MOUSE:DNMT1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Dnmt1 (synonyms: Dnmt, Met1, Uim)
Protein Name(s)	DNA (cytosine-5)-methyltransferase 1 Dnmt1 Met-1 DNA methyltransferase MmuI DNA MTase MmuI M.MmuI MCMT
External Links
UniProt	P13864
EMBL	X14805 AF175432 AF162282 AF175431 AF175412 AF175413 AF175414 AF244089 AF244090 AF175416 AF175417 AF175418 AF175419 AF175420 AF175421 AF175422 AF175423 AF234317 AF175424 AF175425 AF175426 AF234318 AF175427 AF175428 AF175429 AF175430 BC048148 AF036007 AF036008 U70051 AK013247
CCDS	CCDS57654.1 CCDS57655.1
PIR	S01845
RefSeq	NP_001186360.2 NP_001186361.1 NP_001186362.1 NP_034196.5
UniGene	Mm.128580 Mm.485562
PDB	3AV4 3AV5 3AV6 3PT6 3PT9 4DA4
PDBsum	3AV4 3AV5 3AV6 3PT6 3PT9 4DA4
ProteinModelPortal	P13864
SMR	P13864
BioGrid	199259
IntAct	P13864
MINT	MINT-4093291
GuidetoPHARMACOLOGY	2605
REBASE	2844
PhosphoSite	P13864
MaxQB	P13864
PaxDb	P13864
PRIDE	P13864
Ensembl	ENSMUST00000004202 ENSMUST00000178110
GeneID	13433
KEGG	mmu:13433
UCSC	uc009ojo.2
CTD	1786
MGI	MGI:94912
eggNOG	COG0270
GeneTree	ENSGT00390000005100
HOVERGEN	HBG051384
InParanoid	P13864
KO	K00558
OMA	CPNLAVK
OrthoDB	EOG77WWBH
PhylomeDB	P13864
TreeFam	TF328926
BRENDA	2.1.1.37
Reactome	REACT_200667 REACT_214440 REACT_222475 REACT_268475
ChiTaRS	Dnmt1
EvolutionaryTrace	P13864
NextBio	283859
PRO	PR:P13864
Proteomes	UP000000589
Bgee	P13864
CleanEx	MM_DNMT1
ExpressionAtlas	P13864
Genevestigator	P13864
GO	GO:0005737 GO:0000792 GO:0005634 GO:0005721 GO:0005657 GO:0003682 GO:0003886 GO:0003677 GO:0008327 GO:0008168 GO:0003723 GO:0008270 GO:0071230 GO:0016568 GO:0006306 GO:0016458 GO:0010216 GO:0051573 GO:0000122 GO:0045892 GO:0010628 GO:0051571 GO:0042127 GO:0010468 GO:0006351
Gene3D	3.40.50.150
InterPro	IPR001025 IPR018117 IPR001525 IPR022702 IPR010506 IPR017198 IPR029063 IPR002857
Pfam	PF01426 PF06464 PF12047 PF02008
PIRSF	PIRSF037404
PRINTS	PR00105
SMART	SM00439
SUPFAM	SSF53335
PROSITE	PS51038 PS00094 PS00095 PS51679 PS51058

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:1990841	promoter-specific chromatin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26358	F		Seeded From UniProt	complete
involved_in	GO:0090309	positive regulation of methylation-dependent chromatin silencing	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26358	P		Seeded From UniProt	complete
involved_in	GO:0007265	Ras protein signal transduction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26358	P		Seeded From UniProt	complete
involved_in	GO:0016458	gene silencing	PMID:10615135^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010216	maintenance of DNA methylation	PMID:17576694^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008168	methyltransferase activity	PMID:10615135^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005721	pericentric heterochromatin	PMID:17576694^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010424	DNA methylation on cytosine within a CG sequence	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000066774 RGD:620979 TAIR:locus:2155959	P		Seeded From UniProt	complete
involved_in	GO:0010216	maintenance of DNA methylation	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:94912 PANTHER:PTN000066774 RGD:620979 TAIR:locus:2155959 UniProtKB:C0SQ89 UniProtKB:P26358	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:94912 PANTHER:PTN000066775 RGD:620979	C		Seeded From UniProt	complete
enables	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:94912 PANTHER:PTN000066774 RGD:620979 TAIR:locus:2117104 TAIR:locus:2205015 UniProtKB:P26358	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:94912 PANTHER:PTN000066774 UniProtKB:P26358	F		Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P26358	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905931	negative regulation of vascular smooth muscle cell differentiation involved in phenotypic switching	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P26358	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905460	negative regulation of vascular associated smooth muscle cell apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P26358	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904707	positive regulation of vascular smooth muscle cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P26358	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090309	positive regulation of methylation-dependent chromatin silencing	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P26358	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071560	cellular response to transforming growth factor beta stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620979	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071230	cellular response to amino acid stimulus	PMID:20548288^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:16846)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051573	negative regulation of histone H3-K9 methylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P26358	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051571	positive regulation of histone H3-K4 methylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P26358	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046500	S-adenosylmethionine metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620979	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	PMID:17245608^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2156895	P	regulates_o_occurs_in:(CL:0000351) has_regulation_target:(MGI:MGI:1926855)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	PMID:10888872^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044026	DNA hypermethylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620979	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043045	DNA methylation involved in embryo development	PMID:1606615^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857157	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620979	C		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620979	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042493	response to drug	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620979	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042127	regulation of cell population proliferation	PMID:10919675^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104642 MGI:MGI:88039	P	occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620979	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032776	DNA methylation on cytosine	PMID:1606615^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857157	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032776	DNA methylation on cytosine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620979	P		Seeded From UniProt	complete
enables	GO:0030331	estrogen receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620979	F		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620979	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P26358	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P26358	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010468	regulation of gene expression	PMID:23028046^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010468	regulation of gene expression	PMID:16491076^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2156895	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010424	DNA methylation on cytosine within a CG sequence	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620979	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010216	maintenance of DNA methylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P26358	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010216	maintenance of DNA methylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620979	P		Seeded From UniProt	complete
enables	GO:0009008	DNA-methyltransferase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P26358	F		Seeded From UniProt	complete
enables	GO:0008327	methyl-CpG binding	PMID:20573698^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:11399088^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007265	Ras protein signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P26358	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006306	DNA methylation	PMID:24105743^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_direct_input:(MGI:MGI:892014) has_direct_input:(MGI:MGI:95484)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006306	DNA methylation	PMID:16887828^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1930971	P	has_participant:(MGI:MGI:105113)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006306	DNA methylation	PMID:11399088^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620979	C		Seeded From UniProt	complete
part_of	GO:0005657	replication fork	PMID:10888872^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17931718^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16424344^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15063176^[17]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:18686) part_of:(CL:0000586)\|part_of:(CL:0000023)\|part_of:(EMAPA:17386) part_of:(CL:0000586)\|part_of:(EMAPA:17975) part_of:(CL:0000586)\|part_of:(EMAPA:17975) part_of:(CL:0000586)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11942627^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620979	C		Seeded From UniProt	complete
enables	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	PMID:11399088^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P26358	F		Seeded From UniProt	complete
enables	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620979	F		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:20573698^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:24105743^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:11399088^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P26358	F		Seeded From UniProt	complete
part_of	GO:0000792	heterochromatin	PMID:14519686^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:24105743^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:892014) has_regulation_target:(MGI:MGI:95484)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:16887828^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1930971	P	occurs_in:(EMAPA:16052) has_regulation_target:(MGI:MGI:105113)	Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26358 ensembl:ENSP00000352516	F		Seeded From UniProt	complete
involved_in	GO:1905931	negative regulation of vascular smooth muscle cell differentiation involved in phenotypic switching	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26358 ensembl:ENSP00000352516	P		Seeded From UniProt	complete
involved_in	GO:1905460	negative regulation of vascular associated smooth muscle cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26358 ensembl:ENSP00000352516	P		Seeded From UniProt	complete
involved_in	GO:1904707	positive regulation of vascular smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26358 ensembl:ENSP00000352516	P		Seeded From UniProt	complete
involved_in	GO:0090309	positive regulation of methylation-dependent chromatin silencing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26358 ensembl:ENSP00000352516	P		Seeded From UniProt	complete
involved_in	GO:0051573	negative regulation of histone H3-K9 methylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26358 ensembl:ENSP00000352516	P		Seeded From UniProt	complete
involved_in	GO:0051571	positive regulation of histone H3-K4 methylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26358 ensembl:ENSP00000352516	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26358 ensembl:ENSP00000352516	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26358 ensembl:ENSP00000352516	P		Seeded From UniProt	complete
involved_in	GO:0010216	maintenance of DNA methylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26358 ensembl:ENSP00000352516	P		Seeded From UniProt	complete
enables	GO:0009008	DNA-methyltransferase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26358 ensembl:ENSP00000352516	F		Seeded From UniProt	complete
involved_in	GO:0007265	Ras protein signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26358 ensembl:ENSP00000352516	P		Seeded From UniProt	complete
enables	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26358 ensembl:ENSP00000352516	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26358 ensembl:ENSP00000352516	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002857	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001025	F		Seeded From UniProt	complete
enables	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017198	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017198	C		Seeded From UniProt	complete
enables	GO:0008168	methyltransferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001525	F		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002857	F		Seeded From UniProt	complete
involved_in	GO:0090116	C-5 methylation of cytosine	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017198	P		Seeded From UniProt	complete
enables	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.1.1.37	F		Seeded From UniProt	complete
enables	GO:0051718	DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates	Reactome:R-MMU-5336369	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0009008	DNA-methyltransferase activity	Reactome:R-MMU-573383	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-MMU-573383 Reactome:R-MMU-573376 Reactome:R-MMU-573336 Reactome:R-MMU-5336369 Reactome:R-MMU-5336365	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0021	P		Seeded From UniProt	complete
involved_in	GO:0032259	methylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0489	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0008168	methyltransferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0489	F		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0021	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Fuks, F et al. (2000) DNA methyltransferase Dnmt1 associates with histone deacetylase activity. Nat. Genet. 24 88-91 PubMed GONUTS page
↑ ^2.0 ^2.1 Schermelleh, L et al. (2007) Dynamics of Dnmt1 interaction with the replication machinery and its role in postreplicative maintenance of DNA methylation. Nucleic Acids Res. 35 4301-12 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Pogribny, IP et al. (2010) Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice. Lab. Invest. 90 1437-46 PubMed GONUTS page
↑ Green, K et al. (2007) A developmental window of opportunity for imprinted gene silencing mediated by DNA methylation and the Kcnq1ot1 noncoding RNA. Mamm. Genome 18 32-42 PubMed GONUTS page
↑ ^6.0 ^6.1 Rountree, MR et al. (2000) DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. Nat. Genet. 25 269-77 PubMed GONUTS page
↑ ^7.0 ^7.1 Li, E et al. (1992) Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69 915-26 PubMed GONUTS page
↑ Cormier, RT & Dove, WF (2000) Dnmt1N/+ reduces the net growth rate and multiplicity of intestinal adenomas in C57BL/6-multiple intestinal neoplasia (Min)/+ mice independently of p53 but demonstrates strong synergy with the modifier of Min 1(AKR) resistance allele. Cancer Res. 60 3965-70 PubMed GONUTS page
↑ Ha, SD et al. (2012) Cellular adaptation to anthrax lethal toxin-induced mitochondrial cholesterol enrichment, hyperpolarization, and reactive oxygen species generation through downregulating MLN64 in macrophages. Mol. Cell. Biol. 32 4846-60 PubMed GONUTS page
↑ Bilic, I et al. (2006) Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR. Nat. Immunol. 7 392-400 PubMed GONUTS page
↑ ^11.0 ^11.1 Mohammad, F et al. (2010) Kcnq1ot1 noncoding RNA mediates transcriptional gene silencing by interacting with Dnmt1. Development 137 2493-9 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Fatemi, M et al. (2001) The activity of the murine DNA methyltransferase Dnmt1 is controlled by interaction of the catalytic domain with the N-terminal part of the enzyme leading to an allosteric activation of the enzyme after binding to methylated DNA. J. Mol. Biol. 309 1189-99 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Wajapeyee, N et al. (2013) Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors. Genes Dev. 27 2221-6 PubMed GONUTS page
↑ ^14.0 ^14.1 Maatouk, DM et al. (2006) DNA methylation is a primary mechanism for silencing postmigratory primordial germ cell genes in both germ cell and somatic cell lineages. Development 133 3411-8 PubMed GONUTS page
↑ Sajedi, E et al. (2008) DNMT1 interacts with the developmental transcriptional repressor HESX1. Biochim. Biophys. Acta 1783 131-43 PubMed GONUTS page
↑ Goll, MG et al. (2006) Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2. Science 311 395-8 PubMed GONUTS page
↑ La Salle, S et al. (2004) Windows for sex-specific methylation marked by DNA methyltransferase expression profiles in mouse germ cells. Dev. Biol. 268 403-15 PubMed GONUTS page
↑ Sakai, Y et al. (2001) Expression of DNA methyltransferase (Dnmt1) in testicular germ cells during development of mouse embryo. Cell Struct. Funct. 26 685-91 PubMed GONUTS page
↑ Craig, JM et al. (2003) Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patterns. Hum. Mol. Genet. 12 3109-21 PubMed GONUTS page

[PMID:10615135-1] 1.0 ^1.1 Fuks, F et al. (2000) DNA methyltransferase Dnmt1 associates with histone deacetylase activity. Nat. Genet. 24 88-91 PubMed GONUTS page

[PMID:17576694-2] 2.0 ^2.1 Schermelleh, L et al. (2007) Dynamics of Dnmt1 interaction with the replication machinery and its role in postreplicative maintenance of DNA methylation. Nucleic Acids Res. 35 4301-12 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:20548288-4] Pogribny, IP et al. (2010) Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice. Lab. Invest. 90 1437-46 PubMed GONUTS page

[PMID:17245608-5] Green, K et al. (2007) A developmental window of opportunity for imprinted gene silencing mediated by DNA methylation and the Kcnq1ot1 noncoding RNA. Mamm. Genome 18 32-42 PubMed GONUTS page

[PMID:10888872-6] 6.0 ^6.1 Rountree, MR et al. (2000) DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. Nat. Genet. 25 269-77 PubMed GONUTS page

[PMID:1606615-7] 7.0 ^7.1 Li, E et al. (1992) Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69 915-26 PubMed GONUTS page

[PMID:10919675-8] Cormier, RT & Dove, WF (2000) Dnmt1N/+ reduces the net growth rate and multiplicity of intestinal adenomas in C57BL/6-multiple intestinal neoplasia (Min)/+ mice independently of p53 but demonstrates strong synergy with the modifier of Min 1(AKR) resistance allele. Cancer Res. 60 3965-70 PubMed GONUTS page

[PMID:23028046-9] Ha, SD et al. (2012) Cellular adaptation to anthrax lethal toxin-induced mitochondrial cholesterol enrichment, hyperpolarization, and reactive oxygen species generation through downregulating MLN64 in macrophages. Mol. Cell. Biol. 32 4846-60 PubMed GONUTS page

[PMID:16491076-10] Bilic, I et al. (2006) Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR. Nat. Immunol. 7 392-400 PubMed GONUTS page

[PMID:20573698-11] 11.0 ^11.1 Mohammad, F et al. (2010) Kcnq1ot1 noncoding RNA mediates transcriptional gene silencing by interacting with Dnmt1. Development 137 2493-9 PubMed GONUTS page

[PMID:11399088-12] 12.0 ^12.1 ^12.2 ^12.3 Fatemi, M et al. (2001) The activity of the murine DNA methyltransferase Dnmt1 is controlled by interaction of the catalytic domain with the N-terminal part of the enzyme leading to an allosteric activation of the enzyme after binding to methylated DNA. J. Mol. Biol. 309 1189-99 PubMed GONUTS page

[PMID:24105743-13] 13.0 ^13.1 ^13.2 Wajapeyee, N et al. (2013) Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors. Genes Dev. 27 2221-6 PubMed GONUTS page

[PMID:16887828-14] 14.0 ^14.1 Maatouk, DM et al. (2006) DNA methylation is a primary mechanism for silencing postmigratory primordial germ cell genes in both germ cell and somatic cell lineages. Development 133 3411-8 PubMed GONUTS page

[PMID:17931718-15] Sajedi, E et al. (2008) DNMT1 interacts with the developmental transcriptional repressor HESX1. Biochim. Biophys. Acta 1783 131-43 PubMed GONUTS page

[PMID:16424344-16] Goll, MG et al. (2006) Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2. Science 311 395-8 PubMed GONUTS page

[PMID:15063176-17] La Salle, S et al. (2004) Windows for sex-specific methylation marked by DNA methyltransferase expression profiles in mouse germ cells. Dev. Biol. 268 403-15 PubMed GONUTS page

[PMID:11942627-18] Sakai, Y et al. (2001) Expression of DNA methyltransferase (Dnmt1) in testicular germ cells during development of mouse embryo. Cell Struct. Funct. 26 685-91 PubMed GONUTS page

[PMID:14519686-19] Craig, JM et al. (2003) Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patterns. Hum. Mol. Genet. 12 3109-21 PubMed GONUTS page

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