PMID:21483791

Citation	Um, JH, Pendergast, JS, Springer, DA, Foretz, M, Viollet, B, Brown, A, Kim, MK, Yamazaki, S and Chung, JH (2011) AMPK regulates circadian rhythms in a tissue- and isoform-specific manner. PLoS ONE 6:e18450
Abstract	AMP protein kinase (AMPK) plays an important role in food intake and energy metabolism, which are synchronized to the light-dark cycle. In vitro, AMPK affects the circadian rhythm by regulating at least two clock components, CKIα and CRY1, via direct phosphorylation. However, it is not known whether the catalytic activity of AMPK actually regulates circadian rhythm in vivo.
Links	PubMed PMC3069094 Online version:10.1371/journal.pone.0018450
Keywords	AMP-Activated Protein Kinases/genetics; AMP-Activated Protein Kinases/metabolism; Animals; Body Temperature; Body Weight/genetics; Body Weight/physiology; Calorimetry, Indirect; Circadian Rhythm/genetics; Circadian Rhythm/physiology; Eating/genetics; Eating/physiology; Immunoblotting; Isoenzymes/genetics; Isoenzymes/metabolism; Male; Mice; Mice, Knockout; Mice, Mutant Strains; Muscle, Skeletal/metabolism; Myocardium/metabolism; Polymerase Chain Reaction
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
MOUSE:AAPK2		GO:0032922: circadian regulation of gene expression	ECO:0000315:		P		Fig. 5B The cyclic expression pattern of the core clock genes were significantly blunted in AMPKα2−/− mice. The cyclic expression pattern of PGC-1α was disrupted in the heart and skeletal muscle of AMPKα2−/− mice. The cyclic expression pattern of leptin was disrupted in the fat of AMPKα2−/− mice.	complete
MOUSE:AAPK2		GO:0060259: regulation of feeding behavior	ECO:0000315:		P		Fig 3D AMPKα2−/− mice ate more food during the light phase than their wild-type littermates (21.8% vs. 28%), indicating that AMPK-deficient mice have blunted feeding rhythm.	complete
MOUSE:AAPK1		GO:0032922: circadian regulation of gene expression	ECO:0000315:		P		Fig.5 A The cyclic expression pattern of clock genes was blunted in AMPKα1−/− fat. The cyclic expression pattern of PGC-1α was disrupted in the heart and skeletal muscle of AMPKα1−/− mice. The cyclic expression pattern of leptin was disrupted in the fat of AMPKα1−/− mice.	complete
MOUSE:AAPK1		GO:0060086: circadian temperature homeostasis	ECO:0000315:		P		Fig. 4A,C,D,E AMPKα1−/− mice had significantly dampened circadian rhythm of core temperature compared to WT mice.	complete
MOUSE:AAPK1		GO:0045475: locomotor rhythm	ECO:0000315:		P		Fig 3A In the absence of light entrainment, the free running locomotor period of AMPKα1−/− mice was shorter than that of AMPKα1+/+ littermates (23.2 hr vs. 23.7 hr, P = 0.0003).	complete
MOUSE:AAPK1		GO:0060259: regulation of feeding behavior	ECO:0000315:		P		Fig 3C. AMPKα1−/− mice ate more food during the light phase than their wild-type littermates (20.6% vs. 25.1%), indicating that AMPK-deficient mice have blunted feeding rhythm.	complete

References

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