MOUSE:AAPK1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Prkaa1
Protein Name(s)	5'-AMP-activated protein kinase catalytic subunit alpha-1 AMPK subunit alpha-1 Acetyl-CoA carboxylase kinase ACACA kinase Hydroxymethylglutaryl-CoA reductase kinase HMGCR kinase Tau-protein kinase PRKAA1
External Links
UniProt	Q5EG47
EMBL	AC131919 AC135079 AY885266
CCDS	CCDS49574.1
RefSeq	NP_001013385.3
UniGene	Mm.207004
ProteinModelPortal	Q5EG47
SMR	Q5EG47
BioGrid	222923
IntAct	Q5EG47
ChEMBL	CHEMBL1075161
PhosphoSite	Q5EG47
MaxQB	Q5EG47
PaxDb	Q5EG47
PRIDE	Q5EG47
Ensembl	ENSMUST00000051186
GeneID	105787
KEGG	mmu:105787
UCSC	uc007vct.1
CTD	5562
MGI	MGI:2145955
eggNOG	COG0515
GeneTree	ENSGT00760000118892
HOGENOM	HOG000233016
HOVERGEN	HBG050432
InParanoid	Q5EG47
KO	K07198
OMA	MKRATIR
OrthoDB	EOG7RRF6K
PhylomeDB	Q5EG47
TreeFam	TF314032
Reactome	REACT_220701 REACT_257725
NextBio	357894
PRO	PR:Q5EG47
Proteomes	UP000000589
Bgee	Q5EG47
ExpressionAtlas	Q5EG47
Genevestigator	Q5EG47
GO	GO:0031588 GO:0016324 GO:0005737 GO:0005634 GO:0050405 GO:0047322 GO:0004679 GO:0005524 GO:0003682 GO:0035174 GO:0046872 GO:0050321 GO:0000187 GO:0006914 GO:0071361 GO:0042149 GO:0070301 GO:0071456 GO:0031669 GO:0071417 GO:0006695 GO:0009631 GO:0006633 GO:0055089 GO:0019395 GO:0042593 GO:0006006 GO:0035404 GO:0008610 GO:0043066 GO:2001274 GO:0050995 GO:0032007 GO:0010508 GO:0008284 GO:0010628 GO:0045821 GO:0051291 GO:0042752 GO:2000505 GO:0006355 GO:0060627 GO:0014823 GO:0031000 GO:1901563 GO:0010332 GO:0042542 GO:0009411 GO:0048511 GO:0006351 GO:0016055
InterPro	IPR028375 IPR011009 IPR028797 IPR000719 IPR017441 IPR002290 IPR008271
PANTHER	PTHR24343:SF81
Pfam	PF00069
SMART	SM00220
SUPFAM	SSF103243 SSF56112
PROSITE	PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0032922	circadian regulation of gene expression	PMID:21483791^[1]	ECO:0000315			P		Fig.5 A The cyclic expression pattern of clock genes was blunted in AMPKα1−/− fat. The cyclic expression pattern of PGC-1α was disrupted in the heart and skeletal muscle of AMPKα1−/− mice. The cyclic expression pattern of leptin was disrupted in the fat of AMPKα1−/− mice.	complete
	GO:0060086	circadian temperature homeostasis	PMID:21483791^[1]	ECO:0000315			P		Fig. 4A,C,D,E AMPKα1−/− mice had significantly dampened circadian rhythm of core temperature compared to WT mice.	complete
	GO:0045475	locomotor rhythm	PMID:21483791^[1]	ECO:0000315			P		Fig 3A In the absence of light entrainment, the free running locomotor period of AMPKα1−/− mice was shorter than that of AMPKα1+/+ littermates (23.2 hr vs. 23.7 hr, P = 0.0003).	complete
	GO:0060259	regulation of feeding behavior	PMID:21483791^[1]	ECO:0000315			P		Fig 3C. AMPKα1−/− mice ate more food during the light phase than their wild-type littermates (20.6% vs. 25.1%), indicating that AMPK-deficient mice have blunted feeding rhythm.	complete
part_of	GO:0005737	cytoplasm	PMID:21768291^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0002435)	Seeded From UniProt	complete
involved_in	GO:0071333	cellular response to glucose stimulus	PMID:25788287^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q8BRK8	P	occurs_in:(GO:0030424) occurs_in:(CL:0002608)\|occurs_in:(GO:0030425) occurs_in:(CL:0002608)\|occurs_in:(GO:0043025) occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0071277	cellular response to calcium ion	PMID:25788287^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q8BRK8	P	occurs_in:(GO:0030424) occurs_in:(CL:0002608)\|occurs_in:(GO:0030425) occurs_in:(CL:0002608)\|occurs_in:(GO:0043025) occurs_in:(CL:0002608)	Seeded From UniProt	complete
enables	GO:0004679	AMP-activated protein kinase activity	PMID:25788287^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q8BRK8	F	occurs_in:(GO:0030424) occurs_in:(CL:0002608) activated_by:(CHEBI:39124) part_of:(GO:0071277)\|occurs_in(GO:0030425) occurs_in:(CL:0002608) activated_by:(CHEBI:39124) part_of:(GO:0071277)\|occurs_in(GO:0043025) occurs_in:(CL:0002608) activated_by:(CHEBI:39124) part_of:(GO:0071277)\|occurs_in(GO:0030424) occurs_in:(CL:0002608) activated_by:(CHEBI:15866) part_of:(GO:0071333)\|occurs_in(GO:0030425) occurs_in:(CL:0002608) activated_by:(CHEBI:15866) part_of:(GO:0071333)\|occurs_in(GO:0043025) occurs_in:(CL:0002608) activated_by:(CHEBI:15866) part_of:(GO:0071333)	Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:25788287^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q8BRK8	C	part_of:(CL:0002608)	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:25788287^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q8BRK8	C	part_of:(CL:0002608)	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:25788287^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q8BRK8	C	part_of:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0062028	regulation of stress granule assembly	PMID:27430620^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q8BRK8	P	part_of:(GO:0034599)	Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	PMID:27430620^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q8BRK8	P	positively_regulates:(GO:0034063)	Seeded From UniProt	complete
enables	GO:0004679	AMP-activated protein kinase activity	PMID:27430620^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q8BRK8	F	part_of:(GO:0034599) positively_regulates:(GO:0034063) has_input:(UniProtKB:Q5SWU9)\|part_of(GO:0034599) positively_regulates:(GO:0034063) has_input:(UniProtKB:Q6ZWX6)\|part_of(GO:0034599) regulates:(GO:0034613)	Seeded From UniProt	complete
involved_in	GO:0070507	regulation of microtubule cytoskeleton organization	PMID:27430620^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q8BRK8	P	part_of:(GO:0034599)	Seeded From UniProt	complete
involved_in	GO:1904428	negative regulation of tubulin deacetylation	PMID:27430620^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q8BRK8	P	part_of:(GO:0034599) has_regulation_target:(UniProtKB:Q9Z2V5)	Seeded From UniProt	complete
involved_in	GO:2000758	positive regulation of peptidyl-lysine acetylation	PMID:27430620^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q8BRK8	P	part_of:(GO:0034599) has_regulation_target:(UniProtKB:P68369)	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:27430620^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q8BRK8	P	part_of:(GO:0034599) positively_regulates:(GO:0034063) regulates_expression_of:(ENSEMBL:ENSMUSG00000045983)\|part_of(GO:0034599) positively_regulates:(GO:0034063) regulates_expression_of:(ENSEMBL:ENSMUSG00000028156)\|part_of(GO:0034599) regulates_expression_of:(ENSEMBL:ENSMUSG00000031161)	Seeded From UniProt	complete
involved_in	GO:1903829	positive regulation of cellular protein localization	PMID:27430620^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q8BRK8	P	part_of:(GO:0034599) has_regulation_target:(UniProtKB:P70335)	Seeded From UniProt	complete
involved_in	GO:1903109	positive regulation of mitochondrial transcription	PMID:23283301^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0042149)	Seeded From UniProt	complete
involved_in	GO:1903955	positive regulation of protein targeting to mitochondrion	PMID:23283301^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q9WVH4) happens_during:(GO:0042149)	Seeded From UniProt	complete
involved_in	GO:0097009	energy homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P54645	P		Seeded From UniProt	complete
involved_in	GO:1901563	response to camptothecin	PMID:20647423^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0055089	fatty acid homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P54645	P		Seeded From UniProt	complete
involved_in	GO:0050995	negative regulation of lipid catabolic process	PMID:15878856^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045821	positive regulation of glycolytic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P54645	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:18439900^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042752	regulation of circadian rhythm	PMID:19833968^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	PMID:16308421^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042542	response to hydrogen peroxide	PMID:20647423^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042149	cellular response to glucose starvation	PMID:21258367^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0035174	histone serine kinase activity	PMID:20647423^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032007	negative regulation of TOR signaling	PMID:18439900^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031669	cellular response to nutrient levels	PMID:21258367^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031588	nucleotide-activated protein kinase complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P54645	C		Seeded From UniProt	complete
involved_in	GO:0010508	positive regulation of autophagy	PMID:21258367^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010332	response to gamma radiation	PMID:20647423^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009411	response to UV	PMID:20647423^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008610	lipid biosynthetic process	PMID:21459323^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19833968^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004679	AMP-activated protein kinase activity	PMID:16308421^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004679	AMP-activated protein kinase activity	PMID:21459323^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004679	AMP-activated protein kinase activity	PMID:21258367^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004679	AMP-activated protein kinase activity	PMID:19833968^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004679	AMP-activated protein kinase activity	PMID:15878856^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004679	AMP-activated protein kinase activity	PMID:18439900^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:20647423^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0042149	cellular response to glucose starvation	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1336173 MGI:MGI:2145955 PANTHER:PTN001217363	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104754 MGI:MGI:2445031 PANTHER:PTN000678822 UniProtKB:P57059 UniProtKB:Q9H0K1 UniProtKB:Q9IA88	P		Seeded From UniProt	complete
involved_in	GO:0032007	negative regulation of TOR signaling	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1336173 MGI:MGI:2145955 PANTHER:PTN001217363	P		Seeded From UniProt	complete
part_of	GO:0031588	nucleotide-activated protein kinase complex	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001217363 RGD:3387 RGD:620893	C		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023169 FB:FBgn0261278 MGI:MGI:104754 MGI:MGI:1202065 MGI:MGI:1336173 MGI:MGI:1347352 MGI:MGI:1351488 MGI:MGI:1923020 MGI:MGI:2445031 MGI:MGI:3037705 PANTHER:PTN000678822 RGD:1359167 RGD:3387 RGD:620545 RGD:620893 RGD:69407 RGD:69653 SGD:S000000931 SGD:S000001531 SGD:S000001584 SGD:S000002529 SGD:S000002885 SGD:S000004086 SGD:S000005127 TAIR:locus:2094672 UniProtKB:O60285 UniProtKB:P57059 UniProtKB:Q13131 UniProtKB:Q6SA08 UniProtKB:Q8IWQ3 UniProtKB:Q8IY84 UniProtKB:Q8TDC3 UniProtKB:Q9BXA6 UniProtKB:Q9BXA7 UniProtKB:Q9H093 UniProtKB:Q9H0K1 UniProtKB:Q9IA88 UniProtKB:Q9NRH2	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104754 MGI:MGI:106924 MGI:MGI:1347559 MGI:MGI:2145955 MGI:MGI:2445031 PANTHER:PTN000678822 PomBase:SPAC23H4.02 PomBase:SPBC32C12.03c PomBase:SPCC297.03 PomBase:SPCC74.03c RGD:3387 RGD:620893 SGD:S000000601 SGD:S000000931 SGD:S000001124 SGD:S000001651 SGD:S000002885 SGD:S000003820 SGD:S000005127 SGD:S000006062 TAIR:locus:2009812 TAIR:locus:2032075 TAIR:locus:2140104 TAIR:locus:2174999 UniProtKB:O14757 UniProtKB:O60285 UniProtKB:P57059 UniProtKB:Q39192 UniProtKB:Q57YE4 UniProtKB:Q7XQP4 UniProtKB:Q8I3C7 UniProtKB:Q8IWQ3 UniProtKB:Q8TDC3 UniProtKB:Q940H6 UniProtKB:Q9IA88 WB:WBGene00002210 WB:WBGene00003919 WB:WBGene00020142 WB:WBGene00021012	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023169 FB:FBgn0261278 MGI:MGI:104754 MGI:MGI:1202065 MGI:MGI:1336173 MGI:MGI:2145955 MGI:MGI:2445031 PANTHER:PTN000678822 PomBase:SPAC23H4.02 PomBase:SPBC19C2.05 PomBase:SPCC74.03c RGD:69407 RGD:69653 SGD:S000001124 SGD:S000002885 SGD:S000003820 SGD:S000005947 TAIR:locus:2009812 TAIR:locus:2032075 TAIR:locus:2140104 TAIR:locus:2159597 TAIR:locus:2160559 TAIR:locus:2174999 UniProtKB:O14757 UniProtKB:O60285 UniProtKB:P43291 UniProtKB:P57059 UniProtKB:Q39192 UniProtKB:Q5N942 UniProtKB:Q7XQP4 UniProtKB:Q8TDC3 UniProtKB:Q940H6 WB:WBGene00002210	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0025625 MGI:MGI:104754 MGI:MGI:106924 MGI:MGI:1336173 MGI:MGI:1347559 MGI:MGI:1923020 MGI:MGI:2445031 MGI:MGI:2685946 PANTHER:PTN000678822 PomBase:SPAC57A10.02 PomBase:SPAC644.06c PomBase:SPBC19C2.05 PomBase:SPBC4F6.06 PomBase:SPCC1020.10 PomBase:SPCC297.03 PomBase:SPCC74.03c RGD:1359167 RGD:1563268 RGD:1566256 RGD:3387 RGD:620893 RGD:69407 RGD:69653 SGD:S000000931 SGD:S000001531 SGD:S000001584 SGD:S000002529 SGD:S000002885 SGD:S000004086 SGD:S000005127 SGD:S000005759 TAIR:locus:2009812 TAIR:locus:2094672 TAIR:locus:2102132 UniProtKB:O14757 UniProtKB:O60285 UniProtKB:P57059 UniProtKB:Q14680 UniProtKB:Q6SA08 UniProtKB:Q8IWQ3 UniProtKB:Q8IY84 UniProtKB:Q8TDC3 UniProtKB:Q96PF2 UniProtKB:Q9BXA6 UniProtKB:Q9BXA7 UniProtKB:Q9H093 UniProtKB:Q9H0K1 UniProtKB:Q9IA88 UniProtKB:Q9NRH2 UniProtKB:Q9STV4 WB:WBGene00003919	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097009	energy homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3387	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071380	cellular response to prostaglandin E stimulus	PMID:23479225^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1336173	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071333	cellular response to glucose stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3387	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071277	cellular response to calcium ion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3387	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070050	neuron cellular homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13131	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061762	CAMKK-AMPK signaling cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13131	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061744	motor behavior	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13131	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060627	regulation of vesicle-mediated transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3387	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0055089	fatty acid homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3387	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051291	protein heterooligomerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3387	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048643	positive regulation of skeletal muscle tissue development	PMID:23926128^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3029359	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046627	negative regulation of insulin receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3387	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045821	positive regulation of glycolytic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3387	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3387	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033135	regulation of peptidyl-serine phosphorylation	PMID:23926128^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3029359	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3387	C		Seeded From UniProt	complete
part_of	GO:0031588	nucleotide-activated protein kinase complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3387	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031000	response to caffeine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3387	P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3387	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3387	C		Seeded From UniProt	complete
enables	GO:0019900	kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3387	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019395	fatty acid oxidation	PMID:12802337^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13131	C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3387	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014823	response to activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3387	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	PMID:23926128^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3029359	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13131	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010508	positive regulation of autophagy	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13131	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009631	cold acclimation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3387	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3387	P		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3387	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13131	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3387	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006006	glucose metabolic process	PMID:12802337^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13131	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:18381428^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13131	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3387	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3387	F		Seeded From UniProt	complete
enables	GO:0004679	AMP-activated protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13131	F		Seeded From UniProt	complete
enables	GO:0004679	AMP-activated protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3387	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3387	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13131	F		Seeded From UniProt	complete
involved_in	GO:0035404	histone-serine phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0035174	P		Seeded From UniProt	complete
involved_in	GO:0097009	energy homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54645 ensembl:ENSRNOP00000017626	P		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54645 ensembl:ENSRNOP00000017626	P		Seeded From UniProt	complete
involved_in	GO:0071417	cellular response to organonitrogen compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54645 ensembl:ENSRNOP00000017626	P		Seeded From UniProt	complete
involved_in	GO:0071361	cellular response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54645 ensembl:ENSRNOP00000017626	P		Seeded From UniProt	complete
involved_in	GO:0071333	cellular response to glucose stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54645 ensembl:ENSRNOP00000017626	P		Seeded From UniProt	complete
involved_in	GO:0071277	cellular response to calcium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54645 ensembl:ENSRNOP00000017626	P		Seeded From UniProt	complete
involved_in	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54645 ensembl:ENSRNOP00000017626	P		Seeded From UniProt	complete
involved_in	GO:0060627	regulation of vesicle-mediated transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54645 ensembl:ENSRNOP00000017626	P		Seeded From UniProt	complete
involved_in	GO:0055089	fatty acid homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54645 ensembl:ENSRNOP00000017626	P		Seeded From UniProt	complete
involved_in	GO:0051291	protein heterooligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54645 ensembl:ENSRNOP00000017626	P		Seeded From UniProt	complete
involved_in	GO:0046627	negative regulation of insulin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54645 ensembl:ENSRNOP00000017626	P		Seeded From UniProt	complete
involved_in	GO:0045821	positive regulation of glycolytic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54645 ensembl:ENSRNOP00000017626	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54645 ensembl:ENSRNOP00000017626	C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54645 ensembl:ENSRNOP00000017626	C		Seeded From UniProt	complete
part_of	GO:0031588	nucleotide-activated protein kinase complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54645 ensembl:ENSRNOP00000017626	C		Seeded From UniProt	complete
involved_in	GO:0031000	response to caffeine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54645 ensembl:ENSRNOP00000017626	P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54645 ensembl:ENSRNOP00000017626	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54645 ensembl:ENSRNOP00000017626	C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54645 ensembl:ENSRNOP00000017626	C		Seeded From UniProt	complete
involved_in	GO:0014823	response to activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54645 ensembl:ENSRNOP00000017626	P		Seeded From UniProt	complete
involved_in	GO:0009631	cold acclimation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54645 ensembl:ENSRNOP00000017626	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54645 ensembl:ENSRNOP00000017626	P		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54645 ensembl:ENSRNOP00000017626	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54645 ensembl:ENSRNOP00000017626	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54645 ensembl:ENSRNOP00000017626	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54645 ensembl:ENSRNOP00000017626	F		Seeded From UniProt	complete
enables	GO:0004679	AMP-activated protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54645 ensembl:ENSRNOP00000017626	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54645 ensembl:ENSRNOP00000017626	F		Seeded From UniProt	complete
involved_in	GO:0070050	neuron cellular homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13131 ensembl:ENSP00000346148	P		Seeded From UniProt	complete
involved_in	GO:0061762	CAMKK-AMPK signaling cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13131 ensembl:ENSP00000346148	P		Seeded From UniProt	complete
involved_in	GO:0061744	motor behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13131 ensembl:ENSP00000346148	P		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13131 ensembl:ENSP00000346148	C		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13131 ensembl:ENSP00000346148	P		Seeded From UniProt	complete
involved_in	GO:0010508	positive regulation of autophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13131 ensembl:ENSP00000346148	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13131 ensembl:ENSP00000346148	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13131 ensembl:ENSP00000346148	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13131 ensembl:ENSP00000346148	C		Seeded From UniProt	complete
enables	GO:0004679	AMP-activated protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13131 ensembl:ENSP00000346148	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13131 ensembl:ENSP00000346148	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004679	AMP-activated protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039137	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P		Seeded From UniProt	complete
enables	GO:0050321	tau-protein kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.26	F		Seeded From UniProt	complete
enables	GO:0050405	[acetyl-CoA carboxylase] kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.27	F		Seeded From UniProt	complete
enables	GO:0047322	[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.31	F		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
involved_in	GO:0016126	sterol biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0756	P		Seeded From UniProt	complete
involved_in	GO:0006695	cholesterol biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0152	P		Seeded From UniProt	complete
involved_in	GO:0006694	steroid biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0752	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0008202	steroid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0753	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P		Seeded From UniProt	complete
involved_in	GO:0006633	fatty acid biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0275	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0006631	fatty acid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0276	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0072	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0008203	cholesterol metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0153	P		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Um, JH et al. (2011) AMPK regulates circadian rhythms in a tissue- and isoform-specific manner. PLoS ONE 6 e18450 PubMed GONUTS page
↑ Ju, TC et al. (2011) Nuclear translocation of AMPK-alpha1 potentiates striatal neurodegeneration in Huntington's disease. J. Cell Biol. 194 209-27 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Sample, V et al. (2015) Polarized activities of AMPK and BRSK in primary hippocampal neurons. Mol. Biol. Cell 26 1935-46 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Mahboubi, H et al. (2016) AMP Kinase Activation Alters Oxidant-Induced Stress Granule Assembly by Modulating Cell Signaling and Microtubule Organization. Mol. Pharmacol. 90 460-8 PubMed GONUTS page
↑ ^5.0 ^5.1 Peserico, A et al. (2013) A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels. Cell. Mol. Life Sci. 70 2015-29 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Bungard, D et al. (2010) Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation. Science 329 1201-5 PubMed GONUTS page
↑ ^7.0 ^7.1 Daval, M et al. (2005) Anti-lipolytic action of AMP-activated protein kinase in rodent adipocytes. J. Biol. Chem. 280 25250-7 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Gwinn, DM et al. (2008) AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol. Cell 30 214-26 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Lamia, KA et al. (2009) AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. Science 326 437-40 PubMed GONUTS page
↑ ^10.0 ^10.1 Shaw, RJ et al. (2005) The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 310 1642-6 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Kim, J et al. (2011) AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat. Cell Biol. 13 132-41 PubMed GONUTS page
↑ ^12.0 ^12.1 Li, Y et al. (2011) AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab. 13 376-88 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 ^13.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Través, PG et al. (2013) Selective impairment of P2Y signaling by prostaglandin E2 in macrophages: implications for Ca2+-dependent responses. J. Immunol. 190 4226-35 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Fu, X et al. (2013) AMP-activated protein kinase mediates myogenin expression and myogenesis via histone deacetylase 5. Am. J. Physiol., Cell Physiol. 305 C887-95 PubMed GONUTS page
↑ ^16.0 ^16.1 Yamauchi, T et al. (2003) Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 423 762-9 PubMed GONUTS page
↑ Pearson, HB et al. (2008) Lkb1 deficiency causes prostate neoplasia in the mouse. Cancer Res. 68 2223-32 PubMed GONUTS page

[PMID:21483791-1] 1.0 ^1.1 ^1.2 ^1.3 Um, JH et al. (2011) AMPK regulates circadian rhythms in a tissue- and isoform-specific manner. PLoS ONE 6 e18450 PubMed GONUTS page

[PMID:21768291-2] Ju, TC et al. (2011) Nuclear translocation of AMPK-alpha1 potentiates striatal neurodegeneration in Huntington's disease. J. Cell Biol. 194 209-27 PubMed GONUTS page

[PMID:25788287-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Sample, V et al. (2015) Polarized activities of AMPK and BRSK in primary hippocampal neurons. Mol. Biol. Cell 26 1935-46 PubMed GONUTS page

[PMID:27430620-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Mahboubi, H et al. (2016) AMP Kinase Activation Alters Oxidant-Induced Stress Granule Assembly by Modulating Cell Signaling and Microtubule Organization. Mol. Pharmacol. 90 460-8 PubMed GONUTS page

[PMID:23283301-5] 5.0 ^5.1 Peserico, A et al. (2013) A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels. Cell. Mol. Life Sci. 70 2015-29 PubMed GONUTS page

[PMID:20647423-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Bungard, D et al. (2010) Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation. Science 329 1201-5 PubMed GONUTS page

[PMID:15878856-7] 7.0 ^7.1 Daval, M et al. (2005) Anti-lipolytic action of AMP-activated protein kinase in rodent adipocytes. J. Biol. Chem. 280 25250-7 PubMed GONUTS page

[PMID:18439900-8] 8.0 ^8.1 ^8.2 Gwinn, DM et al. (2008) AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol. Cell 30 214-26 PubMed GONUTS page

[PMID:19833968-9] 9.0 ^9.1 ^9.2 Lamia, KA et al. (2009) AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. Science 326 437-40 PubMed GONUTS page

[PMID:16308421-10] 10.0 ^10.1 Shaw, RJ et al. (2005) The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 310 1642-6 PubMed GONUTS page

[PMID:21258367-11] 11.0 ^11.1 ^11.2 ^11.3 Kim, J et al. (2011) AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat. Cell Biol. 13 132-41 PubMed GONUTS page

[PMID:21459323-12] 12.0 ^12.1 Li, Y et al. (2011) AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab. 13 376-88 PubMed GONUTS page

[PMID:21873635-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 ^13.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23479225-14] Través, PG et al. (2013) Selective impairment of P2Y signaling by prostaglandin E2 in macrophages: implications for Ca2+-dependent responses. J. Immunol. 190 4226-35 PubMed GONUTS page

[PMID:23926128-15] 15.0 ^15.1 ^15.2 Fu, X et al. (2013) AMP-activated protein kinase mediates myogenin expression and myogenesis via histone deacetylase 5. Am. J. Physiol., Cell Physiol. 305 C887-95 PubMed GONUTS page

[PMID:12802337-16] 16.0 ^16.1 Yamauchi, T et al. (2003) Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 423 762-9 PubMed GONUTS page

[PMID:18381428-17] Pearson, HB et al. (2008) Lkb1 deficiency causes prostate neoplasia in the mouse. Cancer Res. 68 2223-32 PubMed GONUTS page

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