MOUSE:CD1D1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Cd1d1 (synonyms: Cd1.1)
Protein Name(s)	Antigen-presenting glycoprotein CD1d1
External Links
UniProt	P11609
EMBL	M63695 AK002582 X13170
CCDS	CCDS17449.1
PIR	I49581 S01297
RefSeq	NP_031665.2
UniGene	Mm.1894
PDB	1CD1 1Z5L 1ZHN 2AKR 2FIK 2GAZ 2Q7Y 3ARB 3ARD 3ARE 3ARF 3ARG 3AU1 3G08 3GML 3GMM 3GMN 3GMO 3GMP 3GMQ 3GMR 3HE6 3HE7 3ILP 3ILQ 3MA7 3O8X 3O9W 3QI9 3QUX 3QUY 3QUZ 3RTQ 3RUG 3RZC 3SCM 3SDA 3SDC 3SDD 3T1F 3TA3 3TN0 3TO4 3TVM 3UBX 4APQ 4EI5 4ELM 4IRJ 4IRS 4MX7
PDBsum	1CD1 1Z5L 1ZHN 2AKR 2FIK 2GAZ 2Q7Y 3ARB 3ARD 3ARE 3ARF 3ARG 3AU1 3G08 3GML 3GMM 3GMN 3GMO 3GMP 3GMQ 3GMR 3HE6 3HE7 3ILP 3ILQ 3MA7 3O8X 3O9W 3QI9 3QUX 3QUY 3QUZ 3RTQ 3RUG 3RZC 3SCM 3SDA 3SDC 3SDD 3T1F 3TA3 3TN0 3TO4 3TVM 3UBX 4APQ 4EI5 4ELM 4IRJ 4IRS 4MX7
ProteinModelPortal	P11609
SMR	P11609
DIP	DIP-6127N
IntAct	P11609
MINT	MINT-1864400
PhosphoSite	P11609
PaxDb	P11609
PRIDE	P11609
Ensembl	ENSMUST00000029717
GeneID	12479
KEGG	mmu:12479
UCSC	uc012cre.1
CTD	12479
MGI	MGI:107674
eggNOG	NOG26626
GeneTree	ENSGT00480000042665
HOGENOM	HOG000111666
HOVERGEN	HBG004453
InParanoid	P11609
KO	K06448
OrthoDB	EOG7DZ8K9
PhylomeDB	P11609
TreeFam	TF336723
EvolutionaryTrace	P11609
NextBio	281370
PRO	PR:P11609
Proteomes	UP000000589
Bgee	P11609
CleanEx	MM_CD1D1
ExpressionAtlas	P11609
Genevestigator	P11609
GO	GO:0005769 GO:0010008 GO:0009897 GO:0016021 GO:0005770 GO:0005765 GO:0005764 GO:0030883 GO:0042608 GO:0019882 GO:0048007 GO:0045087 GO:0045078 GO:0045086 GO:0045404 GO:0043032 GO:0051135 GO:0051138 GO:0001916 GO:0045059 GO:0050776
Gene3D	2.60.40.10 3.30.500.10
InterPro	IPR007110 IPR013783 IPR003597 IPR011161 IPR011162
Pfam	PF07654
SMART	SM00407
SUPFAM	SSF54452
PROSITE	PS50835

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0033084	regulation of immature T cell proliferation in thymus	PMID:11550008^[1]	ECO:0000315			P		Fig 1c: DPdull tetramers are derived from CD1d-mediated selection; they were no longer present in 9-day old mice thymi	complete CACAO 2867
	GO:0001865	NK T cell differentiation	PMID:9133426^[2]	ECO:0000315			P		Fig 3: the number of NT cells in thymus reduced 5-6x in mutant strain	complete CACAO 2871
involved_in	GO:0001865	NK T cell differentiation	PMID:9133426^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033084	regulation of immature T cell proliferation in thymus	PMID:11550008^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0071723	lipopeptide binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000422284 UniProtKB:P29017	F		Seeded From UniProt	complete
involved_in	GO:0048007	antigen processing and presentation, exogenous lipid antigen via MHC class Ib	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107674 PANTHER:PTN000422284	P		Seeded From UniProt	complete
involved_in	GO:0048006	antigen processing and presentation, endogenous lipid antigen via MHC class Ib	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000422284 UniProtKB:P15813	P		Seeded From UniProt	complete
enables	GO:0030884	exogenous lipid antigen binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000422284 UniProtKB:P15813 UniProtKB:P29017	F		Seeded From UniProt	complete
enables	GO:0030883	endogenous lipid antigen binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107674 PANTHER:PTN000422284 UniProtKB:P29017	F		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107674 MGI:MGI:109431 MGI:MGI:109432 MGI:MGI:1861032 MGI:MGI:1925027 MGI:MGI:2179988 MGI:MGI:2179989 MGI:MGI:95896 MGI:MGI:95904 MGI:MGI:95915 MGI:MGI:95938 PANTHER:PTN002314307 UniProtKB:Q30201	C		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002314307 UniProtKB:P01891 UniProtKB:Q31612	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95896 PANTHER:PTN002314307 UniProtKB:Q95460 UniProtKB:Q9BZM6	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95929 PANTHER:PTN002314307 UniProtKB:P25311 UniProtKB:Q29983 UniProtKB:Q30201 UniProtKB:Q9BZM5	C		Seeded From UniProt	complete
involved_in	GO:0001916	positive regulation of T cell mediated cytotoxicity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107674 PANTHER:PTN000422284	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051138	positive regulation of NK T cell differentiation	PMID:9133426^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180711	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051138	positive regulation of NK T cell differentiation	PMID:10201995^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180713	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051135	positive regulation of NK T cell activation	PMID:7538697^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051135	positive regulation of NK T cell activation	PMID:11754812^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051135	positive regulation of NK T cell activation	PMID:10201995^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0050839	cell adhesion molecule binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15813	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050776	regulation of immune response	PMID:9133426^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180711	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048007	antigen processing and presentation, exogenous lipid antigen via MHC class Ib	PMID:14557411^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048006	antigen processing and presentation, endogenous lipid antigen via MHC class Ib	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15813	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045404	positive regulation of interleukin-4 biosynthetic process	PMID:9133426^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180711	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045404	positive regulation of interleukin-4 biosynthetic process	PMID:10201995^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180713	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045404	positive regulation of interleukin-4 biosynthetic process	PMID:7538697^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045404	positive regulation of interleukin-4 biosynthetic process	PMID:11754812^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045086	positive regulation of interleukin-2 biosynthetic process	PMID:7538697^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045086	positive regulation of interleukin-2 biosynthetic process	PMID:14557411^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045086	positive regulation of interleukin-2 biosynthetic process	PMID:11754812^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045086	positive regulation of interleukin-2 biosynthetic process	PMID:10201995^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045078	positive regulation of interferon-gamma biosynthetic process	PMID:9133426^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180711	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045059	positive thymic T cell selection	PMID:9133426^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180711	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043032	positive regulation of macrophage activation	PMID:21460847^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042608	T cell receptor binding	PMID:22065767^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042393	histone binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15813	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042102	positive regulation of T cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15813	P		Seeded From UniProt	complete
enables	GO:0030884	exogenous lipid antigen binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15813	F		Seeded From UniProt	complete
enables	GO:0030883	endogenous lipid antigen binding	PMID:14722359^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0030882	lipid antigen binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15813	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019882	antigen processing and presentation	PMID:11754812^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15813	C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:9133426^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:17082577^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:14557411^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:11754812^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:10201995^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15813	C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	PMID:11754812^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:11754812^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:14557411^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000236)	Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:11754812^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)\|part_of:(CL:0000236)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15813	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001916	positive regulation of T cell mediated cytotoxicity	PMID:10201995^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0458	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C		Seeded From UniProt	complete
part_of	GO:0010008	endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0100	C		Seeded From UniProt	complete
part_of	GO:0005765	lysosomal membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0157	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Gapin, L et al. (2001) NKT cells derive from double-positive thymocytes that are positively selected by CD1d. Nat. Immunol. 2 971-8 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Mendiratta, SK et al. (1997) CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4. Immunity 6 469-77 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 ^3.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Chen, YH et al. (1999) Expression of CD1d2 on thymocytes is not sufficient for the development of NK T cells in CD1d1-deficient mice. J. Immunol. 162 4560-6 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Bendelac, A et al. (1995) CD1 recognition by mouse NK1+ T lymphocytes. Science 268 863-5 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Jayawardena-Wolf, J et al. (2001) CD1d endosomal trafficking is independently regulated by an intrinsic CD1d-encoded tyrosine motif and by the invariant chain. Immunity 15 897-908 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Elewaut, D et al. (2003) The adaptor protein AP-3 is required for CD1d-mediated antigen presentation of glycosphingolipids and development of Valpha14i NKT cells. J. Exp. Med. 198 1133-46 PubMed GONUTS page
↑ Motomura, Y et al. (2011) The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells. Nat. Immunol. 12 450-9 PubMed GONUTS page
↑ Patel, O et al. (2011) Vβ2 natural killer T cell antigen receptor-mediated recognition of CD1d-glycolipid antigen. Proc. Natl. Acad. Sci. U.S.A. 108 19007-12 PubMed GONUTS page
↑ Park, JJ et al. (2004) Lipid-protein interactions: biosynthetic assembly of CD1 with lipids in the endoplasmic reticulum is evolutionarily conserved. Proc. Natl. Acad. Sci. U.S.A. 101 1022-6 PubMed GONUTS page
↑ Kim, PJ et al. (2006) GATA-3 regulates the development and function of invariant NKT cells. J. Immunol. 177 6650-9 PubMed GONUTS page

[PMID:11550008-1] 1.0 ^1.1 Gapin, L et al. (2001) NKT cells derive from double-positive thymocytes that are positively selected by CD1d. Nat. Immunol. 2 971-8 PubMed GONUTS page

[PMID:9133426-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Mendiratta, SK et al. (1997) CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4. Immunity 6 469-77 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 ^3.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:10201995-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Chen, YH et al. (1999) Expression of CD1d2 on thymocytes is not sufficient for the development of NK T cells in CD1d1-deficient mice. J. Immunol. 162 4560-6 PubMed GONUTS page

[PMID:7538697-5] 5.0 ^5.1 ^5.2 Bendelac, A et al. (1995) CD1 recognition by mouse NK1+ T lymphocytes. Science 268 863-5 PubMed GONUTS page

[PMID:11754812-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Jayawardena-Wolf, J et al. (2001) CD1d endosomal trafficking is independently regulated by an intrinsic CD1d-encoded tyrosine motif and by the invariant chain. Immunity 15 897-908 PubMed GONUTS page

[PMID:14557411-7] 7.0 ^7.1 ^7.2 ^7.3 Elewaut, D et al. (2003) The adaptor protein AP-3 is required for CD1d-mediated antigen presentation of glycosphingolipids and development of Valpha14i NKT cells. J. Exp. Med. 198 1133-46 PubMed GONUTS page

[PMID:21460847-8] Motomura, Y et al. (2011) The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells. Nat. Immunol. 12 450-9 PubMed GONUTS page

[PMID:22065767-9] Patel, O et al. (2011) Vβ2 natural killer T cell antigen receptor-mediated recognition of CD1d-glycolipid antigen. Proc. Natl. Acad. Sci. U.S.A. 108 19007-12 PubMed GONUTS page

[PMID:14722359-10] Park, JJ et al. (2004) Lipid-protein interactions: biosynthetic assembly of CD1 with lipids in the endoplasmic reticulum is evolutionarily conserved. Proc. Natl. Acad. Sci. U.S.A. 101 1022-6 PubMed GONUTS page

[PMID:17082577-11] Kim, PJ et al. (2006) GATA-3 regulates the development and function of invariant NKT cells. J. Immunol. 177 6650-9 PubMed GONUTS page

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MOUSE:CD1D1

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