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HUMAN:ZN143
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | ZNF143 (synonyms: SBF, STAF) | |
| Protein Name(s) | Zinc finger protein 143
SPH-binding factor Selenocysteine tRNA gene transcription-activating factor hStaf | |
| External Links | ||
| UniProt | P52747 | |
| EMBL | AK291133 AK297214 AK313330 AC127030 AC132192 BC020219 U09850 AF071771 | |
| CCDS | CCDS60720.1 CCDS60721.1 CCDS7799.2 | |
| PIR | I38618 | |
| RefSeq | NP_001269585.1 NP_001269586.1 NP_003433.3 | |
| UniGene | Hs.523471 | |
| ProteinModelPortal | P52747 | |
| SMR | P52747 | |
| BioGrid | 113496 | |
| IntAct | P52747 | |
| STRING | 9606.ENSP00000379847 | |
| PhosphoSite | P52747 | |
| DMDM | 229462806 | |
| MaxQB | P52747 | |
| PaxDb | P52747 | |
| PRIDE | P52747 | |
| DNASU | 7702 | |
| Ensembl | ENST00000396597 ENST00000396602 ENST00000396604 ENST00000530463 | |
| GeneID | 7702 | |
| KEGG | hsa:7702 | |
| UCSC | uc001mhr.3 uc010rby.2 | |
| CTD | 7702 | |
| GeneCards | GC11P009483 | |
| HGNC | HGNC:12928 | |
| HPA | HPA003263 | |
| MIM | 603433 | |
| neXtProt | NX_P52747 | |
| PharmGKB | PA37515 | |
| eggNOG | COG5048 | |
| GeneTree | ENSGT00760000118771 | |
| HOGENOM | HOG000118073 | |
| HOVERGEN | HBG053078 | |
| InParanoid | P52747 | |
| OMA | KMQIVLQ | |
| OrthoDB | EOG7WX080 | |
| PhylomeDB | P52747 | |
| TreeFam | TF333498 | |
| Reactome | REACT_22339 REACT_571 | |
| ChiTaRS | ZNF143 | |
| GeneWiki | ZNF143 | |
| GenomeRNAi | 7702 | |
| NextBio | 29854 | |
| PRO | PR:P52747 | |
| Proteomes | UP000005640 | |
| Bgee | P52747 | |
| CleanEx | HS_ZNF143 | |
| ExpressionAtlas | P52747 | |
| Genevestigator | P52747 | |
| GO | GO:0005654 GO:0003677 GO:0046872 GO:0010467 GO:0006357 GO:0006359 GO:0006366 GO:0006383 | |
| Gene3D | 3.30.160.60 | |
| InterPro | IPR007087 IPR015880 IPR013087 | |
| Pfam | PF00096 | |
| SMART | SM00355 | |
| PROSITE | PS00028 PS50157 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0045449 |
regulation of transcription |
ECO:0000314 |
P |
See Figure 5, pg. 10. |
complete | |||||
| GO:0016563 |
transcription activator activity |
ECO:0000314 |
F |
See Figure 2A, 2C, 2D, and 2E. See Figure 5. |
complete | |||||
| GO:0045787 |
positive regulation of cell cycle |
ECO:0000314 |
P |
See Figure 2. |
complete | |||||
|
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
| GO:0016563 |
transcription activator activity |
ECO:0000315 |
F |
See Figure 1. |
complete | |||||
|
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0005556 |
multiple sequence alignment evidence used in manual assertion |
UniProtKB:E9Q3T6 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0001228 |
DNA-binding transcription activator activity, RNA polymerase II-specific |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_regulation_target:(NCBI_Gene:21454) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0000978 |
RNA polymerase II proximal promoter sequence-specific DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_regulation_target:(NCBI_Gene:21454) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0037618 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0000286 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0037618 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0003448 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O70230 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003676 |
nucleic acid binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006383 |
transcription by RNA polymerase III |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006366 |
transcription by RNA polymerase II |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006359 |
regulation of transcription by RNA polymerase III |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006357 |
regulation of transcription by RNA polymerase II |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042795 |
snRNA transcription by RNA polymerase II |
Reactome:R-HSA-6807505 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-83803 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Anno, YN et al. (2011) Genome-wide evidence for an essential role of the human Staf/ZNF143 transcription factor in bidirectional transcription. Nucleic Acids Res. 39 3116-27 PubMed GONUTS page
- ↑ Izumi, H et al. (2010) Role of ZNF143 in tumor growth through transcriptional regulation of DNA replication and cell-cycle-associated genes. Cancer Sci. 101 2538-45 PubMed GONUTS page
- ↑ Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
- ↑ Yuan, CC et al. (2007) CHD8 associates with human Staf and contributes to efficient U6 RNA polymerase III transcription. Mol. Cell. Biol. 27 8729-38 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Kubota, H et al. (2000) Transcriptional regulation of the mouse cytosolic chaperonin subunit gene Ccta/t-complex polypeptide 1 by selenocysteine tRNA gene transcription activating factor family zinc finger proteins. J. Biol. Chem. 275 28641-8 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 7.0 7.1 Schaub, M et al. (1997) Staf, a promiscuous activator for enhanced transcription by RNA polymerases II and III. EMBO J. 16 173-81 PubMed GONUTS page
- ↑ 8.0 8.1 Schuster, C et al. (1998) Two distinct domains in Staf to selectively activate small nuclear RNA-type and mRNA promoters. Mol. Cell. Biol. 18 2650-8 PubMed GONUTS page
d
p
r
- GO:0006357 ! regulation of transcription by RNA polymerase II
- GO:0006359 ! regulation of transcription by RNA polymerase III
- GO:0006355 ! regulation of DNA-templated transcription
- GO:0045449 ! regulation of transcription
- GO:0000978 ! RNA polymerase II cis-regulatory region sequence-specific DNA binding
