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HUMAN:TMPS3

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) TMPRSS3 (synonyms: ECHOS1, TADG12)
Protein Name(s) Transmembrane protease serine 3

Serine protease TADG-12 Tumor-associated differentially-expressed gene 12 protein

External Links
UniProt P57727
EMBL AF201380
AB038157
AB038158
AB038159
AB038160
AY633572
AY358458
AK172842
AP001623
CH471079
CH471079
BC074846
BC074847
CCDS CCDS13686.1
CCDS42939.1
CCDS58790.1
RefSeq NP_001243246.1
NP_076927.1
NP_115780.1
NP_115781.1
UniGene Hs.208600
ProteinModelPortal P57727
SMR P57727
BioGrid 122236
IntAct P57727
MINT MINT-1379704
STRING 9606.ENSP00000291532
MEROPS S01.079
PhosphoSite P57727
DMDM 13124582
PaxDb P57727
PRIDE P57727
Ensembl ENST00000291532
ENST00000398397
ENST00000433957
GeneID 64699
KEGG hsa:64699
UCSC uc002zay.2
uc002zaz.3
uc002zbc.3
uc002zbd.4
CTD 64699
GeneCards GC21M043791
GeneReviews TMPRSS3
HGNC HGNC:11877
HPA HPA031305
MIM 601072
605511
neXtProt NX_P57727
Orphanet 90636
PharmGKB PA36578
eggNOG COG5640
GeneTree ENSGT00760000118962
HOGENOM HOG000251822
HOVERGEN HBG013304
InParanoid P57727
KO K09634
OMA VITPLWI
PhylomeDB P57727
TreeFam TF351678
ChiTaRS TMPRSS3
GeneWiki TMPRSS3
GenomeRNAi 64699
NextBio 66629
PRO PR:P57727
Proteomes UP000005640
Bgee P57727
CleanEx HS_TMPRSS3
ExpressionAtlas P57727
Genevestigator P57727
GO GO:0005783
GO:0005789
GO:0016021
GO:0043025
GO:0005044
GO:0004252
GO:0017080
GO:0006883
GO:0006508
GO:0007605
Gene3D 3.10.250.10
4.10.400.10
InterPro IPR023415
IPR002172
IPR001254
IPR018114
IPR001314
IPR001190
IPR017448
IPR009003
Pfam PF00057
PF00089
PRINTS PR00722
SMART SM00192
SM00202
SM00020
SUPFAM SSF50494
SSF56487
SSF57424
PROSITE PS01209
PS50068
PS00420
PS50287
PS50240
PS00134
PS00135

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0016021

integral component of membrane

PMID:11137999[1]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

PMID:11068177[2]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

PMID:11068177[2]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

PMID:17918732[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

PMID:16780588[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004252

serine-type endopeptidase activity

PMID:11137999[1]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004252

serine-type endopeptidase activity

PMID:11068177[2]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0017080

sodium channel regulator activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002552988
UniProtKB:P57727

F

Seeded From UniProt

complete

involved_in

GO:0007605

sensory perception of sound

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2155445
PANTHER:PTN002552988
RGD:1310135

P

Seeded From UniProt

complete

involved_in

GO:0006883

cellular sodium ion homeostasis

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002552988
UniProtKB:P57727

P

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002552988
UniProtKB:P57727

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2155445
PANTHER:PTN002552988

C

Seeded From UniProt

complete

enables

GO:0017080

sodium channel regulator activity

PMID:12393794[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006883

cellular sodium ion homeostasis

PMID:12393794[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

PMID:12393794[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0016192

vesicle-mediated transport

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005044

P

Seeded From UniProt

complete

involved_in

GO:0007605

sensory perception of sound

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D3ZY65
ensembl:ENSRNOP00000001540

P

Seeded From UniProt

complete

part_of

GO:0043025

neuronal cell body

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8K1T0
ensembl:ENSMUSP00000110196

C

Seeded From UniProt

complete

involved_in

GO:0007605

sensory perception of sound

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8K1T0
ensembl:ENSMUSP00000110196

P

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8K1T0
ensembl:ENSMUSP00000110196

C

Seeded From UniProt

complete

enables

GO:0004252

serine-type endopeptidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001254
InterPro:IPR001314
InterPro:IPR018114

F

Seeded From UniProt

complete

enables

GO:0005044

scavenger receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001190

F

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001254
InterPro:IPR001314
InterPro:IPR018114

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001190
InterPro:IPR017448
InterPro:IPR036772

C

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

P

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0256

C

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

enables

GO:0008236

serine-type peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0720

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0097

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Scott, HS et al. (2001) Insertion of beta-satellite repeats identifies a transmembrane protease causing both congenital and childhood onset autosomal recessive deafness. Nat. Genet. 27 59-63 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Underwood, LJ et al. (2000) Ovarian tumor cells express a novel multi-domain cell surface serine protease. Biochim. Biophys. Acta 1502 337-50 PubMed GONUTS page
  3. ↑ Guipponi, M et al. (2008) An integrated genetic and functional analysis of the role of type II transmembrane serine proteases (TMPRSSs) in hearing loss. Hum. Mutat. 29 130-41 PubMed GONUTS page
  4. ↑ Hu, YH et al. (2006) Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. BMC Genomics 7 155 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 Guipponi, M et al. (2002) The transmembrane serine protease (TMPRSS3) mutated in deafness DFNB8/10 activates the epithelial sodium channel (ENaC) in vitro. Hum. Mol. Genet. 11 2829-36 PubMed GONUTS page
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