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PMID:27031696
| Citation |
Hofmann, N, Galetskiy, D, Rauch, D, Wittmann, T, Marquardt, A, Griese, M and Zarbock, R (2016) Analysis of the Proteolytic Processing of ABCA3: Identification of Cleavage Site and Involved Proteases. PLoS ONE 11:e0152594 |
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| Abstract |
ABCA3 is a lipid transporter in the limiting membrane of lamellar bodies in alveolar type II cells. Mutations in the ABCA3 gene cause respiratory distress syndrome in new-borns and childhood interstitial lung disease. ABCA3 is N-terminally cleaved by an as yet unknown protease, a process believed to regulate ABCA3 activity. |
| Links |
PubMed PMC4816274 Online version:10.1371/journal.pone.0152594 |
| Keywords |
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Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0006508: proteolysis |
ECO:0000314: |
P |
Figure 6 shows inhibition of CTSL1 results in accumulation of ABCA3 species. |
complete | ||||
Notes
See also
References
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