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HUMAN:TGM2
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | TGM2 | |
| Protein Name(s) | Protein-glutamine gamma-glutamyltransferase 2
Tissue transglutaminase Transglutaminase C TG(C) TGC TGase C Transglutaminase H TGase H Transglutaminase-2 TGase-2 | |
| External Links | ||
| UniProt | P21980 | |
| EMBL | M55153 M98478 S81734 AY675221 AK291714 AK314618 DQ523828 AL031651 CH471077 CH471077 CH471077 BC003551 | |
| CCDS | CCDS13302.1 | |
| PIR | A39045 A44302 S68092 | |
| RefSeq | NP_004604.2 NP_945189.1 | |
| UniGene | Hs.517033 | |
| PDB | 1FAU 1KV3 2Q3Z 3LY6 3S3J 3S3P 3S3S | |
| PDBsum | 1FAU 1KV3 2Q3Z 3LY6 3S3J 3S3P 3S3S | |
| ProteinModelPortal | P21980 | |
| SMR | P21980 | |
| BioGrid | 112910 | |
| DIP | DIP-33557N | |
| IntAct | P21980 | |
| MINT | MINT-88880 | |
| STRING | 9606.ENSP00000355330 | |
| BindingDB | P21980 | |
| ChEMBL | CHEMBL2730 | |
| DrugBank | DB00130 | |
| PhosphoSite | P21980 | |
| DMDM | 20141877 | |
| MaxQB | P21980 | |
| PaxDb | P21980 | |
| PeptideAtlas | P21980 | |
| PRIDE | P21980 | |
| Ensembl | ENST00000361475 | |
| GeneID | 7052 | |
| KEGG | hsa:7052 | |
| UCSC | uc002xhr.3 uc002xht.3 uc002xhu.3 | |
| CTD | 7052 | |
| GeneCards | GC20M036756 | |
| HGNC | HGNC:11778 | |
| HPA | CAB002598 HPA021019 HPA029518 | |
| MIM | 190196 | |
| neXtProt | NX_P21980 | |
| PharmGKB | PA36491 | |
| eggNOG | NOG80379 | |
| HOGENOM | HOG000231695 | |
| HOVERGEN | HBG004342 | |
| InParanoid | P21980 | |
| KO | K05625 | |
| OMA | ANGRDHH | |
| OrthoDB | EOG7WT40M | |
| PhylomeDB | P21980 | |
| TreeFam | TF324278 | |
| SignaLink | P21980 | |
| ChiTaRS | TGM2 | |
| EvolutionaryTrace | P21980 | |
| GeneWiki | Tissue_transglutaminase | |
| GenomeRNAi | 7052 | |
| NextBio | 27573 | |
| PMAP-CutDB | P21980 | |
| PRO | PR:P21980 | |
| Proteomes | UP000005640 | |
| Bgee | P21980 | |
| CleanEx | HS_TGM2 | |
| ExpressionAtlas | P21980 | |
| Genevestigator | P21980 | |
| GO | GO:0005829 GO:0070062 GO:0005925 GO:0005739 GO:0005886 GO:0005525 GO:0046872 GO:0003810 GO:0043277 GO:0001974 GO:0060445 GO:0018153 GO:0032471 GO:0043065 GO:0045785 GO:0051482 GO:0043123 GO:0050729 GO:0051561 GO:0048661 GO:0051260 GO:0060662 | |
| Gene3D | 2.60.40.10 3.90.260.10 | |
| InterPro | IPR023608 IPR013783 IPR014756 IPR002931 IPR008958 IPR013808 IPR001102 | |
| PANTHER | PTHR11590 | |
| Pfam | PF00927 PF01841 PF00868 | |
| PIRSF | PIRSF000459 | |
| SMART | SM00460 | |
| SUPFAM | SSF49309 SSF81296 | |
| PROSITE | PS00547 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
Contributes to |
GO:0071078 |
fibronectin-tissue transglutaminase complex |
ECO:0000314 |
C |
Decreases cell apoptotic rate |
complete | ||||
| GO:0031226 |
intrinsic to plasma membrane |
ECO:0000315 |
C |
TGK becomes quickly membrane bound. When mutated, TGK mutant is not membrane bound. Figure 2 identifies the localization of native and mutant using fractionation and then immunoblotting of the immunoprecipitation. |
complete | |||||
| GO:0031226 |
intrinsic to plasma membrane |
ECO:0000314 |
C |
Figure 2, 3, 4: distribution of TGM activity |
complete | |||||
|
colocalizes_with |
GO:0062023 |
collagen-containing extracellular matrix |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(CL:0002540)|part_of:(CL:0002570)|part_of:(CL:0002551) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0062023 |
collagen-containing extracellular matrix |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0002107) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0062023 |
collagen-containing extracellular matrix |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0003688) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0062023 |
collagen-containing extracellular matrix |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001155) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0062023 |
collagen-containing extracellular matrix |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(CL:0002543) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031226 |
intrinsic component of plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031226 |
intrinsic component of plasma membrane |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005925 |
focal adhesion |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(CL:0000057) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001088) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051561 |
positive regulation of mitochondrial calcium ion concentration |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043065 |
positive regulation of apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032471 |
negative regulation of endoplasmic reticulum calcium ion concentration |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003810 |
protein-glutamine gamma-glutamyltransferase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
has_input:(UniProtKB:P52306) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045785 |
positive regulation of cell adhesion |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043277 |
apoptotic cell clearance |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003810 |
protein-glutamine gamma-glutamyltransferase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0032471 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0032471 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060662 |
salivary gland cavitation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P21981 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060445 |
branching involved in salivary gland morphogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P21981 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051561 |
positive regulation of mitochondrial calcium ion concentration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P21981 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045785 |
positive regulation of cell adhesion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P21981 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032471 |
negative regulation of endoplasmic reticulum calcium ion concentration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P21981 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003810 |
protein-glutamine gamma-glutamyltransferase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P21981 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051482 |
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9WVJ6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051260 |
protein homooligomerization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9WVJ6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050729 |
positive regulation of inflammatory response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9WVJ6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048661 |
positive regulation of smooth muscle cell proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9WVJ6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043123 |
positive regulation of I-kappaB kinase/NF-kappaB signaling |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9WVJ6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043065 |
positive regulation of apoptotic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9WVJ6 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0019904 |
protein domain specific binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9WVJ6 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0018153 |
isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9WVJ6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007200 |
phospholipase C-activating G protein-coupled receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9WVJ6 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9WVJ6 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9WVJ6 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9WVJ6 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005525 |
GTP binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9WVJ6 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001974 |
blood vessel remodeling |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9WVJ6 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003810 |
protein-glutamine gamma-glutamyltransferase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0018149 |
peptide cross-linking |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001102 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003810 |
protein-glutamine gamma-glutamyltransferase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016746 |
transferase activity, transferring acyl groups |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Wang, W et al. (2015) Transglutaminase-2 is Involved in Cell Apoptosis of Osteosarcoma Cell Line U2OS Under Hypoxia Condition. Cell Biochem. Biophys. PubMed GONUTS page
- ↑ 2.0 2.1 Phillips, MA et al. (1993) Keratinocyte transglutaminase membrane anchorage: analysis of site-directed mutants. Biochemistry 32 11057-63 PubMed GONUTS page
- ↑ 3.0 3.1 Thacher, SM & Rice, RH (1985) Keratinocyte-specific transglutaminase of cultured human epidermal cells: relation to cross-linked envelope formation and terminal differentiation. Cell 40 685-95 PubMed GONUTS page
- ↑ Ragelle, H et al. (2017) Comprehensive proteomic characterization of stem cell-derived extracellular matrices. Biomaterials 128 147-159 PubMed GONUTS page
- ↑ 5.0 5.1 Naba, A et al. (2014) Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC Cancer 14 518 PubMed GONUTS page
- ↑ Naba, A et al. (2017) Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. J. Proteome Res. 16 3083-3091 PubMed GONUTS page
- ↑ Zanivan, S et al. (2013) SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers. Mol. Cell Proteomics 12 3599-611 PubMed GONUTS page
- ↑ Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page
- ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
- ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 11.3 11.4 11.5 Hsieh, YF et al. (2013) Transglutaminase 2 contributes to apoptosis induction in Jurkat T cells by modulating Ca2+ homeostasis via cross-linking RAP1GDS1. PLoS ONE 8 e81516 PubMed GONUTS page
- ↑ Rébé, C et al. (2009) Induction of transglutaminase 2 by a liver X receptor/retinoic acid receptor alpha pathway increases the clearance of apoptotic cells by human macrophages. Circ. Res. 105 393-401 PubMed GONUTS page
b
c
e
o
p
- GO:0018149 ! peptide cross-linking
- GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway
- GO:0005886 ! plasma membrane
- GO:0050729 ! positive regulation of inflammatory response
- GO:0048661 ! positive regulation of smooth muscle cell proliferation
- GO:0045785 ! positive regulation of cell adhesion
- GO:0043123 ! positive regulation of canonical NF-kappaB signal transduction
- GO:0043065 ! positive regulation of apoptotic process
- GO:0051561 ! positive regulation of mitochondrial calcium ion concentration
- Primates
- GO:0003810 ! protein-glutamine gamma-glutamyltransferase activity
- GO:0019904 ! protein domain specific binding
- GO:0051260 ! protein homooligomerization
