HUMAN:ZEB2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	ZEB2 (synonyms: KIAA0569, SIP1, ZFHX1B, ZFX1B)
Protein Name(s)	Zinc finger E-box-binding homeobox 2 Smad-interacting protein 1 SMADIP1 Zinc finger homeobox protein 1b
External Links
UniProt	O60315
EMBL	AY029472 AB056507 AB011141 AK294928 AC009951 AC010130 BC127102 AB015341
CCDS	CCDS2186.1 CCDS54403.1
RefSeq	NP_001165124.1 NP_055610.1 XP_006712944.1 XP_006712945.1
UniGene	Hs.34871
PDB	2DA7
PDBsum	2DA7
ProteinModelPortal	O60315
SMR	O60315
BioGrid	115175
IntAct	O60315
MINT	MINT-1181379
STRING	9606.ENSP00000302501
PhosphoSite	O60315
MaxQB	O60315
PaxDb	O60315
PRIDE	O60315
Ensembl	ENST00000303660 ENST00000409487 ENST00000539609 ENST00000558170
GeneID	9839
KEGG	hsa:9839
UCSC	uc002tvu.3
CTD	9839
GeneCards	GC02M145121
GeneReviews	ZEB2
HGNC	HGNC:14881
HPA	HPA003456
MIM	235730 605802
neXtProt	NX_O60315
Orphanet	261552 261537
PharmGKB	PA162409612
eggNOG	COG5048
GeneTree	ENSGT00630000089829
HOGENOM	HOG000264256
HOVERGEN	HBG004697
InParanoid	O60315
KO	K09299
OMA	LDHSRSN
OrthoDB	EOG790G0D
PhylomeDB	O60315
TreeFam	TF331759
SignaLink	O60315
ChiTaRS	ZEB2
EvolutionaryTrace	O60315
GeneWiki	ZEB2
GenomeRNAi	9839
NextBio	37070
PRO	PR:O60315
Proteomes	UP000005640
Bgee	O60315
CleanEx	HS_SIP1 HS_ZEB2
ExpressionAtlas	O60315
Genevestigator	O60315
GO	GO:0005634 GO:0003677 GO:0046872 GO:0019208 GO:0021846 GO:0048066 GO:0021766 GO:0097324 GO:0000122 GO:0007399 GO:0001755 GO:0001843 GO:0043507 GO:0048023 GO:0045636 GO:0045944 GO:0030177 GO:1903056 GO:0001756 GO:0006351
Gene3D	3.30.160.60
InterPro	IPR008598 IPR001356 IPR009057 IPR007087 IPR015880 IPR013087
Pfam	PF05605
SMART	SM00389 SM00355
SUPFAM	SSF46689
PROSITE	PS00028 PS50157

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
Contributes to	GO:0003700	sequence-specific DNA binding transcription factor activity	PMID:16959974^[1]	ECO:0000314			F		Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues	complete CACAO 9661
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[2]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[2]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR001356	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:Q64318	F		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:20516212^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(ENSEMBL:ENSG00000106511)	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:20516212^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002618) regulates_transcription_of:(ENSEMBL:ENSG00000106511)	Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:20516212^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	coincident_with:(ENSEMBL:ENSG00000106511) coincident_with:(SO:0000167)	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:20516212^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(ENSEMBL:ENSG00000106511) occurs_at:(SO:0000167)	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:12837246^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSG00000164362) part_of:(GO:0071560)	Seeded From UniProt	complete
involved_in	GO:1903056	regulation of melanosome organization	PMID:24769727^[5]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9R0G7	P		Seeded From UniProt	complete
involved_in	GO:0097324	melanocyte migration	PMID:24769727^[5]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9R0G7	P	occurs_in:(UBERON:0001003)	Seeded From UniProt	complete
involved_in	GO:0048066	developmental pigmentation	PMID:24769727^[5]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9R0G7	P		Seeded From UniProt	complete
involved_in	GO:0048023	positive regulation of melanin biosynthetic process	PMID:24769727^[5]	ECO:0000305	curator inference used in manual assertion	GO:0045944	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:24769727^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O75030)	Seeded From UniProt	complete
involved_in	GO:0045636	positive regulation of melanocyte differentiation	PMID:24769727^[5]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9R0G7	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:24769727^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:24769727^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P37275)	Seeded From UniProt	complete
enables	GO:0019208	phosphatase regulator activity	PMID:11477103^[6]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	PMID:11279515^[7]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1903056	regulation of melanosome organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0G7 ensembl:ENSMUSP00000134849	P		Seeded From UniProt	complete
involved_in	GO:1902748	positive regulation of lens fiber cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0G7 ensembl:ENSMUSP00000134849	P		Seeded From UniProt	complete
involved_in	GO:0097324	melanocyte migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0G7 ensembl:ENSMUSP00000134849	P		Seeded From UniProt	complete
enables	GO:0070412	R-SMAD binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0G7 ensembl:ENSMUSP00000134849	F		Seeded From UniProt	complete
involved_in	GO:0061373	mammillary axonal complex development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0G7 ensembl:ENSMUSP00000134849	P		Seeded From UniProt	complete
involved_in	GO:0050772	positive regulation of axonogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0G7 ensembl:ENSMUSP00000134849	P		Seeded From UniProt	complete
involved_in	GO:0048668	collateral sprouting	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0G7 ensembl:ENSMUSP00000134849	P		Seeded From UniProt	complete
involved_in	GO:0048598	embryonic morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0G7 ensembl:ENSMUSP00000134849	P		Seeded From UniProt	complete
involved_in	GO:0048066	developmental pigmentation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0G7 ensembl:ENSMUSP00000134849	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0G7 ensembl:ENSMUSP00000134849	P		Seeded From UniProt	complete
involved_in	GO:0045636	positive regulation of melanocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0G7 ensembl:ENSMUSP00000134849	P		Seeded From UniProt	complete
involved_in	GO:0043507	positive regulation of JUN kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0G7 ensembl:ENSMUSP00000134849	P		Seeded From UniProt	complete
involved_in	GO:0030177	positive regulation of Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0G7 ensembl:ENSMUSP00000134849	P		Seeded From UniProt	complete
involved_in	GO:0021957	corticospinal tract morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0G7 ensembl:ENSMUSP00000134849	P		Seeded From UniProt	complete
involved_in	GO:0021846	cell proliferation in forebrain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0G7 ensembl:ENSMUSP00000134849	P		Seeded From UniProt	complete
involved_in	GO:0021766	hippocampus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0G7 ensembl:ENSMUSP00000134849	P		Seeded From UniProt	complete
involved_in	GO:0021540	corpus callosum morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0G7 ensembl:ENSMUSP00000134849	P		Seeded From UniProt	complete
involved_in	GO:0007417	central nervous system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0G7 ensembl:ENSMUSP00000134849	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0G7 ensembl:ENSMUSP00000134849	C		Seeded From UniProt	complete
involved_in	GO:0001843	neural tube closure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0G7 ensembl:ENSMUSP00000134849	P		Seeded From UniProt	complete
involved_in	GO:0001756	somitogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0G7 ensembl:ENSMUSP00000134849	P		Seeded From UniProt	complete
involved_in	GO:0001755	neural crest cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0G7 ensembl:ENSMUSP00000134849	P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0G7 ensembl:ENSMUSP00000134849	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0G7 ensembl:ENSMUSP00000134849	P		Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013087	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001356 InterPro:IPR009057	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238 UniProtKB-KW:KW-0371	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Sjöblom, T et al. (2006) The consensus coding sequences of human breast and colorectal cancers. Science 314 268-74 PubMed GONUTS page
↑ ^2.0 ^2.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Chen, Y et al. (2010) Regulation of the expression and activity of the antiangiogenic homeobox gene GAX/MEOX2 by ZEB2 and microRNA-221. Mol. Cell. Biol. 30 3902-13 PubMed GONUTS page
↑ Lin, SY & Elledge, SJ (2003) Multiple tumor suppressor pathways negatively regulate telomerase. Cell 113 881-9 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Denecker, G et al. (2014) Identification of a ZEB2-MITF-ZEB1 transcriptional network that controls melanogenesis and melanoma progression. Cell Death Differ. 21 1250-61 PubMed GONUTS page
↑ Tylzanowski, P et al. (2001) Smad-interacting protein 1 is a repressor of liver/bone/kidney alkaline phosphatase transcription in bone morphogenetic protein-induced osteogenic differentiation of C2C12 cells. J. Biol. Chem. 276 40001-7 PubMed GONUTS page
↑ Wakamatsu, N et al. (2001) Mutations in SIP1, encoding Smad interacting protein-1, cause a form of Hirschsprung disease. Nat. Genet. 27 369-70 PubMed GONUTS page

[PMID:16959974-1] Sjöblom, T et al. (2006) The consensus coding sequences of human breast and colorectal cancers. Science 314 268-74 PubMed GONUTS page

[PMID:19274049-2] 2.0 ^2.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:20516212-3] 3.0 ^3.1 ^3.2 ^3.3 Chen, Y et al. (2010) Regulation of the expression and activity of the antiangiogenic homeobox gene GAX/MEOX2 by ZEB2 and microRNA-221. Mol. Cell. Biol. 30 3902-13 PubMed GONUTS page

[PMID:12837246-4] Lin, SY & Elledge, SJ (2003) Multiple tumor suppressor pathways negatively regulate telomerase. Cell 113 881-9 PubMed GONUTS page

[PMID:24769727-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Denecker, G et al. (2014) Identification of a ZEB2-MITF-ZEB1 transcriptional network that controls melanogenesis and melanoma progression. Cell Death Differ. 21 1250-61 PubMed GONUTS page

[PMID:11477103-6] Tylzanowski, P et al. (2001) Smad-interacting protein 1 is a repressor of liver/bone/kidney alkaline phosphatase transcription in bone morphogenetic protein-induced osteogenic differentiation of C2C12 cells. J. Biol. Chem. 276 40001-7 PubMed GONUTS page

[PMID:11279515-7] Wakamatsu, N et al. (2001) Mutations in SIP1, encoding Smad interacting protein-1, cause a form of Hirschsprung disease. Nat. Genet. 27 369-70 PubMed GONUTS page

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HUMAN:ZEB2

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