MOUSE:EYA1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Eya1
Protein Name(s)	Eyes absent homolog 1
External Links
UniProt	P97767
EMBL	U61110 Y10263 AC119875 AC156988 CH466536 AF097544 AJ007995
RefSeq	XP_006495511.1
UniGene	Mm.250185
ProteinModelPortal	P97767
SMR	P97767
IntAct	P97767
PhosphoSite	P97767
PRIDE	P97767
Ensembl	ENSMUST00000027066 ENSMUST00000190337
GeneID	14048
KEGG	mmu:14048
UCSC	uc007aiw.1
CTD	2138
MGI	MGI:109344
eggNOG	NOG297494
GeneTree	ENSGT00390000008860
HOGENOM	HOG000293149
HOVERGEN	HBG002447
InParanoid	P97767
KO	K15616
OMA	GQPYGIS
TreeFam	TF319337
SABIO-RK	P97767
PRO	PR:P97767
Proteomes	UP000000589
CleanEx	MM_EYA1
ExpressionAtlas	P97767
Genevestigator	P97767
GO	GO:0005737 GO:0005634 GO:0043234 GO:0032993 GO:0046872 GO:0004725 GO:0003723 GO:0048856 GO:0035909 GO:0001658 GO:0045165 GO:0034613 GO:0090103 GO:0006302 GO:0048704 GO:0000132 GO:0035088 GO:0016576 GO:0042472 GO:0060487 GO:0007501 GO:0001656 GO:0042474 GO:2001240 GO:0048665 GO:0009887 GO:0071599 GO:0071600 GO:0042473 GO:0003151 GO:0007389 GO:0060037 GO:0045739 GO:0050679 GO:0045747 GO:0072513 GO:0045944 GO:0045893 GO:0006470 GO:0016925 GO:0045664 GO:0010212 GO:0048752 GO:0014706 GO:0006351 GO:0001657
InterPro	IPR006545 IPR028472 IPR028471
PANTHER	PTHR10190 PTHR10190:SF11
TIGRFAMs	TIGR01658

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:17785448^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045739	positive regulation of DNA repair	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99502	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:17785448^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:17785448^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016925	protein sumoylation	PMID:16990542^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016576	histone dephosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99502	P		Seeded From UniProt	complete
involved_in	GO:0010212	response to ionizing radiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99502	P		Seeded From UniProt	complete
involved_in	GO:0007501	mesodermal cell fate specification	PMID:17785448^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99502	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99502	C		Seeded From UniProt	complete
involved_in	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109344 PANTHER:PTN000022641	P		Seeded From UniProt	complete
involved_in	GO:0048856	anatomical structure development	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109344 PANTHER:PTN000022641	P		Seeded From UniProt	complete
involved_in	GO:0045739	positive regulation of DNA repair	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000022641 UniProtKB:Q99502 UniProtKB:Q99504	P		Seeded From UniProt	complete
involved_in	GO:0016576	histone dephosphorylation	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000022641 UniProtKB:O00167 UniProtKB:Q99502 UniProtKB:Q99504	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000320 MGI:MGI:109339 MGI:MGI:109341 MGI:MGI:109344 PANTHER:PTN000022641 RGD:1309932 UniProtKB:Q99502 UniProtKB:Q99504 WB:WBGene00001377	C		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000320 MGI:MGI:109339 MGI:MGI:109341 MGI:MGI:109344 PANTHER:PTN000022641 UniProtKB:O00167 UniProtKB:Q99502 UniProtKB:Q99504	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	PMID:15817220^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857803	P	regulates_o_occurs_in:(EMAPA:16538) regulates_o_occurs_in:(CL:0000066)\|regulates_o_occurs_in:(EMAPA:16999) regulates_o_occurs_in:(CL:0000066)\|regulates_o_occurs_in:(EMAPA:17600) regulates_o_occurs_in:(CL:0000066)\|regulates_o_occurs_in:(EMAPA:17600) regulates_o_occurs_in:(CL:0000066)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090103	cochlea morphogenesis	PMID:10072433^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857803	P	has_participant:(EMAPA:17597)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072513	positive regulation of secondary heart field cardioblast proliferation	PMID:21364285^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102780	P	regulates_o_occurs_in:(EMAPA:16105)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071600	otic vesicle morphogenesis	PMID:16916509^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2150426	P	has_participant:(EMAPA:16994)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071600	otic vesicle morphogenesis	PMID:16916509^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2150426	P	has_participant:(EMAPA:16538)\|has_participant:(EMAPA:16197)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071599	otic vesicle development	PMID:22513373^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102780	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060037	pharyngeal system development	PMID:21364285^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:102780 MGI:MGI:98493 MGI:MGI:99604	P	results_in_development_of:(EMAPA:16117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050679	positive regulation of epithelial cell proliferation	PMID:16916509^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2150426	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048856	anatomical structure development	PMID:16530750^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102780	P	results_in_development_of:(EMAPA:16272)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048752	semicircular canal morphogenesis	PMID:10072433^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857803	P	has_participant:(EMAPA:32832)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048704	embryonic skeletal system morphogenesis	PMID:10471511^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2150426	P	has_participant:(EMAPA:17680)\|has_participant:(EMAPA:18010)\|has_participant:(EMAPA:17674)\|has_participant:(EMAPA:18028)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048665	neuron fate specification	PMID:22513373^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102780	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:22513373^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102780	P	has_regulation_target:(MGI:MGI:1339708)\|has_regulation_target:(MGI:MGI:107754)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21364285^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102780	P	has_regulation_target:(MGI:MGI:99604)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045739	positive regulation of DNA repair	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99502	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045664	regulation of neuron differentiation	PMID:22513373^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102780 MGI:MGI:107754 MGI:MGI:1339708 MGI:MGI:98364	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045664	regulation of neuron differentiation	PMID:15496442^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2150426	P	regulates_o_occurs_in:(EMAPA:16669) regulates_o_results_in_acquisition_of_features_of:(CL:0000101)\|regulates_o_occurs_in(EMAPA:16982) regulates_o_results_in_acquisition_of_features_of:(CL:0000101)\|regulates_o_occurs_in(EMAPA:16795) regulates_o_results_in_acquisition_of_features_of:(CL:0000101)\|regulates_o_occurs_in(EMAPA:16798) regulates_o_results_in_acquisition_of_features_of:(CL:0000101)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045165	cell fate commitment	PMID:16018995^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2150426	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045165	cell fate commitment	PMID:15817220^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857803	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042474	middle ear morphogenesis	PMID:10471511^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2150426	P	has_participant:(EMAPA:18583)\|has_participant:(EMAPA:18584)\|has_participant:(EMAPA:18585)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042473	outer ear morphogenesis	PMID:10471511^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2150426	P	has_participant:(EMAPA:16991)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042472	inner ear morphogenesis	PMID:16916509^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97486	P	has_participant:(EMAPA:16194)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042472	inner ear morphogenesis	PMID:15817220^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857803	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042472	inner ear morphogenesis	PMID:10471511^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2150426	P	has_participant:(EMAPA:16194)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035909	aorta morphogenesis	PMID:21364285^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:102780 MGI:MGI:98493 MGI:MGI:99604	P	has_participant:(EMAPA:16204)	Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99502	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016576	histone dephosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99502	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014706	striated muscle tissue development	PMID:17098221^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109341	P	results_in_development_of:(EMAPA:16405)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010212	response to ionizing radiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99502	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009887	animal organ morphogenesis	PMID:12070080^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2150426	P	has_participant:(EMAPA:17523)\|has_participant:(EMAPA:16558)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007389	pattern specification process	PMID:16530750^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102780	P	occurs_in:(EMAPA:16586)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007389	pattern specification process	PMID:16916509^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2150426	P	occurs_in:(EMAPA:16669)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006470	protein dephosphorylation	PMID:14628052^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006302	double-strand break repair	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99502	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16024294^[16]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16543)\|part_of:(EMAPA:16801)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99502	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99502	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16024294^[16]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16543)\|part_of:(EMAPA:16801)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99502	C		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	PMID:14628052^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99502	F		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:21936910^[17]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(MGI:MGI:1925118)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003151	outflow tract morphogenesis	PMID:21364285^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:102780 MGI:MGI:98493 MGI:MGI:99604	P	has_participant:(EMAPA:16346)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001658	branching involved in ureteric bud morphogenesis	PMID:12783782^[18]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102780	P	has_participant:(EMAPA:17373)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001657	ureteric bud development	PMID:16018995^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102780 MGI:MGI:97486	P	results_in_development_of:(EMAPA:17376)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001656	metanephros development	PMID:16018995^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2150426	P	results_in_development_of:(EMAPA:17207)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001656	metanephros development	PMID:10072433^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857803	P	results_in_development_of:(EMAPA:36589)	Seeded From UniProt	complete
involved_in	GO:0045739	positive regulation of DNA repair	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99502 ensembl:ENSP00000496255	P		Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99502 ensembl:ENSP00000496255	C		Seeded From UniProt	complete
involved_in	GO:0016576	histone dephosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99502 ensembl:ENSP00000496255	P		Seeded From UniProt	complete
involved_in	GO:0010212	response to ionizing radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99502 ensembl:ENSP00000496255	P		Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99502 ensembl:ENSP00000496255	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99502 ensembl:ENSP00000496255	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99502 ensembl:ENSP00000496255	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99502 ensembl:ENSP00000496255	C		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99502 ensembl:ENSP00000496255	F		Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A024R813 ensembl:ENSP00000496255	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A024R813 ensembl:ENSP00000496255	C		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028471 InterPro:IPR028472	F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006545	P		Seeded From UniProt	complete
involved_in	GO:0009887	animal organ morphogenesis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028471	P		Seeded From UniProt	complete
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028471	P		Seeded From UniProt	complete
involved_in	GO:0042471	ear morphogenesis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028471	P		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.3.48	F		Seeded From UniProt	complete
enables	GO:0004721	phosphoprotein phosphatase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.3.16	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
enables	GO:0004721	phosphoprotein phosphatase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0904	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Gong, KQ et al. (2007) A Hox-Eya-Pax complex regulates early kidney developmental gene expression. Mol. Cell. Biol. 27 7661-8 PubMed GONUTS page
↑ Alkuraya, FS et al. (2006) SUMO1 haploinsufficiency leads to cleft lip and palate. Science 313 1751 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Friedman, RA et al. (2005) Eya1 acts upstream of Tbx1, Neurogenin 1, NeuroD and the neurotrophins BDNF and NT-3 during inner ear development. Mech. Dev. 122 625-34 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Johnson, KR et al. (1999) Inner ear and kidney anomalies caused by IAP insertion in an intron of the Eya1 gene in a mouse model of BOR syndrome. Hum. Mol. Genet. 8 645-53 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Guo, C et al. (2011) A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis. J. Clin. Invest. 121 1585-95 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Zou, D et al. (2006) Eya1 regulates the growth of otic epithelium and interacts with Pax2 during the development of all sensory areas in the inner ear. Dev. Biol. 298 430-41 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Ahmed, M et al. (2012) EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear. Development 139 1965-77 PubMed GONUTS page
↑ ^9.0 ^9.1 Zou, D et al. (2006) Patterning of the third pharyngeal pouch into thymus/parathyroid by Six and Eya1. Dev. Biol. 293 499-512 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Xu, PX et al. (1999) Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia. Nat. Genet. 23 113-7 PubMed GONUTS page
↑ Zou, D et al. (2004) Eya1 and Six1 are essential for early steps of sensory neurogenesis in mammalian cranial placodes. Development 131 5561-72 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Sajithlal, G et al. (2005) Eya 1 acts as a critical regulator for specifying the metanephric mesenchyme. Dev. Biol. 284 323-36 PubMed GONUTS page
↑ Grifone, R et al. (2007) Eya1 and Eya2 proteins are required for hypaxial somitic myogenesis in the mouse embryo. Dev. Biol. 302 602-16 PubMed GONUTS page
↑ Xu, PX et al. (2002) Eya1 is required for the morphogenesis of mammalian thymus, parathyroid and thyroid. Development 129 3033-44 PubMed GONUTS page
↑ ^15.0 ^15.1 Rayapureddi, JP et al. (2003) Eyes absent represents a class of protein tyrosine phosphatases. Nature 426 295-8 PubMed GONUTS page
↑ ^16.0 ^16.1 Purcell, P et al. (2005) Pax6-dependence of Six3, Eya1 and Dach1 expression during lens and nasal placode induction. Gene Expr. Patterns 6 110-8 PubMed GONUTS page
↑ Rapicavoli, NA et al. (2011) The long noncoding RNA Six3OS acts in trans to regulate retinal development by modulating Six3 activity. Neural Dev 6 32 PubMed GONUTS page
↑ Xu, PX et al. (2003) Six1 is required for the early organogenesis of mammalian kidney. Development 130 3085-94 PubMed GONUTS page

[PMID:17785448-1] 1.0 ^1.1 ^1.2 ^1.3 Gong, KQ et al. (2007) A Hox-Eya-Pax complex regulates early kidney developmental gene expression. Mol. Cell. Biol. 27 7661-8 PubMed GONUTS page

[PMID:16990542-2] Alkuraya, FS et al. (2006) SUMO1 haploinsufficiency leads to cleft lip and palate. Science 313 1751 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:15817220-4] 4.0 ^4.1 ^4.2 Friedman, RA et al. (2005) Eya1 acts upstream of Tbx1, Neurogenin 1, NeuroD and the neurotrophins BDNF and NT-3 during inner ear development. Mech. Dev. 122 625-34 PubMed GONUTS page

[PMID:10072433-5] 5.0 ^5.1 ^5.2 Johnson, KR et al. (1999) Inner ear and kidney anomalies caused by IAP insertion in an intron of the Eya1 gene in a mouse model of BOR syndrome. Hum. Mol. Genet. 8 645-53 PubMed GONUTS page

[PMID:21364285-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Guo, C et al. (2011) A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis. J. Clin. Invest. 121 1585-95 PubMed GONUTS page

[PMID:16916509-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Zou, D et al. (2006) Eya1 regulates the growth of otic epithelium and interacts with Pax2 during the development of all sensory areas in the inner ear. Dev. Biol. 298 430-41 PubMed GONUTS page

[PMID:22513373-8] 8.0 ^8.1 ^8.2 ^8.3 Ahmed, M et al. (2012) EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear. Development 139 1965-77 PubMed GONUTS page

[PMID:16530750-9] 9.0 ^9.1 Zou, D et al. (2006) Patterning of the third pharyngeal pouch into thymus/parathyroid by Six and Eya1. Dev. Biol. 293 499-512 PubMed GONUTS page

[PMID:10471511-10] 10.0 ^10.1 ^10.2 ^10.3 Xu, PX et al. (1999) Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia. Nat. Genet. 23 113-7 PubMed GONUTS page

[PMID:15496442-11] Zou, D et al. (2004) Eya1 and Six1 are essential for early steps of sensory neurogenesis in mammalian cranial placodes. Development 131 5561-72 PubMed GONUTS page

[PMID:16018995-12] 12.0 ^12.1 ^12.2 Sajithlal, G et al. (2005) Eya 1 acts as a critical regulator for specifying the metanephric mesenchyme. Dev. Biol. 284 323-36 PubMed GONUTS page

[PMID:17098221-13] Grifone, R et al. (2007) Eya1 and Eya2 proteins are required for hypaxial somitic myogenesis in the mouse embryo. Dev. Biol. 302 602-16 PubMed GONUTS page

[PMID:12070080-14] Xu, PX et al. (2002) Eya1 is required for the morphogenesis of mammalian thymus, parathyroid and thyroid. Development 129 3033-44 PubMed GONUTS page

[PMID:14628052-15] 15.0 ^15.1 Rayapureddi, JP et al. (2003) Eyes absent represents a class of protein tyrosine phosphatases. Nature 426 295-8 PubMed GONUTS page

[PMID:16024294-16] 16.0 ^16.1 Purcell, P et al. (2005) Pax6-dependence of Six3, Eya1 and Dach1 expression during lens and nasal placode induction. Gene Expr. Patterns 6 110-8 PubMed GONUTS page

[PMID:21936910-17] Rapicavoli, NA et al. (2011) The long noncoding RNA Six3OS acts in trans to regulate retinal development by modulating Six3 activity. Neural Dev 6 32 PubMed GONUTS page

[PMID:12783782-18] Xu, PX et al. (2003) Six1 is required for the early organogenesis of mammalian kidney. Development 130 3085-94 PubMed GONUTS page

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