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HUMAN:TRIB3

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) TRIB3 (synonyms: C20orf97, NIPK, SKIP3, TRB3)
Protein Name(s) Tribbles homolog 3

TRB-3 Neuronal cell death-inducible putative kinase SINK p65-interacting inhibitor of NF-kappa-B

External Links
UniProt Q96RU7
EMBL AF250311
AJ697936
AY247738
AK026945
CR457366
AK222837
AL034548
BC019363
BC027484
CCDS CCDS12997.1
RefSeq NP_001288117.1
NP_001288119.1
NP_001288122.1
NP_001288125.1
NP_001288130.1
NP_066981.2
UniGene Hs.516826
ProteinModelPortal Q96RU7
SMR Q96RU7
BioGrid 121756
IntAct Q96RU7
MINT MINT-1384866
STRING 9606.ENSP00000217233
PhosphoSite Q96RU7
DMDM 28201830
MaxQB Q96RU7
PaxDb Q96RU7
PRIDE Q96RU7
DNASU 57761
Ensembl ENST00000217233
GeneID 57761
KEGG hsa:57761
UCSC uc002wdm.3
CTD 57761
GeneCards GC20P000361
HGNC HGNC:16228
HPA HPA015272
HPA055442
MIM 607898
neXtProt NX_Q96RU7
PharmGKB PA25804
eggNOG COG0515
GeneTree ENSGT00760000119244
HOGENOM HOG000231872
HOVERGEN HBG067729
InParanoid Q96RU7
KO K08814
OrthoDB EOG7RJPR4
PhylomeDB Q96RU7
TreeFam TF329785
Reactome REACT_116145
REACT_12447
REACT_19358
REACT_228016
REACT_75829
REACT_790
SignaLink Q96RU7
ChiTaRS TRIB3
GeneWiki TRIB3
GenomeRNAi 57761
NextBio 64708
PRO PR:Q96RU7
Proteomes UP000005640
Bgee Q96RU7
CleanEx HS_TRIB3
ExpressionAtlas Q96RU7
Genevestigator Q96RU7
GO GO:0005829
GO:0005634
GO:0005886
GO:0005524
GO:0019901
GO:0004860
GO:0003714
GO:0016772
GO:0031625
GO:0055106
GO:0044255
GO:0032869
GO:0007173
GO:0038095
GO:0008543
GO:0045087
GO:0008286
GO:0070059
GO:0045599
GO:0045717
GO:0006469
GO:0045892
GO:0048011
GO:0048015
GO:0032092
GO:0051443
GO:0006468
GO:0010827
GO:0043405
GO:0034976
GO:0044281
GO:0006351
InterPro IPR011009
IPR000719
IPR024104
IPR024106
PANTHER PTHR22961
PTHR22961:SF12
Pfam PF00069
SUPFAM SSF56112
PROSITE PS50011

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0010506

regulation of autophagy

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9WTQ6

P

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:15775988[1]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(UniProtKB:Q96RU7)

Seeded From UniProt

complete

enables

GO:0055106

ubiquitin-protein transferase regulator activity

PMID:20410507[2]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K4K2

F

Seeded From UniProt

complete

involved_in

GO:0051443

positive regulation of ubiquitin-protein transferase activity

PMID:16794074[3]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K4K2

P

Seeded From UniProt

complete

involved_in

GO:0045717

negative regulation of fatty acid biosynthetic process

PMID:16794074[3]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K4K2

P

Seeded From UniProt

complete

involved_in

GO:0045599

negative regulation of fat cell differentiation

PMID:17576771[4]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K4K2

P

Seeded From UniProt

complete

involved_in

GO:0032869

cellular response to insulin stimulus

PMID:12791994[5]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K4K2

P

Seeded From UniProt

complete

involved_in

GO:0032092

positive regulation of protein binding

PMID:16794074[3]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K4K2

P

Seeded From UniProt

complete

enables

GO:0031625

ubiquitin protein ligase binding

PMID:16794074[3]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K4K2

F

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

PMID:12791994[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P31749

F

Seeded From UniProt

complete

involved_in

GO:0010827

regulation of glucose transmembrane transport

PMID:12791994[5]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K4K2

P

Seeded From UniProt

complete

involved_in

GO:0006469

negative regulation of protein kinase activity

PMID:12791994[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070059

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

PMID:15775988[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:15775988[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043405

regulation of MAP kinase activity

PMID:15299019[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034976

response to endoplasmic reticulum stress

PMID:15775988[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

PMID:15299019[6]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O14733

F

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

PMID:15299019[6]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q02750

F

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K4K2

F

Seeded From UniProt

complete

NOT|enables

GO:0016301

kinase activity

PMID:12743605[7]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K4K2

C

Seeded From UniProt

complete

enables

GO:0003714

transcription corepressor activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K4K2

F

Seeded From UniProt

complete

involved_in

GO:0043405

regulation of MAP kinase activity

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001121144
UniProtKB:Q96RU7
UniProtKB:Q96RU8

P

Seeded From UniProt

complete

involved_in

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2145021
MGI:MGI:2443397
PANTHER:PTN001121144

P

Seeded From UniProt

complete

enables

GO:0031434

mitogen-activated protein kinase kinase binding

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001121144
UniProtKB:Q96RU8

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0028978
MGI:MGI:1345675
PANTHER:PTN001121144
UniProtKB:Q96RU7
UniProtKB:Q96RU8

C

Seeded From UniProt

complete

enables

GO:0003714

transcription corepressor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024106

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719

P

Seeded From UniProt

complete

involved_in

GO:0070059

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

PMID:22934019[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051898

negative regulation of protein kinase B signaling

Reactome:R-HSA-199443

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0019216

regulation of lipid metabolic process

Reactome:R-HSA-400206

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-199443
Reactome:R-HSA-1989767

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-109700

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004860

protein kinase inhibitor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0649

F

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Ohoka, N et al. (2005) TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death. EMBO J. 24 1243-55 PubMed GONUTS page
  2. ↑ Dedhia, PH et al. (2010) Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia. Blood 116 1321-8 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 Qi, L et al. (2006) TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. Science 312 1763-6 PubMed GONUTS page
  4. ↑ Naiki, T et al. (2007) TRB2, a mouse Tribbles ortholog, suppresses adipocyte differentiation by inhibiting AKT and C/EBPbeta. J. Biol. Chem. 282 24075-82 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 Du, K et al. (2003) TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver. Science 300 1574-7 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 Kiss-Toth, E et al. (2004) Human tribbles, a protein family controlling mitogen-activated protein kinase cascades. J. Biol. Chem. 279 42703-8 PubMed GONUTS page
  7. ↑ Bowers, AJ et al. (2003) SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia. Oncogene 22 2823-35 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 8.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  9. ↑ Brown, MK & Naidoo, N (2012) The endoplasmic reticulum stress response in aging and age-related diseases. Front Physiol 3 263 PubMed GONUTS page
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