GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
HUMAN:TRAF1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | TRAF1 (synonyms: EBI6) | |
| Protein Name(s) | TNF receptor-associated factor 1
Epstein-Barr virus-induced protein 6 | |
| External Links | ||
| UniProt | Q13077 | |
| EMBL | U19261 AK090468 AK295959 AK315476 AL832989 BT019408 AC006430 CH471090 BC024145 | |
| CCDS | CCDS55335.1 CCDS6825.1 | |
| PIR | B55649 | |
| RefSeq | NP_001177874.1 NP_001177876.1 NP_005649.1 | |
| UniGene | Hs.531251 | |
| PDB | 3M0D | |
| PDBsum | 3M0D | |
| ProteinModelPortal | Q13077 | |
| SMR | Q13077 | |
| BioGrid | 113037 | |
| DIP | DIP-27514N | |
| IntAct | Q13077 | |
| MINT | MINT-1131534 | |
| STRING | 9606.ENSP00000362994 | |
| PhosphoSite | Q13077 | |
| DMDM | 6707734 | |
| MaxQB | Q13077 | |
| PaxDb | Q13077 | |
| PRIDE | Q13077 | |
| DNASU | 7185 | |
| Ensembl | ENST00000373887 ENST00000540010 ENST00000546084 | |
| GeneID | 7185 | |
| KEGG | hsa:7185 | |
| UCSC | uc004bku.2 | |
| CTD | 7185 | |
| GeneCards | GC09M123664 | |
| HGNC | HGNC:12031 | |
| HPA | CAB009593 HPA001852 | |
| MIM | 601711 | |
| neXtProt | NX_Q13077 | |
| PharmGKB | PA36708 | |
| eggNOG | NOG264247 | |
| GeneTree | ENSGT00550000074359 | |
| HOGENOM | HOG000231558 | |
| HOVERGEN | HBG058222 | |
| InParanoid | Q13077 | |
| KO | K03172 | |
| OMA | HFMKEKL | |
| OrthoDB | EOG7966G5 | |
| PhylomeDB | Q13077 | |
| TreeFam | TF321154 | |
| SignaLink | Q13077 | |
| EvolutionaryTrace | Q13077 | |
| GeneWiki | TRAF1 | |
| GenomeRNAi | 7185 | |
| NextBio | 28168 | |
| PMAP-CutDB | Q13077 | |
| PRO | PR:Q13077 | |
| Proteomes | UP000005640 | |
| Bgee | Q13077 | |
| CleanEx | HS_TRAF1 | |
| Genevestigator | Q13077 | |
| GO | GO:0005737 GO:0031996 GO:0005164 GO:0031625 GO:0008270 GO:0006915 GO:0051092 GO:0006461 GO:2001236 GO:0007165 | |
| InterPro | IPR002083 IPR012227 IPR008974 IPR027136 | |
| PANTHER | PTHR10131:SF29 | |
| Pfam | PF00917 | |
| PIRSF | PIRSF015614 | |
| SMART | SM00061 | |
| SUPFAM | SSF49599 | |
| PROSITE | PS50144 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0005164 |
tumor necrosis factor receptor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2001236 |
regulation of extrinsic apoptotic signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051092 |
positive regulation of NF-kappaB transcription factor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0031996 |
thioesterase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0031625 |
ubiquitin protein ligase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:101835 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0031996 |
thioesterase binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002562131 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0031625 |
ubiquitin protein ligase binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002562131 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005164 |
tumor necrosis factor receptor binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002562131 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005164 |
tumor necrosis factor receptor binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042981 |
regulation of apoptotic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0065003 |
protein-containing complex assembly |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010803 |
regulation of tumor necrosis factor-mediated signaling pathway |
Reactome:R-HSA-5357905 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-5693108 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Wiley, SR et al. (2001) A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis. Immunity 15 837-46 PubMed GONUTS page
- ↑ 2.0 2.1 Irmler, M et al. (2000) Caspase-induced inactivation of the anti-apoptotic TRAF1 during Fas ligand-mediated apoptosis. FEBS Lett. 468 129-33 PubMed GONUTS page
- ↑ 3.0 3.1 Zapata, JM et al. (2001) A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains. J. Biol. Chem. 276 24242-52 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Rothe, M et al. (1994) A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. Cell 78 681-92 PubMed GONUTS page
- ↑ Yachie, N et al. (2016) Pooled-matrix protein interaction screens using Barcode Fusion Genetics. Mol. Syst. Biol. 12 863 PubMed GONUTS page
- ↑ Rolland, T et al. (2014) A proteome-scale map of the human interactome network. Cell 159 1212-26 PubMed GONUTS page
p
r
