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HUMAN:TINF2
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | TINF2 (synonyms: TIN2) | |
| Protein Name(s) | TERF1-interacting nuclear factor 2
TRF1-interacting nuclear protein 2 | |
| External Links | ||
| UniProt | Q9BSI4 | |
| EMBL | AF195512 AK023166 BC005030 BC019343 EU851975 | |
| CCDS | CCDS41936.1 CCDS41937.1 | |
| RefSeq | NP_001092744.1 NP_036593.2 | |
| UniGene | Hs.496191 | |
| PDB | 3BQO 3BU8 | |
| PDBsum | 3BQO 3BU8 | |
| ProteinModelPortal | Q9BSI4 | |
| BioGrid | 117660 | |
| DIP | DIP-29413N | |
| IntAct | Q9BSI4 | |
| MINT | MINT-221357 | |
| STRING | 9606.ENSP00000267415 | |
| iPTMnet | Q9BSI4 | |
| PhosphoSite | Q9BSI4 | |
| BioMuta | TINF2 | |
| DMDM | 21542262 | |
| EPD | Q9BSI4 | |
| MaxQB | Q9BSI4 | |
| PaxDb | Q9BSI4 | |
| PRIDE | Q9BSI4 | |
| DNASU | 26277 | |
| Ensembl | ENST00000267415 ENST00000399423 | |
| GeneID | 26277 | |
| KEGG | hsa:26277 | |
| UCSC | uc001woa.5 | |
| CTD | 26277 | |
| GeneCards | TINF2 | |
| GeneReviews | TINF2 | |
| HGNC | HGNC:11824 | |
| MalaCards | TINF2 | |
| MIM | 268130 604319 613990 | |
| neXtProt | NX_Q9BSI4 | |
| Orphanet | 1775 3322 3088 | |
| PharmGKB | PA36530 | |
| eggNOG | ENOG410IHMP ENOG410Z499 | |
| GeneTree | ENSGT00400000022326 | |
| HOGENOM | HOG000247003 | |
| HOVERGEN | HBG057120 | |
| InParanoid | Q9BSI4 | |
| KO | K11112 | |
| OMA | GGHKERP | |
| PhylomeDB | Q9BSI4 | |
| TreeFam | TF334731 | |
| Reactome | [www.reactome.org/content/detail/R-HSA-1221632 R-HSA-1221632] [www.reactome.org/content/detail/R-HSA-171306 R-HSA-171306] [www.reactome.org/content/detail/R-HSA-2559586 R-HSA-2559586] | |
| SIGNOR | Q9BSI4 | |
| EvolutionaryTrace | Q9BSI4 | |
| GeneWiki | TINF2 | |
| GenomeRNAi | 26277 | |
| PRO | PR:Q9BSI4 | |
| Proteomes | UP000005640 | |
| Bgee | Q9BSI4 | |
| CleanEx | HS_TINF2 | |
| ExpressionAtlas | Q9BSI4 | |
| Genevisible | Q9BSI4 | |
| GO | GO:0000781 GO:0000784 GO:0016363 GO:0000783 GO:0005654 GO:0005634 GO:0010370 GO:0070187 GO:0010521 GO:0042162 GO:0050680 GO:0010836 GO:0051974 GO:0032211 GO:0032206 GO:0034502 GO:0070198 GO:0032202 GO:0016233 GO:0010833 | |
| InterPro | IPR029400 | |
| Pfam | PF14973 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0016233 |
telomere capping |
ECO:0000305 |
curator inference used in manual assertion |
GO:0032211 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010836 |
negative regulation of protein ADP-ribosylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:O95271) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032211 |
negative regulation of telomere maintenance via telomerase |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:O14746) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0000784 |
nuclear chromosome, telomeric region |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000784 |
nuclear chromosome, telomeric region |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070187 |
shelterin complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070187 |
shelterin complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000784 |
nuclear chromosome, telomeric region |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042162 |
telomeric DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070187 |
shelterin complex |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000784 |
nuclear chromosome, telomeric region |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070198 |
protein localization to chromosome, telomeric region |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050680 |
negative regulation of epithelial cell proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070198 |
protein localization to chromosome, telomeric region |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_direct_input:(UniProtKB:P54274) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032211 |
negative regulation of telomere maintenance via telomerase |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
Missing: with/from | |||
|
involved_in |
GO:0016233 |
telomere capping |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032202 |
telomere assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1904356 |
regulation of telomere maintenance via telomere lengthening |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0010370 |
perinucleolar chromocenter |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
NOT|enables |
GO:0003677 |
DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000783 |
nuclear telomere cap complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000784 |
nuclear chromosome, telomeric region |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000781 |
chromosome, telomeric region |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000781 |
chromosome, telomeric region |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042162 |
telomeric DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016604 |
nuclear body |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016233 |
telomere capping |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0070198 |
protein localization to chromosome, telomeric region |
ECO:0000314 |
P |
Figure 6: After knockdown of TPP1, introduction of an shRNA-resistant TPP1 restores hTr localization to the telomere Evidence code: IMP |
complete | |||||
|
part_of |
GO:0070187 |
shelterin complex |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016233 |
telomere capping |
Reactome:R-HSA-181450 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
P |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-3785711 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0000781 |
chromosome, telomeric region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005694 |
chromosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016363 |
nuclear matrix |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Ye, JZ & de Lange, T (2004) TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex. Nat. Genet. 36 618-23 PubMed GONUTS page
- ↑ Déjardin, J & Kingston, RE (2009) Purification of proteins associated with specific genomic Loci. Cell 136 175-86 PubMed GONUTS page
- ↑ Liu, D et al. (2004) Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins. J. Biol. Chem. 279 51338-42 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Kappei, D et al. (2013) HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment. EMBO J. 32 1681-701 PubMed GONUTS page
- ↑ Choi, KH et al. (2011) Characterization of the DNA binding specificity of Shelterin complexes. Nucleic Acids Res. 39 9206-23 PubMed GONUTS page
- ↑ Grolimund, L et al. (2013) A quantitative telomeric chromatin isolation protocol identifies different telomeric states. Nat Commun 4 2848 PubMed GONUTS page
- ↑ 7.0 7.1 Kim, SH et al. (2008) Telomere dysfunction and cell survival: roles for distinct TIN2-containing complexes. J. Cell Biol. 181 447-60 PubMed GONUTS page
- ↑ 8.0 8.1 Kaminker, P et al. (2005) Higher-order nuclear organization in growth arrest of human mammary epithelial cells: a novel role for telomere-associated protein TIN2. J. Cell. Sci. 118 1321-30 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 Kim, SH et al. (1999) TIN2, a new regulator of telomere length in human cells. Nat. Genet. 23 405-12 PubMed GONUTS page
- ↑ 10.0 10.1 O'Connor, MS et al. (2006) A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly. Proc. Natl. Acad. Sci. U.S.A. 103 11874-9 PubMed GONUTS page
- ↑ Walne, AJ et al. (2008) TINF2 mutations result in very short telomeres: analysis of a large cohort of patients with dyskeratosis congenita and related bone marrow failure syndromes. Blood 112 3594-600 PubMed GONUTS page
- ↑ Houghtaling, BR et al. (2004) A dynamic molecular link between the telomere length regulator TRF1 and the chromosome end protector TRF2. Curr. Biol. 14 1621-31 PubMed GONUTS page
- ↑ 13.0 13.1 Loayza, D & De Lange, T (2003) POT1 as a terminal transducer of TRF1 telomere length control. Nature 423 1013-8 PubMed GONUTS page
- ↑ Abreu, E et al. (2010) TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo. Mol. Cell. Biol. 30 2971-82 PubMed GONUTS page
n
- GO:0032211 ! negative regulation of telomere maintenance via telomerase
- GO:0050680 ! negative regulation of epithelial cell proliferation
- GO:0010836 ! negative regulation of protein ADP-ribosylation
- GO:0016604 ! nuclear body
- GO:0000784 ! nuclear chromosome, telomeric region
- GO:0016363 ! nuclear matrix
- GO:0000783 ! nuclear telomere cap complex
- GO:0005654 ! nucleoplasm
- GO:0005634 ! nucleus
p
