MOUSE:CD36

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Cd36
Protein Name(s)	Platelet glycoprotein 4 Glycoprotein IIIb GPIIIB PAS IV PAS-4 Platelet glycoprotein IV GPIV
External Links
UniProt	Q08857
EMBL	L23108 BC010262
CCDS	CCDS19100.1
PIR	I49590
RefSeq	NP_001153027.1 NP_001153028.1 NP_001153029.1 NP_001153030.1 NP_031669.3 XP_006535683.1 XP_006535684.1 XP_006535685.1 XP_006535686.1 XP_006535687.1 XP_006535688.1
UniGene	Mm.18628 Mm.406799
ProteinModelPortal	Q08857
SMR	Q08857
BioGrid	198587
IntAct	Q08857
MINT	MINT-4090233
ChEMBL	CHEMBL2176845
TCDB	9.B.39.1.1
MaxQB	Q08857
PaxDb	Q08857
PRIDE	Q08857
Ensembl	ENSMUST00000082367 ENSMUST00000165232 ENSMUST00000169095 ENSMUST00000170051
GeneID	12491
KEGG	mmu:12491
UCSC	uc008wnn.2
CTD	948
MGI	MGI:107899
eggNOG	NOG257244
HOGENOM	HOG000252951
HOVERGEN	HBG002754
InParanoid	Q08857
KO	K06259
OMA	KRNYIVP
OrthoDB	EOG79SDWX
PhylomeDB	Q08857
TreeFam	TF317925
Reactome	REACT_196592 REACT_198602 REACT_199093 REACT_230045 REACT_252217 REACT_254406
NextBio	281412
PRO	PR:Q08857
Proteomes	UP000000589
Bgee	Q08857
CleanEx	MM_CD36
ExpressionAtlas	Q08857
Genevestigator	Q08857
GO	GO:0009986 GO:0009897 GO:0005615 GO:0005794 GO:0016021 GO:0045121 GO:0005886 GO:0008035 GO:0008289 GO:0070892 GO:0030169 GO:0005041 GO:0043277 GO:0007155 GO:0007166 GO:0071221 GO:0071447 GO:0071222 GO:0071223 GO:0019934 GO:0030301 GO:0050830 GO:0019915 GO:0042953 GO:0044539 GO:0034383 GO:0055096 GO:0010629 GO:0044130 GO:0042992 GO:0000122 GO:0007263 GO:0002221 GO:0006910 GO:0034381 GO:0015911 GO:0030194 GO:2000334 GO:0001954 GO:0010886 GO:0043123 GO:0032735 GO:0032755 GO:0060907 GO:0010744 GO:0043410 GO:0050731 GO:0060100 GO:2000379 GO:0032760 GO:2000121 GO:0043619 GO:0035634
InterPro	IPR002159 IPR005428
PANTHER	PTHR11923
Pfam	PF01130
PRINTS	PR01610 PR01609

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0010670	positive regulation of oxygen and reactive oxygen species metabolic process	PMID:20978343^[1]	ECO:0000315			P		The level of ROS in the vessel walls of cd36–/– mice was similar to that seen in WT mice treated with edaravone (3-methyl-1 phenyl-2-pyrazoline-5-1), a potent free radical scavenger (Figure 1C).	complete
	GO:0032582	negative regulation of gene-specific transcription	PMID:20978343^[1]	ECO:0000315			P		As shown in Figure 2A, Prdx2 levels were 3- to 4-fold higher in the cd36–/– mice than in the WT.	complete
	GO:0033159	negative regulation of protein import into nucleus, translocation	PMID:20978343^[1]	ECO:0000315			P		Importantly, cellular fractionation studies showed that Nrf2 accumulated in the nuclei of cd36–/– cells to a far greater extent than in WT cells (Figure 5C).	complete
	GO:0006911	phagocytosis, engulfment	PMID:24058538^[2]	ECO:0000314			P		Page 13 describes the roll of CD36 in engulfment of pathogens in the cells of mice.	complete CACAO 8672
involved_in	GO:0098900	regulation of action potential	PMID:29111364^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:1001571)	Seeded From UniProt	complete
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	PMID:25596128^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903428	positive regulation of reactive oxygen species biosynthetic process	PMID:20037584^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000235) positively_regulates:(GO:0002269) part_of:(GO:0071404)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:20037584^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000235) positively_regulates:(GO:0002269) part_of:(GO:0071404) regulates_expression_of:(ENSEMBL:ENSMUSG00000029380)\|regulates_o_occurs_in(CL:0000235) positively_regulates:(GO:0002269) part_of:(GO:0071404) regulates_expression_of:(ENSEMBL:ENSMUSG00000058427)\|regulates_o_occurs_in(CL:0000235) positively_regulates:(GO:0002269) part_of:(GO:0071404) regulates_expression_of:(ENSEMBL:ENSMUSG00000035042)	Seeded From UniProt	complete
involved_in	GO:0045429	positive regulation of nitric oxide biosynthetic process	PMID:20037584^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000092	P	part_of:(GO:1904646) regulates_o_occurs_in:(CL:0000129) positively_regulates:(GO:0070997)	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:23395392^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:21610069^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070542	response to fatty acid	PMID:21610069^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033993	response to lipid	PMID:21610069^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097009	energy homeostasis	PMID:23557700^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070542	response to fatty acid	PMID:23557700^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050702	interleukin-1 beta secretion	PMID:23812099^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071726	cellular response to diacyl bacterial lipopeptide	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P16671	P		Seeded From UniProt	complete
involved_in	GO:1990000	amyloid fibril formation	PMID:23812099^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly	PMID:23812099^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050909	sensory perception of taste	PMID:18162488^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070543	response to linoleic acid	PMID:18162488^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071404	cellular response to low-density lipoprotein particle stimulus	PMID:23395392^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031623	receptor internalization	PMID:23395392^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050892	intestinal absorption	PMID:17507371^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030299	intestinal cholesterol absorption	PMID:17507371^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034197	triglyceride transport	PMID:17507371^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0044539	long-chain fatty acid import into cell	PMID:17507371^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070508	cholesterol import	PMID:17507371^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031526	brush border membrane	PMID:21610069^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	PMID:18162488^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0045177	apical part of cell	PMID:16276419^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000379	positive regulation of reactive oxygen species metabolic process	PMID:20978343^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000334	positive regulation of blood microparticle formation	PMID:20978343^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000121	regulation of removal of superoxide radicals	PMID:20978343^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071447	cellular response to hydroperoxide	PMID:20978343^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0055096	low-density lipoprotein particle mediated signaling	PMID:20978343^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:20978343^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress	PMID:20978343^[1]	ECO:0000305	curator inference used in manual assertion	GO:0000122	P		Seeded From UniProt	complete
involved_in	GO:0042308	negative regulation of protein import into nucleus	PMID:20978343^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_transport_of:(UniProtKB:Q60795) part_of:(GO:0000122)	Seeded From UniProt	complete
involved_in	GO:0042953	lipoprotein transport	PMID:10772654^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034383	low-density lipoprotein particle clearance	PMID:10772654^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034381	plasma lipoprotein particle clearance	PMID:12376530^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030301	cholesterol transport	PMID:12376530^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030194	positive regulation of blood coagulation	PMID:20978343^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0030169	low-density lipoprotein particle binding	PMID:12376530^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0030169	low-density lipoprotein particle binding	PMID:10772654^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0019915	lipid storage	PMID:10772654^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010886	positive regulation of cholesterol storage	PMID:12376530^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010744	positive regulation of macrophage derived foam cell differentiation	PMID:12376530^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010744	positive regulation of macrophage derived foam cell differentiation	PMID:10772654^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:20978343^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000233)\|occurs_in:(CL:0000235)\|occurs_in:(UBERON:0000948)	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:10772654^[13]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P16671	C		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	PMID:10772654^[13]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P16671	F		Seeded From UniProt	complete
involved_in	GO:0007166	cell surface receptor signaling pathway	PMID:20978343^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005041	low-density lipoprotein particle receptor activity	PMID:10772654^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:20978343^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035634	response to stilbenoid	PMID:17086191^[15]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904646	cellular response to amyloid-beta	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16671	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0150094	amyloid-beta clearance by cellular catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16671	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0150094	amyloid-beta clearance by cellular catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2301	P		Seeded From UniProt	complete
enables	GO:0150025	oxidised low-density lipoprotein particle receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16671	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0150024	oxidised low-density lipoprotein particle clearance	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16671	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0140052	cellular response to oxidised low-density lipoprotein particle stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16671	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097009	energy homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2301	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090208	positive regulation of triglyceride metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2301	P		Seeded From UniProt	complete
enables	GO:0071813	lipoprotein particle binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16671	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071726	cellular response to diacyl bacterial lipopeptide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16671	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071223	cellular response to lipoteichoic acid	PMID:16061696^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2447190	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071223	cellular response to lipoteichoic acid	PMID:15690042^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1931790 MGI:MGI:3573941	P	occurs_in:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071223	cellular response to lipoteichoic acid	PMID:15690042^[17]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071222	cellular response to lipopolysaccharide	PMID:16061696^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2447190	P	occurs_in:(CL:0000581)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071221	cellular response to bacterial lipopeptide	PMID:15690042^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1931790 MGI:MGI:3573941	P	occurs_in:(CL:0000235)	Seeded From UniProt	complete
enables	GO:0070892	lipoteichoic acid receptor activity	PMID:16061696^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2447190	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070542	response to fatty acid	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2301	P		Seeded From UniProt	complete
enables	GO:0070538	oleic acid binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2301	F		Seeded From UniProt	complete
enables	GO:0070053	thrombospondin receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2301	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060907	positive regulation of macrophage cytokine production	PMID:16061696^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2447190	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060100	positive regulation of phagocytosis, engulfment	PMID:16061696^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2447190	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060100	positive regulation of phagocytosis, engulfment	PMID:16061696^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16671	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050830	defense response to Gram-positive bacterium	PMID:16061696^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2447190	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050830	defense response to Gram-positive bacterium	PMID:15690042^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3573941	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050766	positive regulation of phagocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2301	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050715	positive regulation of cytokine secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2301	P		Seeded From UniProt	complete
enables	GO:0050431	transforming growth factor beta binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2301	F		Seeded From UniProt	complete
part_of	GO:0045177	apical part of cell	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2301	C		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:23444136^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:15496455^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16671	C		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16671	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044539	long-chain fatty acid import into cell	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16671	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044130	negative regulation of growth of symbiont in host	PMID:16061696^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2447190	P	regulates_o_occurs_in:(EMAPA:16332)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044130	negative regulation of growth of symbiont in host	PMID:15690042^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3573941	P	regulates_o_occurs_in:(EMAPA:25765)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043497	regulation of protein heterodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16671	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043410	positive regulation of MAPK cascade	PMID:15690042^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3573941	P	regulates_o_occurs_in:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043277	apoptotic cell clearance	PMID:15647754^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16671	C		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2301	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:16061696^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2447190	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042953	lipoprotein transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16671	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042755	eating behavior	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2301	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042593	glucose homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2301	P		Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2301	C		Seeded From UniProt	complete
enables	GO:0035325	Toll-like receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16671	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034383	low-density lipoprotein particle clearance	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16671	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034121	regulation of toll-like receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16671	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033993	response to lipid	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2301	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2301	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032760	positive regulation of tumor necrosis factor production	PMID:16061696^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2447190	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032760	positive regulation of tumor necrosis factor production	PMID:15690042^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3573941	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032755	positive regulation of interleukin-6 production	PMID:16061696^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2447190	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032735	positive regulation of interleukin-12 production	PMID:16061696^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2447190	P		Seeded From UniProt	complete
part_of	GO:0031526	brush border membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2301	C		Seeded From UniProt	complete
enables	GO:0030169	low-density lipoprotein particle binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16671	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019934	cGMP-mediated signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16671	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019915	lipid storage	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16671	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019395	fatty acid oxidation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2301	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016525	negative regulation of angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2301	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0015909	long-chain fatty acid transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2301	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0015908	fatty acid transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2301	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010942	positive regulation of cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16671	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010744	positive regulation of macrophage derived foam cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16671	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16671	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2301	C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:16061696^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:15690042^[17]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009617	response to bacterium	PMID:23012479^[21]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009612	response to mechanical stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2301	P		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16671	F		Seeded From UniProt	complete
enables	GO:0008035	high-density lipoprotein particle binding	PMID:14729860^[22]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007263	nitric oxide mediated signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16671	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006910	phagocytosis, recognition	PMID:16061696^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006898	receptor-mediated endocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16671	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006898	receptor-mediated endocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2301	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006641	triglyceride metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2301	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006631	fatty acid metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2301	P		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2301	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:20582536^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:15496455^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16671	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2301	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:15496455^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16671	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2301	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2301	C		Seeded From UniProt	complete
part_of	GO:0005623	cell	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16671	C		Seeded From UniProt	complete
enables	GO:0005044	scavenger receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16671	F		Seeded From UniProt	complete
enables	GO:0005044	scavenger receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2301	F		Seeded From UniProt	complete
enables	GO:0005041	low-density lipoprotein particle receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16671	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003085	negative regulation of systemic arterial blood pressure	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2301	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001954	positive regulation of cell-matrix adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16671	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001676	long-chain fatty acid metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2301	P		Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16671	F		Seeded From UniProt	complete
involved_in	GO:0002221	pattern recognition receptor signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0070892	P		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A4D1B1 ensembl:ENSP00000415743	C		Seeded From UniProt	complete
involved_in	GO:1904646	cellular response to amyloid-beta	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16671 ensembl:ENSP00000415743	P		Seeded From UniProt	complete
involved_in	GO:0150094	amyloid-beta clearance by cellular catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16671 ensembl:ENSP00000415743	P		Seeded From UniProt	complete
enables	GO:0150025	oxidised low-density lipoprotein particle receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16671 ensembl:ENSP00000415743	F		Seeded From UniProt	complete
involved_in	GO:0150024	oxidised low-density lipoprotein particle clearance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16671 ensembl:ENSP00000415743	P		Seeded From UniProt	complete
involved_in	GO:0140052	cellular response to oxidised low-density lipoprotein particle stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16671 ensembl:ENSP00000415743	P		Seeded From UniProt	complete
enables	GO:0071813	lipoprotein particle binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16671 ensembl:ENSP00000415743	F		Seeded From UniProt	complete
involved_in	GO:0071726	cellular response to diacyl bacterial lipopeptide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16671 ensembl:ENSP00000415743	P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16671 ensembl:ENSP00000415743	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16671 ensembl:ENSP00000415743	C		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16671 ensembl:ENSP00000415743	F		Seeded From UniProt	complete
involved_in	GO:0044539	long-chain fatty acid import into cell	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16671 ensembl:ENSP00000415743	P		Seeded From UniProt	complete
involved_in	GO:0043497	regulation of protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16671 ensembl:ENSP00000415743	P		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16671 ensembl:ENSP00000415743	C		Seeded From UniProt	complete
involved_in	GO:0042953	lipoprotein transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16671 ensembl:ENSP00000415743	P		Seeded From UniProt	complete
enables	GO:0035325	Toll-like receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16671 ensembl:ENSP00000415743	F		Seeded From UniProt	complete
involved_in	GO:0034383	low-density lipoprotein particle clearance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16671 ensembl:ENSP00000415743	P		Seeded From UniProt	complete
involved_in	GO:0034121	regulation of toll-like receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16671 ensembl:ENSP00000415743	P		Seeded From UniProt	complete
enables	GO:0030169	low-density lipoprotein particle binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16671 ensembl:ENSP00000415743	F		Seeded From UniProt	complete
involved_in	GO:0019934	cGMP-mediated signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16671 ensembl:ENSP00000415743	P		Seeded From UniProt	complete
involved_in	GO:0019915	lipid storage	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16671 ensembl:ENSP00000415743	P		Seeded From UniProt	complete
involved_in	GO:0010942	positive regulation of cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16671 ensembl:ENSP00000415743	P		Seeded From UniProt	complete
involved_in	GO:0010744	positive regulation of macrophage derived foam cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16671 ensembl:ENSP00000415743	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16671 ensembl:ENSP00000415743	C		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16671 ensembl:ENSP00000415743	F		Seeded From UniProt	complete
involved_in	GO:0007263	nitric oxide mediated signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16671 ensembl:ENSP00000415743	P		Seeded From UniProt	complete
involved_in	GO:0006898	receptor-mediated endocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16671 ensembl:ENSP00000415743	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16671 ensembl:ENSP00000415743	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16671 ensembl:ENSP00000415743	C		Seeded From UniProt	complete
part_of	GO:0005623	cell	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16671 ensembl:ENSP00000415743	C		Seeded From UniProt	complete
enables	GO:0005044	scavenger receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16671 ensembl:ENSP00000415743	F		Seeded From UniProt	complete
enables	GO:0005041	low-density lipoprotein particle receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16671 ensembl:ENSP00000415743	F		Seeded From UniProt	complete
involved_in	GO:0001954	positive regulation of cell-matrix adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16671 ensembl:ENSP00000415743	P		Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16671 ensembl:ENSP00000415743	F		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033076	P		Seeded From UniProt	complete
involved_in	GO:0007166	cell surface receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033076	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002159	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-MMU-2187263	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333 UniProtKB-SubCell:SL-0132	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0015	C		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0370	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 Li, W et al. (2010) CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs. J. Clin. Invest. 120 3996-4006 PubMed GONUTS page
↑ Yimin, et al. (2013) Contribution of toll-like receptor 2 to the innate response against Staphylococcus aureus infection in mice. PLoS ONE 8 e74287 PubMed GONUTS page
↑ Zheng, F et al. (2017) CD36 Deficiency Suppresses Epileptic Seizures. Neuroscience 367 110-120 PubMed GONUTS page
↑ Putri, M et al. (2015) CD36 is indispensable for thermogenesis under conditions of fasting and cold stress. Biochem. Biophys. Res. Commun. 457 520-5 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Stewart, CR et al. (2010) CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer. Nat. Immunol. 11 155-61 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Heit, B et al. (2013) Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalization. Dev. Cell 24 372-83 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Tran, TT et al. (2011) Luminal lipid regulates CD36 levels and downstream signaling to stimulate chylomicron synthesis. J. Biol. Chem. 286 25201-10 PubMed GONUTS page
↑ ^8.0 ^8.1 Le Foll, C et al. (2013) FAT/CD36: a major regulator of neuronal fatty acid sensing and energy homeostasis in rats and mice. Diabetes 62 2709-16 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Sheedy, FJ et al. (2013) CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation. Nat. Immunol. 14 812-20 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Gaillard, D et al. (2008) The gustatory pathway is involved in CD36-mediated orosensory perception of long-chain fatty acids in the mouse. FASEB J. 22 1458-68 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 Nassir, F et al. (2007) CD36 is important for fatty acid and cholesterol uptake by the proximal but not distal intestine. J. Biol. Chem. 282 19493-501 PubMed GONUTS page
↑ Laugerette, F et al. (2005) CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions. J. Clin. Invest. 115 3177-84 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 ^13.7 Podrez, EA et al. (2000) Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species. J. Clin. Invest. 105 1095-108 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 Kunjathoor, VV et al. (2002) Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages. J. Biol. Chem. 277 49982-8 PubMed GONUTS page
↑ Baur, JA et al. (2006) Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444 337-42 PubMed GONUTS page
↑ ^16.00 ^16.01 ^16.02 ^16.03 ^16.04 ^16.05 ^16.06 ^16.07 ^16.08 ^16.09 ^16.10 ^16.11 ^16.12 ^16.13 Stuart, LM et al. (2005) Response to Staphylococcus aureus requires CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain. J. Cell Biol. 170 477-85 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 ^17.6 ^17.7 Hoebe, K et al. (2005) CD36 is a sensor of diacylglycerides. Nature 433 523-7 PubMed GONUTS page
↑ Meiler, S et al. (2013) Selenoprotein K is required for palmitoylation of CD36 in macrophages: implications in foam cell formation and atherogenesis. J. Leukoc. Biol. 93 771-80 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 Pohl, J et al. (2005) FAT/CD36-mediated long-chain fatty acid uptake in adipocytes requires plasma membrane rafts. Mol. Biol. Cell 16 24-31 PubMed GONUTS page
↑ Monks, J et al. (2005) Epithelial cells as phagocytes: apoptotic epithelial cells are engulfed by mammary alveolar epithelial cells and repress inflammatory mediator release. Cell Death Differ. 12 107-14 PubMed GONUTS page
↑ Archambaud, C et al. (2012) Impact of lactobacilli on orally acquired listeriosis. Proc. Natl. Acad. Sci. U.S.A. 109 16684-9 PubMed GONUTS page
↑ de Beer, MC et al. (2004) ApoA-II modulates the association of HDL with class B scavenger receptors SR-BI and CD36. J. Lipid Res. 45 706-15 PubMed GONUTS page
↑ Schwenk, RW et al. (2010) Requirement for distinct vesicle-associated membrane proteins in insulin- and AMP-activated protein kinase (AMPK)-induced translocation of GLUT4 and CD36 in cultured cardiomyocytes. Diabetologia 53 2209-19 PubMed GONUTS page

[PMID:20978343-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 Li, W et al. (2010) CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs. J. Clin. Invest. 120 3996-4006 PubMed GONUTS page

[PMID:24058538-2] Yimin, et al. (2013) Contribution of toll-like receptor 2 to the innate response against Staphylococcus aureus infection in mice. PLoS ONE 8 e74287 PubMed GONUTS page

[PMID:29111364-3] Zheng, F et al. (2017) CD36 Deficiency Suppresses Epileptic Seizures. Neuroscience 367 110-120 PubMed GONUTS page

[PMID:25596128-4] Putri, M et al. (2015) CD36 is indispensable for thermogenesis under conditions of fasting and cold stress. Biochem. Biophys. Res. Commun. 457 520-5 PubMed GONUTS page

[PMID:20037584-5] 5.0 ^5.1 ^5.2 Stewart, CR et al. (2010) CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer. Nat. Immunol. 11 155-61 PubMed GONUTS page

[PMID:23395392-6] 6.0 ^6.1 ^6.2 Heit, B et al. (2013) Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalization. Dev. Cell 24 372-83 PubMed GONUTS page

[PMID:21610069-7] 7.0 ^7.1 ^7.2 ^7.3 Tran, TT et al. (2011) Luminal lipid regulates CD36 levels and downstream signaling to stimulate chylomicron synthesis. J. Biol. Chem. 286 25201-10 PubMed GONUTS page

[PMID:23557700-8] 8.0 ^8.1 Le Foll, C et al. (2013) FAT/CD36: a major regulator of neuronal fatty acid sensing and energy homeostasis in rats and mice. Diabetes 62 2709-16 PubMed GONUTS page

[PMID:23812099-9] 9.0 ^9.1 ^9.2 Sheedy, FJ et al. (2013) CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation. Nat. Immunol. 14 812-20 PubMed GONUTS page

[PMID:18162488-10] 10.0 ^10.1 ^10.2 Gaillard, D et al. (2008) The gustatory pathway is involved in CD36-mediated orosensory perception of long-chain fatty acids in the mouse. FASEB J. 22 1458-68 PubMed GONUTS page

[PMID:17507371-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 Nassir, F et al. (2007) CD36 is important for fatty acid and cholesterol uptake by the proximal but not distal intestine. J. Biol. Chem. 282 19493-501 PubMed GONUTS page

[PMID:16276419-12] Laugerette, F et al. (2005) CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions. J. Clin. Invest. 115 3177-84 PubMed GONUTS page

[PMID:10772654-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 ^13.7 Podrez, EA et al. (2000) Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species. J. Clin. Invest. 105 1095-108 PubMed GONUTS page

[PMID:12376530-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 Kunjathoor, VV et al. (2002) Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages. J. Biol. Chem. 277 49982-8 PubMed GONUTS page

[PMID:17086191-15] Baur, JA et al. (2006) Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444 337-42 PubMed GONUTS page

[PMID:16061696-16] 16.00 ^16.01 ^16.02 ^16.03 ^16.04 ^16.05 ^16.06 ^16.07 ^16.08 ^16.09 ^16.10 ^16.11 ^16.12 ^16.13 Stuart, LM et al. (2005) Response to Staphylococcus aureus requires CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain. J. Cell Biol. 170 477-85 PubMed GONUTS page

[PMID:15690042-17] 17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 ^17.6 ^17.7 Hoebe, K et al. (2005) CD36 is a sensor of diacylglycerides. Nature 433 523-7 PubMed GONUTS page

[PMID:23444136-18] Meiler, S et al. (2013) Selenoprotein K is required for palmitoylation of CD36 in macrophages: implications in foam cell formation and atherogenesis. J. Leukoc. Biol. 93 771-80 PubMed GONUTS page

[PMID:15496455-19] 19.0 ^19.1 ^19.2 Pohl, J et al. (2005) FAT/CD36-mediated long-chain fatty acid uptake in adipocytes requires plasma membrane rafts. Mol. Biol. Cell 16 24-31 PubMed GONUTS page

[PMID:15647754-20] Monks, J et al. (2005) Epithelial cells as phagocytes: apoptotic epithelial cells are engulfed by mammary alveolar epithelial cells and repress inflammatory mediator release. Cell Death Differ. 12 107-14 PubMed GONUTS page

[PMID:23012479-21] Archambaud, C et al. (2012) Impact of lactobacilli on orally acquired listeriosis. Proc. Natl. Acad. Sci. U.S.A. 109 16684-9 PubMed GONUTS page

[PMID:14729860-22] Beer, MC et al. (2004) ApoA-II modulates the association of HDL with class B scavenger receptors SR-BI and CD36. J. Lipid Res. 45 706-15 PubMed GONUTS page

[PMID:20582536-23] Schwenk, RW et al. (2010) Requirement for distinct vesicle-associated membrane proteins in insulin- and AMP-activated protein kinase (AMPK)-induced translocation of GLUT4 and CD36 in cultured cardiomyocytes. Diabetologia 53 2209-19 PubMed GONUTS page

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MOUSE:CD36

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