MOUSE:FLNA

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Flna (synonyms: Fln, Fln1)
Protein Name(s)	Filamin-A FLN-A Actin-binding protein 280 ABP-280 Alpha-filamin Endothelial actin-binding protein Filamin-1 Non-muscle filamin
External Links
UniProt	Q8BTM8
EMBL	AK044856 AK089195 AK089311 AL807376 BC004061 BC038478 BC054432 AF034129 AF353668 AF353671
RefSeq	XP_006527974.1
UniGene	Mm.295533
ProteinModelPortal	Q8BTM8
SMR	Q8BTM8
BioGrid	228662
IntAct	Q8BTM8
MINT	MINT-1867095
STRING	10090.ENSMUSP00000098997
PhosphoSite	Q8BTM8
MaxQB	Q8BTM8
PaxDb	Q8BTM8
PRIDE	Q8BTM8
Ensembl	ENSMUST00000033699
GeneID	192176
UCSC	uc009tnz.1
CTD	2316
MGI	MGI:95556
eggNOG	KOG0518 COG5069
GeneTree	ENSGT00660000095431
HOVERGEN	HBG004163
InParanoid	Q8BTM8
OMA	VQDNEGC
OrthoDB	EOG76T9QC
TreeFam	TF313685
Reactome	R-MMU-114608 R-MMU-430116 R-MMU-446353 R-MMU-5627123
ChiTaRS	Flna
NextBio	371188
PRO	PR:Q8BTM8
Proteomes	UP000000589
Bgee	Q8BTM8
CleanEx	MM_FLNA
ExpressionAtlas	Q8BTM8
Genevisible	Q8BTM8
GO	GO:0015629 GO:0032432 GO:0005903 GO:0005938 GO:0005737 GO:0070062 GO:0005925 GO:0016020 GO:0031523 GO:0005730 GO:0005634 GO:0005886 GO:0005802 GO:0003779 GO:0051015 GO:0034988 GO:0001948 GO:0044822 GO:0042803 GO:0005080 GO:0048365 GO:0017160 GO:0017048 GO:0004871 GO:0031267 GO:0008134 GO:0051764 GO:0030036 GO:0031532 GO:0007195 GO:0042384 GO:0051220 GO:0045022 GO:0001837 GO:0045184 GO:0090307 GO:0043066 GO:0042177 GO:0043433 GO:0016479 GO:0070527 GO:0043123 GO:2001046 GO:1900026 GO:0042993 GO:0034394 GO:0050821 GO:0043113
Gene3D	1.10.418.10 2.60.40.10
InterPro	IPR001589 IPR001715 IPR017868 IPR001298 IPR028559 IPR013783 IPR014756
PANTHER	PTHR11915:SF173
Pfam	PF00307 PF00630
SMART	SM00033 SM00557
SUPFAM	SSF47576 SSF81296
PROSITE	PS00019 PS00020 PS50021 PS50194

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:1901381	positive regulation of potassium ion transmembrane transport	PMID:24951510^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0015459	potassium channel regulator activity	PMID:24951510^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0072659	protein localization to plasma membrane	PMID:24951510^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	transports_or_maintains_localization_of:(UniProtKB:P58390) occurs_in:(CL:0002495)	Seeded From UniProt	complete
involved_in	GO:1905000	regulation of membrane repolarization during atrial cardiac muscle cell action potential	PMID:24951510^[1]	ECO:0000305	curator inference used in manual assertion	GO:1905031	P		Seeded From UniProt	complete
involved_in	GO:1905031	regulation of membrane repolarization during cardiac muscle cell action potential	PMID:24951510^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002495)	Seeded From UniProt	complete
part_of	GO:0030018	Z disc	PMID:24951510^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002129)	Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21333	C		Seeded From UniProt	complete
involved_in	GO:0044319	wound healing, spreading of cells	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21333	P		Seeded From UniProt	complete
involved_in	GO:0030334	regulation of cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21333	P		Seeded From UniProt	complete
involved_in	GO:0071526	semaphorin-plexin signaling pathway	PMID:25358863^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O08665	P		Seeded From UniProt	complete
involved_in	GO:0071526	semaphorin-plexin signaling pathway	PMID:25358863^[2]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
colocalizes_with	GO:0031941	filamentous actin	PMID:25358863^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0071526)	Seeded From UniProt	complete
part_of	GO:0030426	growth cone	PMID:25358863^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0032231	regulation of actin filament bundle assembly	PMID:20713593^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010977	negative regulation of neuron projection development	PMID:25358863^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q14194	P		Seeded From UniProt	complete
involved_in	GO:0045216	cell-cell junction organization	PMID:17172441^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
	GO:0044295	axonal growth cone	PMID:26157139^[5]	ECO:0000314			C		Figure 5A	complete CACAO 11099
	GO:0048680	positive regulation of axon regeneration	PMID:26157139^[5]	ECO:0000315			P		Figure 7A-C	complete CACAO 11100
involved_in	GO:0003007	heart morphogenesis	PMID:17172441^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001974	blood vessel remodeling	PMID:17172441^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:17172441^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005903	brush border	PMID:22114352^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000584)	Seeded From UniProt	complete
involved_in	GO:0051764	actin crosslink formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21333	P		Seeded From UniProt	complete
involved_in	GO:0051220	cytoplasmic sequestering of protein	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21333	P		Seeded From UniProt	complete
enables	GO:0051015	actin filament binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21333	F		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21333	P		Seeded From UniProt	complete
enables	GO:0048365	Rac GTPase binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21333	F		Seeded From UniProt	complete
involved_in	GO:0045184	establishment of protein localization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21333	P		Seeded From UniProt	complete
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21333	P		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21333	P		Seeded From UniProt	complete
involved_in	GO:0043113	receptor clustering	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21333	P		Seeded From UniProt	complete
involved_in	GO:0042307	positive regulation of protein import into nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21333	P	has_direct_input:(UniProtKB:P40424-1)	Seeded From UniProt	complete
involved_in	GO:0042177	negative regulation of protein catabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21333	P		Seeded From UniProt	complete
enables	GO:0034988	Fc-gamma receptor I complex binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21333	F		Seeded From UniProt	complete
involved_in	GO:0034394	protein localization to cell surface	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21333	P		Seeded From UniProt	complete
involved_in	GO:0031532	actin cytoskeleton reorganization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21333	P		Seeded From UniProt	complete
enables	GO:0017048	Rho GTPase binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21333	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21333	F		Seeded From UniProt	complete
involved_in	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21333	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21333	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21333	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21333	C		Seeded From UniProt	complete
involved_in	GO:0050808	synapse organization	PMID:26972007^[7]	ECO:0006052	RNAi evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050808	synapse organization	PMID:26972007^[7]	ECO:0005589	confocal microscopy evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001224	positive regulation of neuron migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1560614	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001046	positive regulation of integrin-mediated signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21333	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000179	positive regulation of neural precursor cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1560614	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902396	protein localization to bicellular tight junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1560614	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901381	positive regulation of potassium ion transmembrane transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21333	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21333	P		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1560614	C		Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1560614	C		Seeded From UniProt	complete
part_of	GO:0097440	apical dendrite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1560614	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097368	establishment of Sertoli cell barrier	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1560614	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090307	mitotic spindle assembly	PMID:18548008^[8]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21333	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072659	protein localization to plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21333	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071526	semaphorin-plexin signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21333	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060271	cilium assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21333	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051764	actin crosslink formation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21333	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051220	cytoplasmic sequestering of protein	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21333	P		Seeded From UniProt	complete
enables	GO:0051020	GTPase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21333	F		Seeded From UniProt	complete
enables	GO:0051015	actin filament binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21333	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050821	protein stabilization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21333	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1560614	C		Seeded From UniProt	complete
enables	GO:0048365	Rac GTPase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21333	F		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1560614	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045184	establishment of protein localization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21333	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045022	early endosome to late endosome transport	PMID:9412467^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1560614	F		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21333	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044319	wound healing, spreading of cells	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21333	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043433	negative regulation of DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21333	P		Seeded From UniProt	complete
part_of	GO:0043198	dendritic shaft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1560614	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043113	receptor clustering	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21333	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21333	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1560614	C		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21333	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042789	mRNA transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1560614	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042307	positive regulation of protein import into nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21333	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042177	negative regulation of protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21333	P		Seeded From UniProt	complete
enables	GO:0034988	Fc-gamma receptor I complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21333	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034394	protein localization to cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21333	P		Seeded From UniProt	complete
part_of	GO:0032432	actin filament bundle	PMID:24436304^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000138)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032233	positive regulation of actin filament bundle assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1560614	P		Seeded From UniProt	complete
colocalizes_with	GO:0031941	filamentous actin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21333	C		Seeded From UniProt	complete
enables	GO:0031852	mu-type opioid receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1560614	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031532	actin cytoskeleton reorganization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21333	P		Seeded From UniProt	complete
part_of	GO:0031523	Myb complex	PMID:18548008^[8]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21333	C		Seeded From UniProt	complete
enables	GO:0031267	small GTPase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21333	F		Seeded From UniProt	complete
part_of	GO:0030863	cortical cytoskeleton	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1560614	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030334	regulation of cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21333	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030036	actin cytoskeleton organization	PMID:21709252^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1923816	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021943	formation of radial glial scaffolds	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1560614	P		Seeded From UniProt	complete
enables	GO:0019900	kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21333	F		Seeded From UniProt	complete
enables	GO:0017160	Ral GTPase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21333	F		Seeded From UniProt	complete
enables	GO:0017048	Rho GTPase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21333	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016479	negative regulation of transcription by RNA polymerase I	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21333	P		Seeded From UniProt	complete
part_of	GO:0015629	actin cytoskeleton	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21333	C		Seeded From UniProt	complete
part_of	GO:0015629	actin cytoskeleton	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1560614	C		Seeded From UniProt	complete
enables	GO:0015459	potassium channel regulator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21333	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21333	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21333	P		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1560614	C		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21333	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21333	C		Seeded From UniProt	complete
part_of	GO:0005884	actin filament	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1560614	C		Seeded From UniProt	complete
colocalizes_with	GO:0005884	actin filament	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1560614	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21333	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1560614	C		Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	PMID:9412467^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21333	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21333	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21333	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1560614	C		Seeded From UniProt	complete
enables	GO:0005080	protein kinase C binding	PMID:12704190^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001837	epithelial to mesenchymal transition	PMID:21709252^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1923816	P		Seeded From UniProt	complete
enables	GO:0001664	G protein-coupled receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21333	F		Seeded From UniProt	complete
enables	GO:0051015	actin filament binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028559	F		Seeded From UniProt	complete
enables	GO:0003779	actin binding	PMID:9412467^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
involved_in	GO:0030030	cell projection organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0970	P		Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0009	F		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0138	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Rafizadeh, S et al. (2014) Functional interaction with filamin A and intracellular Ca2+ enhance the surface membrane expression of a small-conductance Ca2+-activated K+ (SK2) channel. Proc. Natl. Acad. Sci. U.S.A. 111 9989-94 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Nakamura, F et al. (2014) Amino- and carboxyl-terminal domains of Filamin-A interact with CRMP1 to mediate Sema3A signalling. Nat Commun 5 5325 PubMed GONUTS page
↑ Falet, H et al. (2010) A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function. J. Exp. Med. 207 1967-79 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Feng, Y et al. (2006) Filamin A (FLNA) is required for cell-cell contact in vascular development and cardiac morphogenesis. Proc. Natl. Acad. Sci. U.S.A. 103 19836-41 PubMed GONUTS page
↑ ^5.0 ^5.1 Cho, Y et al. (2015) Filamin A is required in injured axons for HDAC5 activity and axon regeneration. J. Biol. Chem. 290 22759-70 PubMed GONUTS page
↑ Revenu, C et al. (2012) A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins. Mol. Biol. Cell 23 324-36 PubMed GONUTS page
↑ ^7.0 ^7.1 Segura, I et al. (2016) The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A. Cell Rep 14 2653-67 PubMed GONUTS page
↑ ^8.0 ^8.1 Yamauchi, T et al. (2008) A B-Myb complex containing clathrin and filamin is required for mitotic spindle function. EMBO J. 27 1852-62 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Liu, G et al. (1997) Cytoskeletal protein ABP-280 directs the intracellular trafficking of furin and modulates proprotein processing in the endocytic pathway. J. Cell Biol. 139 1719-33 PubMed GONUTS page
↑ Mizuhashi, K et al. (2014) Filamin-interacting proteins, Cfm1 and Cfm2, are essential for the formation of cartilaginous skeletal elements. Hum. Mol. Genet. 23 2953-67 PubMed GONUTS page
↑ ^11.0 ^11.1 Gay, O et al. (2011) RefilinB (FAM101B) targets filamin A to organize perinuclear actin networks and regulates nuclear shape. Proc. Natl. Acad. Sci. U.S.A. 108 11464-9 PubMed GONUTS page
↑ Tigges, U et al. (2003) The F-actin cross-linking and focal adhesion protein filamin A is a ligand and in vivo substrate for protein kinase C alpha. J. Biol. Chem. 278 23561-9 PubMed GONUTS page

[PMID:24951510-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Rafizadeh, S et al. (2014) Functional interaction with filamin A and intracellular Ca2+ enhance the surface membrane expression of a small-conductance Ca2+-activated K+ (SK2) channel. Proc. Natl. Acad. Sci. U.S.A. 111 9989-94 PubMed GONUTS page

[PMID:25358863-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Nakamura, F et al. (2014) Amino- and carboxyl-terminal domains of Filamin-A interact with CRMP1 to mediate Sema3A signalling. Nat Commun 5 5325 PubMed GONUTS page

[PMID:20713593-3] Falet, H et al. (2010) A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function. J. Exp. Med. 207 1967-79 PubMed GONUTS page

[PMID:17172441-4] 4.0 ^4.1 ^4.2 ^4.3 Feng, Y et al. (2006) Filamin A (FLNA) is required for cell-cell contact in vascular development and cardiac morphogenesis. Proc. Natl. Acad. Sci. U.S.A. 103 19836-41 PubMed GONUTS page

[PMID:26157139-5] 5.0 ^5.1 Cho, Y et al. (2015) Filamin A is required in injured axons for HDAC5 activity and axon regeneration. J. Biol. Chem. 290 22759-70 PubMed GONUTS page

[PMID:22114352-6] Revenu, C et al. (2012) A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins. Mol. Biol. Cell 23 324-36 PubMed GONUTS page

[PMID:26972007-7] 7.0 ^7.1 Segura, I et al. (2016) The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A. Cell Rep 14 2653-67 PubMed GONUTS page

[PMID:18548008-8] 8.0 ^8.1 Yamauchi, T et al. (2008) A B-Myb complex containing clathrin and filamin is required for mitotic spindle function. EMBO J. 27 1852-62 PubMed GONUTS page

[PMID:9412467-9] 9.0 ^9.1 ^9.2 Liu, G et al. (1997) Cytoskeletal protein ABP-280 directs the intracellular trafficking of furin and modulates proprotein processing in the endocytic pathway. J. Cell Biol. 139 1719-33 PubMed GONUTS page

[PMID:24436304-10] Mizuhashi, K et al. (2014) Filamin-interacting proteins, Cfm1 and Cfm2, are essential for the formation of cartilaginous skeletal elements. Hum. Mol. Genet. 23 2953-67 PubMed GONUTS page

[PMID:21709252-11] 11.0 ^11.1 Gay, O et al. (2011) RefilinB (FAM101B) targets filamin A to organize perinuclear actin networks and regulates nuclear shape. Proc. Natl. Acad. Sci. U.S.A. 108 11464-9 PubMed GONUTS page

[PMID:12704190-12] Tigges, U et al. (2003) The F-actin cross-linking and focal adhesion protein filamin A is a ligand and in vivo substrate for protein kinase C alpha. J. Biol. Chem. 278 23561-9 PubMed GONUTS page

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