MOUSE:DAB2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Dab2 (synonyms: Doc2)
Protein Name(s)	Disabled homolog 2 DOC-2 Mitogen-responsive phosphoprotein
External Links
UniProt	P98078
EMBL	U18869 U18869 U18869 AF260580 AK154716 BC016887 BC006588
CCDS	CCDS37029.1 CCDS37030.1
RefSeq	NP_001008702.1 NP_001032994.1 NP_075607.2 XP_006520023.1
UniGene	Mm.240830
PDB	1M7E 1P3R
PDBsum	1M7E 1P3R
ProteinModelPortal	P98078
SMR	P98078
BioGrid	199043
DIP	DIP-39422N
IntAct	P98078
MINT	MINT-259116
PhosphoSite	P98078
MaxQB	P98078
PaxDb	P98078
PRIDE	P98078
Ensembl	ENSMUST00000080880
GeneID	13132
KEGG	mmu:13132
UCSC	uc007vde.1
CTD	1601
MGI	MGI:109175
eggNOG	NOG328122
GeneTree	ENSGT00520000055585
HOGENOM	HOG000060158
HOVERGEN	HBG018945
InParanoid	P98078
KO	K12475
OrthoDB	EOG7HQN7R
PhylomeDB	P98078
TreeFam	TF316724
Reactome	REACT_209040 REACT_220352
ChiTaRS	Dab2
EvolutionaryTrace	P98078
NextBio	283182
PRO	PR:P98078
Proteomes	UP000000589
Bgee	P98078
CleanEx	MM_DAB2
ExpressionAtlas	P98078
Genevestigator	P98078
GO	GO:0016324 GO:0030132 GO:0030665 GO:0005737 GO:0070062 GO:0005730 GO:0005634 GO:0005886 GO:0070022 GO:0035612 GO:0038024 GO:0035615 GO:0030276 GO:0005178 GO:0035091 GO:0005546 GO:0007257 GO:0006915 GO:0000904 GO:0071560 GO:0048268 GO:0007492 GO:0007588 GO:0001701 GO:0030099 GO:0060766 GO:0043066 GO:0090090 GO:2001237 GO:0032091 GO:1903077 GO:0045892 GO:0006907 GO:0045785 GO:0030335 GO:2000370 GO:2000643 GO:0010718 GO:2001046 GO:0010862 GO:0032436 GO:0001921 GO:0060391 GO:1900026 GO:0032968 GO:0030511 GO:2000096 GO:0015031 GO:0006898 GO:0016055
Gene3D	2.30.29.30
InterPro	IPR011993 IPR006020
Pfam	PF00640
SMART	SM00462
PROSITE	PS01179

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0002092	positive regulation of receptor internalization	PMID:23354168^[1]	ECO:0000315			P		Figure 4: While Alexa dye-coupled VEGF-A and VEGF-C were readily taken up by cultured mouse control endothelial cells, knockdown of Pard3 or Dab2 significantly decreased the perinuclear accumulation of VEGF-A and VEGF-C (Fig. 4a–c). Surface biotinylation experiments further confirmed that VEGF-C-induced internalization of VEGFR3 and VEGFR2 was impaired in Dab2 knockdown or Pard3 knockdown cells (Fig. 4d,e).	complete CACAO 7192
involved_in	GO:0002092	positive regulation of receptor internalization	PMID:23354168^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903077	negative regulation of protein localization to plasma membrane	PMID:19581412^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:P09055)	Seeded From UniProt	complete
involved_in	GO:2001046	positive regulation of integrin-mediated signaling pathway	PMID:15734730^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000370	positive regulation of clathrin-dependent endocytosis	PMID:16984970^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	PMID:15734730^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	PMID:11823414^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071560	cellular response to transforming growth factor beta stimulus	PMID:15734730^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071560	cellular response to transforming growth factor beta stimulus	PMID:15894542^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048268	clathrin coat assembly	PMID:12234931^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045785	positive regulation of cell adhesion	PMID:15734730^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045785	positive regulation of cell adhesion	PMID:11823414^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:15734730^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0038024	cargo receptor activity	PMID:16984970^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0035615	clathrin adaptor activity	PMID:16984970^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0035612	AP-2 adaptor complex binding	PMID:12234931^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0035091	phosphatidylinositol binding	PMID:12234931^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter	PMID:15894542^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:15894542^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0030276	clathrin binding	PMID:12234931^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0030132	clathrin coat of coated pit	PMID:11247302^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030099	myeloid cell differentiation	PMID:11823414^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	PMID:20881059^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010718	positive regulation of epithelial to mesenchymal transition	PMID:15734730^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007257	activation of JUN kinase activity	PMID:15894542^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	PMID:12826668^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	PMID:15734730^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001921	positive regulation of receptor recycling	PMID:20881059^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	PMID:15734730^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0002327)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000860	positive regulation of aldosterone secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621007	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000643	positive regulation of early endosome to late endosome transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98082	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000370	positive regulation of clathrin-dependent endocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98082	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000298	regulation of Rho-dependent protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621007	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000096	positive regulation of Wnt signaling pathway, planar cell polarity pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98082	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903077	negative regulation of protein localization to plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98082	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621007	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98082	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621007	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071364	cellular response to epidermal growth factor stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621007	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070373	negative regulation of ERK1 and ERK2 cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621007	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060766	negative regulation of androgen receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98082	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060391	positive regulation of SMAD protein signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98082	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050680	negative regulation of epithelial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621007	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048545	response to steroid hormone	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621007	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621007	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048268	clathrin coat assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621007	P		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98082	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98082	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98082	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045807	positive regulation of endocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98082	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045807	positive regulation of endocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621007	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98082	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98082	P		Seeded From UniProt	complete
enables	GO:0038024	cargo receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98082	F		Seeded From UniProt	complete
enables	GO:0035615	clathrin adaptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98082	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035026	leading edge cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98082	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98082	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032349	positive regulation of aldosterone biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621007	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032091	negative regulation of protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98082	P		Seeded From UniProt	complete
part_of	GO:0030665	clathrin-coated vesicle membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621007	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98082	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030335	positive regulation of cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98082	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030308	negative regulation of cell growth	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621007	P		Seeded From UniProt	complete
part_of	GO:0030136	clathrin-coated vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98082	C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	PMID:21146513^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16039)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010977	negative regulation of neuron projection development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621007	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98082	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010718	positive regulation of epithelial to mesenchymal transition	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98082	P		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98082	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007588	excretion	PMID:11927540^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2387168	P		Seeded From UniProt	complete
part_of	GO:0005905	clathrin-coated pit	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98082	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21146513^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16039)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98082	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621007	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98082	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:12413896^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2429678	P		Seeded From UniProt	complete
part_of	GO:0001650	fibrillar center	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98082	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000904	cell morphogenesis involved in differentiation	PMID:12413896^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2429678	P	occurs_in:(EMAPA:16058) results_in_morphogenesis_of:(CL:0000223)	Seeded From UniProt	complete
involved_in	GO:0006898	receptor-mediated endocytosis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0035615	P		Seeded From UniProt	complete
involved_in	GO:0006898	receptor-mediated endocytosis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0035615	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007492	endoderm development	PMID:22411869^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006907	pinocytosis	PMID:16263760^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2387168	P	occurs_in:(EMAPA:16058) occurs_in:(CL:0000223) has_participant:(MGI:MGI:95794)\|occurs_in(EMAPA:16058) occurs_in:(CL:0000223) has_participant:(MGI:MGI:1931256)\|occurs_in(EMAPA:16058) occurs_in:(CL:0000223) has_participant:(MGI:MGI:2140175)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11104669^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11104669^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0254	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
involved_in	GO:0015031	protein transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0653	P		Seeded From UniProt	complete
part_of	GO:0005905	clathrin-coated pit	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0168 UniProtKB-SubCell:SL-0069	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0030665	clathrin-coated vesicle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0071	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Nakayama, M et al. (2013) Spatial regulation of VEGF receptor endocytosis in angiogenesis. Nat. Cell Biol. 15 249-60 PubMed GONUTS page
↑ Teckchandani, A et al. (2009) Quantitative proteomics identifies a Dab2/integrin module regulating cell migration. J. Cell Biol. 186 99-111 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Prunier, C & Howe, PH (2005) Disabled-2 (Dab2) is required for transforming growth factor beta-induced epithelial to mesenchymal transition (EMT). J. Biol. Chem. 280 17540-8 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Maurer, ME & Cooper, JA (2006) The adaptor protein Dab2 sorts LDL receptors into coated pits independently of AP-2 and ARH. J. Cell. Sci. 119 4235-46 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Rosenbauer, F et al. (2002) Disabled-2 is transcriptionally regulated by ICSBP and augments macrophage spreading and adhesion. EMBO J. 21 211-20 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Hocevar, BA et al. (2005) Disabled-2 (Dab2) mediates transforming growth factor beta (TGFbeta)-stimulated fibronectin synthesis through TGFbeta-activated kinase 1 and activation of the JNK pathway. J. Biol. Chem. 280 25920-7 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Mishra, SK et al. (2002) Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor. EMBO J. 21 4915-26 PubMed GONUTS page
↑ Morris, SM & Cooper, JA (2001) Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2. Traffic 2 111-23 PubMed GONUTS page
↑ ^9.0 ^9.1 Penheiter, SG et al. (2010) Type II transforming growth factor-beta receptor recycling is dependent upon the clathrin adaptor protein Dab2. Mol. Biol. Cell 21 4009-19 PubMed GONUTS page
↑ Yun, M et al. (2003) Crystal structures of the Dab homology domains of mouse disabled 1 and 2. J. Biol. Chem. 278 36572-81 PubMed GONUTS page
↑ ^11.0 ^11.1 Artus, J et al. (2011) The primitive endoderm lineage of the mouse blastocyst: sequential transcription factor activation and regulation of differentiation by Sox17. Dev. Biol. 350 393-404 PubMed GONUTS page
↑ Morris, SM et al. (2002) Dual roles for the Dab2 adaptor protein in embryonic development and kidney transport. EMBO J. 21 1555-64 PubMed GONUTS page
↑ ^13.0 ^13.1 Yang, DH et al. (2002) Disabled-2 is essential for endodermal cell positioning and structure formation during mouse embryogenesis. Dev. Biol. 251 27-44 PubMed GONUTS page
↑ Westerberg, LS et al. (2012) Wiskott-Aldrich syndrome protein (WASP) and N-WASP are critical for peripheral B-cell development and function. Blood 119 3966-74 PubMed GONUTS page
↑ Maurer, ME & Cooper, JA (2005) Endocytosis of megalin by visceral endoderm cells requires the Dab2 adaptor protein. J. Cell. Sci. 118 5345-55 PubMed GONUTS page
↑ ^16.0 ^16.1 Cho, SY et al. (2000) p67 isoform of mouse disabled 2 protein acts as a transcriptional activator during the differentiation of F9 cells. Biochem. J. 352 Pt 3 645-50 PubMed GONUTS page

[PMID:23354168-1] 1.0 ^1.1 Nakayama, M et al. (2013) Spatial regulation of VEGF receptor endocytosis in angiogenesis. Nat. Cell Biol. 15 249-60 PubMed GONUTS page

[PMID:19581412-2] Teckchandani, A et al. (2009) Quantitative proteomics identifies a Dab2/integrin module regulating cell migration. J. Cell Biol. 186 99-111 PubMed GONUTS page

[PMID:15734730-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Prunier, C & Howe, PH (2005) Disabled-2 (Dab2) is required for transforming growth factor beta-induced epithelial to mesenchymal transition (EMT). J. Biol. Chem. 280 17540-8 PubMed GONUTS page

[PMID:16984970-4] 4.0 ^4.1 ^4.2 Maurer, ME & Cooper, JA (2006) The adaptor protein Dab2 sorts LDL receptors into coated pits independently of AP-2 and ARH. J. Cell. Sci. 119 4235-46 PubMed GONUTS page

[PMID:11823414-5] 5.0 ^5.1 ^5.2 Rosenbauer, F et al. (2002) Disabled-2 is transcriptionally regulated by ICSBP and augments macrophage spreading and adhesion. EMBO J. 21 211-20 PubMed GONUTS page

[PMID:15894542-6] 6.0 ^6.1 ^6.2 ^6.3 Hocevar, BA et al. (2005) Disabled-2 (Dab2) mediates transforming growth factor beta (TGFbeta)-stimulated fibronectin synthesis through TGFbeta-activated kinase 1 and activation of the JNK pathway. J. Biol. Chem. 280 25920-7 PubMed GONUTS page

[PMID:12234931-7] 7.0 ^7.1 ^7.2 ^7.3 Mishra, SK et al. (2002) Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor. EMBO J. 21 4915-26 PubMed GONUTS page

[PMID:11247302-8] Morris, SM & Cooper, JA (2001) Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2. Traffic 2 111-23 PubMed GONUTS page

[PMID:20881059-9] 9.0 ^9.1 Penheiter, SG et al. (2010) Type II transforming growth factor-beta receptor recycling is dependent upon the clathrin adaptor protein Dab2. Mol. Biol. Cell 21 4009-19 PubMed GONUTS page

[PMID:12826668-10] Yun, M et al. (2003) Crystal structures of the Dab homology domains of mouse disabled 1 and 2. J. Biol. Chem. 278 36572-81 PubMed GONUTS page

[PMID:21146513-11] 11.0 ^11.1 Artus, J et al. (2011) The primitive endoderm lineage of the mouse blastocyst: sequential transcription factor activation and regulation of differentiation by Sox17. Dev. Biol. 350 393-404 PubMed GONUTS page

[PMID:11927540-12] Morris, SM et al. (2002) Dual roles for the Dab2 adaptor protein in embryonic development and kidney transport. EMBO J. 21 1555-64 PubMed GONUTS page

[PMID:12413896-13] 13.0 ^13.1 Yang, DH et al. (2002) Disabled-2 is essential for endodermal cell positioning and structure formation during mouse embryogenesis. Dev. Biol. 251 27-44 PubMed GONUTS page

[PMID:22411869-14] Westerberg, LS et al. (2012) Wiskott-Aldrich syndrome protein (WASP) and N-WASP are critical for peripheral B-cell development and function. Blood 119 3966-74 PubMed GONUTS page

[PMID:16263760-15] Maurer, ME & Cooper, JA (2005) Endocytosis of megalin by visceral endoderm cells requires the Dab2 adaptor protein. J. Cell. Sci. 118 5345-55 PubMed GONUTS page

[PMID:11104669-16] 16.0 ^16.1 Cho, SY et al. (2000) p67 isoform of mouse disabled 2 protein acts as a transcriptional activator during the differentiation of F9 cells. Biochem. J. 352 Pt 3 645-50 PubMed GONUTS page

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MOUSE:DAB2

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