GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

HUMAN:UB2E1

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) UBE2E1 (synonyms: UBCH6)
Protein Name(s) Ubiquitin-conjugating enzyme E2 E1

UbcH6 Ubiquitin carrier protein E1 Ubiquitin-protein ligase E1

External Links
UniProt P51965
EMBL X92963
AK314854
AC020626
AC124914
CH471055
CH471055
CH471055
BC009139
BI223271
BI666638
CCDS CCDS2638.1
CCDS2639.1
CCDS56244.1
RefSeq NP_001189405.1
NP_003332.1
NP_872607.1
UniGene Hs.164853
PDB 1XR9
3BZH
4JJQ
PDBsum 1XR9
3BZH
4JJQ
ProteinModelPortal P51965
SMR P51965
BioGrid 113172
IntAct P51965
MINT MINT-109083
STRING 9606.ENSP00000303709
PhosphoSite P51965
DMDM 1717857
MaxQB P51965
PaxDb P51965
PRIDE P51965
Ensembl ENST00000306627
ENST00000346855
ENST00000424381
GeneID 7324
KEGG hsa:7324
UCSC uc003cch.3
uc003cci.3
uc021wua.1
CTD 7324
GeneCards GC03P023847
HGNC HGNC:12477
HPA HPA030445
MIM 602916
neXtProt NX_P51965
PharmGKB PA37127
eggNOG COG5078
GeneTree ENSGT00760000119012
HOGENOM HOG000233455
HOVERGEN HBG063308
InParanoid P51965
KO K06689
OMA ISNPDPY
OrthoDB EOG7PCJGX
PhylomeDB P51965
TreeFam TF101117
Reactome REACT_1072
REACT_115831
REACT_150471
REACT_169168
REACT_6761
REACT_6781
REACT_6785
REACT_6820
REACT_6837
REACT_6867
REACT_6871
REACT_6904
REACT_75842
SignaLink P51965
UniPathway UPA00143
ChiTaRS UBE2E1
EvolutionaryTrace P51965
GeneWiki UBE2E1
GenomeRNAi 7324
NextBio 28656
PRO PR:P51965
Proteomes UP000005640
Bgee P51965
CleanEx HS_UBE2E1
ExpressionAtlas P51965
Genevestigator P51965
GO GO:0005829
GO:0005654
GO:0005634
GO:0000151
GO:0005524
GO:0042296
GO:0004842
GO:0031145
GO:0019221
GO:0033523
GO:0010390
GO:0032020
GO:0000278
GO:0007094
GO:0051436
GO:0051437
GO:0070936
GO:0000209
GO:0016567
GO:0051439
GO:0006511
Gene3D 3.10.110.10
InterPro IPR000608
IPR023313
IPR016135
Pfam PF00179
SUPFAM SSF54495
PROSITE PS00183
PS50127

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0042787

protein ubiquitination involved in ubiquitin-dependent protein catabolic process

PMID:18439907[1]

ECO:0000315

P

Figure 4

complete

involved_in

GO:0016567

protein ubiquitination

PMID:9990509[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0061631

ubiquitin conjugating enzyme activity

PMID:15247280[3]

ECO:0000314

direct assay evidence used in manual assertion

F

has_input:(UniProtKB:P04637)

Seeded From UniProt

complete

involved_in

GO:0000209

protein polyubiquitination

PMID:15247280[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0000151

ubiquitin ligase complex

PMID:15247280[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0042296

ISG15 transferase activity

PMID:16428300[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0032020

ISG15-protein conjugation

PMID:16428300[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070936

protein K48-linked ubiquitination

PMID:20061386[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0033523

histone H2B ubiquitination

PMID:16307923[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010390

histone monoubiquitination

PMID:16307923[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:18845142[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

PMID:20061386[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

PMID:16522193[8]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

PMID:16307923[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000209

protein polyubiquitination

PMID:16522193[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0000151

ubiquitin ligase complex

PMID:16307923[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0070936

protein K48-linked ubiquitination

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000630972
UniProtKB:P51965

P

Seeded From UniProt

complete

enables

GO:0061631

ubiquitin conjugating enzyme activity

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000173
FB:FBgn0011217
FB:FBgn0026316
FB:FBgn0035601
FB:FBgn0264848
MGI:MGI:104632
MGI:MGI:107411
MGI:MGI:107412
MGI:MGI:109240
MGI:MGI:1913839
MGI:MGI:1914049
MGI:MGI:1917343
MGI:MGI:1917870
MGI:MGI:1934835
MGI:MGI:2384911
MGI:MGI:2388672
PANTHER:PTN002514495
PomBase:SPAC11E3.04c
PomBase:SPBC119.02
PomBase:SPCC1259.15c
PomBase:SPCC338.05c
UniProtKB:A1L167
UniProtKB:O00762
UniProtKB:P51668
UniProtKB:P51965
UniProtKB:P61077
UniProtKB:P61085
UniProtKB:P62837
UniProtKB:P68036
UniProtKB:Q16763
UniProtKB:Q8N2K1
UniProtKB:Q96LR5
UniProtKB:Q9NPD8
UniProtKB:Q9Y2X8
UniProtKB:Q9Y385
WB:WBGene00006713

F

Seeded From UniProt

complete

enables

GO:0042296

ISG15 transferase activity

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000630972
UniProtKB:P51965

F

Seeded From UniProt

complete

involved_in

GO:0033523

histone H2B ubiquitination

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000630972
UniProtKB:P51965

P

Seeded From UniProt

complete

involved_in

GO:0032020

ISG15-protein conjugation

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000630972
UniProtKB:P51965

P

Seeded From UniProt

complete

enables

GO:0061631

ubiquitin conjugating enzyme activity

PMID:20061386[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0061631

ubiquitin conjugating enzyme activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P52482
ensembl:ENSMUSP00000022296

F

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P52482
ensembl:ENSMUSP00000022296

P

Seeded From UniProt

complete

involved_in

GO:0006511

ubiquitin-dependent protein catabolic process

PMID:8576257[10]
Reactome:R-HSA-174227
Reactome:R-HSA-174195
Reactome:R-HSA-174144
Reactome:R-HSA-174104
Reactome:R-HSA-174057

ECO:0000304

author statement supported by traceable reference used in manual assertion






P

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

PMID:8576257[10]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:1901990

regulation of mitotic cell cycle phase transition

Reactome:R-HSA-174238

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031145

anaphase-promoting complex-dependent catabolic process

Reactome:R-HSA-174184
Reactome:R-HSA-174178
Reactome:R-HSA-174154
Reactome:R-HSA-174143
Reactome:R-HSA-174048

ECO:0000304

author statement supported by traceable reference used in manual assertion





P

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

Reactome:R-HSA-8866654
Reactome:R-HSA-8866652

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-8939335
Reactome:R-HSA-8939323
Reactome:R-HSA-69015
Reactome:R-HSA-188191
Reactome:R-HSA-179421
Reactome:R-HSA-179417
Reactome:R-HSA-179410
Reactome:R-HSA-174255
Reactome:R-HSA-174238
Reactome:R-HSA-174227
Reactome:R-HSA-174224
Reactome:R-HSA-174202
Reactome:R-HSA-174195
Reactome:R-HSA-174171
Reactome:R-HSA-174157
Reactome:R-HSA-174144
Reactome:R-HSA-174121
Reactome:R-HSA-174120
Reactome:R-HSA-174105
Reactome:R-HSA-174104
Reactome:R-HSA-174088
Reactome:R-HSA-174070
Reactome:R-HSA-1678841
Reactome:R-HSA-141423
Reactome:R-HSA-1169406
Reactome:R-HSA-1169402

ECO:0000304

author statement supported by traceable reference used in manual assertion


























C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-8852130
Reactome:R-HSA-3788725
Reactome:R-HSA-3788724
Reactome:R-HSA-3788708
Reactome:R-HSA-3788705
Reactome:R-HSA-188371
Reactome:R-HSA-174139
Reactome:R-HSA-174132
Reactome:R-HSA-174119
Reactome:R-HSA-174079
Reactome:R-HSA-174058
Reactome:R-HSA-174057

ECO:0000304

author statement supported by traceable reference used in manual assertion












C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00143

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Hong, S et al. (2008) UbcH6 interacts with and ubiquitinates the SCA1 gene product ataxin-1. Biochem. Biophys. Res. Commun. 371 256-60 PubMed GONUTS page
  2. ↑ Anan, T et al. (1998) Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes. Genes Cells 3 751-63 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Rajendra, R et al. (2004) Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53. J. Biol. Chem. 279 36440-4 PubMed GONUTS page
  4. ↑ 4.0 4.1 Takeuchi, T et al. (2005) Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme. J. Biochem. 138 711-9 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 David, Y et al. (2010) The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. J. Biol. Chem. 285 8595-604 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 Zhu, B et al. (2005) Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. Mol. Cell 20 601-11 PubMed GONUTS page
  7. ↑ Espinosa, A et al. (2008) The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but enters the nucleus upon cellular exposure to nitric oxide. Exp. Cell Res. 314 3605-13 PubMed GONUTS page
  8. ↑ 8.0 8.1 Nishito, Y et al. (2006) MEX is a testis-specific E3 ubiquitin ligase that promotes death receptor-induced apoptosis. Biochem. J. 396 411-7 PubMed GONUTS page
  9. ↑ 9.0 9.1 9.2 9.3 9.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  10. ↑ 10.0 10.1 Nuber, U et al. (1996) Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 (E2-F1) and characterization of their interaction with E6-AP and RSP5. J. Biol. Chem. 271 2795-800 PubMed GONUTS page
Retrieved from "https://gowiki.tamu.edu/wiki/index.php?title=HUMAN:UB2E1&oldid=5933656"