MOUSE:CATL1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Ctsl (synonyms: Ctsl1)
Protein Name(s)	Cathepsin L1 Cathepsin L Major excreted protein MEP p39 cysteine proteinase Cathepsin L1 heavy chain Cathepsin L1 light chain
External Links
UniProt	P06797
EMBL	X06086 J02583 M20495 AF121837 AF121838 AF121839 BC068163 X04392
CCDS	CCDS26600.1
PIR	S01177
RefSeq	NP_034114.1 XP_006517143.1 XP_006517144.1
UniGene	Mm.930
PDB	1MVV
PDBsum	1MVV
ProteinModelPortal	P06797
SMR	P06797
IntAct	P06797
MINT	MINT-1863740
BindingDB	P06797
ChEMBL	CHEMBL5291
MEROPS	C01.032
PhosphoSite	P06797
MaxQB	P06797
PaxDb	P06797
PRIDE	P06797
Ensembl	ENSMUST00000021933
GeneID	13039
KEGG	mmu:13039
UCSC	uc007qyw.1
CTD	1514
MGI	MGI:88564
eggNOG	COG4870
HOGENOM	HOG000230774
HOVERGEN	HBG011513
InParanoid	P06797
KO	K01365
OMA	METAFEF
OrthoDB	EOG786H3P
PhylomeDB	P06797
TreeFam	TF313739
BioCyc	MetaCyc:MONOMER-14812
BRENDA	3.4.22.15
Reactome	REACT_196550 REACT_198976 REACT_199000 REACT_199046 REACT_199052 REACT_199055
NextBio	282928
PRO	PR:P06797
Proteomes	UP000000589
Bgee	P06797
CleanEx	MM_CTSL
ExpressionAtlas	P06797
Genevestigator	P06797
GO	GO:0045177 GO:0005737 GO:0031410 GO:0009897 GO:0005615 GO:0070062 GO:0005764 GO:0005902 GO:0043005 GO:0005730 GO:0005634 GO:0043204 GO:0030141 GO:0005773 GO:0004177 GO:0016807 GO:0004197 GO:0042393 GO:0042277 GO:0048102 GO:0007154 GO:0009267 GO:0046697 GO:0031069 GO:0008584 GO:0010259 GO:0010839 GO:0021675 GO:0016540 GO:0016485 GO:0006508 GO:2000249 GO:0051384 GO:0009749 GO:0034698 GO:0014070 GO:0060008 GO:0007283
InterPro	IPR025661 IPR000169 IPR025660 IPR013128 IPR000668 IPR013201
PANTHER	PTHR12411
Pfam	PF08246 PF00112
PRINTS	PR00705
SMART	SM00848 SM00645
PROSITE	PS00640 PS00139 PS00639

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:28071719^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0000006)	Seeded From UniProt	complete
	GO:0046718	viral entry into host cell	PMID:15831716^[2]	ECO:0000315			P		Fig. 1C and Fig. 1D, murine CatB is an essential host factor for EboV GP-dependent entry.	complete CACAO 2058
enables	GO:0004197	cysteine-type endopeptidase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07711	F		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	PMID:28835281^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0060008	Sertoli cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07154	P		Seeded From UniProt	complete
involved_in	GO:0051384	response to glucocorticoid	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07154	P		Seeded From UniProt	complete
involved_in	GO:0048102	autophagic cell death	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07154	P		Seeded From UniProt	complete
involved_in	GO:0046697	decidualization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07154	P		Seeded From UniProt	complete
colocalizes_with	GO:0045177	apical part of cell	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07154	C		Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07154	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07154	C		Seeded From UniProt	complete
enables	GO:0042393	histone binding	PMID:18957203^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042277	peptide binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07154	F		Seeded From UniProt	complete
involved_in	GO:0034698	response to gonadotropin	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07154	P		Seeded From UniProt	complete
colocalizes_with	GO:0030141	secretory granule	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07154	C		Seeded From UniProt	complete
involved_in	GO:0021675	nerve development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07154	P		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07154	P		Seeded From UniProt	complete
	GO:0006508	proteolysis	PMID:27031696^[5]	ECO:0000314			P		Figure 6 shows inhibition of CTSL1 results in accumulation of ABCA3 species.	complete CACAO 11833
involved_in	GO:0010259	multicellular organism aging	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07154	P		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07154	C		Seeded From UniProt	complete
involved_in	GO:0009749	response to glucose	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07154	P		Seeded From UniProt	complete
involved_in	GO:0009267	cellular response to starvation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07154	P		Seeded From UniProt	complete
involved_in	GO:0008584	male gonad development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07154	P		Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07154	P		Seeded From UniProt	complete
involved_in	GO:0007154	cell communication	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07154	P		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	PMID:18957203^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07154	P		Seeded From UniProt	complete
part_of	GO:0005902	microvillus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07154	C		Seeded From UniProt	complete
part_of	GO:0005773	vacuole	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07154	C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07154	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07154	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:20338168^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18957203^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07154	F		Seeded From UniProt	complete
enables	GO:0004177	aminopeptidase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07154	F		Seeded From UniProt	complete
NOT\|involved_in	GO:0060441	epithelial tube branching involved in lung morphogenesis	PMID:17500053^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051603	proteolysis involved in cellular protein catabolic process	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107341 PANTHER:PTN000274640 UniProtKB:P07711 UniProtKB:P07858 UniProtKB:P25774 UniProtKB:P43235	P		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0013770 MGI:MGI:107341 MGI:MGI:1860262 MGI:MGI:88561 MGI:MGI:88564 PANTHER:PTN000274640 RGD:2445 RGD:2447 RGD:2448 RGD:61810 RGD:621509 UniProtKB:P07711 UniProtKB:P07858 UniProtKB:P09668 UniProtKB:P25774 UniProtKB:Q9UBR2 WB:WBGene00000786 dictyBase:DDB_G0279187	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0034229 FB:FBgn0034709 MGI:MGI:88564 PANTHER:PTN000274640 RGD:2447 RGD:61810 RGD:621509 RGD:708479 UniProtKB:P07711 UniProtKB:P07858 UniProtKB:P09668 UniProtKB:P25774 UniProtKB:P43235 UniProtKB:Q9UBR2	C		Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0013770 FB:FBgn0030521 MGI:MGI:107285 MGI:MGI:107341 PANTHER:PTN000274640 RGD:2448 RGD:621509 TAIR:locus:2133402 TAIR:locus:2157712 TAIR:locus:2204873 TAIR:locus:505006093 UniProtKB:P07711 UniProtKB:P07858 UniProtKB:P09668 UniProtKB:P25774 UniProtKB:P43235 UniProtKB:Q8IIL0	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046697	decidualization	PMID:9310336^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88561	P	has_participant:(EMAPA:16059)	Seeded From UniProt	complete
colocalizes_with	GO:0045177	apical part of cell	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2448	C		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2448	F		Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2448	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2448	C		Seeded From UniProt	complete
enables	GO:0042277	peptide binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2448	F		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	PMID:9310336^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16046) part_of:(CL:0002488)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031069	hair follicle morphogenesis	PMID:11023992^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136432	P	has_participant:(EMAPA:36392)	Seeded From UniProt	complete
enables	GO:0030984	kininogen binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2448	F		Seeded From UniProt	complete
colocalizes_with	GO:0030141	secretory granule	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2448	C		Seeded From UniProt	complete
enables	GO:0016807	cysteine-type carboxypeptidase activity	PMID:11023992^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010839	negative regulation of keratinocyte proliferation	PMID:11023992^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136432	P	regulates_o_occurs_in:(EMAPA:36392)	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2448	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007154	cell communication	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2448	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006508	proteolysis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2448	P		Seeded From UniProt	complete
part_of	GO:0005902	microvillus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2448	C		Seeded From UniProt	complete
part_of	GO:0005773	vacuole	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2448	C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:15099520^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:11023992^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2448	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2448	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:9310336^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2448	F		Seeded From UniProt	complete
enables	GO:0004177	aminopeptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2448	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000668	P		Seeded From UniProt	complete
enables	GO:0008234	cysteine-type peptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000668 InterPro:IPR013128	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016540	protein autoprocessing	PMID:1482371^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
enables	GO:0008234	cysteine-type peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0788	F		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0458 UniProtKB-SubCell:SL-0158	C		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Naba, A et al. (2017) Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep 7 40495 PubMed GONUTS page
↑ Chandran, K et al. (2005) Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection. Science 308 1643-5 PubMed GONUTS page
↑ Zhou, X et al. (2017) Lysosomal processing of progranulin. Mol Neurodegener 12 62 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Duncan, EM et al. (2008) Cathepsin L proteolytically processes histone H3 during mouse embryonic stem cell differentiation. Cell 135 284-94 PubMed GONUTS page
↑ Hofmann, N et al. (2016) Analysis of the Proteolytic Processing of ABCA3: Identification of Cleavage Site and Involved Proteases. PLoS ONE 11 e0152594 PubMed GONUTS page
↑ Konjar, S et al. (2010) Increased nucleolar localization of SpiA3G in classically but not alternatively activated macrophages. FEBS Lett. 584 2201-6 PubMed GONUTS page
↑ Lü, J et al. (2007) Cathespin H is an Fgf10 target involved in Bmp4 degradation during lung branching morphogenesis. J. Biol. Chem. 282 22176-84 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Afonso, S et al. (1997) The expression and function of cystatin C and cathepsin B and cathepsin L during mouse embryo implantation and placentation. Development 124 3415-25 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Roth, W et al. (2000) Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair follicle cycling. FASEB J. 14 2075-86 PubMed GONUTS page
↑ Goulet, B et al. (2004) A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor. Mol. Cell 14 207-19 PubMed GONUTS page
↑ Mason, RW & Massey, SD (1992) Surface activation of pro-cathepsin L. Biochem. Biophys. Res. Commun. 189 1659-66 PubMed GONUTS page

[PMID:28071719-1] Naba, A et al. (2017) Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep 7 40495 PubMed GONUTS page

[PMID:15831716-2] Chandran, K et al. (2005) Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection. Science 308 1643-5 PubMed GONUTS page

[PMID:28835281-3] Zhou, X et al. (2017) Lysosomal processing of progranulin. Mol Neurodegener 12 62 PubMed GONUTS page

[PMID:18957203-4] 4.0 ^4.1 ^4.2 Duncan, EM et al. (2008) Cathepsin L proteolytically processes histone H3 during mouse embryonic stem cell differentiation. Cell 135 284-94 PubMed GONUTS page

[PMID:27031696-5] Hofmann, N et al. (2016) Analysis of the Proteolytic Processing of ABCA3: Identification of Cleavage Site and Involved Proteases. PLoS ONE 11 e0152594 PubMed GONUTS page

[PMID:20338168-6] Konjar, S et al. (2010) Increased nucleolar localization of SpiA3G in classically but not alternatively activated macrophages. FEBS Lett. 584 2201-6 PubMed GONUTS page

[PMID:17500053-7] Lü, J et al. (2007) Cathespin H is an Fgf10 target involved in Bmp4 degradation during lung branching morphogenesis. J. Biol. Chem. 282 22176-84 PubMed GONUTS page

[PMID:21873635-8] 8.0 ^8.1 ^8.2 ^8.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9310336-9] 9.0 ^9.1 ^9.2 Afonso, S et al. (1997) The expression and function of cystatin C and cathepsin B and cathepsin L during mouse embryo implantation and placentation. Development 124 3415-25 PubMed GONUTS page

[PMID:11023992-10] 10.0 ^10.1 ^10.2 ^10.3 Roth, W et al. (2000) Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair follicle cycling. FASEB J. 14 2075-86 PubMed GONUTS page

[PMID:15099520-11] Goulet, B et al. (2004) A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor. Mol. Cell 14 207-19 PubMed GONUTS page

[PMID:1482371-12] Mason, RW & Massey, SD (1992) Surface activation of pro-cathepsin L. Biochem. Biophys. Res. Commun. 189 1659-66 PubMed GONUTS page

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MOUSE:CATL1

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