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PMID:14628052
| Citation |
Rayapureddi, JP, Kattamuri, C, Steinmetz, BD, Frankfort, BJ, Ostrin, EJ, Mardon, G and Hegde, RS (2003) Eyes absent represents a class of protein tyrosine phosphatases. Nature 426:295-8 |
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| Abstract |
The Eyes absent proteins are members of a conserved regulatory network implicated in the development of the eye, muscle, kidney and ear. Mutations in the Eyes absent genes have been associated with several congenital disorders including the multi-organ disease bronchio-oto-renal syndrome, congenital cataracts and late-onset deafness. On the basis of previous analyses it has been shown that Eyes absent is a nuclear transcription factor, acting through interaction with homeodomain-containing Sine oculis (also known as Six) proteins. Here we show that Eyes absent is also a protein tyrosine phosphatase. It does not resemble the classical tyrosine phosphatases that use cysteine as a nucleophile and proceed by means of a thiol-phosphate intermediate. Rather, Eyes absent is the prototype for a class of protein tyrosine phosphatases that use a nucleophilic aspartic acid in a metal-dependent reaction. Furthermore, the phosphatase activity of Eyes absent contributes to its ability to induce eye formation in Drosophila. |
| Links |
PubMed Online version:10.1038/nature02093 |
| Keywords |
Amino Acid Sequence; Animals; Drosophila Proteins/antagonists & inhibitors; Drosophila Proteins/chemistry; Drosophila Proteins/metabolism; Drosophila melanogaster/embryology; Drosophila melanogaster/enzymology; Drosophila melanogaster/genetics; Eye/embryology; Eye/enzymology; Eye/metabolism; Eye Proteins/antagonists & inhibitors; Eye Proteins/chemistry; Eye Proteins/metabolism; Molecular Sequence Data; Mutation; Phosphorylation; Protein Tyrosine Phosphatases/antagonists & inhibitors; Protein Tyrosine Phosphatases/chemistry; Protein Tyrosine Phosphatases/metabolism; Substrate Specificity |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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