HUMAN:TGFR2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	TGFBR2
Protein Name(s)	TGF-beta receptor type-2 TGFR-2 TGF-beta type II receptor Transforming growth factor-beta receptor type II TGF-beta receptor type II TbetaR-II
External Links
UniProt	P37173
EMBL	M85079 D28131 U52246 U52240 U52241 U52242 U52244 U52245 U69152 U69146 U69147 U69148 U69149 U69150 U69151 D50683 AY675319 AK300383 CH471055
CCDS	CCDS2648.1 CCDS33727.1
PIR	A42100
RefSeq	NP_001020018.1 NP_003233.4
UniGene	Hs.604277 Hs.82028
PDB	1KTZ 1M9Z 1PLO 2PJY 3KFD
PDBsum	1KTZ 1M9Z 1PLO 2PJY 3KFD
ProteinModelPortal	P37173
SMR	P37173
BioGrid	112906
DIP	DIP-5939N
IntAct	P37173
MINT	MINT-206666
STRING	9606.ENSP00000351905
BindingDB	P37173
ChEMBL	CHEMBL4267
GuidetoPHARMACOLOGY	1795
PhosphoSite	P37173
DMDM	116242818
MaxQB	P37173
PaxDb	P37173
PRIDE	P37173
DNASU	7048
Ensembl	ENST00000295754 ENST00000359013
GeneID	7048
KEGG	hsa:7048
UCSC	uc003ceo.3
CTD	7048
GeneCards	GC03P030623
GeneReviews	TGFBR2
H-InvDB	HIX0024332
HGNC	HGNC:11773
MIM	133239 190182 610168 614331
neXtProt	NX_P37173
Orphanet	91387 144 60030 284973
PharmGKB	PA36486
eggNOG	COG0515
GeneTree	ENSGT00760000118876
HOGENOM	HOG000231495
HOVERGEN	HBG104975
InParanoid	P37173
KO	K04388
OMA	HIISWED
OrthoDB	EOG7JHM5B
PhylomeDB	P37173
TreeFam	TF314724
BRENDA	2.7.10.2
Reactome	REACT_120726 REACT_120727 REACT_120850 REACT_169103 REACT_169165 REACT_169192 REACT_169263 REACT_169440 REACT_169445
SignaLink	P37173
ChiTaRS	TGFBR2
EvolutionaryTrace	P37173
GeneWiki	TGF_beta_receptor_2
GenomeRNAi	7048
NextBio	27541
PRO	PR:P37173
Proteomes	UP000005640
Bgee	P37173
CleanEx	HS_TGFBR2
ExpressionAtlas	P37173
Genevestigator	P37173
GO	GO:0005901 GO:0005829 GO:0009897 GO:0016021 GO:0005886 GO:0043235 GO:0070022 GO:0005524 GO:0005539 GO:0046872 GO:0004702 GO:0046332 GO:0050431 GO:0005026 GO:0005024 GO:0004675 GO:0034713 GO:0034714 GO:0032147 GO:0007568 GO:0006915 GO:0001568 GO:0007420 GO:0060434 GO:0051216 GO:0007182 GO:0048565 GO:0007566 GO:0048701 GO:0035162 GO:0007369 GO:0007507 GO:0001701 GO:0002088 GO:1990086 GO:0060463 GO:0060443 GO:0043011 GO:0060044 GO:0030512 GO:0031100 GO:0060021 GO:0060389 GO:0001569 GO:0018105 GO:0018107 GO:0045766 GO:0002663 GO:0008284 GO:0010634 GO:0002053 GO:0051138 GO:2000379 GO:0043415 GO:0048661 GO:0002666 GO:0002651 GO:0006468 GO:0006898 GO:0042127 GO:0070723 GO:0042493 GO:0043627 GO:0009749 GO:0009612 GO:0007584 GO:0007224 GO:0060440 GO:0007179 GO:0001570 GO:0042060
InterPro	IPR011009 IPR000719 IPR017441 IPR008271 IPR000333 IPR017194 IPR015013
PANTHER	PTHR23255
Pfam	PF08917 PF00069
PIRSF	PIRSF037393
PRINTS	PR00653
SUPFAM	SSF56112
PROSITE	PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:1990428	miRNA transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62312	P	transports_or_maintains_localization_of:(RNAcentral:URS00005C2A6D_9606) occurs_in:(CL:0000192)\|transports_or_maintains_localization_of(RNAcentral:URS0000527F89_9606) occurs_in:(CL:0000192)	Seeded From UniProt	complete
involved_in	GO:1905317	inferior endocardial cushion morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62312	P		Seeded From UniProt	complete
NOT\|involved_in	GO:1905316	superior endocardial cushion morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62312	P		Seeded From UniProt	complete
involved_in	GO:2000563	positive regulation of CD4-positive, alpha-beta T cell proliferation	PMID:17164348^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003274	endocardial cushion fusion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62312	P	occurs_in:(UBERON:0002087)	Seeded From UniProt	complete
involved_in	GO:0003214	cardiac left ventricle morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62312	P		Seeded From UniProt	complete
involved_in	GO:0003186	tricuspid valve morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62312	P		Seeded From UniProt	complete
involved_in	GO:0003181	atrioventricular valve morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62312	P		Seeded From UniProt	complete
involved_in	GO:0003149	membranous septum morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62312	P		Seeded From UniProt	complete
involved_in	GO:0003148	outflow tract septum morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62312	P		Seeded From UniProt	complete
NOT\|involved_in	GO:1905315	cell proliferation involved in endocardial cushion morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62312	P		Seeded From UniProt	complete
involved_in	GO:1905007	positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62312	P	occurs_in:(UBERON:0002087) occurs_in:(UBERON:0008307)	Seeded From UniProt	complete
involved_in	GO:0060412	ventricular septum morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62312	P	occurs_in:(UBERON:0002349)	Seeded From UniProt	complete
involved_in	GO:0003151	outflow tract morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62312	P		Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62312	P	occurs_in:(UBERON:0008307)	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:25893292^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010718	positive regulation of epithelial to mesenchymal transition	PMID:26459119^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:1000497)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:25893292^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:7852346^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000379	positive regulation of reactive oxygen species metabolic process	PMID:20160708^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070723	response to cholesterol	PMID:17878231^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060389	pathway-restricted SMAD protein phosphorylation	PMID:18453574^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0062009	secondary palate development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62312	P		Seeded From UniProt	complete
involved_in	GO:0051138	positive regulation of NK T cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62312	P		Seeded From UniProt	complete
enables	GO:0050431	transforming growth factor beta binding	PMID:1333888^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P61812	F		Seeded From UniProt	complete
enables	GO:0050431	transforming growth factor beta binding	PMID:1333888^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P10600	F		Seeded From UniProt	complete
enables	GO:0050431	transforming growth factor beta binding	PMID:1333888^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P01137	F		Seeded From UniProt	complete
enables	GO:0050431	transforming growth factor beta binding	PMID:1326540^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P01137	F		Seeded From UniProt	complete
enables	GO:0050431	transforming growth factor beta binding	PMID:18243111^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0050431	transforming growth factor beta binding	PMID:18453574^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0050431	transforming growth factor beta binding	PMID:7852346^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0048701	embryonic cranial skeleton morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62312	P		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	PMID:18453574^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	PMID:11157754^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:8774881^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043011	myeloid dendritic cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62312	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	PMID:17878231^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62312	P		Seeded From UniProt	complete
involved_in	GO:0035162	embryonic hemopoiesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62312	P		Seeded From UniProt	complete
enables	GO:0034713	type I transforming growth factor beta receptor binding	PMID:1333888^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P36897	F		Seeded From UniProt	complete
involved_in	GO:0032147	activation of protein kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62312	P		Seeded From UniProt	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	PMID:12015308^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:12015308^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:7852346^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:18453574^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62312	P		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62312	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:1333888^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:18453574^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:1326540^[9]	ECO:0000305	curator inference used in manual assertion	GO:0050431	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:12015308^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005901	caveola	PMID:17878231^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005539	glycosaminoglycan binding	PMID:7852346^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0050431	transforming growth factor beta binding	PMID:7852346^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P61812	F		Seeded From UniProt	complete
enables	GO:0005024	transforming growth factor beta-activated receptor activity	PMID:1333888^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005024	transforming growth factor beta-activated receptor activity	PMID:18453574^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005024	transforming growth factor beta-activated receptor activity	PMID:7852346^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005024	transforming growth factor beta-activated receptor activity	PMID:1326540^[9]	ECO:0000305	curator inference used in manual assertion	GO:0050431	F		Seeded From UniProt	complete
enables	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	PMID:12015308^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002666	positive regulation of T cell tolerance induction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62312	P		Seeded From UniProt	complete
involved_in	GO:0002663	positive regulation of B cell tolerance induction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62312	P		Seeded From UniProt	complete
involved_in	GO:0002651	positive regulation of tolerance induction to self antigen	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62312	P		Seeded From UniProt	complete
involved_in	GO:0002053	positive regulation of mesenchymal cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62312	P		Seeded From UniProt	complete
involved_in	GO:0001570	vasculogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62312	P		Seeded From UniProt	complete
involved_in	GO:0001569	branching involved in blood vessel morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62312	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:17471240^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98728 MGI:MGI:98729 PANTHER:PTN000583675 RGD:621789 UniProtKB:O00238 UniProtKB:P36894 UniProtKB:P36896 UniProtKB:P36897 UniProtKB:P37023 UniProtKB:P37173 UniProtKB:Q04771	F		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000583675 UniProtKB:P27037 UniProtKB:P36896 UniProtKB:P36897 UniProtKB:P37173 UniProtKB:Q13705	C		Seeded From UniProt	complete
enables	GO:0034713	type I transforming growth factor beta receptor binding	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001147373 UniProtKB:P37173 UniProtKB:Q90999	F		Seeded From UniProt	complete
enables	GO:0019838	growth factor binding	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102806 MGI:MGI:87911 MGI:MGI:87912 PANTHER:PTN000583675 RGD:71082 UniProtKB:P36896 UniProtKB:P36897 UniProtKB:Q13705 UniProtKB:Q8NER5	F		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98729 PANTHER:PTN000583682 UniProtKB:Q90999	P		Seeded From UniProt	complete
involved_in	GO:0007389	pattern specification process	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1338938 MGI:MGI:87912 PANTHER:PTN000583675	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003716 MGI:MGI:1338946 MGI:MGI:87911 MGI:MGI:98728 MGI:MGI:98729 PANTHER:PTN000583675 RGD:3852 RGD:620200 RGD:69651 RGD:70964 UniProtKB:A0A0B4KG59 UniProtKB:P36897 UniProtKB:P37023 UniProtKB:P37173 UniProtKB:Q04771 UniProtKB:Q06900 UniProtKB:Q90ZK6	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87911 PANTHER:PTN000583675 RGD:69651 RGD:70964 UniProtKB:P36896 UniProtKB:P37023 UniProtKB:Q04771 UniProtKB:Q13873	C		Seeded From UniProt	complete
enables	GO:0005026	transforming growth factor beta receptor activity, type II	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001147373 RGD:69651	F		Seeded From UniProt	complete
enables	GO:0005024	transforming growth factor beta-activated receptor activity	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98728 MGI:MGI:98729 PANTHER:PTN000583675 UniProtKB:A0A0B4KG59 UniProtKB:P36897 UniProtKB:P37023 UniProtKB:P37173 ZFIN:ZDB-GENE-070618-1	F		Seeded From UniProt	complete
involved_in	GO:0060044	negative regulation of cardiac muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38438 ensembl:ENSRNOP00000035501	P		Seeded From UniProt	complete
involved_in	GO:0048661	positive regulation of smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38438 ensembl:ENSRNOP00000035501	P		Seeded From UniProt	complete
involved_in	GO:0048565	digestive tract development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38438 ensembl:ENSRNOP00000035501	P		Seeded From UniProt	complete
involved_in	GO:0048545	response to steroid hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38438 ensembl:ENSRNOP00000035501	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38438 ensembl:ENSRNOP00000035501	C		Seeded From UniProt	complete
involved_in	GO:0043627	response to estrogen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38438 ensembl:ENSRNOP00000035501	P		Seeded From UniProt	complete
involved_in	GO:0043415	positive regulation of skeletal muscle tissue regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38438 ensembl:ENSRNOP00000035501	P		Seeded From UniProt	complete
involved_in	GO:0042060	wound healing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38438 ensembl:ENSRNOP00000035501	P		Seeded From UniProt	complete
enables	GO:0031435	mitogen-activated protein kinase kinase kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38438 ensembl:ENSRNOP00000035501	F		Seeded From UniProt	complete
involved_in	GO:0031100	animal organ regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38438 ensembl:ENSRNOP00000035501	P		Seeded From UniProt	complete
involved_in	GO:0030324	lung development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38438 ensembl:ENSRNOP00000035501	P		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38438 ensembl:ENSRNOP00000035501	P		Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38438 ensembl:ENSRNOP00000035501	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38438 ensembl:ENSRNOP00000035501	C		Seeded From UniProt	complete
involved_in	GO:0009887	animal organ morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38438 ensembl:ENSRNOP00000035501	P		Seeded From UniProt	complete
involved_in	GO:0009749	response to glucose	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38438 ensembl:ENSRNOP00000035501	P		Seeded From UniProt	complete
involved_in	GO:0009612	response to mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38438 ensembl:ENSRNOP00000035501	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38438 ensembl:ENSRNOP00000035501	P		Seeded From UniProt	complete
involved_in	GO:0007584	response to nutrient	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38438 ensembl:ENSRNOP00000035501	P		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38438 ensembl:ENSRNOP00000035501	P		Seeded From UniProt	complete
involved_in	GO:0007566	embryo implantation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38438 ensembl:ENSRNOP00000035501	P		Seeded From UniProt	complete
involved_in	GO:0007182	common-partner SMAD protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38438 ensembl:ENSRNOP00000035501	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38438 ensembl:ENSRNOP00000035501	P		Seeded From UniProt	complete
involved_in	GO:0006898	receptor-mediated endocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38438 ensembl:ENSRNOP00000035501	P		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38438 ensembl:ENSRNOP00000035501	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38438 ensembl:ENSRNOP00000035501	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38438 ensembl:ENSRNOP00000035501	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38438 ensembl:ENSRNOP00000035501	C		Seeded From UniProt	complete
enables	GO:0005026	transforming growth factor beta receptor activity, type II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38438 ensembl:ENSRNOP00000035501	F		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38438 ensembl:ENSRNOP00000035501	P		Seeded From UniProt	complete
involved_in	GO:0001570	vasculogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38438 ensembl:ENSRNOP00000035501	P		Seeded From UniProt	complete
involved_in	GO:1990428	miRNA transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
involved_in	GO:1990086	lens fiber cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
involved_in	GO:1905317	inferior endocardial cushion morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
involved_in	GO:1905007	positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
involved_in	GO:0070723	response to cholesterol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
involved_in	GO:0062009	secondary palate development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
involved_in	GO:0060463	lung lobe morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
involved_in	GO:0060443	mammary gland morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
involved_in	GO:0060440	trachea formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
involved_in	GO:0060439	trachea morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
involved_in	GO:0060434	bronchus morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
involved_in	GO:0060433	bronchus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
involved_in	GO:0060425	lung morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
involved_in	GO:0060412	ventricular septum morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
involved_in	GO:0051216	cartilage development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
involved_in	GO:0051138	positive regulation of NK T cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
enables	GO:0050431	transforming growth factor beta binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	F		Seeded From UniProt	complete
involved_in	GO:0048701	embryonic cranial skeleton morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	F		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
involved_in	GO:0043011	myeloid dendritic cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
involved_in	GO:0035162	embryonic hemopoiesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
involved_in	GO:0032147	activation of protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
involved_in	GO:0030324	lung development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
involved_in	GO:0010634	positive regulation of epithelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	C		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
involved_in	GO:0007369	gastrulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
involved_in	GO:0007224	smoothened signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
involved_in	GO:0007219	Notch signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
enables	GO:0005024	transforming growth factor beta-activated receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	F		Seeded From UniProt	complete
involved_in	GO:0003430	growth plate cartilage chondrocyte growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
involved_in	GO:0003417	growth plate cartilage development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
involved_in	GO:0003274	endocardial cushion fusion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
involved_in	GO:0003214	cardiac left ventricle morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
involved_in	GO:0003186	tricuspid valve morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
involved_in	GO:0003181	atrioventricular valve morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
involved_in	GO:0003151	outflow tract morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
involved_in	GO:0003149	membranous septum morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
involved_in	GO:0003148	outflow tract septum morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
involved_in	GO:0002666	positive regulation of T cell tolerance induction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
involved_in	GO:0002663	positive regulation of B cell tolerance induction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
involved_in	GO:0002651	positive regulation of tolerance induction to self antigen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
involved_in	GO:0002088	lens development in camera-type eye	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
involved_in	GO:0002053	positive regulation of mesenchymal cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
involved_in	GO:0001701	in utero embryonic development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
involved_in	GO:0001570	vasculogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
involved_in	GO:0001569	branching involved in blood vessel morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62312 ensembl:ENSMUSP00000062333	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017194	F		Seeded From UniProt	complete
enables	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333	F		Seeded From UniProt	complete
enables	GO:0005026	transforming growth factor beta receptor activity, type II	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015013	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333 InterPro:IPR000719 InterPro:IPR015013 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008271 InterPro:IPR015013	P		Seeded From UniProt	complete
involved_in	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017194	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333 InterPro:IPR015013	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017194	C		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017194	F		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017194	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015013 InterPro:IPR017194	F		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:11157754^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:11157754^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
contributes_to	GO:0050431	transforming growth factor beta binding	PMID:11157754^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P61812	F		Seeded From UniProt	complete
involved_in	GO:0060389	pathway-restricted SMAD protein phosphorylation	PMID:11157754^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0050431	transforming growth factor beta binding	PMID:11157754^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	PMID:11157754^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0034714	type III transforming growth factor beta receptor binding	PMID:11157754^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0034713	type I transforming growth factor beta receptor binding	PMID:11157754^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:11157754^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:7761852^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001568	blood vessel development	PMID:10092230^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	Reactome:R-HSA-2173788 Reactome:R-HSA-173512 Reactome:R-HSA-173483	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	Reactome:R-HSA-2173791 Reactome:R-HSA-2173789	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-NUL-2179313 Reactome:R-NUL-2179307 Reactome:R-NUL-2176431 Reactome:R-NUL-2176427 Reactome:R-NUL-2176396 Reactome:R-NUL-2176393 Reactome:R-NUL-2169043 Reactome:R-NUL-2169036 Reactome:R-NUL-2167890 Reactome:R-NUL-2167872 Reactome:R-NUL-2161165 Reactome:R-NUL-2161160 Reactome:R-NUL-2128982 Reactome:R-HSA-4332236 Reactome:R-HSA-4332235 Reactome:R-HSA-3713560 Reactome:R-HSA-3702186 Reactome:R-HSA-3702184 Reactome:R-HSA-3702153 Reactome:R-HSA-3656523 Reactome:R-HSA-3656517 Reactome:R-HSA-3656484 Reactome:R-HSA-3656382 Reactome:R-HSA-3645786 Reactome:R-HSA-3645780 Reactome:R-HSA-3645778 Reactome:R-HSA-3304394 Reactome:R-HSA-2169046 Reactome:R-HSA-2160935 Reactome:R-HSA-2160932 Reactome:R-HSA-2160931 Reactome:R-HSA-2128994 Reactome:R-HSA-173512 Reactome:R-HSA-173483 Reactome:R-HSA-170868 Reactome:R-HSA-170861 Reactome:R-HSA-170850 Reactome:R-HSA-170846 Reactome:R-HSA-170843 Reactome:R-HSA-170835	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-3642203	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0040008	regulation of growth	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0341	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0370	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Tzachanis, D et al. (2007) Twisted gastrulation (Tsg) is regulated by Tob and enhances TGF-beta signaling in activated T lymphocytes. Blood 109 2944-52 PubMed GONUTS page
↑ ^2.0 ^2.1 Hwangbo, C et al. (2016) Syntenin regulates TGF-β1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-β type I receptor internalization. Oncogene 35 389-401 PubMed GONUTS page
↑ Liu, T et al. (2015) MicroRNA-590 is an EMT-suppressive microRNA involved in the TGFβ signaling pathway. Mol Med Rep 12 7403-11 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Lin, HY et al. (1995) The soluble exoplasmic domain of the type II transforming growth factor (TGF)-beta receptor. A heterogeneously glycosylated protein with high affinity and selectivity for TGF-beta ligands. J. Biol. Chem. 270 2747-54 PubMed GONUTS page
↑ Passos, JF et al. (2010) Feedback between p21 and reactive oxygen production is necessary for cell senescence. Mol. Syst. Biol. 6 347 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Chen, CL et al. (2007) Cholesterol suppresses cellular TGF-beta responsiveness: implications in atherogenesis. J. Cell. Sci. 120 3509-21 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Gratchev, A et al. (2008) Activation of a TGF-beta-specific multistep gene expression program in mature macrophages requires glucocorticoid-mediated surface expression of TGF-beta receptor II. J. Immunol. 180 6553-65 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Wrana, JL et al. (1992) TGF beta signals through a heteromeric protein kinase receptor complex. Cell 71 1003-14 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Cheifetz, S et al. (1992) Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells. J. Biol. Chem. 267 19027-30 PubMed GONUTS page
↑ Groppe, J et al. (2008) Cooperative assembly of TGF-beta superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding. Mol. Cell 29 157-68 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 ^11.8 ^11.9 Rotzer, D et al. (2001) Type III TGF-beta receptor-independent signalling of TGF-beta2 via TbetaRII-B, an alternatively spliced TGF-beta type II receptor. EMBO J. 20 480-90 PubMed GONUTS page
↑ Zhang, Y et al. (1996) Receptor-associated Mad homologues synergize as effectors of the TGF-beta response. Nature 383 168-72 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 Guerrero-Esteo, M et al. (2002) Extracellular and cytoplasmic domains of endoglin interact with the transforming growth factor-beta receptors I and II. J. Biol. Chem. 277 29197-209 PubMed GONUTS page
↑ Saeki, N et al. (2007) GASDERMIN, suppressed frequently in gastric cancer, is a target of LMO1 in TGF-beta-dependent apoptotic signalling. Oncogene 26 6488-98 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 ^15.6 ^15.7 ^15.8 ^15.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Markowitz, S et al. (1995) Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. Science 268 1336-8 PubMed GONUTS page
↑ Brown, CB et al. (1999) Requirement of type III TGF-beta receptor for endocardial cell transformation in the heart. Science 283 2080-2 PubMed GONUTS page

[PMID:17164348-1] Tzachanis, D et al. (2007) Twisted gastrulation (Tsg) is regulated by Tob and enhances TGF-beta signaling in activated T lymphocytes. Blood 109 2944-52 PubMed GONUTS page

[PMID:25893292-2] 2.0 ^2.1 Hwangbo, C et al. (2016) Syntenin regulates TGF-β1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-β type I receptor internalization. Oncogene 35 389-401 PubMed GONUTS page

[PMID:26459119-3] Liu, T et al. (2015) MicroRNA-590 is an EMT-suppressive microRNA involved in the TGFβ signaling pathway. Mol Med Rep 12 7403-11 PubMed GONUTS page

[PMID:7852346-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Lin, HY et al. (1995) The soluble exoplasmic domain of the type II transforming growth factor (TGF)-beta receptor. A heterogeneously glycosylated protein with high affinity and selectivity for TGF-beta ligands. J. Biol. Chem. 270 2747-54 PubMed GONUTS page

[PMID:20160708-5] Passos, JF et al. (2010) Feedback between p21 and reactive oxygen production is necessary for cell senescence. Mol. Syst. Biol. 6 347 PubMed GONUTS page

[PMID:17878231-6] 6.0 ^6.1 ^6.2 Chen, CL et al. (2007) Cholesterol suppresses cellular TGF-beta responsiveness: implications in atherogenesis. J. Cell. Sci. 120 3509-21 PubMed GONUTS page

[PMID:18453574-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Gratchev, A et al. (2008) Activation of a TGF-beta-specific multistep gene expression program in mature macrophages requires glucocorticoid-mediated surface expression of TGF-beta receptor II. J. Immunol. 180 6553-65 PubMed GONUTS page

[PMID:1333888-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Wrana, JL et al. (1992) TGF beta signals through a heteromeric protein kinase receptor complex. Cell 71 1003-14 PubMed GONUTS page

[PMID:1326540-9] 9.0 ^9.1 ^9.2 Cheifetz, S et al. (1992) Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells. J. Biol. Chem. 267 19027-30 PubMed GONUTS page

[PMID:18243111-10] Groppe, J et al. (2008) Cooperative assembly of TGF-beta superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding. Mol. Cell 29 157-68 PubMed GONUTS page

[PMID:11157754-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 ^11.8 ^11.9 Rotzer, D et al. (2001) Type III TGF-beta receptor-independent signalling of TGF-beta2 via TbetaRII-B, an alternatively spliced TGF-beta type II receptor. EMBO J. 20 480-90 PubMed GONUTS page

[PMID:8774881-12] Zhang, Y et al. (1996) Receptor-associated Mad homologues synergize as effectors of the TGF-beta response. Nature 383 168-72 PubMed GONUTS page

[PMID:12015308-13] 13.0 ^13.1 ^13.2 ^13.3 Guerrero-Esteo, M et al. (2002) Extracellular and cytoplasmic domains of endoglin interact with the transforming growth factor-beta receptors I and II. J. Biol. Chem. 277 29197-209 PubMed GONUTS page

[PMID:17471240-14] Saeki, N et al. (2007) GASDERMIN, suppressed frequently in gastric cancer, is a target of LMO1 in TGF-beta-dependent apoptotic signalling. Oncogene 26 6488-98 PubMed GONUTS page

[PMID:21873635-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 ^15.6 ^15.7 ^15.8 ^15.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:7761852-16] Markowitz, S et al. (1995) Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. Science 268 1336-8 PubMed GONUTS page

[PMID:10092230-17] Brown, CB et al. (1999) Requirement of type III TGF-beta receptor for endocardial cell transformation in the heart. Science 283 2080-2 PubMed GONUTS page

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