MOUSE:FGFR2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Fgfr2 (synonyms: Bek, Ect1)
Protein Name(s)	Fibroblast growth factor receptor 2 FGFR-2 Keratinocyte growth factor receptor KGFR
External Links
UniProt	P21803
EMBL	X55441 M63503 M86441 Y16152 Y16167 M23362
PIR	A38429 A44142 S17295
RefSeq	NP_034337.2 NP_963895.2
UniGene	Mm.16340
PDB	4HWU
PDBsum	4HWU
ProteinModelPortal	P21803
SMR	P21803
BioGrid	199657
DIP	DIP-6038N
IntAct	P21803
ChEMBL	CHEMBL2111391
PhosphoSite	P21803
MaxQB	P21803
PaxDb	P21803
PRIDE	P21803
GeneID	14183
KEGG	mmu:14183
CTD	2263
MGI	MGI:95523
eggNOG	COG0515
HOGENOM	HOG000263410
HOVERGEN	HBG000345
InParanoid	P21803
KO	K05093
PhylomeDB	P21803
BRENDA	2.7.10.1
ChiTaRS	Fgfr2
NextBio	285386
PRO	PR:P21803
Proteomes	UP000000589
CleanEx	MM_FGFR2
Genevestigator	P21803
GO	GO:0016023 GO:0060076 GO:0005576 GO:0005794 GO:0016021 GO:0005634 GO:0005886 GO:0005524 GO:0017134 GO:0005007 GO:0008201 GO:0001525 GO:0006915 GO:0007409 GO:0060348 GO:0030282 GO:0060349 GO:0060667 GO:0060670 GO:0060442 GO:0060445 GO:0048755 GO:0060449 GO:0045165 GO:0007267 GO:0060365 GO:0048565 GO:0048701 GO:0048557 GO:0048568 GO:0048562 GO:0009880 GO:0061031 GO:0048730 GO:0030855 GO:0050673 GO:0060664 GO:0060441 GO:0008543 GO:0035603 GO:0060595 GO:0035602 GO:0035607 GO:0035604 GO:0022612 GO:0031069 GO:0001701 GO:0042472 GO:0032808 GO:0060601 GO:0070307 GO:0060174 GO:0048286 GO:0030324 GO:0060463 GO:0060484 GO:0060615 GO:0003149 GO:0048762 GO:0060915 GO:0060916 GO:0030901 GO:0016331 GO:0035264 GO:0008285 GO:0045839 GO:0000122 GO:0007528 GO:0042476 GO:0021769 GO:0035265 GO:0009887 GO:0030916 GO:0003148 GO:0090263 GO:0060045 GO:0045787 GO:0051781 GO:0008284 GO:0050679 GO:0060501 GO:0070374 GO:0002053 GO:0045944 GO:0030177 GO:0009791 GO:0060527 GO:0060523 GO:0060512 GO:0021860 GO:0060687 GO:0010453 GO:0042127 GO:0050678 GO:0070372 GO:0040036 GO:0060688 GO:0040014 GO:0051150 GO:0008589 GO:0048608 GO:0060529 GO:0048489 GO:0001657 GO:0060979 GO:0055010 GO:0021847
Gene3D	2.60.40.10
InterPro	IPR028175 IPR016248 IPR007110 IPR013783 IPR013098 IPR003598 IPR011009 IPR000719 IPR017441 IPR001245 IPR008266 IPR020635
PANTHER	PTHR24416:SF130
Pfam	PF07679 PF07714
PIRSF	PIRSF000628
PRINTS	PR00109
SMART	SM00408 SM00219
SUPFAM	SSF56112
PROSITE	PS50835 PS00107 PS50011 PS00109

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0060076	excitatory synapse	PMID:20410112^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20410112^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045787	positive regulation of cell cycle	PMID:20410112^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035607	fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development	PMID:20410112^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035604	fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow	PMID:20345253^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035603	fibroblast growth factor receptor signaling pathway involved in hemopoiesis	PMID:20345253^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035602	fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell	PMID:20345253^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021860	pyramidal neuron development	PMID:20410112^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021847	ventricular zone neuroblast division	PMID:20410112^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021769	orbitofrontal cortex development	PMID:20410112^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:20410112^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015380 FB:FBgn0024245 FB:FBgn0033791 PANTHER:PTN002356460 UniProtKB:A6QR62 UniProtKB:O15146 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P11362 UniProtKB:P14616 UniProtKB:P17948 UniProtKB:P21860 UniProtKB:P35916 UniProtKB:Q01973 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q16288 UniProtKB:Q16620	C		Seeded From UniProt	complete
enables	GO:0017134	fibroblast growth factor binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95522 MGI:MGI:95523 PANTHER:PTN000699279 RGD:2611 RGD:620714 UniProtKB:P11362 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 ZFIN:ZDB-GENE-030323-1	F		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95522 MGI:MGI:95523 MGI:MGI:95524 MGI:MGI:95525 PANTHER:PTN001230353 RGD:620714 UniProtKB:P11362 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607	P		Seeded From UniProt	complete
involved_in	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003366 FB:FBgn0003731 FB:FBgn0003733 FB:FBgn0283499 MGI:MGI:104757 MGI:MGI:109378 MGI:MGI:1096337 MGI:MGI:1339758 MGI:MGI:1345277 MGI:MGI:95276 MGI:MGI:95278 MGI:MGI:95294 MGI:MGI:95522 MGI:MGI:95523 MGI:MGI:95524 MGI:MGI:95525 MGI:MGI:95558 MGI:MGI:95561 MGI:MGI:96575 MGI:MGI:96677 MGI:MGI:96683 MGI:MGI:96969 MGI:MGI:97384 MGI:MGI:97530 MGI:MGI:97531 MGI:MGI:97902 MGI:MGI:98277 MGI:MGI:99216 MGI:MGI:99611 MGI:MGI:99612 MGI:MGI:99654 PANTHER:PTN002356460 RGD:2543 RGD:2611 RGD:2612 RGD:2621 RGD:2869 RGD:2917 RGD:2965 RGD:3082 RGD:3213 RGD:3214 RGD:3284 RGD:3285 RGD:620144 RGD:620714 RGD:620831 RGD:621737 RGD:69323 UniProtKB:A6QR62 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P09619 UniProtKB:P10721 UniProtKB:P11362 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35916 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:P54764 UniProtKB:Q02763 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q15375 UniProtKB:Q16288 UniProtKB:Q16620 UniProtKB:Q16832 UniProtKB:Q5JZY3 UniProtKB:Q91987 WB:WBGene00001184 WB:WBGene00006868 ZFIN:ZDB-GENE-020503-1 ZFIN:ZDB-GENE-020503-2 ZFIN:ZDB-GENE-060503-14 ZFIN:ZDB-GENE-070713-2 ZFIN:ZDB-GENE-980526-255 ZFIN:ZDB-GENE-980526-326 ZFIN:ZDB-GENE-990415-62	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003366 FB:FBgn0003731 FB:FBgn0003733 FB:FBgn0011829 FB:FBgn0015380 FB:FBgn0032006 FB:FBgn0283499 MGI:MGI:103581 MGI:MGI:104771 MGI:MGI:109378 MGI:MGI:98277 MGI:MGI:99611 PANTHER:PTN002356460 RGD:1560587 RGD:3213 RGD:3214 RGD:70957 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:Q02763 UniProtKB:Q16620 UniProtKB:Q9UM73 WB:WBGene00000289 WB:WBGene00000898	C		Seeded From UniProt	complete
enables	GO:0005007	fibroblast growth factor-activated receptor activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95522 MGI:MGI:95524 PANTHER:PTN000699279 RGD:2611 RGD:620714 UniProtKB:P11362 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 ZFIN:ZDB-GENE-980526-255	F		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003733 FB:FBgn0040505 FB:FBgn0283499 MGI:MGI:109378 MGI:MGI:1339758 MGI:MGI:1345277 MGI:MGI:95276 MGI:MGI:95294 MGI:MGI:95522 MGI:MGI:95524 MGI:MGI:95558 MGI:MGI:95561 MGI:MGI:96677 MGI:MGI:96683 MGI:MGI:96969 MGI:MGI:97384 MGI:MGI:97530 MGI:MGI:97902 MGI:MGI:98277 MGI:MGI:99611 MGI:MGI:99612 MGI:MGI:99654 PANTHER:PTN002356460 RGD:2543 RGD:2611 RGD:2621 RGD:2869 RGD:2917 RGD:2965 RGD:3082 RGD:3213 RGD:3214 RGD:3284 RGD:3285 RGD:620144 RGD:620714 RGD:620831 RGD:621737 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07333 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P09619 UniProtKB:P10721 UniProtKB:P11362 UniProtKB:P14616 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35916 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q16620 UniProtKB:Q16832 UniProtKB:Q5JZY3 UniProtKB:Q91987 UniProtKB:Q9UM73 WB:WBGene00000289 WB:WBGene00006868 WB:WBGene00020504 ZFIN:ZDB-GENE-980526-255	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090263	positive regulation of canonical Wnt signaling pathway	PMID:18533146^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95522	P	regulates_o_occurs_in:(EMAPA:16728) regulates_o_occurs_in:(CL:0000134)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090263	positive regulation of canonical Wnt signaling pathway	PMID:16720875^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153811	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:17202188^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1099809	P	regulates_o_occurs_in:(EMAPA:29771)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070372	regulation of ERK1 and ERK2 cascade	PMID:16989802^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3629660	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070307	lens fiber cell development	PMID:18455718^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95524	P	occurs_in:(EMAPA:16198) results_in_development_of:(CL:0002228)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070307	lens fiber cell development	PMID:23136392^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3044679,MGI:MGI:3045749	P	occurs_in:(EMAPA:16799)	Seeded From UniProt	complete
colocalizes_with	GO:0062023	collagen-containing extracellular matrix	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21802	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061031	endodermal digestive tract morphogenesis	PMID:21550054^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183527	P	has_participant:(EMAPA:35197)\|has_participant:(EMAPA:16039)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060916	mesenchymal cell proliferation involved in lung development	PMID:16989802^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3629660	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060915	mesenchymal cell differentiation involved in lung development	PMID:16989802^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1099809	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060688	regulation of morphogenesis of a branching structure	PMID:17202188^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856633	P	regulates_o_results_in_morphogenesis_of:(EMAPA:29771)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060687	regulation of branching involved in prostate gland morphogenesis	PMID:17202188^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856633	P	regulates_o_occurs_in:(EMAPA:32290)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060670	branching involved in labyrinthine layer morphogenesis	PMID:9435295^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153790	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060667	branch elongation involved in salivary gland morphogenesis	PMID:15972105^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1099809	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060667	branch elongation involved in salivary gland morphogenesis	PMID:15972105^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153811	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis	PMID:15972105^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1099809	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis	PMID:15972105^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153811	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060615	mammary gland bud formation	PMID:11782400^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153811	P	results_in_formation_of:(EMAPA:17759)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060601	lateral sprouting from an epithelium	PMID:12666202^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856633	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060595	fibroblast growth factor receptor signaling pathway involved in mammary gland specification	PMID:16720875^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153811	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060529	squamous basal epithelial stem cell differentiation involved in prostate gland acinus development	PMID:17215304^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3044679	P	occurs_in:(EMAPA:32290)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060527	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis	PMID:17215304^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3044679	P	has_participant:(EMAPA:19287)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060523	prostate epithelial cord elongation	PMID:17215304^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3044679	P	has_participant:(EMAPA:19287)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060512	prostate gland morphogenesis	PMID:18184727^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis	PMID:16989802^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3629660	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060484	lung-associated mesenchyme development	PMID:18533146^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95522	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060484	lung-associated mesenchyme development	PMID:16989802^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3629660	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060463	lung lobe morphogenesis	PMID:16989802^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3629660	P	has_participant:(EMAPA:17661)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060449	bud elongation involved in lung branching	PMID:16989802^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3629660	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060445	branching involved in salivary gland morphogenesis	PMID:11731698^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153814	P	has_participant:(EMAPA:18813)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060442	branching involved in prostate gland morphogenesis	PMID:17215304^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3044679	P	has_participant:(EMAPA:29794)\|has_participant:(EMAPA:29836)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060442	branching involved in prostate gland morphogenesis	PMID:12666202^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856633	P	has_participant:(EMAPA:32290)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060441	epithelial tube branching involved in lung morphogenesis	PMID:24058167^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3044679	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060365	coronal suture morphogenesis	PMID:19389359^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3603464	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060349	bone morphogenesis	PMID:10518547^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153799	P	has_participant:(EMAPA:18722)\|has_participant:(EMAPA:18028)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060348	bone development	PMID:16989802^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3629660	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060174	limb bud formation	PMID:9435295^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153790	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060174	limb bud formation	PMID:10518547^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153799	P	results_in_formation_of:(EMAPA:16405)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060045	positive regulation of cardiac muscle cell proliferation	PMID:15621532^[21]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95522	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060045	positive regulation of cardiac muscle cell proliferation	PMID:15621532^[21]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104723	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0055010	ventricular cardiac muscle tissue morphogenesis	PMID:16687131^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153818	P	has_participant:(EMAPA:17331)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051781	positive regulation of cell division	PMID:14530295^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153818	P	regulates_o_occurs_in:(EMAPA:17528) regulates_o_results_in_division_of:(CL:0000646)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051150	regulation of smooth muscle cell differentiation	PMID:16989802^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3629660	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050680	negative regulation of epithelial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2611	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050679	positive regulation of epithelial cell proliferation	PMID:15972105^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1098809	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050678	regulation of epithelial cell proliferation	PMID:18184727^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050678	regulation of epithelial cell proliferation	PMID:17215304^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3044679	P	regulates_o_occurs_in:(EMAPA:32290)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050673	epithelial cell proliferation	PMID:15843416^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153818	P	occurs_in:(EMAPA:18692) acts_on_population_of:(CL:0000731)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050673	epithelial cell proliferation	PMID:11312155^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153811	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048762	mesenchymal cell differentiation	PMID:16442091^[26]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95522	P	occurs_in:(EMAPA:17208) results_in_acquisition_of_features_of:(CL:0000134)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048755	branching morphogenesis of a nerve	PMID:17951031^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153811	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048730	epidermis morphogenesis	PMID:14530295^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153818	P	has_participant:(EMAPA:17528)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048701	embryonic cranial skeleton morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21802	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048661	positive regulation of smooth muscle cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2611	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048608	reproductive structure development	PMID:12666202^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856633	P	results_in_development_of:(EMAPA:19180)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048568	embryonic organ development	PMID:9435295^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153790	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048565	digestive tract development	PMID:15234214^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153811	P	results_in_development_of:(EMAPA:16246)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048562	embryonic organ morphogenesis	PMID:15843416^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153818	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048557	embryonic digestive tract morphogenesis	PMID:21550054^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183527	P	has_participant:(EMAPA:35197)\|has_participant:(EMAPA:16039)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048557	embryonic digestive tract morphogenesis	PMID:21492869^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153811	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048557	embryonic digestive tract morphogenesis	PMID:16618415^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153811	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048489	synaptic vesicle transport	PMID:17418794^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183527	P	occurs_in:(EMAPA:17701) occurs_in:(CL:0000100)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048286	lung alveolus development	PMID:16989802^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1099809	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048286	lung alveolus development	PMID:16989802^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3629660	P	results_in_development_of:(EMAPA:32692)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046777	protein autophosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21802	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16989802^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3629660	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045839	negative regulation of mitotic nuclear division	PMID:18455718^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95524	P	regulates_o_occurs_in:(EMAPA:17163) regulates_o_occurs_in:(CL:0002228)\|regulates_o_occurs_in:(EMAPA:17163) regulates_o_occurs_in:(CL:0002228)\|regulates_o_occurs_in:(EMAPA:17841) regulates_o_occurs_in:(CL:0002228)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045165	cell fate commitment	PMID:15509736^[32]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043410	positive regulation of MAPK cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21802	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21802	C		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21802	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21802	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042476	odontogenesis	PMID:17951031^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153811	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042472	inner ear morphogenesis	PMID:10934262^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153811	P	has_participant:(EMAPA:16994)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042127	regulation of cell population proliferation	PMID:12756187^[34]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3044427	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0040036	regulation of fibroblast growth factor receptor signaling pathway	PMID:16989802^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153817	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0040014	regulation of multicellular organism growth	PMID:9435295^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153790	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035265	organ growth	PMID:16618415^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153811	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035264	multicellular organism growth	PMID:16989802^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3629660	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032808	lacrimal gland development	PMID:10821755^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031069	hair follicle morphogenesis	PMID:14530295^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153818	P	has_participant:(EMAPA:18771)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030916	otic vesicle formation	PMID:9435295^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153790	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030901	midbrain development	PMID:17687036^[36]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95522	P	results_in_development_of:(EMAPA:16140)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030855	epithelial cell differentiation	PMID:16618415^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153811	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030324	lung development	PMID:16540513^[37]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95522	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030324	lung development	PMID:10518547^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153799	P	results_in_development_of:(EMAPA:16728)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030282	bone mineralization	PMID:12756187^[34]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3044427	P	has_participant:(EMAPA:32782)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030177	positive regulation of Wnt signaling pathway	PMID:16989802^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3629660	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022612	gland morphogenesis	PMID:17202188^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856633	P	has_participant:(EMAPA:29771)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21802	P		Seeded From UniProt	complete
enables	GO:0017134	fibroblast growth factor binding	PMID:9435295^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0017134	fibroblast growth factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2611	F		Seeded From UniProt	complete
enables	GO:0017134	fibroblast growth factor binding	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21802-18	F		Seeded From UniProt	complete
enables	GO:0017134	fibroblast growth factor binding	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21802	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016331	morphogenesis of embryonic epithelium	PMID:15843416^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153818	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	PMID:21492869^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153811	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010518	positive regulation of phospholipase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21802	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010453	regulation of cell fate commitment	PMID:16989802^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3629660	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21802	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2611	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009887	animal organ morphogenesis	PMID:12666202^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856633	P	has_participant:(EMAPA:19180)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009880	embryonic pattern specification	PMID:16618415^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153811	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009791	post-embryonic development	PMID:16989802^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3629660	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008589	regulation of smoothened signaling pathway	PMID:16618415^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153811	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:18187602^[38]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O95750 UniProtKB:P05230	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:17202188^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1099809	P	occurs_in:(EMAPA:29771)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:16778080^[39]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95522	P	occurs_in:(EMAPA:16105) occurs_in:(CL:0000746)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:15972105^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1099809	P	occurs_in:(EMAPA:17756) occurs_in:(CL:0000066)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:15621532^[21]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104723	P	occurs_in:(EMAPA:17331) occurs_in:(CL:0000746)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:9435295^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153790	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008543	fibroblast growth factor receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2611	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008543	fibroblast growth factor receptor signaling pathway	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21802	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:18455718^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95524	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:18187602^[38]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O95750 UniProtKB:P05230	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:16778080^[39]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95522	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:15199404^[40]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153811	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:14530295^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153818	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21802	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007528	neuromuscular junction development	PMID:17418794^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183527	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007409	axonogenesis	PMID:17951031^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153811	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007267	cell-cell signaling	PMID:15199404^[40]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153811	P		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21802	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21802	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21802	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2611	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21802	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15944199^[41]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17972) part_of:(CL:0000216)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15229180^[42]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17383) part_of:(CL:0000216)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21802	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2611	C		Seeded From UniProt	complete
enables	GO:0005007	fibroblast growth factor-activated receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2611	F		Seeded From UniProt	complete
enables	GO:0005007	fibroblast growth factor-activated receptor activity	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21802	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003149	membranous septum morphogenesis	PMID:16687131^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153818	P	has_participant:(EMAPA:17333)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003148	outflow tract septum morphogenesis	PMID:16687131^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153818	P	has_participant:(EMAPA:16827)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002053	positive regulation of mesenchymal cell proliferation	PMID:16540513^[37]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95522	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001837	epithelial to mesenchymal transition	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2611	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:17687036^[36]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95522	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:9435295^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153790	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001657	ureteric bud development	PMID:16442091^[26]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95522	P	results_in_development_of:(EMAPA:17376)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001525	angiogenesis	PMID:16778080^[39]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95522	P	has_participant:(EMAPA:17331)\|has_participant:(EMAPA:16201)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:16989802^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3629660	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020635	F		Seeded From UniProt	complete
enables	GO:0005007	fibroblast growth factor-activated receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016248	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR016248 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266 InterPro:IPR016248 InterPro:IPR020635	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016248	P		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016248	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016248	C		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.10.1	F		Seeded From UniProt	complete
involved_in	GO:0030916	otic vesicle formation	PMID:22235191^[43]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060979	vasculogenesis involved in coronary vascular morphogenesis	PMID:20299672^[44]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-NUL-8853328 Reactome:R-MMU-8851711 PMID:12024206^[45]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333 UniProtKB-SubCell:SL-0132	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0829	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0358	F		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
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Notes

References

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↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Stevens, HE et al. (2010) Fgfr2 is required for the development of the medial prefrontal cortex and its connections with limbic circuits. J. Neurosci. 30 5590-602 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Shigematsu, A et al. (2010) Signaling from fibroblast growth factor receptor 2 in immature hematopoietic cells facilitates donor hematopoiesis after intra-bone marrow-bone marrow transplantation. Stem Cells Dev. 19 1679-86 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^4.0 ^4.1 Yin, Y et al. (2008) An FGF-WNT gene regulatory network controls lung mesenchyme development. Dev. Biol. 319 426-36 PubMed GONUTS page
↑ ^5.0 ^5.1 Veltmaat, JM et al. (2006) Gli3-mediated somitic Fgf10 expression gradients are required for the induction and patterning of mammary epithelium along the embryonic axes. Development 133 2325-35 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Kuslak, SL et al. (2007) The mouse seminal vesicle shape mutation is allelic with Fgfr2. Development 134 557-65 PubMed GONUTS page
↑ ^7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 ^7.11 ^7.12 ^7.13 ^7.14 ^7.15 ^7.16 ^7.17 De Langhe, SP et al. (2006) Levels of mesenchymal FGFR2 signaling modulate smooth muscle progenitor cell commitment in the lung. Dev. Biol. 299 52-62 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Zhao, H et al. (2008) Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation. Dev. Biol. 318 276-88 PubMed GONUTS page
↑ Madakashira, BP et al. (2012) Frs2α enhances fibroblast growth factor-mediated survival and differentiation in lens development. Development 139 4601-12 PubMed GONUTS page
↑ ^10.0 ^10.1 Nichol, PF & Saijoh, Y (2011) Pitx2 is a critical early regulatory gene in normal cecal development. J. Surg. Res. 170 107-11 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 Xu, X et al. (1998) Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction. Development 125 753-65 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Jaskoll, T et al. (2005) FGF10/FGFR2b signaling plays essential roles during in vivo embryonic submandibular salivary gland morphogenesis. BMC Dev. Biol. 5 11 PubMed GONUTS page
↑ Mailleux, AA et al. (2002) Role of FGF10/FGFR2b signaling during mammary gland development in the mouse embryo. Development 129 53-60 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 Marker, PC et al. (2003) Spontaneous mutation in mice provides new insight into the genetic mechanisms that pattern the seminal vesicles and prostate gland. Dev. Dyn. 226 643-53 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 Lin, Y et al. (2007) Fibroblast growth factor receptor 2 tyrosine kinase is required for prostatic morphogenesis and the acquisition of strict androgen dependency for adult tissue homeostasis. Development 134 723-34 PubMed GONUTS page
↑ ^16.0 ^16.1 Zhang, Y et al. (2008) Role of epithelial cell fibroblast growth factor receptor substrate 2alpha in prostate development, regeneration and tumorigenesis. Development 135 775-84 PubMed GONUTS page
↑ Jaskoll, T et al. (2002) Embryonic submandibular gland morphogenesis: stage-specific protein localization of FGFs, BMPs, Pax6 and Pax9 in normal mice and abnormal SMG phenotypes in FgfR2-IIIc(+/Delta), BMP7(-/-) and Pax6(-/-) mice. Cells Tissues Organs (Print) 170 83-98 PubMed GONUTS page
↑ Chang, DR et al. (2013) Lung epithelial branching program antagonizes alveolar differentiation. Proc. Natl. Acad. Sci. U.S.A. 110 18042-51 PubMed GONUTS page
↑ Holmes, G et al. (2009) Early onset of craniosynostosis in an Apert mouse model reveals critical features of this pathology. Dev. Biol. 328 273-84 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 Arman, E et al. (1999) Fgfr2 is required for limb outgrowth and lung-branching morphogenesis. Proc. Natl. Acad. Sci. U.S.A. 96 11895-9 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 Lavine, KJ et al. (2005) Endocardial and epicardial derived FGF signals regulate myocardial proliferation and differentiation in vivo. Dev. Cell 8 85-95 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 Marguerie, A et al. (2006) Congenital heart defects in Fgfr2-IIIb and Fgf10 mutant mice. Cardiovasc. Res. 71 50-60 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 ^23.3 Petiot, A et al. (2003) A crucial role for Fgfr2-IIIb signalling in epidermal development and hair follicle patterning. Development 130 5493-501 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 Petiot, A et al. (2005) Development of the mammalian urethra is controlled by Fgfr2-IIIb. Development 132 2441-50 PubMed GONUTS page
↑ Pérez-Romero, A et al. (2001) GH gene expression in the submaxillary gland in normal and Ames dwarf mice. J. Endocrinol. 169 389-96 PubMed GONUTS page
↑ ^26.0 ^26.1 Poladia, DP et al. (2006) Role of fibroblast growth factor receptors 1 and 2 in the metanephric mesenchyme. Dev. Biol. 291 325-39 PubMed GONUTS page
↑ ^27.0 ^27.1 ^27.2 Kettunen, P et al. () Fgfr2b mediated epithelial-mesenchymal interactions coordinate tooth morphogenesis and dental trigeminal axon patterning. Mech. Dev. 124 868-83 PubMed GONUTS page
↑ Fairbanks, TJ et al. (2004) A genetic mechanism for cecal atresia: the role of the Fgf10 signaling pathway. J. Surg. Res. 120 201-9 PubMed GONUTS page
↑ ^29.0 ^29.1 Nichol, PF et al. (2012) Retinaldehyde dehydrogenase 2 is down-regulated during duodenal atresia formation in Fgfr2IIIb-/- mice. J. Surg. Res. 175 82-7 PubMed GONUTS page
↑ ^30.0 ^30.1 ^30.2 ^30.3 ^30.4 Spencer-Dene, B et al. (2006) Stomach development is dependent on fibroblast growth factor 10/fibroblast growth factor receptor 2b-mediated signaling. Gastroenterology 130 1233-44 PubMed GONUTS page
↑ ^31.0 ^31.1 Fox, MA et al. (2007) Distinct target-derived signals organize formation, maturation, and maintenance of motor nerve terminals. Cell 129 179-93 PubMed GONUTS page
↑ Yoon, K et al. (2004) Fibroblast growth factor receptor signaling promotes radial glial identity and interacts with Notch1 signaling in telencephalic progenitors. J. Neurosci. 24 9497-506 PubMed GONUTS page
↑ Pirvola, U et al. (2000) FGF/FGFR-2(IIIb) signaling is essential for inner ear morphogenesis. J. Neurosci. 20 6125-34 PubMed GONUTS page
↑ ^34.0 ^34.1 Yu, K et al. (2003) Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth. Development 130 3063-74 PubMed GONUTS page
↑ Makarenkova, HP et al. (2000) FGF10 is an inducer and Pax6 a competence factor for lacrimal gland development. Development 127 2563-72 PubMed GONUTS page
↑ ^36.0 ^36.1 Saarimäki-Vire, J et al. (2007) Fibroblast growth factor receptors cooperate to regulate neural progenitor properties in the developing midbrain and hindbrain. J. Neurosci. 27 8581-92 PubMed GONUTS page
↑ ^37.0 ^37.1 White, AC et al. (2006) FGF9 and SHH signaling coordinate lung growth and development through regulation of distinct mesenchymal domains. Development 133 1507-17 PubMed GONUTS page
↑ ^38.0 ^38.1 Suzuki, M et al. (2008) betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c. Mol. Endocrinol. 22 1006-14 PubMed GONUTS page
↑ ^39.0 ^39.1 ^39.2 Lavine, KJ et al. (2006) Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development. Genes Dev. 20 1651-66 PubMed GONUTS page
↑ ^40.0 ^40.1 Rice, R et al. (2004) Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate. J. Clin. Invest. 113 1692-700 PubMed GONUTS page
↑ Ottolenghi, C et al. (2005) Foxl2 is required for commitment to ovary differentiation. Hum. Mol. Genet. 14 2053-62 PubMed GONUTS page
↑ Schmahl, J et al. (2004) Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination. Development 131 3627-36 PubMed GONUTS page
↑ Huh, SH et al. (2012) Differentiation of the lateral compartment of the cochlea requires a temporally restricted FGF20 signal. PLoS Biol. 10 e1001231 PubMed GONUTS page
↑ Olivey, HE & Svensson, EC (2010) Epicardial-myocardial signaling directing coronary vasculogenesis. Circ. Res. 106 818-32 PubMed GONUTS page
↑ Cheng, MY et al. (2002) Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus. Nature 417 405-10 PubMed GONUTS page

[PMID:20410112-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Stevens, HE et al. (2010) Fgfr2 is required for the development of the medial prefrontal cortex and its connections with limbic circuits. J. Neurosci. 30 5590-602 PubMed GONUTS page

[PMID:20345253-2] 2.0 ^2.1 ^2.2 Shigematsu, A et al. (2010) Signaling from fibroblast growth factor receptor 2 in immature hematopoietic cells facilitates donor hematopoiesis after intra-bone marrow-bone marrow transplantation. Stem Cells Dev. 19 1679-86 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18533146-4] 4.0 ^4.1 Yin, Y et al. (2008) An FGF-WNT gene regulatory network controls lung mesenchyme development. Dev. Biol. 319 426-36 PubMed GONUTS page

[PMID:16720875-5] 5.0 ^5.1 Veltmaat, JM et al. (2006) Gli3-mediated somitic Fgf10 expression gradients are required for the induction and patterning of mammary epithelium along the embryonic axes. Development 133 2325-35 PubMed GONUTS page

[PMID:17202188-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Kuslak, SL et al. (2007) The mouse seminal vesicle shape mutation is allelic with Fgfr2. Development 134 557-65 PubMed GONUTS page

[PMID:16989802-7] 7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 ^7.11 ^7.12 ^7.13 ^7.14 ^7.15 ^7.16 ^7.17 De Langhe, SP et al. (2006) Levels of mesenchymal FGFR2 signaling modulate smooth muscle progenitor cell commitment in the lung. Dev. Biol. 299 52-62 PubMed GONUTS page

[PMID:18455718-8] 8.0 ^8.1 ^8.2 Zhao, H et al. (2008) Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation. Dev. Biol. 318 276-88 PubMed GONUTS page

[PMID:23136392-9] Madakashira, BP et al. (2012) Frs2α enhances fibroblast growth factor-mediated survival and differentiation in lens development. Development 139 4601-12 PubMed GONUTS page

[PMID:21550054-10] 10.0 ^10.1 Nichol, PF & Saijoh, Y (2011) Pitx2 is a critical early regulatory gene in normal cecal development. J. Surg. Res. 170 107-11 PubMed GONUTS page

[PMID:9435295-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 Xu, X et al. (1998) Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction. Development 125 753-65 PubMed GONUTS page

[PMID:15972105-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Jaskoll, T et al. (2005) FGF10/FGFR2b signaling plays essential roles during in vivo embryonic submandibular salivary gland morphogenesis. BMC Dev. Biol. 5 11 PubMed GONUTS page

[PMID:11782400-13] Mailleux, AA et al. (2002) Role of FGF10/FGFR2b signaling during mammary gland development in the mouse embryo. Development 129 53-60 PubMed GONUTS page

[PMID:12666202-14] 14.0 ^14.1 ^14.2 ^14.3 Marker, PC et al. (2003) Spontaneous mutation in mice provides new insight into the genetic mechanisms that pattern the seminal vesicles and prostate gland. Dev. Dyn. 226 643-53 PubMed GONUTS page

[PMID:17215304-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 Lin, Y et al. (2007) Fibroblast growth factor receptor 2 tyrosine kinase is required for prostatic morphogenesis and the acquisition of strict androgen dependency for adult tissue homeostasis. Development 134 723-34 PubMed GONUTS page

[PMID:18184727-16] 16.0 ^16.1 Zhang, Y et al. (2008) Role of epithelial cell fibroblast growth factor receptor substrate 2alpha in prostate development, regeneration and tumorigenesis. Development 135 775-84 PubMed GONUTS page

[PMID:11731698-17] Jaskoll, T et al. (2002) Embryonic submandibular gland morphogenesis: stage-specific protein localization of FGFs, BMPs, Pax6 and Pax9 in normal mice and abnormal SMG phenotypes in FgfR2-IIIc(+/Delta), BMP7(-/-) and Pax6(-/-) mice. Cells Tissues Organs (Print) 170 83-98 PubMed GONUTS page

[PMID:24058167-18] Chang, DR et al. (2013) Lung epithelial branching program antagonizes alveolar differentiation. Proc. Natl. Acad. Sci. U.S.A. 110 18042-51 PubMed GONUTS page

[PMID:19389359-19] Holmes, G et al. (2009) Early onset of craniosynostosis in an Apert mouse model reveals critical features of this pathology. Dev. Biol. 328 273-84 PubMed GONUTS page

[PMID:10518547-20] 20.0 ^20.1 ^20.2 Arman, E et al. (1999) Fgfr2 is required for limb outgrowth and lung-branching morphogenesis. Proc. Natl. Acad. Sci. U.S.A. 96 11895-9 PubMed GONUTS page

[PMID:15621532-21] 21.0 ^21.1 ^21.2 Lavine, KJ et al. (2005) Endocardial and epicardial derived FGF signals regulate myocardial proliferation and differentiation in vivo. Dev. Cell 8 85-95 PubMed GONUTS page

[PMID:16687131-22] 22.0 ^22.1 ^22.2 Marguerie, A et al. (2006) Congenital heart defects in Fgfr2-IIIb and Fgf10 mutant mice. Cardiovasc. Res. 71 50-60 PubMed GONUTS page

[PMID:14530295-23] 23.0 ^23.1 ^23.2 ^23.3 Petiot, A et al. (2003) A crucial role for Fgfr2-IIIb signalling in epidermal development and hair follicle patterning. Development 130 5493-501 PubMed GONUTS page

[PMID:15843416-24] 24.0 ^24.1 ^24.2 Petiot, A et al. (2005) Development of the mammalian urethra is controlled by Fgfr2-IIIb. Development 132 2441-50 PubMed GONUTS page

[PMID:11312155-25] Pérez-Romero, A et al. (2001) GH gene expression in the submaxillary gland in normal and Ames dwarf mice. J. Endocrinol. 169 389-96 PubMed GONUTS page

[PMID:16442091-26] 26.0 ^26.1 Poladia, DP et al. (2006) Role of fibroblast growth factor receptors 1 and 2 in the metanephric mesenchyme. Dev. Biol. 291 325-39 PubMed GONUTS page

[PMID:17951031-27] 27.0 ^27.1 ^27.2 Kettunen, P et al. () Fgfr2b mediated epithelial-mesenchymal interactions coordinate tooth morphogenesis and dental trigeminal axon patterning. Mech. Dev. 124 868-83 PubMed GONUTS page

[PMID:15234214-28] Fairbanks, TJ et al. (2004) A genetic mechanism for cecal atresia: the role of the Fgf10 signaling pathway. J. Surg. Res. 120 201-9 PubMed GONUTS page

[PMID:21492869-29] 29.0 ^29.1 Nichol, PF et al. (2012) Retinaldehyde dehydrogenase 2 is down-regulated during duodenal atresia formation in Fgfr2IIIb-/- mice. J. Surg. Res. 175 82-7 PubMed GONUTS page

[PMID:16618415-30] 30.0 ^30.1 ^30.2 ^30.3 ^30.4 Spencer-Dene, B et al. (2006) Stomach development is dependent on fibroblast growth factor 10/fibroblast growth factor receptor 2b-mediated signaling. Gastroenterology 130 1233-44 PubMed GONUTS page

[PMID:17418794-31] 31.0 ^31.1 Fox, MA et al. (2007) Distinct target-derived signals organize formation, maturation, and maintenance of motor nerve terminals. Cell 129 179-93 PubMed GONUTS page

[PMID:15509736-32] Yoon, K et al. (2004) Fibroblast growth factor receptor signaling promotes radial glial identity and interacts with Notch1 signaling in telencephalic progenitors. J. Neurosci. 24 9497-506 PubMed GONUTS page

[PMID:10934262-33] Pirvola, U et al. (2000) FGF/FGFR-2(IIIb) signaling is essential for inner ear morphogenesis. J. Neurosci. 20 6125-34 PubMed GONUTS page

[PMID:12756187-34] 34.0 ^34.1 Yu, K et al. (2003) Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth. Development 130 3063-74 PubMed GONUTS page

[PMID:10821755-35] Makarenkova, HP et al. (2000) FGF10 is an inducer and Pax6 a competence factor for lacrimal gland development. Development 127 2563-72 PubMed GONUTS page

[PMID:17687036-36] 36.0 ^36.1 Saarimäki-Vire, J et al. (2007) Fibroblast growth factor receptors cooperate to regulate neural progenitor properties in the developing midbrain and hindbrain. J. Neurosci. 27 8581-92 PubMed GONUTS page

[PMID:16540513-37] 37.0 ^37.1 White, AC et al. (2006) FGF9 and SHH signaling coordinate lung growth and development through regulation of distinct mesenchymal domains. Development 133 1507-17 PubMed GONUTS page

[PMID:18187602-38] 38.0 ^38.1 Suzuki, M et al. (2008) betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c. Mol. Endocrinol. 22 1006-14 PubMed GONUTS page

[PMID:16778080-39] 39.0 ^39.1 ^39.2 Lavine, KJ et al. (2006) Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development. Genes Dev. 20 1651-66 PubMed GONUTS page

[PMID:15199404-40] 40.0 ^40.1 Rice, R et al. (2004) Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate. J. Clin. Invest. 113 1692-700 PubMed GONUTS page

[PMID:15944199-41] Ottolenghi, C et al. (2005) Foxl2 is required for commitment to ovary differentiation. Hum. Mol. Genet. 14 2053-62 PubMed GONUTS page

[PMID:15229180-42] Schmahl, J et al. (2004) Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination. Development 131 3627-36 PubMed GONUTS page

[PMID:22235191-43] Huh, SH et al. (2012) Differentiation of the lateral compartment of the cochlea requires a temporally restricted FGF20 signal. PLoS Biol. 10 e1001231 PubMed GONUTS page

[PMID:20299672-44] Olivey, HE & Svensson, EC (2010) Epicardial-myocardial signaling directing coronary vasculogenesis. Circ. Res. 106 818-32 PubMed GONUTS page

[PMID:12024206-45] Cheng, MY et al. (2002) Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus. Nature 417 405-10 PubMed GONUTS page

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MOUSE:FGFR2

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