MOUSE:ADA17

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Adam17 (synonyms: Tace)
Protein Name(s)	Disintegrin and metalloproteinase domain-containing protein 17 ADAM 17 TNF-alpha convertase TNF-alpha-converting enzyme
External Links
UniProt	Q9Z0F8
EMBL	AF056359 AF056345 AF056346 AF056347 AF056348 AF056349 AF056350 AF056351 AF056352 AF056353 AF056354 AF056355 AF056356 AF056357 AF056358 AJ007365 AB021709 U69613 U69614 AK139471 BC094655
CCDS	CCDS25836.1
RefSeq	NP_001264195.1 NP_001278800.1 NP_033745.4
UniGene	Mm.27681
ProteinModelPortal	Q9Z0F8
SMR	Q9Z0F8
IntAct	Q9Z0F8
MINT	MINT-246289
ChEMBL	CHEMBL4379
MEROPS	M12.217
PhosphoSite	Q9Z0F8
MaxQB	Q9Z0F8
PaxDb	Q9Z0F8
PRIDE	Q9Z0F8
Ensembl	ENSMUST00000064536 ENSMUST00000145118
GeneID	11491
KEGG	mmu:11491
UCSC	uc007ndu.1
CTD	6868
MGI	MGI:1096335
eggNOG	NOG269976
GeneTree	ENSGT00670000097974
HOGENOM	HOG000033797
HOVERGEN	HBG050457
InParanoid	Q9Z0F8
KO	K06059
TreeFam	TF314733
Reactome	REACT_198574 REACT_198614 REACT_199055 REACT_218614 REACT_242976 REACT_247063 REACT_256171
NextBio	278866
PMAP-CutDB	Q505A7
PRO	PR:Q9Z0F8
Proteomes	UP000000589
Bgee	Q9Z0F8
CleanEx	MM_ADAM17
ExpressionAtlas	Q9Z0F8
Genevestigator	Q9Z0F8
GO	GO:0015629 GO:0016324 GO:0009986 GO:0005911 GO:0005737 GO:0005576 GO:0005925 GO:0005887 GO:0045121 GO:0005886 GO:0032587 GO:0004222 GO:0008237 GO:0005112 GO:0008270 GO:0030183 GO:0033627 GO:0048870 GO:0007173 GO:0035625 GO:0002467 GO:0006509 GO:0032717 GO:0030512 GO:0007220 GO:0007219 GO:0051088 GO:0030307 GO:0008284 GO:0051272 GO:0032722 GO:0031659 GO:0010820 GO:0030511 GO:0006508 GO:0033025 GO:0042493 GO:0055099 GO:0001666 GO:0032496 GO:0048536 GO:0033077 GO:0035313
Gene3D	3.40.390.10 4.10.70.10
InterPro	IPR001762 IPR024079 IPR001590 IPR002870
Pfam	PF00200 PF01562
SMART	SM00050
SUPFAM	SSF57552
PROSITE	PS50215 PS50214 PS00142

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0002532	production of molecular mediator involved in inflammatory response	PMID:20610799^[1]	ECO:0000314			P		ADAM17 is the primary mediator in LPS-induced LRP1 shedding. Fig.2	complete CACAO 3570
involved_in	GO:0006509	membrane protein ectodomain proteolysis	PMID:17245433^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	PMID:17245433^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0120163	negative regulation of cold-induced thermogenesis	PMID:18687778^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:24006456^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	produced_by:(CL:0002548)	Seeded From UniProt	complete
involved_in	GO:0002532	production of molecular mediator involved in inflammatory response	PMID:20610799^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051272	positive regulation of cellular component movement	PMID:18625725^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051088	PMA-inducible membrane protein ectodomain proteolysis	PMID:15691827^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048870	cell motility	PMID:18625725^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048536	spleen development	PMID:17371977^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	PMID:16179345^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033077	T cell differentiation in thymus	PMID:17371977^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033025	regulation of mast cell apoptotic process	PMID:14625290^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	PMID:18625725^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030183	B cell differentiation	PMID:17371977^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008237	metallopeptidase activity	PMID:14761956^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006509	membrane protein ectodomain proteolysis	PMID:9034190^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:P06804)	Seeded From UniProt	complete
involved_in	GO:0002467	germinal center formation	PMID:17371977^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007220	Notch receptor processing	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P78536	P		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P78536	P		Seeded From UniProt	complete
enables	GO:0005112	Notch binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P78536	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001222	regulation of neuron migration	PMID:26651291^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1097159 MGI:MGI:2443718	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905564	positive regulation of vascular endothelial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P78536	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903265	positive regulation of tumor necrosis factor-mediated signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P78536	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P78536	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071403	cellular response to high density lipoprotein particle stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P78536	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620404	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051088	PMA-inducible membrane protein ectodomain proteolysis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P78536	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050830	defense response to Gram-positive bacterium	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P78536	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048679	regulation of axon regeneration	PMID:26651291^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2443718	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P78536	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P78536	P		Seeded From UniProt	complete
part_of	GO:0045177	apical part of cell	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620404	C		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P78536	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043536	positive regulation of blood vessel endothelial cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P78536	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620404	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620404	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035624	receptor transactivation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P78536	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035624	receptor transactivation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620404	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033627	cell adhesion mediated by integrin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P78536	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032722	positive regulation of chemokine production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P78536	P		Seeded From UniProt	complete
colocalizes_with	GO:0032587	ruffle membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P78536	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032496	response to lipopolysaccharide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P78536	P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620404	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P78536	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030335	positive regulation of cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P78536	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030307	positive regulation of cell growth	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P78536	P		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P78536	F		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P78536	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:26651291^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000540)	Seeded From UniProt	complete
part_of	GO:0015629	actin cytoskeleton	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P78536	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010977	negative regulation of neuron projection development	PMID:26651291^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2443718 MGI:MGI:2679262	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010976	positive regulation of neuron projection development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620404	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010820	positive regulation of T cell chemotaxis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P78536	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P78536	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620404	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P78536	P		Seeded From UniProt	complete
enables	GO:0008237	metallopeptidase activity	PMID:26651291^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008237	metallopeptidase activity	PMID:26651291^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008237	metallopeptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P78536	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007220	Notch receptor processing	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P78536	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007173	epidermal growth factor receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P78536	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007155	cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P78536	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006509	membrane protein ectodomain proteolysis	PMID:26651291^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(MGI:MGI:1097159)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006509	membrane protein ectodomain proteolysis	PMID:26651291^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(MGI:MGI:97281)\|has_input:(MGI:MGI:109244)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006509	membrane protein ectodomain proteolysis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P78536	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006509	membrane protein ectodomain proteolysis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620404	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006508	proteolysis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P78536	P		Seeded From UniProt	complete
colocalizes_with	GO:0005925	focal adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P78536	C		Seeded From UniProt	complete
colocalizes_with	GO:0005911	cell-cell junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P78536	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P78536	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620404	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P78536	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15739225^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:32927)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P78536	C		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P78536	F		Seeded From UniProt	complete
enables	GO:0005138	interleukin-6 receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P78536	F		Seeded From UniProt	complete
enables	GO:0005112	Notch binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P78536	F		Seeded From UniProt	complete
enables	GO:0004222	metalloendopeptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P78536	F		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P78536	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P78536	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001666	response to hypoxia	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P78536	P		Seeded From UniProt	complete
enables	GO:0004222	metalloendopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001590	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001590	P		Seeded From UniProt	complete
enables	GO:0008237	metallopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR024079 InterPro:IPR034025	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-NUL-2484957 Reactome:R-NUL-1251988 Reactome:R-MMU-179883	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-MMU-1168790	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004252	serine-type endopeptidase activity	Reactome:R-NUL-2484957	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004222	metalloendopeptidase activity	Reactome:R-MMU-1168790	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0007219	Notch signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0914	P		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
enables	GO:0017124	SH3 domain binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0729	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0008237	metallopeptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0482	F		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Gorovoy, M et al. (2010) Inflammatory mediators promote production of shed LRP1/CD91, which regulates cell signaling and cytokine expression by macrophages. J. Leukoc. Biol. 88 769-78 PubMed GONUTS page
↑ ^2.0 ^2.1 Li, N et al. (2007) Metalloproteases regulate T-cell proliferation and effector function via LAG-3. EMBO J. 26 494-504 PubMed GONUTS page
↑ Gelling, RW et al. (2008) Deficiency of TNFalpha converting enzyme (TACE/ADAM17) causes a lean, hypermetabolic phenotype in mice. Endocrinology 149 6053-64 PubMed GONUTS page
↑ Abonnenc, M et al. (2013) Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Circ. Res. 113 1138-47 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Wang, SE et al. (2008) Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab. Mol. Cell. Biol. 28 5605-20 PubMed GONUTS page
↑ Rabie, T et al. (2005) Evidence for a role of ADAM17 (TACE) in the regulation of platelet glycoprotein V. J. Biol. Chem. 280 14462-8 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Li, N et al. (2007) Non-cell autonomous expression of TNF-alpha-converting enzyme ADAM17 is required for normal lymphocyte development. J. Immunol. 178 4214-21 PubMed GONUTS page
↑ Aktas, B et al. (2005) Aspirin induces platelet receptor shedding via ADAM17 (TACE). J. Biol. Chem. 280 39716-22 PubMed GONUTS page
↑ Cruz, AC et al. (2004) Tumor necrosis factor-alpha-converting enzyme controls surface expression of c-Kit and survival of embryonic stem cell-derived mast cells. J. Biol. Chem. 279 5612-20 PubMed GONUTS page
↑ Naus, S et al. (2004) Ectodomain shedding of the neural recognition molecule CHL1 by the metalloprotease-disintegrin ADAM8 promotes neurite outgrowth and suppresses neuronal cell death. J. Biol. Chem. 279 16083-90 PubMed GONUTS page
↑ Black, RA et al. (1997) A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells. Nature 385 729-33 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 ^12.7 van Erp, S et al. (2015) Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases. Dev. Cell 35 537-52 PubMed GONUTS page
↑ Asayesh, A et al. (2005) Developmental expression of metalloproteases ADAM 9, 10, and 17 becomes restricted to divergent pancreatic compartments. Dev. Dyn. 232 1105-14 PubMed GONUTS page

[PMID:20610799-1] 1.0 ^1.1 Gorovoy, M et al. (2010) Inflammatory mediators promote production of shed LRP1/CD91, which regulates cell signaling and cytokine expression by macrophages. J. Leukoc. Biol. 88 769-78 PubMed GONUTS page

[PMID:17245433-2] 2.0 ^2.1 Li, N et al. (2007) Metalloproteases regulate T-cell proliferation and effector function via LAG-3. EMBO J. 26 494-504 PubMed GONUTS page

[PMID:18687778-3] Gelling, RW et al. (2008) Deficiency of TNFalpha converting enzyme (TACE/ADAM17) causes a lean, hypermetabolic phenotype in mice. Endocrinology 149 6053-64 PubMed GONUTS page

[PMID:24006456-4] Abonnenc, M et al. (2013) Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Circ. Res. 113 1138-47 PubMed GONUTS page

[PMID:18625725-5] 5.0 ^5.1 ^5.2 Wang, SE et al. (2008) Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab. Mol. Cell. Biol. 28 5605-20 PubMed GONUTS page

[PMID:15691827-6] Rabie, T et al. (2005) Evidence for a role of ADAM17 (TACE) in the regulation of platelet glycoprotein V. J. Biol. Chem. 280 14462-8 PubMed GONUTS page

[PMID:17371977-7] 7.0 ^7.1 ^7.2 ^7.3 Li, N et al. (2007) Non-cell autonomous expression of TNF-alpha-converting enzyme ADAM17 is required for normal lymphocyte development. J. Immunol. 178 4214-21 PubMed GONUTS page

[PMID:16179345-8] Aktas, B et al. (2005) Aspirin induces platelet receptor shedding via ADAM17 (TACE). J. Biol. Chem. 280 39716-22 PubMed GONUTS page

[PMID:14625290-9] Cruz, AC et al. (2004) Tumor necrosis factor-alpha-converting enzyme controls surface expression of c-Kit and survival of embryonic stem cell-derived mast cells. J. Biol. Chem. 279 5612-20 PubMed GONUTS page

[PMID:14761956-10] Naus, S et al. (2004) Ectodomain shedding of the neural recognition molecule CHL1 by the metalloprotease-disintegrin ADAM8 promotes neurite outgrowth and suppresses neuronal cell death. J. Biol. Chem. 279 16083-90 PubMed GONUTS page

[PMID:9034190-11] Black, RA et al. (1997) A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells. Nature 385 729-33 PubMed GONUTS page

[PMID:26651291-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 ^12.7 van Erp, S et al. (2015) Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases. Dev. Cell 35 537-52 PubMed GONUTS page

[PMID:15739225-13] Asayesh, A et al. (2005) Developmental expression of metalloproteases ADAM 9, 10, and 17 becomes restricted to divergent pancreatic compartments. Dev. Dyn. 232 1105-14 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

MOUSE:ADA17

Contents

Annotations

Notes

References

a

b

c

d

e

f

g

h

i

m

n

o

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools