HUMAN:TY3H

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	TH (synonyms: TYH)
Protein Name(s)	Tyrosine 3-monooxygenase Tyrosine 3-hydroxylase TH
External Links
UniProt	P07101
EMBL	M17589 X05290 Y00414 DQ677336 DQ677337 AC132217 M24791 M24787 M24789 CH471158 BC104967 BC143611 BC143614 M24791 M24787 M20911
CCDS	CCDS31338.1 CCDS7730.1 CCDS7731.1
PIR	A30002
RefSeq	NP_000351.2 NP_954986.2 NP_954987.2
UniGene	Hs.435609
PDB	2XSN 4J6S
PDBsum	2XSN 4J6S
ProteinModelPortal	P07101
SMR	P07101
BioGrid	112912
IntAct	P07101
MINT	MINT-198913
STRING	9606.ENSP00000370571
BindingDB	P07101
ChEMBL	CHEMBL1969
DrugBank	DB00120 DB00135 DB00765 DB00360
GuidetoPHARMACOLOGY	1243
PhosphoSite	P07101
DMDM	239938945
PaxDb	P07101
PRIDE	P07101
Ensembl	ENST00000333684 ENST00000352909 ENST00000381175 ENST00000381178
GeneID	7054
KEGG	hsa:7054
UCSC	uc001lvp.3 uc001lvq.3 uc001lvr.3 uc010qxj.2
CTD	7054
GeneCards	GC11M002185
GeneReviews	TH
H-InvDB	HIX0035928
HGNC	HGNC:11782
HPA	CAB002522
MIM	191290 605407
neXtProt	NX_P07101
Orphanet	101150
PharmGKB	PA351
eggNOG	COG3186
GeneTree	ENSGT00390000010268
HOGENOM	HOG000233373
HOVERGEN	HBG006841
InParanoid	P07101
KO	K00501
OMA	YATHACG
PhylomeDB	P07101
TreeFam	TF313327
Reactome	REACT_15551
UniPathway	UPA00747
GeneWiki	Tyrosine_hydroxylase
GenomeRNAi	7054
NextBio	27583
PRO	PR:P07101
Proteomes	UP000005640
Bgee	P07101
CleanEx	HS_TH
ExpressionAtlas	P07101
Genevestigator	P07101
GO	GO:0005737 GO:0009898 GO:0031410 GO:0005829 GO:0030425 GO:0033162 GO:0005739 GO:0043005 GO:0005634 GO:0043204 GO:0005790 GO:0008021 GO:0043195 GO:0016597 GO:0035240 GO:0019899 GO:0008199 GO:0008198 GO:0019825 GO:0034617 GO:0004511 GO:0009653 GO:0042423 GO:0034641 GO:0035690 GO:0071333 GO:0071363 GO:0071287 GO:0071316 GO:0021987 GO:0042745 GO:0042416 GO:0006585 GO:0042755 GO:0048596 GO:0042418 GO:0042462 GO:0006631 GO:0016137 GO:0007507 GO:0003007 GO:0033076 GO:0007612 GO:0007626 GO:0007617 GO:0007613 GO:0010259 GO:0042136 GO:0042421 GO:0009887 GO:0018963 GO:0052314 GO:0043473 GO:0008016 GO:0014823 GO:0001975 GO:0051412 GO:0051602 GO:0032355 GO:0045471 GO:0045472 GO:0009635 GO:0001666 GO:0035902 GO:0009416 GO:0032496 GO:0031667 GO:0043434 GO:0046684 GO:0009651 GO:0009414 GO:0010043 GO:0007605 GO:0044281 GO:0035176 GO:0006665 GO:0001963 GO:0015842 GO:0042214 GO:0007601
Gene3D	1.10.800.10
InterPro	IPR001273 IPR018301 IPR019774 IPR005962 IPR019773 IPR021164
PANTHER	PTHR11473
Pfam	PF00351 PF12549
PIRSF	PIRSF000336
PRINTS	PR00372
SUPFAM	SSF56534
TIGRFAMs	TIGR01269
PROSITE	PS00367 PS51410

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0042421	norepinephrine biosynthetic process	PMID:14216443^[1]	ECO:0000314			P	Source: BHF-UCL	complete
enables	GO:0004511	tyrosine 3-monooxygenase activity	PMID:19703902^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:19703902^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P20711	F	Seeded From UniProt	complete
involved_in	GO:0048596	embryonic camera-type eye morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P24529	P	Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	PMID:18343820^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P24529	C	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:17135716^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0042462	eye photoreceptor cell development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P24529	P	Seeded From UniProt	complete
involved_in	GO:0042421	norepinephrine biosynthetic process	PMID:12457228^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042418	epinephrine biosynthetic process	PMID:12457228^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042416	dopamine biosynthetic process	PMID:12457228^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0033162	melanosome membrane	PMID:12631248^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	PMID:12457228^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0009898	cytoplasmic side of plasma membrane	PMID:12457228^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0009887	animal organ morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P24529	P	Seeded From UniProt	complete
involved_in	GO:0008016	regulation of heart contraction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P24529	P	Seeded From UniProt	complete
involved_in	GO:0007626	locomotory behavior	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P24529	P	Seeded From UniProt	complete
involved_in	GO:0007613	memory	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P24529	P	Seeded From UniProt	complete
involved_in	GO:0007612	learning	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P24529	P	Seeded From UniProt	complete
involved_in	GO:0007601	visual perception	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P24529	P	Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P24529	P	Seeded From UniProt	complete
involved_in	GO:0006585	dopamine biosynthetic process from tyrosine	PMID:10907721^[7]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005790	smooth endoplasmic reticulum	PMID:12457228^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P24529	C	Seeded From UniProt	complete
enables	GO:0004511	tyrosine 3-monooxygenase activity	PMID:2896667^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004511	tyrosine 3-monooxygenase activity	PMID:11943812^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004511	tyrosine 3-monooxygenase activity	PMID:12631248^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0003007	heart morphogenesis	PMID:12113410^[10]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001963	synaptic transmission, dopaminergic	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P24529	P	Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	PMID:17520326^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:10907721^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004511	tyrosine 3-monooxygenase activity	PMID:16338639^[12]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000158541 RGD:3853 UniProtKB:P07101	P	Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98735 PANTHER:PTN000158532 RGD:3853	C	Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98735 PANTHER:PTN000158532 RGD:3853 WB:WBGene00000296	C	Seeded From UniProt	complete
involved_in	GO:0007507	heart development	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98735 PANTHER:PTN000158541 RGD:3853	P	Seeded From UniProt	complete
involved_in	GO:0006585	dopamine biosynthetic process from tyrosine	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98735 PANTHER:PTN001690342 RGD:3853	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98735 PANTHER:PTN000158532 RGD:3853 UniProtKB:P07101 UniProtKB:Q9PU40	C	Seeded From UniProt	complete
enables	GO:0004511	tyrosine 3-monooxygenase activity	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000158532 RGD:3853 UniProtKB:P07101 UniProtKB:Q9PU40 WB:WBGene00000296 ZFIN:ZDB-GENE-990621-5	F	Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000158541 RGD:3853 UniProtKB:P07101	P	Seeded From UniProt	complete
involved_in	GO:0071363	cellular response to growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
involved_in	GO:0071333	cellular response to glucose stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
involved_in	GO:0071316	cellular response to nicotine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
involved_in	GO:0071312	cellular response to alkaloid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
involved_in	GO:0071287	cellular response to manganese ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
involved_in	GO:0070848	response to growth factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
involved_in	GO:0052314	phytoalexin metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
involved_in	GO:0051602	response to electrical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
involved_in	GO:0051412	response to corticosterone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
involved_in	GO:0050890	cognition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
involved_in	GO:0048545	response to steroid hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
involved_in	GO:0046684	response to pyrethroid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
involved_in	GO:0045472	response to ether	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
involved_in	GO:0043434	response to peptide hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	C	Seeded From UniProt	complete
part_of	GO:0043195	terminal bouton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	C	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	C	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	C	Seeded From UniProt	complete
involved_in	GO:0042745	circadian sleep/wake cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
involved_in	GO:0042423	catecholamine biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
involved_in	GO:0042214	terpene metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
involved_in	GO:0035902	response to immobilization stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
involved_in	GO:0035900	response to isolation stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
involved_in	GO:0035690	cellular response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
enables	GO:0035240	dopamine binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	F	Seeded From UniProt	complete
involved_in	GO:0035176	social behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
involved_in	GO:0035094	response to nicotine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
enables	GO:0034617	tetrahydrobiopterin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	F	Seeded From UniProt	complete
involved_in	GO:0033076	isoquinoline alkaloid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
involved_in	GO:0031667	response to nutrient levels	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
part_of	GO:0030659	cytoplasmic vesicle membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	C	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	C	Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	C	Seeded From UniProt	complete
involved_in	GO:0021987	cerebral cortex development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	F	Seeded From UniProt	complete
enables	GO:0019825	oxygen binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	F	Seeded From UniProt	complete
involved_in	GO:0018963	phthalate metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
involved_in	GO:0017085	response to insecticide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
enables	GO:0016597	amino acid binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	F	Seeded From UniProt	complete
involved_in	GO:0016137	glycoside metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
involved_in	GO:0015842	aminergic neurotransmitter loading into synaptic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
involved_in	GO:0014823	response to activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
involved_in	GO:0010259	multicellular organism aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
involved_in	GO:0010043	response to zinc ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
involved_in	GO:0010038	response to metal ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
involved_in	GO:0009651	response to salt stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
involved_in	GO:0009635	response to herbicide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
involved_in	GO:0009416	response to light stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
involved_in	GO:0009414	response to water deprivation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
enables	GO:0008199	ferric iron binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	F	Seeded From UniProt	complete
enables	GO:0008198	ferrous iron binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	F	Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	C	Seeded From UniProt	complete
involved_in	GO:0007605	sensory perception of sound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
involved_in	GO:0006665	sphingolipid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
involved_in	GO:0006631	fatty acid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
involved_in	GO:0006585	dopamine biosynthetic process from tyrosine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	C	Seeded From UniProt	complete
enables	GO:0004511	tyrosine 3-monooxygenase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	F	Seeded From UniProt	complete
enables	GO:0004497	monooxygenase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	F	Seeded From UniProt	complete
involved_in	GO:0001975	response to amphetamine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04177 ensembl:ENSRNOP00000027682	P	Seeded From UniProt	complete
involved_in	GO:0048596	embryonic camera-type eye morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24529 ensembl:ENSMUSP00000000219	P	Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24529 ensembl:ENSMUSP00000000219	C	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24529 ensembl:ENSMUSP00000000219	C	Seeded From UniProt	complete
involved_in	GO:0042755	eating behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24529 ensembl:ENSMUSP00000000219	P	Seeded From UniProt	complete
involved_in	GO:0042462	eye photoreceptor cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24529 ensembl:ENSMUSP00000000219	P	Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24529 ensembl:ENSMUSP00000000219	C	Seeded From UniProt	complete
involved_in	GO:0009887	animal organ morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24529 ensembl:ENSMUSP00000000219	P	Seeded From UniProt	complete
involved_in	GO:0008016	regulation of heart contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24529 ensembl:ENSMUSP00000000219	P	Seeded From UniProt	complete
involved_in	GO:0007626	locomotory behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24529 ensembl:ENSMUSP00000000219	P	Seeded From UniProt	complete
involved_in	GO:0007617	mating behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24529 ensembl:ENSMUSP00000000219	P	Seeded From UniProt	complete
involved_in	GO:0007613	memory	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24529 ensembl:ENSMUSP00000000219	P	Seeded From UniProt	complete
involved_in	GO:0007612	learning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24529 ensembl:ENSMUSP00000000219	P	Seeded From UniProt	complete
involved_in	GO:0007601	visual perception	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24529 ensembl:ENSMUSP00000000219	P	Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24529 ensembl:ENSMUSP00000000219	P	Seeded From UniProt	complete
involved_in	GO:0006585	dopamine biosynthetic process from tyrosine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24529 ensembl:ENSMUSP00000000219	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24529 ensembl:ENSMUSP00000000219	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24529 ensembl:ENSMUSP00000000219	C	Seeded From UniProt	complete
involved_in	GO:0001963	synaptic transmission, dopaminergic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24529 ensembl:ENSMUSP00000000219	P	Seeded From UniProt	complete
enables	GO:0004497	monooxygenase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001273 InterPro:IPR018301 InterPro:IPR036951	F	Seeded From UniProt	complete
enables	GO:0004511	tyrosine 3-monooxygenase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005962 InterPro:IPR021164	F	Seeded From UniProt	complete
enables	GO:0005506	iron ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001273 InterPro:IPR018301 InterPro:IPR036951	F	Seeded From UniProt	complete
involved_in	GO:0009072	aromatic amino acid family metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001273 InterPro:IPR018301 InterPro:IPR036951	P	Seeded From UniProt	complete
enables	GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR019773 InterPro:IPR019774	F	Seeded From UniProt	complete
involved_in	GO:0042423	catecholamine biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005962	P	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001273 InterPro:IPR005962 InterPro:IPR018301 InterPro:IPR019773 InterPro:IPR019774 InterPro:IPR021164 InterPro:IPR036951	P	Seeded From UniProt	complete
enables	GO:0004511	tyrosine 3-monooxygenase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.14.16.2	F	Seeded From UniProt	complete
involved_in	GO:0009653	anatomical structure morphogenesis	PMID:7715703^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043473	pigmentation	PMID:12631248^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042423	catecholamine biosynthetic process	Reactome:R-HSA-209905	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-209823	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
involved_in	GO:0042136	neurotransmitter biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0530	P	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P	Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F	Seeded From UniProt	complete
enables	GO:0004497	monooxygenase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0503	F	Seeded From UniProt	complete
involved_in	GO:0042423	catecholamine biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0127	P	Seeded From UniProt	complete
involved_in	GO:0042416	dopamine biosynthetic process	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00747	P	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ NAGATSU, T et al. (1964) TYROSINE HYDROXYLASE. THE INITIAL STEP IN NOREPINEPHRINE BIOSYNTHESIS. J. Biol. Chem. 239 2910-7 PubMed GONUTS page
↑ ^2.0 ^2.1 Ishikawa, S et al. (2009) Oxidative status of DJ-1-dependent activation of dopamine synthesis through interaction of tyrosine hydroxylase and 4-dihydroxy-L-phenylalanine (L-DOPA) decarboxylase with DJ-1. J. Biol. Chem. 284 28832-44 PubMed GONUTS page
↑ He, DY & Ron, D (2008) Glial cell line-derived neurotrophic factor reverses ethanol-mediated increases in tyrosine hydroxylase immunoreactivity via altering the activity of heat shock protein 90. J. Biol. Chem. 283 12811-8 PubMed GONUTS page
↑ Kontostavlaki, DP et al. (2006) Co-expression of tyrosine hydroxylase and GTP cyclohydrolase I in arginine vasopressin-synthesizing neurons of the human supraoptic nucleus demonstrated by laser microdissection and real-time PCR. Neuroendocrinology 84 386-95 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Reguzzoni, M et al. (2002) Ultrastructural localization of tyrosine hydroxylase in human peripheral blood mononuclear cells: effect of stimulation with phytohaemagglutinin. Cell Tissue Res. 310 297-304 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Marles, LK et al. (2003) Tyrosine hydroxylase isoenzyme I is present in human melanosomes: a possible novel function in pigmentation. Exp. Dermatol. 12 61-70 PubMed GONUTS page
↑ ^7.0 ^7.1 Nagatsu, I et al. (1999) Specific localization of the guanosine triphosphate (GTP) cyclohydrolase I-immunoreactivity in the human brain. J Neural Transm (Vienna) 106 607-17 PubMed GONUTS page
↑ Ginns, EI et al. (1988) Expression of human tyrosine hydroxylase cDNA in invertebrate cells using a baculovirus vector. J. Biol. Chem. 263 7406-10 PubMed GONUTS page
↑ Perez, RG et al. (2002) A role for alpha-synuclein in the regulation of dopamine biosynthesis. J. Neurosci. 22 3090-9 PubMed GONUTS page
↑ Linhart, A et al. (2002) Association between tyrosine hydroxylase polymorphisms and left ventricular structure in young normotensive men. Br. J. Biomed. Sci. 59 90-4 PubMed GONUTS page
↑ Rostrup, M et al. (2008) Oxygen dependence of tyrosine hydroxylase. Amino Acids 34 455-64 PubMed GONUTS page
↑ Duan, CL et al. (2005) The assays of activities and function of TH, AADC, and GCH1 and their potential use in ex vivo gene therapy of PD. Brain Res. Brain Res. Protoc. 16 37-43 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 ^13.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Zhou, QY et al. (1995) Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development. Nature 374 640-3 PubMed GONUTS page

[PMID:14216443-1] NAGATSU, T et al. (1964) TYROSINE HYDROXYLASE. THE INITIAL STEP IN NOREPINEPHRINE BIOSYNTHESIS. J. Biol. Chem. 239 2910-7 PubMed GONUTS page

[PMID:19703902-2] 2.0 ^2.1 Ishikawa, S et al. (2009) Oxidative status of DJ-1-dependent activation of dopamine synthesis through interaction of tyrosine hydroxylase and 4-dihydroxy-L-phenylalanine (L-DOPA) decarboxylase with DJ-1. J. Biol. Chem. 284 28832-44 PubMed GONUTS page

[PMID:18343820-3] He, DY & Ron, D (2008) Glial cell line-derived neurotrophic factor reverses ethanol-mediated increases in tyrosine hydroxylase immunoreactivity via altering the activity of heat shock protein 90. J. Biol. Chem. 283 12811-8 PubMed GONUTS page

[PMID:17135716-4] Kontostavlaki, DP et al. (2006) Co-expression of tyrosine hydroxylase and GTP cyclohydrolase I in arginine vasopressin-synthesizing neurons of the human supraoptic nucleus demonstrated by laser microdissection and real-time PCR. Neuroendocrinology 84 386-95 PubMed GONUTS page

[PMID:12457228-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Reguzzoni, M et al. (2002) Ultrastructural localization of tyrosine hydroxylase in human peripheral blood mononuclear cells: effect of stimulation with phytohaemagglutinin. Cell Tissue Res. 310 297-304 PubMed GONUTS page

[PMID:12631248-6] 6.0 ^6.1 ^6.2 Marles, LK et al. (2003) Tyrosine hydroxylase isoenzyme I is present in human melanosomes: a possible novel function in pigmentation. Exp. Dermatol. 12 61-70 PubMed GONUTS page

[PMID:10907721-7] 7.0 ^7.1 Nagatsu, I et al. (1999) Specific localization of the guanosine triphosphate (GTP) cyclohydrolase I-immunoreactivity in the human brain. J Neural Transm (Vienna) 106 607-17 PubMed GONUTS page

[PMID:2896667-8] Ginns, EI et al. (1988) Expression of human tyrosine hydroxylase cDNA in invertebrate cells using a baculovirus vector. J. Biol. Chem. 263 7406-10 PubMed GONUTS page

[PMID:11943812-9] Perez, RG et al. (2002) A role for alpha-synuclein in the regulation of dopamine biosynthesis. J. Neurosci. 22 3090-9 PubMed GONUTS page

[PMID:12113410-10] Linhart, A et al. (2002) Association between tyrosine hydroxylase polymorphisms and left ventricular structure in young normotensive men. Br. J. Biomed. Sci. 59 90-4 PubMed GONUTS page

[PMID:17520326-11] Rostrup, M et al. (2008) Oxygen dependence of tyrosine hydroxylase. Amino Acids 34 455-64 PubMed GONUTS page

[PMID:16338639-12] Duan, CL et al. (2005) The assays of activities and function of TH, AADC, and GCH1 and their potential use in ex vivo gene therapy of PD. Brain Res. Brain Res. Protoc. 16 37-43 PubMed GONUTS page

[PMID:21873635-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 ^13.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:7715703-14] Zhou, QY et al. (1995) Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development. Nature 374 640-3 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

HUMAN:TY3H

Contents

Annotations

Notes

References

a

c

d

e

f

g

h

i

l

m

n

o

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools