MOUSE:AAPK2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Prkaa2 (ECO:0000312 with MGI:MGI:1336173)
Protein Name(s)	5'-AMP-activated protein kinase catalytic subunit alpha-2 AMPK subunit alpha-2 Acetyl-CoA carboxylase kinase ACACA kinase Hydroxymethylglutaryl-CoA reductase kinase HMGCR kinase
External Links
UniProt	Q8BRK8
EMBL	AL627307 AL929466 AL929466 AL627307 BC138565 BC138566 AK044030 AK134573
CCDS	CCDS18416.1
RefSeq	NP_835279.2
UniGene	Mm.48638
ProteinModelPortal	Q8BRK8
SMR	Q8BRK8
BioGrid	223817
ChEMBL	CHEMBL1255154
PhosphoSite	Q8BRK8
MaxQB	Q8BRK8
PaxDb	Q8BRK8
PRIDE	Q8BRK8
Ensembl	ENSMUST00000030243
GeneID	108079
KEGG	mmu:108079
UCSC	uc008tyd.2
CTD	5563
MGI	MGI:1336173
eggNOG	COG0515
GeneTree	ENSGT00760000118892
HOGENOM	HOG000233016
HOVERGEN	HBG050432
InParanoid	Q8BRK8
KO	K07198
OMA	XGVILYA
OrthoDB	EOG7RRF6K
TreeFam	TF314032
Reactome	REACT_199054 REACT_205688 REACT_220701 REACT_250379 REACT_257268 REACT_257725
ChiTaRS	Prkaa2
NextBio	360016
PRO	PR:Q8BRK8
Proteomes	UP000000589
Bgee	Q8BRK8
Genevestigator	Q8BRK8
GO	GO:0005829 GO:0005634 GO:0050405 GO:0047322 GO:0004679 GO:0005524 GO:0003682 GO:0035174 GO:0046872 GO:0004674 GO:0004712 GO:0006914 GO:0042149 GO:0031669 GO:0006695 GO:0006633 GO:0055089 GO:0042593 GO:0035404 GO:0008610 GO:0043066 GO:0032007 GO:0010508 GO:0045821 GO:0042752 GO:2000505 GO:0006355 GO:0006950 GO:0048511 GO:0006351 GO:0016055
InterPro	IPR028375 IPR011009 IPR028783 IPR000719 IPR017441 IPR002290 IPR008271
PANTHER	PTHR24343:SF82
Pfam	PF00069
SMART	SM00220
SUPFAM	SSF103243 SSF56112
PROSITE	PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0032922	circadian regulation of gene expression	PMID:21483791^[1]	ECO:0000315			P		Fig. 5B The cyclic expression pattern of the core clock genes were significantly blunted in AMPKα2−/− mice. The cyclic expression pattern of PGC-1α was disrupted in the heart and skeletal muscle of AMPKα2−/− mice. The cyclic expression pattern of leptin was disrupted in the fat of AMPKα2−/− mice.	complete
	GO:0060259	regulation of feeding behavior	PMID:21483791^[1]	ECO:0000315			P		Fig 3D AMPKα2−/− mice ate more food during the light phase than their wild-type littermates (21.8% vs. 28%), indicating that AMPK-deficient mice have blunted feeding rhythm.	complete
involved_in	GO:0071333	cellular response to glucose stimulus	PMID:25788287^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q5EG47	P	occurs_in:(GO:0030424) occurs_in:(CL:0002608)\|occurs_in:(GO:0030425) occurs_in:(CL:0002608)\|occurs_in:(GO:0043025) occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0071277	cellular response to calcium ion	PMID:25788287^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q5EG47	P	occurs_in:(GO:0030424) occurs_in:(CL:0002608)\|occurs_in:(GO:0030425) occurs_in:(CL:0002608)\|occurs_in:(GO:0043025) occurs_in:(CL:0002608)	Seeded From UniProt	complete
enables	GO:0004679	AMP-activated protein kinase activity	PMID:25788287^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q5EG47	F	occurs_in:(GO:0030424) occurs_in:(CL:0002608) activated_by:(CHEBI:39124) part_of:(GO:0071277)\|occurs_in(GO:0030425) occurs_in:(CL:0002608) activated_by:(CHEBI:39124) part_of:(GO:0071277)\|occurs_in(GO:0043025) occurs_in:(CL:0002608) activated_by:(CHEBI:39124) part_of:(GO:0071277)\|occurs_in(GO:0030424) occurs_in:(CL:0002608) activated_by:(CHEBI:15866) part_of:(GO:0071333)\|occurs_in(GO:0030425) occurs_in:(CL:0002608) activated_by:(CHEBI:15866) part_of:(GO:0071333)\|occurs_in(GO:0043025) occurs_in:(CL:0002608) activated_by:(CHEBI:15866) part_of:(GO:0071333)	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:25788287^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q5EG47	C	part_of:(CL:0002608)	Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:25788287^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q5EG47	C	part_of:(CL:0002608)	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:25788287^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q5EG47	C	part_of:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0062028	regulation of stress granule assembly	PMID:27430620^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q5EG47	P	part_of:(GO:0034599)	Seeded From UniProt	complete
part_of	GO:0010494	cytoplasmic stress granule	PMID:27430620^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0034599)	Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	PMID:27430620^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q5EG47	P	positively_regulates:(GO:0034063)	Seeded From UniProt	complete
enables	GO:0004679	AMP-activated protein kinase activity	PMID:27430620^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q5EG47	F	part_of:(GO:0034599) positively_regulates:(GO:0034063) has_input:(UniProtKB:Q5SWU9)\|part_of(GO:0034599) positively_regulates:(GO:0034063) has_input:(UniProtKB:Q6ZWX6)\|part_of(GO:0034599) regulates:(GO:0034613)	Seeded From UniProt	complete
involved_in	GO:0070507	regulation of microtubule cytoskeleton organization	PMID:27430620^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q5EG47	P	part_of:(GO:0034599)	Seeded From UniProt	complete
involved_in	GO:1904428	negative regulation of tubulin deacetylation	PMID:27430620^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q5EG47	P	part_of:(GO:0034599) has_regulation_target:(UniProtKB:Q9Z2V5)	Seeded From UniProt	complete
involved_in	GO:2000758	positive regulation of peptidyl-lysine acetylation	PMID:27430620^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q5EG47	P	part_of:(GO:0034599) has_regulation_target:(UniProtKB:P68369)	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:27430620^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q5EG47	P	part_of:(GO:0034599) positively_regulates:(GO:0034063) regulates_expression_of:(ENSEMBL:ENSMUSG00000045983)\|part_of(GO:0034599) positively_regulates:(GO:0034063) regulates_expression_of:(ENSEMBL:ENSMUSG00000028156)\|part_of(GO:0034599) regulates_expression_of:(ENSEMBL:ENSMUSG00000031161)	Seeded From UniProt	complete
involved_in	GO:1903829	positive regulation of cellular protein localization	PMID:27430620^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q5EG47	P	part_of:(GO:0034599) has_regulation_target:(UniProtKB:P70335)	Seeded From UniProt	complete
involved_in	GO:0042149	cellular response to glucose starvation	PMID:23332761^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016241	regulation of macroautophagy	PMID:23332761^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:23332761^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097009	energy homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q09137	P		Seeded From UniProt	complete
involved_in	GO:0055089	fatty acid homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q09137	P		Seeded From UniProt	complete
involved_in	GO:0045821	positive regulation of glycolytic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q09137	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:18439900^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042752	regulation of circadian rhythm	PMID:19833968^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	PMID:16308421^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042149	cellular response to glucose starvation	PMID:21258367^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0035174	histone serine kinase activity	PMID:20647423^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032007	negative regulation of TOR signaling	PMID:18439900^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031669	cellular response to nutrient levels	PMID:21258367^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010508	positive regulation of autophagy	PMID:21258367^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008610	lipid biosynthetic process	PMID:21459323^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004679	AMP-activated protein kinase activity	PMID:16308421^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004679	AMP-activated protein kinase activity	PMID:21459323^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004679	AMP-activated protein kinase activity	PMID:21258367^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004679	AMP-activated protein kinase activity	PMID:18439900^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004679	AMP-activated protein kinase activity	PMID:19833968^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:16308421^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:20647423^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0042149	cellular response to glucose starvation	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1336173 MGI:MGI:2145955 PANTHER:PTN001217363	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104754 MGI:MGI:2445031 PANTHER:PTN000678822 UniProtKB:P57059 UniProtKB:Q9H0K1 UniProtKB:Q9IA88	P		Seeded From UniProt	complete
involved_in	GO:0032007	negative regulation of TOR signaling	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1336173 MGI:MGI:2145955 PANTHER:PTN001217363	P		Seeded From UniProt	complete
part_of	GO:0031588	nucleotide-activated protein kinase complex	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001217363 RGD:3387 RGD:620893	C		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023169 FB:FBgn0261278 MGI:MGI:104754 MGI:MGI:1202065 MGI:MGI:1336173 MGI:MGI:1347352 MGI:MGI:1351488 MGI:MGI:1923020 MGI:MGI:2445031 MGI:MGI:3037705 PANTHER:PTN000678822 RGD:1359167 RGD:3387 RGD:620545 RGD:620893 RGD:69407 RGD:69653 SGD:S000000931 SGD:S000001531 SGD:S000001584 SGD:S000002529 SGD:S000002885 SGD:S000004086 SGD:S000005127 TAIR:locus:2094672 UniProtKB:O60285 UniProtKB:P57059 UniProtKB:Q13131 UniProtKB:Q6SA08 UniProtKB:Q8IWQ3 UniProtKB:Q8IY84 UniProtKB:Q8TDC3 UniProtKB:Q9BXA6 UniProtKB:Q9BXA7 UniProtKB:Q9H093 UniProtKB:Q9H0K1 UniProtKB:Q9IA88 UniProtKB:Q9NRH2	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104754 MGI:MGI:106924 MGI:MGI:1347559 MGI:MGI:2145955 MGI:MGI:2445031 PANTHER:PTN000678822 PomBase:SPAC23H4.02 PomBase:SPBC32C12.03c PomBase:SPCC297.03 PomBase:SPCC74.03c RGD:3387 RGD:620893 SGD:S000000601 SGD:S000000931 SGD:S000001124 SGD:S000001651 SGD:S000002885 SGD:S000003820 SGD:S000005127 SGD:S000006062 TAIR:locus:2009812 TAIR:locus:2032075 TAIR:locus:2140104 TAIR:locus:2174999 UniProtKB:O14757 UniProtKB:O60285 UniProtKB:P57059 UniProtKB:Q39192 UniProtKB:Q57YE4 UniProtKB:Q7XQP4 UniProtKB:Q8I3C7 UniProtKB:Q8IWQ3 UniProtKB:Q8TDC3 UniProtKB:Q940H6 UniProtKB:Q9IA88 WB:WBGene00002210 WB:WBGene00003919 WB:WBGene00020142 WB:WBGene00021012	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023169 FB:FBgn0261278 MGI:MGI:104754 MGI:MGI:1202065 MGI:MGI:1336173 MGI:MGI:2145955 MGI:MGI:2445031 PANTHER:PTN000678822 PomBase:SPAC23H4.02 PomBase:SPBC19C2.05 PomBase:SPCC74.03c RGD:69407 RGD:69653 SGD:S000001124 SGD:S000002885 SGD:S000003820 SGD:S000005947 TAIR:locus:2009812 TAIR:locus:2032075 TAIR:locus:2140104 TAIR:locus:2159597 TAIR:locus:2160559 TAIR:locus:2174999 UniProtKB:O14757 UniProtKB:O60285 UniProtKB:P43291 UniProtKB:P57059 UniProtKB:Q39192 UniProtKB:Q5N942 UniProtKB:Q7XQP4 UniProtKB:Q8TDC3 UniProtKB:Q940H6 WB:WBGene00002210	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0025625 MGI:MGI:104754 MGI:MGI:106924 MGI:MGI:1336173 MGI:MGI:1347559 MGI:MGI:1923020 MGI:MGI:2445031 MGI:MGI:2685946 PANTHER:PTN000678822 PomBase:SPAC57A10.02 PomBase:SPAC644.06c PomBase:SPBC19C2.05 PomBase:SPBC4F6.06 PomBase:SPCC1020.10 PomBase:SPCC297.03 PomBase:SPCC74.03c RGD:1359167 RGD:1563268 RGD:1566256 RGD:3387 RGD:620893 RGD:69407 RGD:69653 SGD:S000000931 SGD:S000001531 SGD:S000001584 SGD:S000002529 SGD:S000002885 SGD:S000004086 SGD:S000005127 SGD:S000005759 TAIR:locus:2009812 TAIR:locus:2094672 TAIR:locus:2102132 UniProtKB:O14757 UniProtKB:O60285 UniProtKB:P57059 UniProtKB:Q14680 UniProtKB:Q6SA08 UniProtKB:Q8IWQ3 UniProtKB:Q8IY84 UniProtKB:Q8TDC3 UniProtKB:Q96PF2 UniProtKB:Q9BXA6 UniProtKB:Q9BXA7 UniProtKB:Q9H093 UniProtKB:Q9H0K1 UniProtKB:Q9IA88 UniProtKB:Q9NRH2 UniProtKB:Q9STV4 WB:WBGene00003919	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:20701589^[12]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:19740738^[13]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:19531644^[14]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019216	regulation of lipid metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620893	P		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P54646	C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620893	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014850	response to muscle activity	PMID:23918774^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2448467	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014823	response to activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620893	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010468	regulation of gene expression	PMID:23918774^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2448467	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620893	P		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P54646	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620893	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10098881^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620893	F		Seeded From UniProt	complete
enables	GO:0004712	protein serine/threonine/tyrosine kinase activity	PMID:22797923^[17]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P54646	F		Seeded From UniProt	complete
enables	GO:0004679	AMP-activated protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P54646	F		Seeded From UniProt	complete
enables	GO:0004679	AMP-activated protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620893	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620893	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620893	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097009	energy homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620893	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071380	cellular response to prostaglandin E stimulus	PMID:23479225^[18]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2145955	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071333	cellular response to glucose stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620893	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071277	cellular response to calcium ion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620893	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0055089	fatty acid homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620893	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051291	protein heterooligomerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620893	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045821	positive regulation of glycolytic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620893	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620893	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035690	cellular response to drug	PMID:23918774^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2448467	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620893	C		Seeded From UniProt	complete
part_of	GO:0031588	nucleotide-activated protein kinase complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620893	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031000	response to caffeine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620893	P		Seeded From UniProt	complete
enables	GO:0030674	protein binding, bridging	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620893	F		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620893	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620893	C		Seeded From UniProt	complete
involved_in	GO:0035404	histone-serine phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0035174	P		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54646 ensembl:ENSP00000360290	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54646 ensembl:ENSP00000360290	C		Seeded From UniProt	complete
enables	GO:0004712	protein serine/threonine/tyrosine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54646 ensembl:ENSP00000360290	F		Seeded From UniProt	complete
enables	GO:0004679	AMP-activated protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54646 ensembl:ENSP00000360290	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P		Seeded From UniProt	complete
enables	GO:0047322	[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.31	F		Seeded From UniProt	complete
enables	GO:0050405	[acetyl-CoA carboxylase] kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.27	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-MMU-1454711	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-MMU-1605475	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004679	AMP-activated protein kinase activity	PMID:10098881^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0072	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0006633	fatty acid biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0275	P		Seeded From UniProt	complete
involved_in	GO:0006695	cholesterol biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0152	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0008203	cholesterol metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0153	P		Seeded From UniProt	complete
involved_in	GO:0016126	sterol biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0756	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P		Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0006631	fatty acid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0276	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P		Seeded From UniProt	complete
involved_in	GO:0008202	steroid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0753	P		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P		Seeded From UniProt	complete
involved_in	GO:0006694	steroid biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0752	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Um, JH et al. (2011) AMPK regulates circadian rhythms in a tissue- and isoform-specific manner. PLoS ONE 6 e18450 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Sample, V et al. (2015) Polarized activities of AMPK and BRSK in primary hippocampal neurons. Mol. Biol. Cell 26 1935-46 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 Mahboubi, H et al. (2016) AMP Kinase Activation Alters Oxidant-Induced Stress Granule Assembly by Modulating Cell Signaling and Microtubule Organization. Mol. Pharmacol. 90 460-8 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Kim, J et al. (2013) Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Cell 152 290-303 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Gwinn, DM et al. (2008) AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol. Cell 30 214-26 PubMed GONUTS page
↑ ^6.0 ^6.1 Lamia, KA et al. (2009) AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. Science 326 437-40 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Shaw, RJ et al. (2005) The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 310 1642-6 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Kim, J et al. (2011) AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat. Cell Biol. 13 132-41 PubMed GONUTS page
↑ ^9.0 ^9.1 Bungard, D et al. (2010) Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation. Science 329 1201-5 PubMed GONUTS page
↑ ^10.0 ^10.1 Li, Y et al. (2011) AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab. 13 376-88 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Vichaiwong, K et al. (2010) Contraction regulates site-specific phosphorylation of TBC1D1 in skeletal muscle. Biochem. J. 431 311-20 PubMed GONUTS page
↑ Peck, GR et al. (2009) Insulin-stimulated phosphorylation of the Rab GTPase-activating protein TBC1D1 regulates GLUT4 translocation. J. Biol. Chem. 284 30016-23 PubMed GONUTS page
↑ Pehmøller, C et al. (2009) Genetic disruption of AMPK signaling abolishes both contraction- and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 297 E665-75 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Brandauer, J et al. (2013) AMP-activated protein kinase regulates nicotinamide phosphoribosyl transferase expression in skeletal muscle. J. Physiol. (Lond.) 591 5207-20 PubMed GONUTS page
↑ ^16.0 ^16.1 Turnley, AM et al. (1999) Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system. J. Neurochem. 72 1707-16 PubMed GONUTS page
↑ Hoxhaj, G et al. (2012) ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase. J. Cell. Sci. 125 4662-75 PubMed GONUTS page
↑ Través, PG et al. (2013) Selective impairment of P2Y signaling by prostaglandin E2 in macrophages: implications for Ca2+-dependent responses. J. Immunol. 190 4226-35 PubMed GONUTS page

[PMID:21483791-1] 1.0 ^1.1 Um, JH et al. (2011) AMPK regulates circadian rhythms in a tissue- and isoform-specific manner. PLoS ONE 6 e18450 PubMed GONUTS page

[PMID:25788287-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Sample, V et al. (2015) Polarized activities of AMPK and BRSK in primary hippocampal neurons. Mol. Biol. Cell 26 1935-46 PubMed GONUTS page

[PMID:27430620-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 Mahboubi, H et al. (2016) AMP Kinase Activation Alters Oxidant-Induced Stress Granule Assembly by Modulating Cell Signaling and Microtubule Organization. Mol. Pharmacol. 90 460-8 PubMed GONUTS page

[PMID:23332761-4] 4.0 ^4.1 ^4.2 Kim, J et al. (2013) Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Cell 152 290-303 PubMed GONUTS page

[PMID:18439900-5] 5.0 ^5.1 ^5.2 Gwinn, DM et al. (2008) AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol. Cell 30 214-26 PubMed GONUTS page

[PMID:19833968-6] 6.0 ^6.1 Lamia, KA et al. (2009) AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. Science 326 437-40 PubMed GONUTS page

[PMID:16308421-7] 7.0 ^7.1 ^7.2 Shaw, RJ et al. (2005) The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 310 1642-6 PubMed GONUTS page

[PMID:21258367-8] 8.0 ^8.1 ^8.2 ^8.3 Kim, J et al. (2011) AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat. Cell Biol. 13 132-41 PubMed GONUTS page

[PMID:20647423-9] 9.0 ^9.1 Bungard, D et al. (2010) Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation. Science 329 1201-5 PubMed GONUTS page

[PMID:21459323-10] 10.0 ^10.1 Li, Y et al. (2011) AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab. 13 376-88 PubMed GONUTS page

[PMID:21873635-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:20701589-12] Vichaiwong, K et al. (2010) Contraction regulates site-specific phosphorylation of TBC1D1 in skeletal muscle. Biochem. J. 431 311-20 PubMed GONUTS page

[PMID:19740738-13] Peck, GR et al. (2009) Insulin-stimulated phosphorylation of the Rab GTPase-activating protein TBC1D1 regulates GLUT4 translocation. J. Biol. Chem. 284 30016-23 PubMed GONUTS page

[PMID:19531644-14] Pehmøller, C et al. (2009) Genetic disruption of AMPK signaling abolishes both contraction- and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 297 E665-75 PubMed GONUTS page

[PMID:23918774-15] 15.0 ^15.1 ^15.2 Brandauer, J et al. (2013) AMP-activated protein kinase regulates nicotinamide phosphoribosyl transferase expression in skeletal muscle. J. Physiol. (Lond.) 591 5207-20 PubMed GONUTS page

[PMID:10098881-16] 16.0 ^16.1 Turnley, AM et al. (1999) Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system. J. Neurochem. 72 1707-16 PubMed GONUTS page

[PMID:22797923-17] Hoxhaj, G et al. (2012) ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase. J. Cell. Sci. 125 4662-75 PubMed GONUTS page

[PMID:23479225-18] Través, PG et al. (2013) Selective impairment of P2Y signaling by prostaglandin E2 in macrophages: implications for Ca2+-dependent responses. J. Immunol. 190 4226-35 PubMed GONUTS page

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MOUSE:AAPK2

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