HUMAN:TBX2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	TBX2
Protein Name(s)	T-box transcription factor TBX2 T-box protein 2
External Links
UniProt	Q13207
EMBL	U28049 AC005746 BC052566 S81264
CCDS	CCDS11627.2
PIR	G01840
RefSeq	NP_005985.3
UniGene	Hs.531085
ProteinModelPortal	Q13207
SMR	Q13207
BioGrid	112772
IntAct	Q13207
MINT	MINT-6773947
STRING	9606.ENSP00000240328
PhosphoSite	Q13207
DMDM	294862490
MaxQB	Q13207
PaxDb	Q13207
PRIDE	Q13207
Ensembl	ENST00000240328
GeneID	6909
KEGG	hsa:6909
UCSC	uc002izg.3
CTD	6909
GeneCards	GC17P059477
HGNC	HGNC:11597
HPA	CAB013636 HPA008586
MIM	600747
neXtProt	NX_Q13207
Orphanet	261279
PharmGKB	PA36360
eggNOG	NOG240293
GeneTree	ENSGT00760000118897
HOGENOM	HOG000038046
HOVERGEN	HBG000412
InParanoid	Q13207
KO	K10176
OMA	SPAPEHH
OrthoDB	EOG7W9RV1
PhylomeDB	Q13207
TreeFam	TF106341
SignaLink	Q13207
GeneWiki	TBX2
GenomeRNAi	6909
NextBio	27019
PRO	PR:Q13207
Proteomes	UP000005640
Bgee	Q13207
CleanEx	HS_TBX2
ExpressionAtlas	Q13207
Genevestigator	Q13207
GO	GO:0005634 GO:0005667 GO:0003677 GO:0043565 GO:0003700 GO:0035909 GO:0036302 GO:0048738 GO:0007569 GO:0090398 GO:0060560 GO:0048596 GO:0042733 GO:0003203 GO:0060596 GO:0007521 GO:1901211 GO:1901208 GO:0000122 GO:0045892 GO:0003151 GO:0003148 GO:0060021 GO:0060465 GO:0060045 GO:0008284 GO:0003256 GO:0006351
Gene3D	2.60.40.820
InterPro	IPR008967 IPR022582 IPR002070 IPR001699 IPR018186
PANTHER	PTHR11267
Pfam	PF00907 PF12598
PRINTS	PR00938 PR00937
SMART	SM00425
SUPFAM	SSF49417
PROSITE	PS01283 PS01264 PS50252

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:P70324 UniProtKB:Q7TST9	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[1]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[1]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR001699 InterPro:IPR002070 InterPro:IPR008967	F		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:11111039^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:11111039^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:11111039^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1901211	negative regulation of cardiac chamber formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60707	P		Seeded From UniProt	complete
involved_in	GO:1901208	negative regulation of heart looping	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60707	P		Seeded From UniProt	complete
involved_in	GO:0060465	pharynx development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60707	P		Seeded From UniProt	complete
involved_in	GO:0060045	positive regulation of cardiac muscle cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60707	P		Seeded From UniProt	complete
involved_in	GO:0048738	cardiac muscle tissue development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60707	P		Seeded From UniProt	complete
involved_in	GO:0048596	embryonic camera-type eye morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60707	P		Seeded From UniProt	complete
involved_in	GO:0042733	embryonic digit morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60707	P		Seeded From UniProt	complete
involved_in	GO:0036302	atrioventricular canal development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60707	P		Seeded From UniProt	complete
involved_in	GO:0035909	aorta morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60707	P		Seeded From UniProt	complete
involved_in	GO:0007521	muscle cell fate determination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60707	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15042700^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000569)\|part_of:(CL:0000513)\|part_of:(CL:0000192) part_of:(UBERON:0001621)	Seeded From UniProt	complete
involved_in	GO:0003256	regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60707	P		Seeded From UniProt	complete
involved_in	GO:0003203	endocardial cushion morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60707	P		Seeded From UniProt	complete
involved_in	GO:0003151	outflow tract morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60707	P		Seeded From UniProt	complete
involved_in	GO:0003148	outflow tract septum morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60707	P		Seeded From UniProt	complete
involved_in	GO:0035050	embryonic heart tube development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7ZTU9	P		Seeded From UniProt	complete
involved_in	GO:0008016	regulation of heart contraction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7ZTU9	P		Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7ZTU9	P		Seeded From UniProt	complete
involved_in	GO:0090398	cellular senescence	PMID:22002537^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:11111039^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:10468588^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:11111039^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:11748239^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007569	cell aging	PMID:11748239^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901211	negative regulation of cardiac chamber formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60707 ensembl:ENSMUSP00000000095	P		Seeded From UniProt	complete
involved_in	GO:1901208	negative regulation of heart looping	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60707 ensembl:ENSMUSP00000000095	P		Seeded From UniProt	complete
involved_in	GO:0060596	mammary placode formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60707 ensembl:ENSMUSP00000000095	P		Seeded From UniProt	complete
involved_in	GO:0060560	developmental growth involved in morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60707 ensembl:ENSMUSP00000000095	P		Seeded From UniProt	complete
involved_in	GO:0060465	pharynx development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60707 ensembl:ENSMUSP00000000095	P		Seeded From UniProt	complete
involved_in	GO:0060045	positive regulation of cardiac muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60707 ensembl:ENSMUSP00000000095	P		Seeded From UniProt	complete
involved_in	GO:0060021	roof of mouth development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60707 ensembl:ENSMUSP00000000095	P		Seeded From UniProt	complete
involved_in	GO:0048738	cardiac muscle tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60707 ensembl:ENSMUSP00000000095	P		Seeded From UniProt	complete
involved_in	GO:0048596	embryonic camera-type eye morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60707 ensembl:ENSMUSP00000000095	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60707 ensembl:ENSMUSP00000000095	P		Seeded From UniProt	complete
involved_in	GO:0042733	embryonic digit morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60707 ensembl:ENSMUSP00000000095	P		Seeded From UniProt	complete
involved_in	GO:0036302	atrioventricular canal development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60707 ensembl:ENSMUSP00000000095	P		Seeded From UniProt	complete
involved_in	GO:0035909	aorta morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60707 ensembl:ENSMUSP00000000095	P		Seeded From UniProt	complete
involved_in	GO:0007569	cell aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60707 ensembl:ENSMUSP00000000095	P		Seeded From UniProt	complete
involved_in	GO:0007521	muscle cell fate determination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60707 ensembl:ENSMUSP00000000095	P		Seeded From UniProt	complete
involved_in	GO:0007219	Notch signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60707 ensembl:ENSMUSP00000000095	P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60707 ensembl:ENSMUSP00000000095	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60707 ensembl:ENSMUSP00000000095	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60707 ensembl:ENSMUSP00000000095	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60707 ensembl:ENSMUSP00000000095	F		Seeded From UniProt	complete
involved_in	GO:0003256	regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60707 ensembl:ENSMUSP00000000095	P		Seeded From UniProt	complete
involved_in	GO:0003203	endocardial cushion morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60707 ensembl:ENSMUSP00000000095	P		Seeded From UniProt	complete
involved_in	GO:0003151	outflow tract morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60707 ensembl:ENSMUSP00000000095	P		Seeded From UniProt	complete
involved_in	GO:0003148	outflow tract septum morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60707 ensembl:ENSMUSP00000000095	P		Seeded From UniProt	complete
involved_in	GO:0003007	heart morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60707 ensembl:ENSMUSP00000000095	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60707 ensembl:ENSMUSP00000000095	P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001699 InterPro:IPR002070 InterPro:IPR008967 InterPro:IPR018186 InterPro:IPR036960	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001699 InterPro:IPR002070 InterPro:IPR018186 InterPro:IPR036960	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001699 InterPro:IPR002070 InterPro:IPR008967 InterPro:IPR018186 InterPro:IPR036960	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:8530034^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Sinha, S et al. (2000) Differential DNA binding and transcription modulation by three T-box proteins, T, TBX1 and TBX2. Gene 258 15-29 PubMed GONUTS page
↑ Christoffels, VM et al. (2004) T-box transcription factor Tbx2 represses differentiation and formation of the cardiac chambers. Dev. Dyn. 229 763-70 PubMed GONUTS page
↑ Martin, N et al. (2012) Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence. EMBO J. 31 95-109 PubMed GONUTS page
↑ He, Ml et al. (1999) Transcription repression by Xenopus ET and its human ortholog TBX3, a gene involved in ulnar-mammary syndrome. Proc. Natl. Acad. Sci. U.S.A. 96 10212-7 PubMed GONUTS page
↑ ^6.0 ^6.1 Brummelkamp, TR et al. (2002) TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence. J. Biol. Chem. 277 6567-72 PubMed GONUTS page
↑ Campbell, C et al. (1995) Cloning and mapping of a human gene (TBX2) sharing a highly conserved protein motif with the Drosophila omb gene. Genomics 28 255-60 PubMed GONUTS page

[PMID:19274049-1] 1.0 ^1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:11111039-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Sinha, S et al. (2000) Differential DNA binding and transcription modulation by three T-box proteins, T, TBX1 and TBX2. Gene 258 15-29 PubMed GONUTS page

[PMID:15042700-3] Christoffels, VM et al. (2004) T-box transcription factor Tbx2 represses differentiation and formation of the cardiac chambers. Dev. Dyn. 229 763-70 PubMed GONUTS page

[PMID:22002537-4] Martin, N et al. (2012) Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence. EMBO J. 31 95-109 PubMed GONUTS page

[PMID:10468588-5] He, Ml et al. (1999) Transcription repression by Xenopus ET and its human ortholog TBX3, a gene involved in ulnar-mammary syndrome. Proc. Natl. Acad. Sci. U.S.A. 96 10212-7 PubMed GONUTS page

[PMID:11748239-6] 6.0 ^6.1 Brummelkamp, TR et al. (2002) TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence. J. Biol. Chem. 277 6567-72 PubMed GONUTS page

[PMID:8530034-7] Campbell, C et al. (1995) Cloning and mapping of a human gene (TBX2) sharing a highly conserved protein motif with the Drosophila omb gene. Genomics 28 255-60 PubMed GONUTS page

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HUMAN:TBX2

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