HUMAN:TP53B

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	TP53BP1
Protein Name(s)	Tumor suppressor p53-binding protein 1 53BP1 p53-binding protein 1 p53BP1
External Links
UniProt	Q12888
EMBL	AF078776 AB210025 BX537418 AY904026 AC018924 BC112161 U09477
CCDS	CCDS10096.1 CCDS45250.1 CCDS45251.1
PIR	I38604
RefSeq	NP_001135451.1 NP_001135452.1 NP_005648.1 XP_005254691.1
UniGene	Hs.440968 Hs.584887
PDB	1GZH 1KZY 1XNI 2G3R 2IG0 2LVM 3LGF 3LGL 3LH0 4CRI 4RG2
PDBsum	1GZH 1KZY 1XNI 2G3R 2IG0 2LVM 3LGF 3LGL 3LH0 4CRI 4RG2
ProteinModelPortal	Q12888
SMR	Q12888
BioGrid	113011
DIP	DIP-5978N
IntAct	Q12888
MINT	MINT-276057
STRING	9606.ENSP00000371475
BindingDB	Q12888
ChEMBL	CHEMBL2424509
PhosphoSite	Q12888
DMDM	8928568
MaxQB	Q12888
PaxDb	Q12888
PRIDE	Q12888
Ensembl	ENST00000263801 ENST00000382044 ENST00000450115
GeneID	7158
KEGG	hsa:7158
UCSC	uc001zrr.4 uc001zrs.3
CTD	7158
GeneCards	GC15M043699
HGNC	HGNC:11999
HPA	CAB004083 HPA008788 HPA022133
MIM	605230
neXtProt	NX_Q12888
PharmGKB	PA36680
eggNOG	NOG264535
GeneTree	ENSGT00390000011891
HOGENOM	HOG000231961
HOVERGEN	HBG060882
InParanoid	Q12888
OMA	PEIPFQA
OrthoDB	EOG7RZ5P1
PhylomeDB	Q12888
TreeFam	TF350227
Reactome	REACT_97
ChiTaRS	TP53BP1
EvolutionaryTrace	Q12888
GeneWiki	TP53BP1
GenomeRNAi	7158
NextBio	28010
PMAP-CutDB	Q12888
PRO	PR:Q12888
Proteomes	UP000005640
Bgee	Q12888
CleanEx	HS_TP53BP1
ExpressionAtlas	Q12888
Genevestigator	Q12888
GO	GO:0000777 GO:0005737 GO:0005654 GO:0005634 GO:0005657 GO:0003684 GO:0035064 GO:0002039 GO:0001102 GO:0001104 GO:0042162 GO:0006974 GO:0006281 GO:0006302 GO:0000724 GO:0051091 GO:0045944 GO:0045893 GO:0006366
Gene3D	2.30.30.30 3.40.50.10190
InterPro	IPR015125 IPR001357 IPR014722
Pfam	PF09038
SMART	SM00292
SUPFAM	SSF52113
PROSITE	PS50172

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0035861	site of double-strand break	PMID:23333306^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006303	double-strand break repair via nonhomologous end joining	PMID:23333306^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:2000042	negative regulation of double-strand break repair via homologous recombination	PMID:23333306^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:2000042	negative regulation of double-strand break repair via homologous recombination	PMID:23345425^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045830	positive regulation of isotype switching	PMID:23345425^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	PMID:23345425^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045830	positive regulation of isotype switching	PMID:23760478^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006303	double-strand break repair via nonhomologous end joining	PMID:23760478^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0035861	site of double-strand break	PMID:23760478^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0061649	ubiquitin modification-dependent histone binding	PMID:23760478^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0035064	methylated histone binding	PMID:23760478^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:28241136^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006303	double-strand break repair via nonhomologous end joining	PMID:28241136^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0035064	methylated histone binding	PMID:28241136^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0035861	site of double-strand break	PMID:28241136^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:28241136^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0002039	p53 binding	PMID:14985081^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04637	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:9748285^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	PMID:9748285^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	PMID:17805299^[7]	ECO:0000305	curator inference used in manual assertion	GO:0045944	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17805299^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0002039	p53 binding	PMID:17805299^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04637	F	Seeded From UniProt	complete
enables	GO:0003712	transcription coregulator activity	PMID:17805299^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0001102	RNA polymerase II activating transcription factor binding	PMID:17805299^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04637	F	Seeded From UniProt	complete
colocalizes_with	GO:0000781	chromosome, telomeric region	PMID:15149599^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:9748285^[6]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0035064	methylated histone binding	PMID:22373579^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001809041 SGD:S000002625 UniProtKB:Q12888	P	Seeded From UniProt	complete
enables	GO:0042393	histone binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001809041 SGD:S000002625	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1351320 PANTHER:PTN001809041 PomBase:SPBC342.05 RGD:1308039 UniProtKB:Q12888	C	Seeded From UniProt	complete
involved_in	GO:0000077	DNA damage checkpoint	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001809041 SGD:S000002625 UniProtKB:A0A1D8PNH8	P	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:17500065^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0071481	cellular response to X-ray	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1M842 ensembl:ENSRNOP00000019025	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1M842 ensembl:ENSRNOP00000019025	C	Seeded From UniProt	complete
involved_in	GO:2000042	negative regulation of double-strand break repair via homologous recombination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70399 ensembl:ENSMUSP00000106278	P	Seeded From UniProt	complete
part_of	GO:1990391	DNA repair complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70399 ensembl:ENSMUSP00000106278	C	Seeded From UniProt	complete
involved_in	GO:0045830	positive regulation of isotype switching	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70399 ensembl:ENSMUSP00000106278	P	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70399 ensembl:ENSMUSP00000106278	F	Seeded From UniProt	complete
enables	GO:0042162	telomeric DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70399 ensembl:ENSMUSP00000106278	F	Seeded From UniProt	complete
part_of	GO:0035861	site of double-strand break	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70399 ensembl:ENSMUSP00000106278	C	Seeded From UniProt	complete
enables	GO:0035064	methylated histone binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70399 ensembl:ENSMUSP00000106278	F	Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70399 ensembl:ENSMUSP00000106278	C	Seeded From UniProt	complete
involved_in	GO:0006303	double-strand break repair via nonhomologous end joining	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70399 ensembl:ENSMUSP00000106278	P	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70399 ensembl:ENSMUSP00000106278	P	Seeded From UniProt	complete
part_of	GO:0005657	replication fork	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70399 ensembl:ENSMUSP00000106278	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70399 ensembl:ENSMUSP00000106278	C	Seeded From UniProt	complete
enables	GO:0003684	damaged DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70399 ensembl:ENSMUSP00000106278	F	Seeded From UniProt	complete
part_of	GO:0000784	nuclear chromosome, telomeric region	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70399 ensembl:ENSMUSP00000106278	C	Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70399 ensembl:ENSMUSP00000106278	C	Seeded From UniProt	complete
involved_in	GO:0006303	double-strand break repair via nonhomologous end joining	Reactome:R-HSA-5693571	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-69891 Reactome:R-HSA-5693599 Reactome:R-HSA-5693566 Reactome:R-HSA-5693551 Reactome:R-HSA-5686900 Reactome:R-HSA-5686704 Reactome:R-HSA-5686685 Reactome:R-HSA-5684071 Reactome:R-HSA-5684052 Reactome:R-HSA-5683801 Reactome:R-HSA-5683735 Reactome:R-HSA-5683425 Reactome:R-HSA-5683405 Reactome:R-HSA-5683385 Reactome:R-HSA-5683384 Reactome:R-HSA-2997723	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158 UniProtKB-SubCell:SL-0468	C	Seeded From UniProt	complete
part_of	GO:0000775	chromosome, centromeric region	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0137	C	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0995	C	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
part_of	GO:0000777	condensed chromosome kinetochore	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0149	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Escribano-Díaz, C et al. (2013) A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice. Mol. Cell 49 872-83 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Lottersberger, F et al. (2013) Role of 53BP1 oligomerization in regulating double-strand break repair. Proc. Natl. Acad. Sci. U.S.A. 110 2146-51 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Fradet-Turcotte, A et al. (2013) 53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark. Nature 499 50-4 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Drané, P et al. (2017) TIRR regulates 53BP1 by masking its histone methyl-lysine binding function. Nature 543 211-216 PubMed GONUTS page
↑ Cao, Y et al. (2004) Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis. Biochem. Biophys. Res. Commun. 315 788-95 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Iwabuchi, K et al. (1998) Stimulation of p53-mediated transcriptional activation by the p53-binding proteins, 53BP1 and 53BP2. J. Biol. Chem. 273 26061-8 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Huang, J et al. (2007) p53 is regulated by the lysine demethylase LSD1. Nature 449 105-8 PubMed GONUTS page
↑ Herbig, U et al. (2004) Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol. Cell 14 501-13 PubMed GONUTS page
↑ Mallette, FA et al. (2012) RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites. EMBO J. 31 1865-78 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Cho, YW et al. (2007) PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. J. Biol. Chem. 282 20395-406 PubMed GONUTS page

[PMID:23333306-1] 1.0 ^1.1 ^1.2 Escribano-Díaz, C et al. (2013) A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice. Mol. Cell 49 872-83 PubMed GONUTS page

[PMID:23345425-2] 2.0 ^2.1 ^2.2 Lottersberger, F et al. (2013) Role of 53BP1 oligomerization in regulating double-strand break repair. Proc. Natl. Acad. Sci. U.S.A. 110 2146-51 PubMed GONUTS page

[PMID:23760478-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Fradet-Turcotte, A et al. (2013) 53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark. Nature 499 50-4 PubMed GONUTS page

[PMID:28241136-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Drané, P et al. (2017) TIRR regulates 53BP1 by masking its histone methyl-lysine binding function. Nature 543 211-216 PubMed GONUTS page

[PMID:14985081-5] Cao, Y et al. (2004) Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis. Biochem. Biophys. Res. Commun. 315 788-95 PubMed GONUTS page

[PMID:9748285-6] 6.0 ^6.1 ^6.2 Iwabuchi, K et al. (1998) Stimulation of p53-mediated transcriptional activation by the p53-binding proteins, 53BP1 and 53BP2. J. Biol. Chem. 273 26061-8 PubMed GONUTS page

[PMID:17805299-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Huang, J et al. (2007) p53 is regulated by the lysine demethylase LSD1. Nature 449 105-8 PubMed GONUTS page

[PMID:15149599-8] Herbig, U et al. (2004) Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol. Cell 14 501-13 PubMed GONUTS page

[PMID:22373579-9] Mallette, FA et al. (2012) RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites. EMBO J. 31 1865-78 PubMed GONUTS page

[PMID:21873635-10] 10.0 ^10.1 ^10.2 ^10.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17500065-11] Cho, YW et al. (2007) PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. J. Biol. Chem. 282 20395-406 PubMed GONUTS page

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HUMAN:TP53B

Contents

Annotations

Notes

References

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