MOUSE:DBLOH

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Diablo (synonyms: Smac)
Protein Name(s)	Diablo homolog, mitochondrial Direct IAP-binding protein with low pI Second mitochondria-derived activator of caspase Smac
External Links
UniProt	Q9JIQ3
EMBL	AF203914 AK012760 AK002887 AK077198 AK133194 AC157931
CCDS	CCDS39270.1
RefSeq	NP_075721.3
UniGene	Mm.46716
ProteinModelPortal	Q9JIQ3
SMR	Q9JIQ3
BioGrid	211579
IntAct	Q9JIQ3
MINT	MINT-1341305
PhosphoSite	Q9JIQ3
MaxQB	Q9JIQ3
PaxDb	Q9JIQ3
PRIDE	Q9JIQ3
Ensembl	ENSMUST00000111587 ENSMUST00000125652
GeneID	66593
KEGG	mmu:66593
UCSC	uc008znx.1
CTD	56616
MGI	MGI:1913843
eggNOG	NOG42122
GeneTree	ENSGT00390000007237
HOGENOM	HOG000217916
HOVERGEN	HBG051315
InParanoid	Q9JIQ3
KO	K10522
OMA	QKLEPHS
OrthoDB	EOG7SJD66
PhylomeDB	Q9JIQ3
TreeFam	TF102048
Reactome	REACT_211550
NextBio	322104
PRO	PR:Q9JIQ3
Proteomes	UP000000589
CleanEx	MM_DIABLO
ExpressionAtlas	Q9JIQ3
Genevestigator	Q9JIQ3
GO	GO:0035631 GO:0005737 GO:0009898 GO:0005758 GO:0005739 GO:0006919 GO:0008635 GO:0097193 GO:0008631 GO:0051402 GO:0043065
InterPro	IPR015142 IPR009062
Pfam	PF09057
SUPFAM	SSF46984

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005515	protein binding	PMID:20614026^[1]	ECO:0000021		UniProtKB:P27512	F		Figures 1 & 2 show co-immunoprecipitation using Western blot verification of mass spectrometry results of hmCD40 and hmCD40D67 ARC ‘‘activated receptor capture’’ samples.	complete
	GO:0009898	internal side of plasma membrane	PMID:20614026^[1]	ECO:0000314			C		Figure 2. Western blot verification of mass spectrometry results. hmCD40 and hmCD40D67 ARC ‘‘activated receptor capture’’ samples.	complete
part_of	GO:0035631	CD40 receptor complex	PMID:20614026^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009898	cytoplasmic side of plasma membrane	PMID:20614026^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:11604410^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P98170)	Seeded From UniProt	complete
involved_in	GO:0051402	neuron apoptotic process	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1913843 PANTHER:PTN001283560	P		Seeded From UniProt	complete
involved_in	GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1913843 PANTHER:PTN001283560	P		Seeded From UniProt	complete
involved_in	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1913843 PANTHER:PTN001283560	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1913843 PANTHER:PTN001283560 RGD:1310885 UniProtKB:Q9NR28	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051402	neuron apoptotic process	PMID:14623868^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c	PMID:14623868^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	PMID:16085184^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:16085184^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:16085184^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:12011074^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005758	mitochondrial intermembrane space	PMID:17376863^[7]	ECO:0000266	sequence orthology evidence used in manual assertion	RefSeq:NP_001008293	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:18614015^[8]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:14651853^[9]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(EMAPA:16846)\|part_of:(EMAPA:16894)\|part_of:(EMAPA:17373)	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:16085184^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:15882989^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16039) part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:15814844^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:14623868^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NR28	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:18385140^[12]	ECO:0000250	sequence similarity evidence used in manual assertion	RefSeq:NP_001008293	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16085184^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15882989^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16039) part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009062 InterPro:IPR015142	C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009062 InterPro:IPR015142	P		Seeded From UniProt	complete
involved_in	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009062 InterPro:IPR015142	P		Seeded From UniProt	complete
involved_in	GO:0097193	intrinsic apoptotic signaling pathway	PMID:18309324^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:18309324^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:18309324^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005758	mitochondrial intermembrane space	PMID:18309324^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496 UniProtKB-SubCell:SL-0173	C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Hostager, BS et al. (2010) HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex. PLoS ONE 5 e11380 PubMed GONUTS page
↑ Verhagen, AM et al. (2002) HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins. J. Biol. Chem. 277 445-54 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Potts, PR et al. (2003) Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis. J. Cell Biol. 163 789-99 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Jiang, B et al. (2005) Role of Smac/DIABLO in hydrogen peroxide-induced apoptosis in C2C12 myogenic cells. Free Radic. Biol. Med. 39 658-67 PubMed GONUTS page
↑ Li, S et al. (2002) Relief of extrinsic pathway inhibition by the Bid-dependent mitochondrial release of Smac in Fas-mediated hepatocyte apoptosis. J. Biol. Chem. 277 26912-20 PubMed GONUTS page
↑ Wiley, SE et al. (2007) MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity. Proc. Natl. Acad. Sci. U.S.A. 104 5318-23 PubMed GONUTS page
↑ Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page
↑ Mootha, VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115 629-40 PubMed GONUTS page
↑ ^10.0 ^10.1 Mendoza, FJ et al. (2005) MEKK1-induced apoptosis is mediated by Smac/Diablo release from the mitochondria. Biochem. Biophys. Res. Commun. 331 1089-98 PubMed GONUTS page
↑ Burri, L et al. (2005) Mature DIABLO/Smac is produced by the IMP protease complex on the mitochondrial inner membrane. Mol. Biol. Cell 16 2926-33 PubMed GONUTS page
↑ Rardin, MJ et al. (2008) Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane. J. Biol. Chem. 283 15440-50 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 Galluzzi, L et al. (2008) No death without life: vital functions of apoptotic effectors. Cell Death Differ. 15 1113-23 PubMed GONUTS page

[PMID:20614026-1] 1.0 ^1.1 ^1.2 ^1.3 Hostager, BS et al. (2010) HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex. PLoS ONE 5 e11380 PubMed GONUTS page

[PMID:11604410-2] Verhagen, AM et al. (2002) HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins. J. Biol. Chem. 277 445-54 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:14623868-4] 4.0 ^4.1 ^4.2 Potts, PR et al. (2003) Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis. J. Cell Biol. 163 789-99 PubMed GONUTS page

[PMID:16085184-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Jiang, B et al. (2005) Role of Smac/DIABLO in hydrogen peroxide-induced apoptosis in C2C12 myogenic cells. Free Radic. Biol. Med. 39 658-67 PubMed GONUTS page

[PMID:12011074-6] Li, S et al. (2002) Relief of extrinsic pathway inhibition by the Bid-dependent mitochondrial release of Smac in Fas-mediated hepatocyte apoptosis. J. Biol. Chem. 277 26912-20 PubMed GONUTS page

[PMID:17376863-7] Wiley, SE et al. (2007) MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity. Proc. Natl. Acad. Sci. U.S.A. 104 5318-23 PubMed GONUTS page

[PMID:18614015-8] Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page

[PMID:14651853-9] Mootha, VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115 629-40 PubMed GONUTS page

[PMID:15882989-10] 10.0 ^10.1 Mendoza, FJ et al. (2005) MEKK1-induced apoptosis is mediated by Smac/Diablo release from the mitochondria. Biochem. Biophys. Res. Commun. 331 1089-98 PubMed GONUTS page

[PMID:15814844-11] Burri, L et al. (2005) Mature DIABLO/Smac is produced by the IMP protease complex on the mitochondrial inner membrane. Mol. Biol. Cell 16 2926-33 PubMed GONUTS page

[PMID:18385140-12] Rardin, MJ et al. (2008) Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane. J. Biol. Chem. 283 15440-50 PubMed GONUTS page

[PMID:18309324-13] 13.0 ^13.1 ^13.2 ^13.3 Galluzzi, L et al. (2008) No death without life: vital functions of apoptotic effectors. Cell Death Differ. 15 1113-23 PubMed GONUTS page

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MOUSE:DBLOH

Contents

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References

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