MOUSE:BMI1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Bmi1 (synonyms: Bmi-1, Pcgf4)
Protein Name(s)	Polycomb complex protein BMI-1 Polycomb group RING finger protein 4
External Links
UniProt	P25916
EMBL	M64067 M64068 M64279 BC053708 BC056384
CCDS	CCDS15711.1
PIR	A39523
RefSeq	NP_031578.2 XP_006497374.1 XP_006497375.1
UniGene	Mm.289584
PDB	2CKL
PDBsum	2CKL
ProteinModelPortal	P25916
SMR	P25916
BioGrid	198359
DIP	DIP-132N
IntAct	P25916
PhosphoSite	P25916
MaxQB	P25916
PaxDb	P25916
PRIDE	P25916
Ensembl	ENSMUST00000028071 ENSMUST00000051929
GeneID	12151
KEGG	mmu:12151
UCSC	uc008ily.1
CTD	648
MGI	MGI:88174
eggNOG	NOG304672
HOGENOM	HOG000231945
HOVERGEN	HBG052826
InParanoid	P25916
KO	K11459
OMA	NKRYLQC
OrthoDB	EOG77T14W
PhylomeDB	P25916
TreeFam	TF324206
Reactome	REACT_188970
EvolutionaryTrace	P25916
NextBio	280483
PRO	PR:P25916
Proteomes	UP000000589
Bgee	P25916
CleanEx	MM_BMI1
ExpressionAtlas	P25916
Genevestigator	P25916
GO	GO:0005737 GO:0000792 GO:0016604 GO:0005634 GO:0031519 GO:0000151 GO:0003682 GO:0043565 GO:0097027 GO:0008270 GO:0007420 GO:0009987 GO:0006306 GO:0048706 GO:0048704 GO:0016573 GO:0016574 GO:0006959 GO:0001701 GO:2001234 GO:0000122 GO:0030890 GO:0033092 GO:0051443 GO:0021903 GO:0001501 GO:0048103 GO:0006351
Gene3D	3.30.40.10
InterPro	IPR018957 IPR001841 IPR013083 IPR017907
Pfam	PF00097
SMART	SM00184
PROSITE	PS00518 PS50089

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0036353	histone H2A-K119 monoubiquitination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35226	P		Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35226	F		Seeded From UniProt	complete
involved_in	GO:0045814	negative regulation of gene expression, epigenetic	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35226	P		Seeded From UniProt	complete
involved_in	GO:0033092	positive regulation of immature T cell proliferation in thymus	PMID:15964995^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030890	positive regulation of B cell proliferation	PMID:15964995^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051443	positive regulation of ubiquitin-protein transferase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35226	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35226	F		Seeded From UniProt	complete
part_of	GO:0000151	ubiquitin ligase complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35226	C		Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88174 PANTHER:PTN000850589 UniProtKB:P35226	F		Seeded From UniProt	complete
involved_in	GO:0036353	histone H2A-K119 monoubiquitination	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000850589 UniProtKB:P35226 UniProtKB:P35227 UniProtKB:Q9BSM1	P		Seeded From UniProt	complete
part_of	GO:0035102	PRC1 complex	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000850589 UniProtKB:P35226 UniProtKB:P35227 UniProtKB:P35820	C		Seeded From UniProt	complete
involved_in	GO:0006342	chromatin silencing	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0265623 PANTHER:PTN000850589 UniProtKB:P35820	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88174 MGI:MGI:99161 PANTHER:PTN000850589 UniProtKB:P35226 UniProtKB:P35227	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001234	negative regulation of apoptotic signaling pathway	PMID:11290297^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99161	P	regulates_o_occurs_in:(EMAPA:16530)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000011	regulation of adaxial/abaxial pattern formation	PMID:17107999^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95286	P		Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	PMID:22770845^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0097027	ubiquitin-protein transferase activator activity	PMID:16359901^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	regulates_o_has_input:(MGI:MGI:1101759)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061484	hematopoietic stem cell homeostasis	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35266	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048706	embryonic skeletal system development	PMID:11290297^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99161	P	results_in_development_of:(EMAPA:17214)\|results_in_development_of:(EMAPA:32729)\|results_in_development_of:(EMAPA:17680)\|results_in_development_of:(EMAPA:18948)\|results_in_development_of:(EMAPA:18708)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048704	embryonic skeletal system morphogenesis	PMID:11290297^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99161	P	has_participant:(EMAPA:18022)\|has_participant:(EMAPA:18708)\|has_participant:(EMAPA:17214)\|has_participant:(EMAPA:18010)\|has_participant:(EMAPA:18344)\|has_participant:(EMAPA:19431)\|has_participant:(EMAPA:18722)\|has_participant:(EMAPA:25119)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048103	somatic stem cell division	PMID:12714971^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857632	P	occurs_in:(EMAPA:18765) results_in_division_of:(CL:0000037)	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:20956546^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0031519	PcG protein complex	PMID:16624538^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031519	PcG protein complex	PMID:16359901^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021903	rostrocaudal neural tube patterning	PMID:8887324^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857632	P	occurs_in:(EMAPA:16530)	Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	PMID:12183370^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016574	histone ubiquitination	PMID:16359901^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016573	histone acetylation	PMID:16687444^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99161	P	has_participant:(MGI:MGI:96189)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007420	brain development	PMID:7926765^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857632	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006959	humoral immune response	PMID:7926765^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857632	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006306	DNA methylation	PMID:24105743^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_direct_input:(MGI:MGI:892014) has_direct_input:(MGI:MGI:95484)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9367786^[15]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35226	C		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:24105743^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:16359901^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	has_participant:(MGI:MGI:99560)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:11290297^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99161	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001501	skeletal system development	PMID:7926765^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857632	P		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:17107999^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000792	heterochromatin	PMID:18311137^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000151	ubiquitin ligase complex	PMID:16359901^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:17107999^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95286	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:11290297^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99161	P	occurs_in:(EMAPA:16039) has_regulation_target:(MGI:MGI:96187)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:24105743^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:892014) has_regulation_target:(MGI:MGI:95484)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:9367786^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:9312051^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071549	cellular response to dexamethasone stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B4F7B6 ensembl:ENSRNOP00000059998	P		Seeded From UniProt	complete
involved_in	GO:0071347	cellular response to interleukin-1	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B4F7B6 ensembl:ENSRNOP00000059998	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009987	cellular process	PMID:7926765^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Bruggeman, SW et al. (2005) Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice. Genes Dev. 19 1438-43 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Akasaka, T et al. (2001) Mice doubly deficient for the Polycomb Group genes Mel18 and Bmi1 reveal synergy and requirement for maintenance but not initiation of Hox gene expression. Development 128 1587-97 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Kim, SY et al. (2006) Juxtaposed Polycomb complexes co-regulate vertebral identity. Development 133 4957-68 PubMed GONUTS page
↑ Qin, J et al. (2012) The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development. Cell Stem Cell 11 319-32 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Cao, R et al. (2005) Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. Mol. Cell 20 845-54 PubMed GONUTS page
↑ Park, IK et al. (2003) Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature 423 302-5 PubMed GONUTS page
↑ Onodera, A et al. (2010) STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells. J. Exp. Med. 207 2493-506 PubMed GONUTS page
↑ Lorente, M et al. (2006) Homeotic transformations of the axial skeleton of YY1 mutant mice and genetic interaction with the Polycomb group gene Ring1/Ring1A. Mech. Dev. 123 312-20 PubMed GONUTS page
↑ van der Lugt, NM et al. (1996) The Polycomb-group homolog Bmi-1 is a regulator of murine Hox gene expression. Mech. Dev. 58 153-64 PubMed GONUTS page
↑ Suzuki, M et al. (2002) Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice. Development 129 4171-83 PubMed GONUTS page
↑ Fujimura, Y et al. (2006) Distinct roles of Polycomb group gene products in transcriptionally repressed and active domains of Hoxb8. Development 133 2371-81 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 van der Lugt, NM et al. (1994) Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene. Genes Dev. 8 757-69 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Wajapeyee, N et al. (2013) Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors. Genes Dev. 27 2221-6 PubMed GONUTS page
↑ ^15.0 ^15.1 Alkema, MJ et al. (1997) MPc2, a new murine homolog of the Drosophila polycomb protein is a member of the mouse polycomb transcriptional repressor complex. J. Mol. Biol. 273 993-1003 PubMed GONUTS page
↑ Puschendorf, M et al. (2008) PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos. Nat. Genet. 40 411-20 PubMed GONUTS page
↑ Schoorlemmer, J et al. (1997) Ring1A is a transcriptional repressor that interacts with the Polycomb-M33 protein and is expressed at rhombomere boundaries in the mouse hindbrain. EMBO J. 16 5930-42 PubMed GONUTS page

[PMID:15964995-1] 1.0 ^1.1 Bruggeman, SW et al. (2005) Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice. Genes Dev. 19 1438-43 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11290297-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Akasaka, T et al. (2001) Mice doubly deficient for the Polycomb Group genes Mel18 and Bmi1 reveal synergy and requirement for maintenance but not initiation of Hox gene expression. Development 128 1587-97 PubMed GONUTS page

[PMID:17107999-4] 4.0 ^4.1 ^4.2 Kim, SY et al. (2006) Juxtaposed Polycomb complexes co-regulate vertebral identity. Development 133 4957-68 PubMed GONUTS page

[PMID:22770845-5] Qin, J et al. (2012) The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development. Cell Stem Cell 11 319-32 PubMed GONUTS page

[PMID:16359901-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Cao, R et al. (2005) Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. Mol. Cell 20 845-54 PubMed GONUTS page

[PMID:12714971-7] Park, IK et al. (2003) Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature 423 302-5 PubMed GONUTS page

[PMID:20956546-8] Onodera, A et al. (2010) STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells. J. Exp. Med. 207 2493-506 PubMed GONUTS page

[PMID:16624538-9] Lorente, M et al. (2006) Homeotic transformations of the axial skeleton of YY1 mutant mice and genetic interaction with the Polycomb group gene Ring1/Ring1A. Mech. Dev. 123 312-20 PubMed GONUTS page

[PMID:8887324-10] van der Lugt, NM et al. (1996) The Polycomb-group homolog Bmi-1 is a regulator of murine Hox gene expression. Mech. Dev. 58 153-64 PubMed GONUTS page

[PMID:12183370-11] Suzuki, M et al. (2002) Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice. Development 129 4171-83 PubMed GONUTS page

[PMID:16687444-12] Fujimura, Y et al. (2006) Distinct roles of Polycomb group gene products in transcriptionally repressed and active domains of Hoxb8. Development 133 2371-81 PubMed GONUTS page

[PMID:7926765-13] 13.0 ^13.1 ^13.2 ^13.3 van der Lugt, NM et al. (1994) Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene. Genes Dev. 8 757-69 PubMed GONUTS page

[PMID:24105743-14] 14.0 ^14.1 ^14.2 Wajapeyee, N et al. (2013) Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors. Genes Dev. 27 2221-6 PubMed GONUTS page

[PMID:9367786-15] 15.0 ^15.1 Alkema, MJ et al. (1997) MPc2, a new murine homolog of the Drosophila polycomb protein is a member of the mouse polycomb transcriptional repressor complex. J. Mol. Biol. 273 993-1003 PubMed GONUTS page

[PMID:18311137-16] Puschendorf, M et al. (2008) PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos. Nat. Genet. 40 411-20 PubMed GONUTS page

[PMID:9312051-17] Schoorlemmer, J et al. (1997) Ring1A is a transcriptional repressor that interacts with the Polycomb-M33 protein and is expressed at rhombomere boundaries in the mouse hindbrain. EMBO J. 16 5930-42 PubMed GONUTS page

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MOUSE:BMI1

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