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MOUSE:ANG4
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Ang4 | |
| Protein Name(s) | Angiogenin-4 | |
| External Links | ||
| UniProt | Q3TMQ6 | |
| EMBL | AY219870 AK136415 AK165799 AC122877 CH466659 BC042938 BC132444 BC132448 | |
| CCDS | CCDS36911.1 | |
| RefSeq | NP_808212.2 | |
| UniGene | Mm.343899 | |
| PDB | 2J4T | |
| PDBsum | 2J4T | |
| ProteinModelPortal | Q3TMQ6 | |
| SMR | Q3TMQ6 | |
| STRING | 10090.ENSMUSP00000073525 | |
| iPTMnet | Q3TMQ6 | |
| PhosphoSitePlus | Q3TMQ6 | |
| PaxDb | Q3TMQ6 | |
| PeptideAtlas | Q3TMQ6 | |
| PRIDE | Q3TMQ6 | |
| Ensembl | ENSMUST00000073860 | |
| GeneID | 219033 | |
| KEGG | mmu:219033 | |
| UCSC | uc007tnd.1 | |
| CTD | 219033 | |
| MGI | MGI:2656551 | |
| eggNOG | ENOG410IZBW ENOG410Y4FD | |
| GeneTree | ENSGT00840000129759 | |
| HOGENOM | HOG000276883 | |
| HOVERGEN | HBG008396 | |
| InParanoid | Q3TMQ6 | |
| KO | K16631 | |
| OMA | FQITTCT | |
| OrthoDB | EOG091G0YDD | |
| PhylomeDB | Q3TMQ6 | |
| TreeFam | TF333393 | |
| Reactome | [www.reactome.org/content/detail/R-MMU-418990 R-MMU-418990] | |
| PRO | PR:Q3TMQ6 | |
| Proteomes | UP000000589 | |
| Bgee | ENSMUSG00000060615 | |
| ExpressionAtlas | Q3TMQ6 | |
| Genevisible | Q3TMQ6 | |
| GO | GO:0005615 GO:0005730 GO:0030141 GO:0004519 GO:0003676 GO:0004540 GO:0001525 GO:0019731 GO:0061844 GO:0071222 GO:0042742 GO:0045087 GO:0008284 GO:0006401 | |
| Gene3D | 3.10.130.10 | |
| InterPro | IPR001427 IPR023411 IPR023412 | |
| PANTHER | PTHR11437 | |
| Pfam | PF00074 | |
| PRINTS | PR00794 | |
| ProDom | PD000535 | |
| SMART | SM00092 | |
| SUPFAM | SSF54076 | |
| PROSITE | PS00127 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0009986 |
cell surface |
ECO:0000314 |
C |
lysozyme-treated bacteria were bound to the surface of the J774.1 cells, but were not phagocytized. Thus, RNA, the active ingredient of IC-1 cells, was not transferred into the J774.1 cells or recognized by the intracellular TLR7. Consequently, it failed to induce IL-12 production. By author, Fig. 6 Protein: Angiogenin-4 Organism: Mouse |
complete | |||||
|
involved_in |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006401 |
RNA catabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004540 |
ribonuclease activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001525 |
angiogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004540 |
ribonuclease activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:104984 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0042742 |
defense response to bacterium |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030141 |
secretory granule |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0019731 |
antibacterial humoral response |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0009617 |
response to bacterium |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090305 |
nucleic acid phosphodiester bond hydrolysis |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004519 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0090305 |
nucleic acid phosphodiester bond hydrolysis |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004518 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0090501 |
RNA phosphodiester bond hydrolysis |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004540 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0090501 |
RNA phosphodiester bond hydrolysis |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004540 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003676 |
nucleic acid binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0061844 |
antimicrobial humoral immune response mediated by antimicrobial peptide |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045087 |
innate immune response |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071222 |
cellular response to lipopolysaccharide |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
occurs_in:(CL:1000343) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042742 |
defense response to bacterium |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004519 |
endonuclease activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004518 |
nuclease activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001525 |
angiogenesis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031410 |
cytoplasmic vesicle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005730 |
nucleolus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Nakase, J et al. (2017) RNA and a cell wall component of Enterococcus faecalis IC-1 are required for phagocytosis and interleukin 12 production by the mouse macrophage cell line J774.1. Biosci. Biotechnol. Biochem. 1-7 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Crabtree, B et al. (2007) Biological and structural features of murine angiogenin-4, an angiogenic protein. Biochemistry 46 2431-43 PubMed GONUTS page
- ↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 Hooper, LV et al. (2003) Angiogenins: a new class of microbicidal proteins involved in innate immunity. Nat. Immunol. 4 269-73 PubMed GONUTS page
- ↑ Archambaud, C et al. (2012) Impact of lactobacilli on orally acquired listeriosis. Proc. Natl. Acad. Sci. U.S.A. 109 16684-9 PubMed GONUTS page
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