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MOUSE:ASIP
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Asip (synonyms: a) | |
| Protein Name(s) | Agouti-signaling protein
ASP Agouti coat color protein Agouti switch protein | |
| External Links | ||
| UniProt | Q03288 | |
| EMBL | L06451 L06941 AL805955 CH466551 CH466551 BC009122 S63413 S70320 S70326 S70394 S74479 S74489 S74493 | |
| CCDS | CCDS16941.1 | |
| PIR | A46298 | |
| RefSeq | NP_056585.2 XP_006499942.1 | |
| UniGene | Mm.315593 Mm.488809 | |
| ProteinModelPortal | Q03288 | |
| SMR | Q03288 | |
| STRING | 10090.ENSMUSP00000105319 | |
| PhosphoSite | Q03288 | |
| PRIDE | Q03288 | |
| Ensembl | ENSMUST00000029123 ENSMUST00000109697 | |
| GeneID | 50518 | |
| KEGG | mmu:50518 | |
| UCSC | uc008njz.1 | |
| CTD | 50518 | |
| MGI | MGI:87853 | |
| eggNOG | NOG42429 | |
| GeneTree | ENSGT00510000048661 | |
| HOGENOM | HOG000111779 | |
| HOVERGEN | HBG050593 | |
| InParanoid | Q03288 | |
| KO | K08725 | |
| OMA | CSCRVLN | |
| TreeFam | TF330729 | |
| NextBio | 307514 | |
| PRO | PR:Q03288 | |
| Proteomes | UP000000589 | |
| Bgee | Q03288 | |
| CleanEx | MM_A | |
| ExpressionAtlas | Q03288 | |
| Genevestigator | Q03288 | |
| GO | GO:0005576 GO:0031779 GO:0031781 GO:0031782 GO:0008343 GO:0006091 GO:0071514 GO:0009755 GO:0042438 GO:0032438 GO:0032402 GO:0043473 GO:0040030 | |
| Gene3D | 4.10.760.10 | |
| InterPro | IPR007733 IPR027300 | |
| PANTHER | PTHR16551 | |
| Pfam | PF05039 | |
| SMART | SM00792 | |
| SUPFAM | SSF57055 | |
| PROSITE | PS60024 PS51150 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0048023 |
positive regulation of melanin biosynthetic process |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0048023 |
positive regulation of melanin biosynthetic process |
ECO:0000316 |
UniProtKB:P07147 UniProtKB:Q60696
|
P |
Based on results in Table 2 |
complete | ||||
|
acts_upstream_of_or_within |
GO:0071514 |
genetic imprinting |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1855930 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0043473 |
pigmentation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1856798 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0042438 |
melanin biosynthetic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1855937 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0040030 |
regulation of molecular function, epigenetic |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1855930 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0032438 |
melanosome organization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1855937 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0032402 |
melanosome transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1855937 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0031782 |
type 4 melanocortin receptor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0031781 |
type 3 melanocortin receptor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0031779 |
melanocortin receptor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0008343 |
adult feeding behavior |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:2153518 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0008343 |
adult feeding behavior |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1855937 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0006091 |
generation of precursor metabolites and energy |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1343180 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005623 |
cell |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0032402 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009755 |
hormone-mediated signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Hellström, AR et al. (2011) Inactivation of Pmel alters melanosome shape but has only a subtle effect on visible pigmentation. PLoS Genet. 7 e1002285 PubMed GONUTS page
- ↑ 2.0 2.1 Rakyan, VK et al. (2003) Transgenerational inheritance of epigenetic states at the murine Axin(Fu) allele occurs after maternal and paternal transmission. Proc. Natl. Acad. Sci. U.S.A. 100 2538-43 PubMed GONUTS page
- ↑ Markert, CL & Silvers, WK (1956) The Effects of Genotype and Cell Environment on Melanoblast Differentiation in the House Mouse. Genetics 41 429-50 PubMed GONUTS page
- ↑ Ozeki, H et al. (1995) Chemical characterization of hair melanins in various coat-color mutants of mice. J. Invest. Dermatol. 105 361-6 PubMed GONUTS page
- ↑ 5.0 5.1 Hirobe, T et al. (1998) Effects of genic substitution at the agouti, brown, albino, dilute, and pink-eyed dilution loci on the proliferation and differentiation of mouse epidermal melanocytes in serum-free culture. Eur. J. Cell Biol. 75 184-91 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Kiefer, LL et al. (1998) Melanocortin receptor binding determinants in the agouti protein. Biochemistry 37 991-7 PubMed GONUTS page
- ↑ 7.0 7.1 Fujimoto, W et al. (2007) Dmbx1 is essential in agouti-related protein action. Proc. Natl. Acad. Sci. U.S.A. 104 15514-9 PubMed GONUTS page
- ↑ Hahm, S et al. (2002) VGF is required for obesity induced by diet, gold thioglucose treatment, and agouti and is differentially regulated in pro-opiomelanocortin- and neuropeptide Y-containing arcuate neurons in response to fasting. J. Neurosci. 22 6929-38 PubMed GONUTS page
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