Category:GO:0040030 ! obsolete regulation of molecular function, epigenetic

This GO term has been obsoleted. Do not annotate to it.

id: GO:0040030
name: obsolete regulation of molecular function, epigenetic
namespace: biological_process
def: "OBSOLETE. Any heritable epigenetic process that modulates the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya." [GOC:dph, GOC:ems, GOC:tb, PMID:10611975, PMID:11050225, PMID:11447696, PMID:11685242, PMID:11782551]
comment: This term was obsoleted because it is not an active process.
synonym: "regulation of protein activity, epigenetic" EXACT [GOC:dph, GOC:tb]
is_obsolete: true

AmiGO <GOterm>GO:0040030</GOterm>
Gene Ontology Home