GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:14729860
| Citation |
de Beer, MC, Castellani, LW, Cai, L, Stromberg, AJ, de Beer, FC and van der Westhuyzen, DR (2004) ApoA-II modulates the association of HDL with class B scavenger receptors SR-BI and CD36. J. Lipid Res. 45:706-15 |
|---|---|
| Abstract |
The class B scavenger receptors SR-BI and CD36 exhibit a broad ligand binding specificity. SR-BI is well characterized as a HDL receptor that mediates selective cholesteryl ester uptake from HDL. CD36, a receptor for oxidized LDL, also binds HDL and mediates selective cholesteryl ester uptake, although much less efficiently than SR-BI. Apolipoprotein A-II (apoA-II), the second most abundant HDL protein, is considered to be proatherogenic, but the underlying mechanisms are unclear. We previously showed that apoA-II modulates SR-BI-dependent binding and selective uptake of cholesteryl ester from reconstituted HDL. To investigate the effect of apoA-II in naturally occurring HDL on these processes, we compared HDL without apoA-II (from apoA-II null mice) with HDLs containing differing amounts of apoA-II (from C57BL/6 mice and transgenic mice expressing a mouse apoA-II transgene). The level of apoA-II in HDL was inversely correlated with HDL binding and selective cholesteryl ester uptake by both scavenger receptors, particularly CD36. Interestingly, for HDL lacking apoA-II, the efficiency with which CD36 mediated selective uptake reached a level similar to that of SR-BI. These results demonstrate that apoA-II exerts a marked effect on HDL binding and selective lipid uptake by the class B scavenger receptors and establishes a potentially important relationship between apoA-II and CD36. |
| Links |
PubMed Online version:10.1194/jlr.M300417-JLR200 |
| Keywords |
Animals; Antigens, CD36/metabolism; Apolipoprotein A-II/genetics; Apolipoprotein A-II/physiology; Biological Transport; Cholesterol Esters/metabolism; Lipoproteins, HDL/metabolism; Lipoproteins, LDL/metabolism; Mice; Mice, Knockout; Mice, Transgenic; Protein Binding; Receptors, Immunologic/metabolism; Receptors, Scavenger; Scavenger Receptors, Class B |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
