WE1	P		Seeded From UniProt	complete
involved_in	GO:1901800	positive regulation of proteasomal protein catabolic process	PMID:24709664^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:24709664^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0019897	extrinsic component of plasma membrane	PMID:24709664^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000637	positive regulation of gene silencing by miRNA	PMID:20159450^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0035198	miRNA binding	PMID:20159450^[21]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:1990825	sequence-specific mRNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06787	F		Seeded From UniProt	complete
involved_in	GO:0045727	positive regulation of translation	PMID:19166269^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045947	negative regulation of translational initiation	PMID:18805096^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005845	mRNA cap binding complex	PMID:18805096^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0099578	regulation of translation at postsynapse, modulating synaptic transmission	PMID:12032354^[23]	ECO:0001225	knockout evidence used in manual assertion		P	occurs_in:(GO:0098685) occurs_in:(UBERON:0000061)	Seeded From UniProt	complete
part_of	GO:0099523	presynaptic cytosol	PMID:19193898^[19]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0000061) part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0099523	presynaptic cytosol	PMID:19193898^[19]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0000061) part_of:(UBERON:0002264)	Seeded From UniProt	complete
part_of	GO:0099523	presynaptic cytosol	PMID:19193898^[19]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(GO:0098686) part_of:(UBERON:0000061)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:19193898^[19]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:19193898^[19]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0002264)	Seeded From UniProt	complete
part_of	GO:0098686	hippocampal mossy fiber to CA3 synapse	PMID:19193898^[19]	ECO:0006003	electron microscopy evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	PMID:12032354^[23]	ECO:0001225	knockout evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0045182	translation regulator activity	PMID:12032354^[23]	ECO:0001225	knockout evidence used in manual assertion		F	part_of:(GO:0099578) occurs_in:(GO:0098685) occurs_in:(UBERON:0000061)	Seeded From UniProt	complete
involved_in	GO:2001022	positive regulation of response to DNA damage stimulus	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95564 PANTHER:PTN001318101 UniProtKB:Q06787	P		Seeded From UniProt	complete
involved_in	GO:1905244	regulation of modification of synaptic structure	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95564 PANTHER:PTN000063980	P		Seeded From UniProt	complete
part_of	GO:1902737	dendritic filopodium	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95564 PANTHER:PTN001318101 RGD:2623	C		Seeded From UniProt	complete
involved_in	GO:0099578	regulation of translation at postsynapse, modulating synaptic transmission	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95564 PANTHER:PTN000063980	P		Seeded From UniProt	complete
part_of	GO:0098793	presynapse	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95564 PANTHER:PTN001318101	C		Seeded From UniProt	complete
part_of	GO:0071598	neuronal ribonucleoprotein granule	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0028734 MGI:MGI:95564 PANTHER:PTN000063980 RGD:2623	C		Seeded From UniProt	complete
involved_in	GO:0060998	regulation of dendritic spine development	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95564 PANTHER:PTN000063980 UniProtKB:Q06787	P		Seeded From UniProt	complete
involved_in	GO:0051489	regulation of filopodium assembly	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95564 PANTHER:PTN001318101 UniProtKB:Q06787	P		Seeded From UniProt	complete
involved_in	GO:0048814	regulation of dendrite morphogenesis	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0028734 PANTHER:PTN000063980	P		Seeded From UniProt	complete
involved_in	GO:0045727	positive regulation of translation	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95564 PANTHER:PTN001318100 UniProtKB:Q06787	P		Seeded From UniProt	complete
enables	GO:0045182	translation regulator activity	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0028734 PANTHER:PTN001318100	F		Seeded From UniProt	complete
part_of	GO:0044326	dendritic spine neck	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001318101 RGD:2623	C		Seeded From UniProt	complete
involved_in	GO:0043488	regulation of mRNA stability	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95564 PANTHER:PTN001318100	P		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104860 MGI:MGI:95564 PANTHER:PTN000063980 RGD:2623	C		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0028734 PANTHER:PTN000063980 RGD:2623	C		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001318100 UniProtKB:P51114 UniProtKB:P51116 UniProtKB:Q06787	F		Seeded From UniProt	complete
part_of	GO:0036464	cytoplasmic ribonucleoprotein granule	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95564 PANTHER:PTN001318100 RGD:2623 UniProtKB:Q06787	C		Seeded From UniProt	complete
part_of	GO:0035770	ribonucleoprotein granule	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104860 MGI:MGI:95564 PANTHER:PTN001318100	C		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001318101 RGD:2623 UniProtKB:Q06787	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104860 MGI:MGI:95564 PANTHER:PTN000063980 RGD:2623	C		Seeded From UniProt	complete
involved_in	GO:0017148	negative regulation of translation	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0028734 MGI:MGI:104860 MGI:MGI:95564 PANTHER:PTN001318100	P		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000063980 RGD:2623	C		Seeded From UniProt	complete
involved_in	GO:0008089	anterograde axonal transport	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95564 PANTHER:PTN000063980	P		Seeded From UniProt	complete
involved_in	GO:0007417	central nervous system development	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95564 PANTHER:PTN000063980	P		Seeded From UniProt	complete
part_of	GO:0005844	polysome	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104860 MGI:MGI:1346074 MGI:MGI:95564 PANTHER:PTN001318100 RGD:2623 UniProtKB:Q06787	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0028734 MGI:MGI:104860 MGI:MGI:95564 PANTHER:PTN001318100 UniProtKB:P51116 UniProtKB:Q06787	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104860 MGI:MGI:95564 PANTHER:PTN001318100 RGD:2623 UniProtKB:Q06787 Xenbase:XB-GENE-1004708 Xenbase:XB-GENE-977113	C		Seeded From UniProt	complete
enables	GO:0003730	mRNA 3'-UTR binding	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104860 MGI:MGI:95564 PANTHER:PTN001318100 UniProtKB:Q06787	F		Seeded From UniProt	complete
enables	GO:0003729	mRNA binding	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95564 PANTHER:PTN001318100 RGD:2623 UniProtKB:Q06787	F		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001318101 RGD:2623	P		Seeded From UniProt	complete
involved_in	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95564 PANTHER:PTN001318101 UniProtKB:Q06787	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001022	positive regulation of response to DNA damage stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000637	positive regulation of gene silencing by miRNA	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000301	negative regulation of synaptic vesicle exocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2623	P		Seeded From UniProt	complete
part_of	GO:1990904	ribonucleoprotein complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	C		Seeded From UniProt	complete
enables	GO:1990825	sequence-specific mRNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	F		Seeded From UniProt	complete
part_of	GO:1990635	proximal dendrite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2623	C		Seeded From UniProt	complete
part_of	GO:1990124	messenger ribonucleoprotein complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	C		Seeded From UniProt	complete
part_of	GO:1902737	dendritic filopodium	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2623	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902416	positive regulation of mRNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902373	negative regulation of mRNA catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901386	negative regulation of voltage-gated calcium channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2623	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901254	positive regulation of intracellular transport of viral material	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0099577	regulation of translation at presynapse, modulating synaptic transmission	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2623	P		Seeded From UniProt	complete
part_of	GO:0099524	postsynaptic cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2623	C		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2623	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098908	regulation of neuronal action potential	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	P		Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2623	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098586	cellular response to virus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	P		Seeded From UniProt	complete
part_of	GO:0097444	spine apparatus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2623	C		Seeded From UniProt	complete
part_of	GO:0097386	glial cell projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2623	C		Seeded From UniProt	complete
part_of	GO:0071598	neuronal ribonucleoprotein granule	PMID:21933836^[25]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17544) part_of:(CL:0000117)	Seeded From UniProt	complete
part_of	GO:0071598	neuronal ribonucleoprotein granule	PMID:17881655^[26]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q80WE1	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060998	regulation of dendritic spine development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060996	dendritic spine development	PMID:23509247^[27]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1339656 MGI:MGI:1339975 MGI:MGI:1339984 MGI:MGI:1917834	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060964	regulation of gene silencing by miRNA	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051489	regulation of filopodium assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	C		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2623	C		Seeded From UniProt	complete
enables	GO:0048027	mRNA 5'-UTR binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046928	regulation of neurotransmitter secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2623	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045727	positive regulation of translation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045665	negative regulation of neuron differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2623	P		Seeded From UniProt	complete
enables	GO:0045182	translation regulator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2623	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044830	modulation by host of viral RNA genome replication	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	P		Seeded From UniProt	complete
part_of	GO:0044327	dendritic spine head	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2623	C		Seeded From UniProt	complete
part_of	GO:0044326	dendritic spine neck	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2623	C		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	F		Seeded From UniProt	complete
part_of	GO:0044297	cell body	PMID:17881655^[26]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q80WE1	C		Seeded From UniProt	complete
part_of	GO:0043679	axon terminus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2623	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2623	P		Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	C		Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2623	C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2623	C		Seeded From UniProt	complete
part_of	GO:0043195	terminal bouton	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2623	C		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2623	C		Seeded From UniProt	complete
enables	GO:0043022	ribosome binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	F		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2623	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	C		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	F		Seeded From UniProt	complete
part_of	GO:0036464	cytoplasmic ribonucleoprotein granule	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	C		Seeded From UniProt	complete
part_of	GO:0036464	cytoplasmic ribonucleoprotein granule	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2623	C		Seeded From UniProt	complete
part_of	GO:0035770	ribonucleoprotein granule	PMID:26627310^[28]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0035613	RNA stem-loop binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	F		Seeded From UniProt	complete
enables	GO:0035198	miRNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	F		Seeded From UniProt	complete
enables	GO:0035197	siRNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	F		Seeded From UniProt	complete
enables	GO:0035064	methylated histone binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	F		Seeded From UniProt	complete
enables	GO:0034046	poly(G) binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	F		Seeded From UniProt	complete
enables	GO:0033592	RNA strand annealing activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033129	positive regulation of histone phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	P		Seeded From UniProt	complete
colocalizes_with	GO:0032797	SMN complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	C		Seeded From UniProt	complete
enables	GO:0031369	translation initiation factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	F		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	C		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2623	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:22022532^[29]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2623	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2623	C		Seeded From UniProt	complete
enables	GO:0030371	translation repressor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	F		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2623	F		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2623	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2623	F		Seeded From UniProt	complete
part_of	GO:0019034	viral replication complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	C		Seeded From UniProt	complete
part_of	GO:0015030	Cajal body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2623	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010955	negative regulation of protein processing	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2623	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2623	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2623	P		Seeded From UniProt	complete
part_of	GO:0010494	cytoplasmic stress granule	PMID:21933836^[25]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17544) part_of:(CL:0000117)	Seeded From UniProt	complete
part_of	GO:0010494	cytoplasmic stress granule	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2623	C		Seeded From UniProt	complete
enables	GO:0008266	poly(U) RNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	F		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	PMID:17881655^[26]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007417	central nervous system development	PMID:12700164^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2451086	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007215	glutamate receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2623	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	P		Seeded From UniProt	complete
colocalizes_with	GO:0005874	microtubule	PMID:17881655^[26]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q80WE1	C		Seeded From UniProt	complete
part_of	GO:0005844	polysome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	C		Seeded From UniProt	complete
part_of	GO:0005844	polysome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2623	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2623	C		Seeded From UniProt	complete
part_of	GO:0005791	rough endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2623	C		Seeded From UniProt	complete
part_of	GO:0005790	smooth endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2623	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2623	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12700164^[30]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2623	C		Seeded From UniProt	complete
enables	GO:0003730	mRNA 3'-UTR binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	F		Seeded From UniProt	complete
enables	GO:0003729	mRNA binding	PMID:26627310^[28]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(MGI:MGI:101864) has_input:(MGI:MGI:1277959) has_input:(MGI:MGI:2138865) has_input:(MGI:MGI:88059) has_input:(MGI:MGI:88256)	Seeded From UniProt	complete
enables	GO:0003729	mRNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	F		Seeded From UniProt	complete
enables	GO:0003729	mRNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2623	F		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:24349419^[31]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(MGI:MGI:2677850)	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	F		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2623	F		Seeded From UniProt	complete
enables	GO:0002151	G-quadruplex RNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002092	positive regulation of receptor internalization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002091	negative regulation of receptor internalization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2623	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2623	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06787	P		Seeded From UniProt	complete
enables	GO:0000340	RNA 7-methylguanosine cap binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2623	F		Seeded From UniProt	complete
part_of	GO:1904115	axon cytoplasm	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008089	C		Seeded From UniProt	complete
part_of	GO:1904115	axon cytoplasm	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008089	C		Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004087	F		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004088 InterPro:IPR022034 InterPro:IPR036612	F		Seeded From UniProt	complete
enables	GO:0003729	mRNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR040148	F		Seeded From UniProt	complete
involved_in	GO:0006417	regulation of translation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR040148	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966 UniProtKB-SubCell:SL-0280	C		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0771 UniProtKB-SubCell:SL-0261	C		Seeded From UniProt	complete
part_of	GO:0000775	chromosome, centromeric region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0137 UniProtKB-SubCell:SL-0047	C		Seeded From UniProt	complete
involved_in	GO:0006417	regulation of translation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0810	P		Seeded From UniProt	complete
involved_in	GO:0031047	gene silencing by RNA	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0943	P		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0628 UniProtKB-SubCell:SL-0219	C		Seeded From UniProt	complete
involved_in	GO:0006397	mRNA processing	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0507	P		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F		Seeded From UniProt	complete
involved_in	GO:0008380	RNA splicing	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0508	P		Seeded From UniProt	complete
involved_in	GO:0051028	mRNA transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0509	P		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158 UniProtKB-SubCell:SL-0468	C		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770 UniProtKB-SubCell:SL-0258	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0190	C		Seeded From UniProt	complete
part_of	GO:0030175	filopodium	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0286	C		Seeded From UniProt	complete
part_of	GO:0036464	cytoplasmic ribonucleoprotein granule	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0495	C		Seeded From UniProt	complete
part_of	GO:0010494	cytoplasmic stress granule	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0496	C		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0288	C		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0198	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0283	C		Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0197	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0188	C		Seeded From UniProt	complete
part_of	GO:0032433	filopodium tip	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0470	C		Seeded From UniProt	complete
part_of	GO:0042734	presynaptic membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0222	C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0284	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0279	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Bechara, EG et al. (2009) A novel function for fragile X mental retardation protein in translational activation. PLoS Biol. 7 e16 PubMed GONUTS page
↑ Wolfe, SA et al. (2016) FMRP regulates an ethanol-dependent shift in GABABR function and expression with rapid antidepressant properties. Nat Commun 7 12867 PubMed GONUTS page
↑ Darnell, JC et al. (2005) Kissing complex RNAs mediate interaction between the Fragile-X mental retardation protein KH2 domain and brain polyribosomes. Genes Dev. 19 903-18 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 Antar, LN et al. () Local functions for FMRP in axon growth cone motility and activity-dependent regulation of filopodia and spine synapses. Mol. Cell. Neurosci. 32 37-48 PubMed GONUTS page
↑ ^5.0 ^5.1 Zalfa, F et al. (2007) A new function for the fragile X mental retardation protein in regulation of PSD-95 mRNA stability. Nat. Neurosci. 10 578-87 PubMed GONUTS page
↑ ^6.0 ^6.1 Nimchinsky, EA et al. (2001) Abnormal development of dendritic spines in FMR1 knock-out mice. J. Neurosci. 21 5139-46 PubMed GONUTS page
↑ Ascano, M Jr et al. (2012) FMRP targets distinct mRNA sequence elements to regulate protein expression. Nature 492 382-6 PubMed GONUTS page
↑ Ferrari, F et al. (2007) The fragile X mental retardation protein-RNP granules show an mGluR-dependent localization in the post-synaptic spines. Mol. Cell. Neurosci. 34 343-54 PubMed GONUTS page
↑ Piazzon, N et al. (2008) In vitro and in cellulo evidences for association of the survival of motor neuron complex with the fragile X mental retardation protein. J. Biol. Chem. 283 5598-610 PubMed GONUTS page
↑ Didiot, MC et al. (2008) The G-quartet containing FMRP binding site in FMR1 mRNA is a potent exonic splicing enhancer. Nucleic Acids Res. 36 4902-12 PubMed GONUTS page
↑ Koekkoek, SK et al. (2005) Deletion of FMR1 in Purkinje cells enhances parallel fiber LTD, enlarges spines, and attenuates cerebellar eyelid conditioning in Fragile X syndrome. Neuron 47 339-52 PubMed GONUTS page
↑ ^12.0 ^12.1 Lai, D et al. (2006) The fragile X mental retardation protein interacts with a distinct mRNA nuclear export factor NXF2. RNA 12 1446-9 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 ^13.7 Alpatov, R et al. (2014) A chromatin-dependent role of the fragile X mental retardation protein FMRP in the DNA damage response. Cell 157 869-81 PubMed GONUTS page
↑ Zhang, P et al. (2015) Novel RNA- and FMRP-binding protein TRF2-S regulates axonal mRNA transport and presynaptic plasticity. Nat Commun 6 8888 PubMed GONUTS page
↑ Park, S et al. (2008) Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD. Neuron 59 70-83 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 Wang, H et al. (2004) Developmentally-programmed FMRP expression in oligodendrocytes: a potential role of FMRP in regulating translation in oligodendroglia progenitors. Hum. Mol. Genet. 13 79-89 PubMed GONUTS page
↑ ^17.00 ^17.01 ^17.02 ^17.03 ^17.04 ^17.05 ^17.06 ^17.07 ^17.08 ^17.09 ^17.10 Dictenberg, JB et al. (2008) A direct role for FMRP in activity-dependent dendritic mRNA transport links filopodial-spine morphogenesis to fragile X syndrome. Dev. Cell 14 926-39 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 Li, Z et al. (2001) The fragile X mental retardation protein inhibits translation via interacting with mRNA. Nucleic Acids Res. 29 2276-83 PubMed GONUTS page
↑ ^19.00 ^19.01 ^19.02 ^19.03 ^19.04 ^19.05 ^19.06 ^19.07 ^19.08 ^19.09 ^19.10 Christie, SB et al. (2009) The FXG: a presynaptic fragile X granule expressed in a subset of developing brain circuits. J. Neurosci. 29 1514-24 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 Ferron, L et al. (2014) Fragile X mental retardation protein controls synaptic vesicle exocytosis by modulating N-type calcium channel density. Nat Commun 5 3628 PubMed GONUTS page
↑ ^21.0 ^21.1 Edbauer, D et al. (2010) Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132. Neuron 65 373-84 PubMed GONUTS page
↑ ^22.0 ^22.1 Napoli, I et al. (2008) The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP. Cell 134 1042-54 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 Huber, KM et al. (2002) Altered synaptic plasticity in a mouse model of fragile X mental retardation. Proc. Natl. Acad. Sci. U.S.A. 99 7746-50 PubMed GONUTS page
↑ ^24.00 ^24.01 ^24.02 ^24.03 ^24.04 ^24.05 ^24.06 ^24.07 ^24.08 ^24.09 ^24.10 ^24.11 ^24.12 ^24.13 ^24.14 ^24.15 ^24.16 ^24.17 ^24.18 ^24.19 ^24.20 ^24.21 ^24.22 ^24.23 ^24.24 ^24.25 ^24.26 ^24.27 ^24.28 ^24.29 ^24.30 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^25.0 ^25.1 Kunde, SA et al. (2011) The X-chromosome-linked intellectual disability protein PQBP1 is a component of neuronal RNA granules and regulates the appearance of stress granules. Hum. Mol. Genet. 20 4916-31 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 ^26.3 Davidovic, L et al. (2007) The fragile X mental retardation protein is a molecular adaptor between the neurospecific KIF3C kinesin and dendritic RNA granules. Hum. Mol. Genet. 16 3047-58 PubMed GONUTS page
↑ Dolan, BM et al. (2013) Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486. Proc. Natl. Acad. Sci. U.S.A. 110 5671-6 PubMed GONUTS page
↑ ^28.0 ^28.1 Berg, JM et al. (2015) JAKMIP1, a Novel Regulator of Neuronal Translation, Modulates Synaptic Function and Autistic-like Behaviors in Mouse. Neuron 88 1173-1191 PubMed GONUTS page
↑ Cook, D et al. (2011) Fragile X related protein 1 clusters with ribosomes and messenger RNAs at a subset of dendritic spines in the mouse hippocampus. PLoS ONE 6 e26120 PubMed GONUTS page
↑ ^30.0 ^30.1 Willemsen, R et al. (2003) The FMR1 CGG repeat mouse displays ubiquitin-positive intranuclear neuronal inclusions; implications for the cerebellar tremor/ataxia syndrome. Hum. Mol. Genet. 12 949-59 PubMed GONUTS page
↑ Derlig, K et al. (2013) Identification and characterisation of Simiate, a novel protein linked to the fragile X syndrome. PLoS ONE 8 e83007 PubMed GONUTS page

[PMID:19166269-1] 1.0 ^1.1 Bechara, EG et al. (2009) A novel function for fragile X mental retardation protein in translational activation. PLoS Biol. 7 e16 PubMed GONUTS page

[PMID:27666021-2] Wolfe, SA et al. (2016) FMRP regulates an ethanol-dependent shift in GABABR function and expression with rapid antidepressant properties. Nat Commun 7 12867 PubMed GONUTS page

[PMID:15805463-3] Darnell, JC et al. (2005) Kissing complex RNAs mediate interaction between the Fragile-X mental retardation protein KH2 domain and brain polyribosomes. Genes Dev. 19 903-18 PubMed GONUTS page

[PMID:16631377-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 Antar, LN et al. () Local functions for FMRP in axon growth cone motility and activity-dependent regulation of filopodia and spine synapses. Mol. Cell. Neurosci. 32 37-48 PubMed GONUTS page

[PMID:17417632-5] 5.0 ^5.1 Zalfa, F et al. (2007) A new function for the fragile X mental retardation protein in regulation of PSD-95 mRNA stability. Nat. Neurosci. 10 578-87 PubMed GONUTS page

[PMID:11438589-6] 6.0 ^6.1 Nimchinsky, EA et al. (2001) Abnormal development of dendritic spines in FMR1 knock-out mice. J. Neurosci. 21 5139-46 PubMed GONUTS page

[PMID:23235829-7] Ascano, M Jr et al. (2012) FMRP targets distinct mRNA sequence elements to regulate protein expression. Nature 492 382-6 PubMed GONUTS page

[PMID:17254795-8] Ferrari, F et al. (2007) The fragile X mental retardation protein-RNP granules show an mGluR-dependent localization in the post-synaptic spines. Mol. Cell. Neurosci. 34 343-54 PubMed GONUTS page

[PMID:18093976-9] Piazzon, N et al. (2008) In vitro and in cellulo evidences for association of the survival of motor neuron complex with the fragile X mental retardation protein. J. Biol. Chem. 283 5598-610 PubMed GONUTS page

[PMID:18653529-10] Didiot, MC et al. (2008) The G-quartet containing FMRP binding site in FMR1 mRNA is a potent exonic splicing enhancer. Nucleic Acids Res. 36 4902-12 PubMed GONUTS page

[PMID:16055059-11] Koekkoek, SK et al. (2005) Deletion of FMR1 in Purkinje cells enhances parallel fiber LTD, enlarges spines, and attenuates cerebellar eyelid conditioning in Fragile X syndrome. Neuron 47 339-52 PubMed GONUTS page

[PMID:16790844-12] 12.0 ^12.1 Lai, D et al. (2006) The fragile X mental retardation protein interacts with a distinct mRNA nuclear export factor NXF2. RNA 12 1446-9 PubMed GONUTS page

[PMID:24813610-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 ^13.7 Alpatov, R et al. (2014) A chromatin-dependent role of the fragile X mental retardation protein FMRP in the DNA damage response. Cell 157 869-81 PubMed GONUTS page

[PMID:26586091-14] Zhang, P et al. (2015) Novel RNA- and FMRP-binding protein TRF2-S regulates axonal mRNA transport and presynaptic plasticity. Nat Commun 6 8888 PubMed GONUTS page

[PMID:18614030-15] Park, S et al. (2008) Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD. Neuron 59 70-83 PubMed GONUTS page

[PMID:14613971-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 Wang, H et al. (2004) Developmentally-programmed FMRP expression in oligodendrocytes: a potential role of FMRP in regulating translation in oligodendroglia progenitors. Hum. Mol. Genet. 13 79-89 PubMed GONUTS page

[PMID:18539120-17] 17.00 ^17.01 ^17.02 ^17.03 ^17.04 ^17.05 ^17.06 ^17.07 ^17.08 ^17.09 ^17.10 Dictenberg, JB et al. (2008) A direct role for FMRP in activity-dependent dendritic mRNA transport links filopodial-spine morphogenesis to fragile X syndrome. Dev. Cell 14 926-39 PubMed GONUTS page

[PMID:11376146-18] 18.0 ^18.1 ^18.2 Li, Z et al. (2001) The fragile X mental retardation protein inhibits translation via interacting with mRNA. Nucleic Acids Res. 29 2276-83 PubMed GONUTS page

[PMID:19193898-19] 19.00 ^19.01 ^19.02 ^19.03 ^19.04 ^19.05 ^19.06 ^19.07 ^19.08 ^19.09 ^19.10 Christie, SB et al. (2009) The FXG: a presynaptic fragile X granule expressed in a subset of developing brain circuits. J. Neurosci. 29 1514-24 PubMed GONUTS page

[PMID:24709664-20] 20.0 ^20.1 ^20.2 Ferron, L et al. (2014) Fragile X mental retardation protein controls synaptic vesicle exocytosis by modulating N-type calcium channel density. Nat Commun 5 3628 PubMed GONUTS page

[PMID:20159450-21] 21.0 ^21.1 Edbauer, D et al. (2010) Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132. Neuron 65 373-84 PubMed GONUTS page

[PMID:18805096-22] 22.0 ^22.1 Napoli, I et al. (2008) The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP. Cell 134 1042-54 PubMed GONUTS page

[PMID:12032354-23] 23.0 ^23.1 ^23.2 Huber, KM et al. (2002) Altered synaptic plasticity in a mouse model of fragile X mental retardation. Proc. Natl. Acad. Sci. U.S.A. 99 7746-50 PubMed GONUTS page

[PMID:21873635-24] 24.00 ^24.01 ^24.02 ^24.03 ^24.04 ^24.05 ^24.06 ^24.07 ^24.08 ^24.09 ^24.10 ^24.11 ^24.12 ^24.13 ^24.14 ^24.15 ^24.16 ^24.17 ^24.18 ^24.19 ^24.20 ^24.21 ^24.22 ^24.23 ^24.24 ^24.25 ^24.26 ^24.27 ^24.28 ^24.29 ^24.30 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21933836-25] 25.0 ^25.1 Kunde, SA et al. (2011) The X-chromosome-linked intellectual disability protein PQBP1 is a component of neuronal RNA granules and regulates the appearance of stress granules. Hum. Mol. Genet. 20 4916-31 PubMed GONUTS page

[PMID:17881655-26] 26.0 ^26.1 ^26.2 ^26.3 Davidovic, L et al. (2007) The fragile X mental retardation protein is a molecular adaptor between the neurospecific KIF3C kinesin and dendritic RNA granules. Hum. Mol. Genet. 16 3047-58 PubMed GONUTS page

[PMID:23509247-27] Dolan, BM et al. (2013) Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486. Proc. Natl. Acad. Sci. U.S.A. 110 5671-6 PubMed GONUTS page

[PMID:26627310-28] 28.0 ^28.1 Berg, JM et al. (2015) JAKMIP1, a Novel Regulator of Neuronal Translation, Modulates Synaptic Function and Autistic-like Behaviors in Mouse. Neuron 88 1173-1191 PubMed GONUTS page

[PMID:22022532-29] Cook, D et al. (2011) Fragile X related protein 1 clusters with ribosomes and messenger RNAs at a subset of dendritic spines in the mouse hippocampus. PLoS ONE 6 e26120 PubMed GONUTS page

[PMID:12700164-30] 30.0 ^30.1 Willemsen, R et al. (2003) The FMR1 CGG repeat mouse displays ubiquitin-positive intranuclear neuronal inclusions; implications for the cerebellar tremor/ataxia syndrome. Hum. Mol. Genet. 12 949-59 PubMed GONUTS page

[PMID:24349419-31] Derlig, K et al. (2013) Identification and characterisation of Simiate, a novel protein linked to the fragile X syndrome. PLoS ONE 8 e83007 PubMed GONUTS page

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MOUSE:FMR1

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