HUMAN:TAU

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	MAPT (synonyms: MAPTL, MTBT1, TAU)
Protein Name(s)	Microtubule-associated protein tau Neurofibrillary tangle protein Paired helical filament-tau PHF-tau
External Links
UniProt	P10636
EMBL	J03778 X14474 AF047863 AF027491 AF047856 AF047857 AF027492 AF047858 AF027493 AF047859 AF047860 AF047862 AF027494 AF027495 AF027496 AF027491 AF027492 AF027493 AF047860 AF047862 AF027495 AF027496 AF047863 AF027491 AF047856 AF047857 AF027492 AF027493 AF047860 AF047862 AF027494 AF027495 AF027496 AF047863 AF047861 AY730549 BT006772 AC004139 AC010792 AC217771 AC217779 BC000558 BC098281 BC099721 BC101936 BC114504 BC114948 AY526356 M25298 BN000503
CCDS	CCDS11499.1 CCDS11500.1 CCDS11501.1 CCDS11502.1 CCDS45715.1 CCDS45716.1 CCDS56033.1
PIR	I52232 JS0370 PN0001 S26663
RefSeq	NP_001116538.2 NP_001116539.1 NP_001190181.1 NP_005901.2 NP_058518.1 NP_058519.3 NP_058525.1 XP_006725337.1 XP_006725338.1
UniGene	Hs.101174
PDB	1I8H 2ON9 3OVL 4FL5 4GLR 4NP8
PDBsum	1I8H 2ON9 3OVL 4FL5 4GLR 4NP8
DisProt	DP00126
ProteinModelPortal	P10636
BioGrid	110308
DIP	DIP-29753N
IntAct	P10636
MINT	MINT-134394
BindingDB	P10636
ChEMBL	CHEMBL1293224
DrugBank	DB01248 DB01229
PhosphoSite	P10636
DMDM	334302961
MaxQB	P10636
PaxDb	P10636
PRIDE	P10636
DNASU	4137
Ensembl	ENST00000262410 ENST00000334239 ENST00000340799 ENST00000344290 ENST00000351559 ENST00000415613 ENST00000420682 ENST00000431008 ENST00000446361 ENST00000535772 ENST00000571987 ENST00000574436 ENST00000612872 ENST00000620070 ENST00000620818 ENST00000622106
GeneID	4137
KEGG	hsa:4137
UCSC	uc002ijr.4 uc002ijs.4 uc002ijt.4 uc002iju.4 uc002ijx.4 uc010dau.3 uc021tyv.1 uc021tyw.1
CTD	4137
GeneCards	GC17P043971
GeneReviews	MAPT
HGNC	HGNC:6893
HPA	CAB000151
MIM	157140 172700 260540 600274 601104
neXtProt	NX_P10636
Orphanet	275864 240071 100070 240103 240085 240112 240094 100069
PharmGKB	PA238
eggNOG	NOG148882
GeneTree	ENSGT00530000063491
HOVERGEN	HBG000991
InParanoid	P10636
KO	K04380
OMA	MKVKGAD
OrthoDB	EOG738045
TreeFam	TF316358
Reactome	REACT_13541
ChiTaRS	MAPT
EvolutionaryTrace	P10636
GeneWiki	Tau_protein
GenomeRNAi	4137
NextBio	16246
PMAP-CutDB	P10636
PRO	PR:P10636
Proteomes	UP000005640 UP000005640
Bgee	P10636
ExpressionAtlas	P10636
Genevestigator	P10636
GO	GO:0030424 GO:0005930 GO:0036464 GO:0005829 GO:0030426 GO:0005874 GO:0005875 GO:0034399 GO:0005886 GO:0045298 GO:0034185 GO:0019899 GO:0071813 GO:0008017 GO:0017124 GO:0005200 GO:0007628 GO:0006915 GO:0008088 GO:0048675 GO:0006921 GO:0048699 GO:0000226 GO:0047497 GO:0032387 GO:0001764 GO:0045773 GO:0031116 GO:0010506 GO:0031113 GO:0060632
InterPro	IPR027324 IPR001084 IPR002955
PANTHER	PTHR11501
Pfam	PF00418
PRINTS	PR01261
PROSITE	PS00229 PS51491

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
Contributes to	GO:0007015	actin filament organization	GO_REF:0000019	ECO:0000314			P		Figure 3: This RNA blot analysis evaluates 8 brain regions, and 3 organs. When probed with the actin probe, there were only minimal regional changes among alzheimers patients.	complete CACAO 9382
	GO:0007015	actin filament organization	GO_REF:0000019	ECO:0000314			P		Figure 4: RNA blot analysis shows that actin filaments contribute to neurological tangles in the frontal cortex of Alzheimer's patients	complete CACAO 9383
	GO:0031116	positive regulation of microtubule polymerization	PMID:7706316^[1]	ECO:0000314			P		Figure 8	complete CACAO 9384
	GO:0031113	regulation of microtubule polymerization	PMID:1057175^[2]	ECO:0000314			P		Seeded from Uniprot	complete CACAO 9389
involved_in	GO:1904428	negative regulation of tubulin deacetylation	PMID:19457097^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9UBN7	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:17906291^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10637	F	occurs_in:(UBERON:0000955)	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:23362255^[5]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10637	F	occurs_in:(UBERON:0000955) activated_by:(CHEBI:15422) happens_during:(GO:0006468) has_input:(UniProtKB:Q13526)	Seeded From UniProt	complete
part_of	GO:0044304	main axon	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P19332	C	part_of:(CL:1001611) exists_during:(GO:0048666)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P19332	C	part_of:(CL:1001611) exists_during:(GO:0048666)	Seeded From UniProt	complete
part_of	GO:0015630	microtubule cytoskeleton	PMID:28386764^[6]	ECO:0000303	author statement without traceable support used in manual assertion		C	part_of:(GO:0030424)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:23666762^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:23666762^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:27044754^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:27044754^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0051087	chaperone binding	PMID:25051234^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P10909	F	occurs_at:(GO:0005856)	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:24251416^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O08679	F		Seeded From UniProt	complete
involved_in	GO:0098930	axonal transport	PMID:28377597^[11]	ECO:0000303	author statement without traceable support used in manual assertion		P	occurs_in:(CL:0000540)	Seeded From UniProt	complete
part_of	GO:0015630	microtubule cytoskeleton	PMID:28377597^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(GO:0043005)\|part_of:(GO:0043025)	Seeded From UniProt	complete
involved_in	GO:0000226	microtubule cytoskeleton organization	PMID:28377597^[11]	ECO:0000303	author statement without traceable support used in manual assertion		P	occurs_in:(CL:0000540)	Seeded From UniProt	complete
part_of	GO:0097386	glial cell projection	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10637	C	part_of:(CL:0000128)	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10637	C	part_of:(CL:0000128)	Seeded From UniProt	complete
part_of	GO:0044297	cell body	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10637	C	part_of:(CL:0000128)	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10637	F	occurs_in:(CL:0000128) occurs_at:(GO:0045121) positively_regulates:(GO:0106091)	Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	PMID:28386764^[6]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:28386764^[6]	ECO:0000303	author statement without traceable support used in manual assertion		C	part_of:(UBERON:0001017)	Seeded From UniProt	complete
part_of	GO:0005623	cell	PMID:28386764^[6]	ECO:0000303	author statement without traceable support used in manual assertion		C	part_of:(CL:0000540)	Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	PMID:28386764^[6]	ECO:0000303	author statement without traceable support used in manual assertion		F	occurs_in:(CL:0000540)	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:26014385^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:26014385^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010917	negative regulation of mitochondrial membrane potential	PMID:22920254^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903748	negative regulation of establishment of protein localization to mitochondrion	PMID:22920254^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	negatively_regulates:(GO:0000266) has_regulation_target:(UniProtKB:O00429)	Seeded From UniProt	complete
involved_in	GO:0032930	positive regulation of superoxide anion generation	PMID:22920254^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0090258) positively_regulates:(GO:0070997)	Seeded From UniProt	complete
involved_in	GO:0090258	negative regulation of mitochondrial fission	PMID:22920254^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:1001571) positively_regulates:(GO:0070997)	Seeded From UniProt	complete
involved_in	GO:1901216	positive regulation of neuron death	PMID:22920254^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0090258)	Seeded From UniProt	complete
involved_in	GO:0090140	regulation of mitochondrial fission	PMID:22367970^[14]	ECO:0000305	curator inference used in manual assertion	GO:0005515	P	has_regulation_target:(UniProtKB:O00429)	Seeded From UniProt	complete
involved_in	GO:0051258	protein polymerization	PMID:27044754^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:15654759^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0097435	supramolecular fiber organization	PMID:15654759^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1990000	amyloid fibril formation	PMID:7929085^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:7929085^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0015630	microtubule cytoskeleton	PMID:15147841^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0070507	regulation of microtubule cytoskeleton organization	PMID:15147841^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0099609	microtubule lateral binding	PMID:15147841^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0097418	neurofibrillary tangle	PMID:2484340^[18]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
colocalizes_with	GO:0005874	microtubule	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P19332	C	part_of:(UBERON:0000955)	Seeded From UniProt	complete
involved_in	GO:1905689	positive regulation of diacylglycerol kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29172	P	has_regulation_target:(UniProtKB:P52824)	Seeded From UniProt	complete
involved_in	GO:1903829	positive regulation of cellular protein localization	PMID:27356871^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(GO:0043194) has_regulation_target:(UniProtKB:Q12955) has_regulation_target:(UniProtKB:Q9H254)	Seeded From UniProt	complete
involved_in	GO:0031110	regulation of microtubule polymerization or depolymerization	PMID:27356871^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(GO:0043194)	Seeded From UniProt	complete
part_of	GO:0015630	microtubule cytoskeleton	PMID:27356871^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:27356871^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0097435	supramolecular fiber organization	PMID:14769047^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:14769047^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	PMID:10747907^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0030673	axolemma	PMID:10747907^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:10747907^[21]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000540)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:10747907^[21]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000540)	Seeded From UniProt	complete
involved_in	GO:1902474	positive regulation of protein localization to synapse	PMID:20655099^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:1001571) has_regulation_target:(UniProtKB:P06241) has_target_end_location:(GO:0014069)	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:20655099^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	part_of:(CL:1001571)	Seeded From UniProt	complete
part_of	GO:0036477	somatodendritic compartment	PMID:20655099^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	part_of:(CL:1001571)	Seeded From UniProt	complete
colocalizes_with	GO:0016020	membrane	PMID:20655099^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	part_of:(CL:1001571)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10637	C	exists_during:(GO:0034605) exists_during:(GO:0006470) part_of:(CL:0002609)\|exists_during(GO:0070301) exists_during:(GO:0006470) part_of:(CL:0002609)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10637	C	exists_during:(GO:0034605) exists_during:(GO:0006470) part_of:(CL:0002609)\|exists_during(GO:0070301) exists_during:(GO:0006470) part_of:(CL:0002609)	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10637	F	occurs_in:(CL:0000540)	Seeded From UniProt	complete
involved_in	GO:2001020	regulation of response to DNA damage stimulus	PMID:21131359^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000540) part_of:(GO:1900034)	Seeded From UniProt	complete
involved_in	GO:1900034	regulation of cellular response to heat	PMID:21131359^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000540)	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:23164821^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0000956) regulates_expression_of:(ENSEMBL:ENSG00000170345)	Seeded From UniProt	complete
part_of	GO:0097418	neurofibrillary tangle	PMID:25620700^[25]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0044297	cell body	PMID:25620700^[25]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002608)	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:25620700^[25]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001954)	Seeded From UniProt	complete
involved_in	GO:0031116	positive regulation of microtubule polymerization	PMID:7706316^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	PMID:28377597^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0036464	cytoplasmic ribonucleoprotein granule	PMID:15121898^[26]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000031)	Seeded From UniProt	complete
involved_in	GO:0010288	response to lead ion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P19332	P	occurs_in:(UBERON:0001885) causally_upstream_of:(GO:0007416) causally_upstream_of:(GO:0007611)	Seeded From UniProt	complete
involved_in	GO:0048312	intracellular distribution of mitochondria	PMID:21854751^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_end_location:(GO:0043005)	Seeded From UniProt	complete
enables	GO:0048018	receptor ligand activity	PMID:18272392^[28]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(GO:0005615) has_input:(PR:000001488) has_input:(UniProtKB:P11229) regulates:(GO:0019722)\|occurs_in(GO:0005615) has_input:(PR:000001488) has_input:(UniProtKB:P20309) regulates:(GO:0019722)	Seeded From UniProt	complete
involved_in	GO:0050848	regulation of calcium-mediated signaling	PMID:18272392^[28]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0002608) part_of:(GO:1900115)	Seeded From UniProt	complete
involved_in	GO:0050808	synapse organization	PMID:17270732^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0007613	memory	PMID:20655099^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033673	negative regulation of kinase activity	PMID:20655099^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0000955) has_regulation_target:(UniProtKB:P06241)	Seeded From UniProt	complete
enables	GO:0051879	Hsp90 protein binding	PMID:17517623^[30]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P11499	F	occurs_in:(UBERON:0000955)	Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:26363795^[31]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1902988	neurofibrillary tangle assembly	PMID:26363795^[31]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0015630	microtubule cytoskeleton	PMID:26363795^[31]	ECO:0000303	author statement without traceable support used in manual assertion		C	part_of:(GO:0030424)	Seeded From UniProt	complete
enables	GO:0034185	apolipoprotein binding	PMID:7566652^[32]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P02649	F		Seeded From UniProt	complete
enables	GO:0071813	lipoprotein particle binding	PMID:7972031^[33]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P02649	F		Seeded From UniProt	complete
involved_in	GO:0048699	generation of neurons	PMID:8522593^[34]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045773	positive regulation of axon extension	PMID:1389180^[35]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0045298	tubulin complex	PMID:8642405^[36]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0034399	nuclear periphery	PMID:19157893^[37]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0031116	positive regulation of microtubule polymerization	PMID:1421571^[38]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031113	regulation of microtubule polymerization	PMID:1057175^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	PMID:8642405^[36]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:8642405^[36]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:20133804^[39]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P27124	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:12888622^[40]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q14790	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:12888622^[40]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P55210	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:12888622^[40]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P55212	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:12888622^[40]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P29466	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:9736630^[41]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P42574	F		Seeded From UniProt	complete
enables	GO:0017124	SH3 domain binding	PMID:9763511^[42]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P12931	F		Seeded From UniProt	complete
enables	GO:0017124	SH3 domain binding	PMID:9763511^[42]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P06241	F		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	PMID:1918161^[43]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:8522593^[34]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000226	microtubule cytoskeleton organization	PMID:1057175^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:21873635^[44]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97175 PANTHER:PTN000161190 RGD:3044 RGD:69329 WB:WBGene00004212	C		Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	PMID:21873635^[44]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000161190 UniProtKB:P11137	P		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	PMID:21873635^[44]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0266579 MGI:MGI:97175 MGI:MGI:97178 MGI:MGI:97180 PANTHER:PTN000161190 RGD:3044 RGD:69329 UniProtKB:P10636 WB:WBGene00004212	F		Seeded From UniProt	complete
involved_in	GO:0000226	microtubule cytoskeleton organization	PMID:21873635^[44]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0266579 MGI:MGI:97175 MGI:MGI:97178 MGI:MGI:97180 PANTHER:PTN000161190 UniProtKB:P10636	P		Seeded From UniProt	complete
involved_in	GO:0010506	regulation of autophagy	PMID:19074461^[45]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O15118	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:30158706^[46]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P10636	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:16446437^[47]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P10636	F		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0048018	P		Seeded From UniProt	complete
part_of	GO:1904115	axon cytoplasm	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0019896	C		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002955	F		Seeded From UniProt	complete
enables	GO:0015631	tubulin binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001084	F		Seeded From UniProt	complete
involved_in	GO:0046785	microtubule polymerization	PMID:26996940^[48]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	PMID:26704708^[49]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(UBERON:0000112) happens_during:(GO:0018105) occurs_in:(UBERON:0002421) regulates:(GO:0007611)\|happens_during(UBERON:0018241) happens_during:(GO:0018105) occurs_in:(UBERON:0002421) regulates:(GO:0007611)	Seeded From UniProt	complete
involved_in	GO:0007416	synapse assembly	PMID:26704708^[49]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(UBERON:0000112) occurs_in:(UBERON:0003883) regulates:(GO:0007611)\|happens_during(UBERON:0018241) occurs_in:(UBERON:0003883) regulates:(GO:0007611)	Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	PMID:26704708^[49]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(UBERON:0000112)\|happens_during:(UBERON:0018241)	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:26436840^[50]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P10636-8	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:17535890^[51]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P10636-8	F		Seeded From UniProt	complete
involved_in	GO:0061564	axon development	PMID:26609151^[52]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	PMID:26609151^[52] PMID:26363795^[31]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0031113	regulation of microtubule polymerization	PMID:10640627^[53] PMID:28386764^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	occurs_in:(UBERON:0000955) regulates_o_occurs_in:(UBERON:0000955)	Seeded From UniProt	complete
involved_in	GO:1990416	cellular response to brain-derived neurotrophic factor stimulus	PMID:28386764^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	PMID:28386764^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1904428	negative regulation of tubulin deacetylation	PMID:28386764^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	has_regulation_target:(UniProtKB:Q9UBN7)	Seeded From UniProt	complete
enables	GO:0030674	protein binding, bridging	PMID:28386764^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:28386764^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	part_of:(CL:0000540) part_of:(UBERON:0000955) part_of:(GO:0036477)	Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:28386764^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	part_of:(CL:0000540) part_of:(UBERON:0000955)	Seeded From UniProt	complete
involved_in	GO:0006475	internal protein amino acid acetylation	PMID:28386764^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	has_input:(UniProtKB:P10636)	Seeded From UniProt	complete
part_of	GO:0036477	somatodendritic compartment	PMID:28386764^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	part_of:(CL:0000540) part_of:(UBERON:0000955)	Seeded From UniProt	complete
involved_in	GO:1900452	regulation of long-term synaptic depression	PMID:28386764^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016072	rRNA metabolic process	PMID:28386764^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033044	regulation of chromosome organization	PMID:28386764^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003680	AT DNA binding	PMID:28386764^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	causally_upstream_of:(GO:0010468)	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:28386764^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	part_of:(GO:0034614)	Seeded From UniProt	complete
involved_in	GO:0034614	cellular response to reactive oxygen species	PMID:28386764^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:28386764^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003697	single-stranded DNA binding	PMID:28386764^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0099077	histone-dependent DNA binding	PMID:28386764^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0034063	stress granule assembly	PMID:28386764^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1990090	cellular response to nerve growth factor stimulus	PMID:28386764^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	occurs_in:(CL:0001033)	Seeded From UniProt	complete
involved_in	GO:0021954	central nervous system neuron development	PMID:28386764^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	occurs_in:(CL:0001033)	Seeded From UniProt	complete
part_of	GO:0005623	cell	PMID:26996940^[48]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	part_of:(CL:0000540)	Seeded From UniProt	complete
involved_in	GO:0046785	microtubule polymerization	PMID:26996940^[48]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	causally_upstream_of:(GO:0051301)\|causally_upstream_of:(GO:0006810)\|causally_upstream_of:(GO:0048870)\|causally_upstream_of:(GO:0016043)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:28386764^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	part_of:(CL:0000540) part_of:(UBERON:0000955) part_of:(GO:0036477)	Seeded From UniProt	complete
enables	GO:0003779	actin binding	PMID:28386764^[6] PMID:22920254^[13] PMID:27306859^[54]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:28386764^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	PMID:28386764^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:1902936	phosphatidylinositol bisphosphate binding	PMID:28386764^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	causally_upstream_of:(GO:0023052)	Seeded From UniProt	complete
enables	GO:0035091	phosphatidylinositol binding	PMID:28386764^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	causally_upstream_of:(GO:0023052)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:28386764^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	part_of:(CL:0000540) part_of:(UBERON:0000955) part_of:(GO:0036477)	Seeded From UniProt	complete
involved_in	GO:0070507	regulation of microtubule cytoskeleton organization	PMID:28386764^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	regulates:(GO:0098930)	Seeded From UniProt	complete
involved_in	GO:0048167	regulation of synaptic plasticity	PMID:28386764^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	regulates_o_occurs_in:(CL:0002608) occurs_in:(CL:0002608) part_of:(GO:1990416)	Seeded From UniProt	complete
involved_in	GO:0019896	axonal transport of mitochondrion	PMID:26363795^[31]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048143	astrocyte activation	PMID:26363795^[31]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	occurs_in:(GO:0005615)	Seeded From UniProt	complete
involved_in	GO:0001774	microglial cell activation	PMID:26363795^[31]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	occurs_in:(GO:0005615)	Seeded From UniProt	complete
enables	GO:0051721	protein phosphatase 2A binding	PMID:26363795^[31]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	occurs_in:(UBERON:0000955)	Seeded From UniProt	complete
enables	GO:0034452	dynactin binding	PMID:26363795^[31]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0072386	plus-end-directed organelle transport along microtubule	PMID:26363795^[31]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	occurs_in:(CL:0000117) has_target_end_location:(GO:0043679)	Seeded From UniProt	complete
involved_in	GO:0034605	cellular response to heat	PMID:26363795^[31]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	occurs_in:(CL:0000117)	Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	PMID:26363795^[31]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	occurs_in:(CL:0000117)	Seeded From UniProt	complete
involved_in	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:26363795^[31]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031122	cytoplasmic microtubule organization	PMID:26363795^[31]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	occurs_in:(CL:0000117)	Seeded From UniProt	complete
involved_in	GO:0051259	protein complex oligomerization	PMID:26363795^[31]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	occurs_in:(CL:0000117)\|occurs_in:(CL:0000243)	Seeded From UniProt	complete
involved_in	GO:0098930	axonal transport	PMID:26363795^[31]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	occurs_in:(CL:0000117)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-NUL-9619539 Reactome:R-NUL-9619534 Reactome:R-HSA-201629	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C		Seeded From UniProt	complete
part_of	GO:0005874	microtubule	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0493	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0279	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0283	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Drewes, G et al. (1995) Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262. J. Biol. Chem. 270 7679-88 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Weingarten, MD et al. (1975) A protein factor essential for microtubule assembly. Proc. Natl. Acad. Sci. U.S.A. 72 1858-62 PubMed GONUTS page
↑ Perez, M et al. (2009) Tau--an inhibitor of deacetylase HDAC6 function. J. Neurochem. 109 1756-66 PubMed GONUTS page
↑ Ryoo, SR et al. (2007) DYRK1A-mediated hyperphosphorylation of Tau. A functional link between Down syndrome and Alzheimer disease. J. Biol. Chem. 282 34850-7 PubMed GONUTS page
↑ Kimura, T et al. (2013) Isomerase Pin1 stimulates dephosphorylation of tau protein at cyclin-dependent kinase (Cdk5)-dependent Alzheimer phosphorylation sites. J. Biol. Chem. 288 7968-77 PubMed GONUTS page
↑ ^6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 ^6.11 ^6.12 ^6.13 ^6.14 ^6.15 ^6.16 ^6.17 ^6.18 ^6.19 ^6.20 ^6.21 ^6.22 ^6.23 ^6.24 ^6.25 ^6.26 ^6.27 ^6.28 ^6.29 ^6.30 ^6.31 ^6.32 ^6.33 ^6.34 Guo, T et al. (2017) Roles of tau protein in health and disease. Acta Neuropathol. 133 665-704 PubMed GONUTS page
↑ ^7.0 ^7.1 Gu, GJ et al. (2013) Role of individual MARK isoforms in phosphorylation of tau at Ser²⁶² in Alzheimer's disease. Neuromolecular Med. 15 458-69 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Yan, X et al. (2016) FRMD4A-cytohesin signaling modulates the cellular release of tau. J. Cell. Sci. 129 2003-15 PubMed GONUTS page
↑ Zhou, Y et al. (2014) Intracellular clusterin interacts with brain isoforms of the bridging integrator 1 and with the microtubule-associated protein Tau in Alzheimer's disease. PLoS ONE 9 e103187 PubMed GONUTS page
↑ Schwalbe, M et al. (2013) Phosphorylation of human Tau protein by microtubule affinity-regulating kinase 2. Biochemistry 52 9068-79 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Yin, X et al. (2017) Dyrk1A overexpression leads to increase of 3R-tau expression and cognitive deficits in Ts65Dn Down syndrome mice. Sci Rep 7 619 PubMed GONUTS page
↑ ^12.0 ^12.1 Guerreiro, PS et al. (2016) LRRK2 Promotes Tau Accumulation, Aggregation and Release. Mol. Neurobiol. 53 3124-3135 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 DuBoff, B et al. (2012) Tau promotes neurodegeneration via DRP1 mislocalization in vivo. Neuron 75 618-32 PubMed GONUTS page
↑ Manczak, M & Reddy, PH (2012) Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage. Hum. Mol. Genet. 21 2538-47 PubMed GONUTS page
↑ ^15.0 ^15.1 Eliezer, D et al. (2005) Residual structure in the repeat domain of tau: echoes of microtubule binding and paired helical filament formation. Biochemistry 44 1026-36 PubMed GONUTS page
↑ ^16.0 ^16.1 Schweers, O et al. (1994) Structural studies of tau protein and Alzheimer paired helical filaments show no evidence for beta-structure. J. Biol. Chem. 269 24290-7 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 Santarella, RA et al. (2004) Surface-decoration of microtubules by human tau. J. Mol. Biol. 339 539-53 PubMed GONUTS page
↑ Goedert, M et al. (1989) Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease. Neuron 3 519-26 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 Sohn, PD et al. (2016) Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment. Mol Neurodegener 11 47 PubMed GONUTS page
↑ ^20.0 ^20.1 Barghorn, S et al. (2004) Tau paired helical filaments from Alzheimer's disease brain and assembled in vitro are based on beta-structure in the core domain. Biochemistry 43 1694-703 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 Maas, T et al. (2000) Interaction of tau with the neural membrane cortex is regulated by phosphorylation at sites that are modified in paired helical filaments. J. Biol. Chem. 275 15733-40 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 ^22.3 ^22.4 ^22.5 Ittner, LM et al. (2010) Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models. Cell 142 387-97 PubMed GONUTS page
↑ ^23.0 ^23.1 Sultan, A et al. (2011) Nuclear tau, a key player in neuronal DNA protection. J. Biol. Chem. 286 4566-75 PubMed GONUTS page
↑ Killick, R et al. (2014) Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway. Mol. Psychiatry 19 88-98 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 Matarin, M et al. (2015) A genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology. Cell Rep 10 633-44 PubMed GONUTS page
↑ Villacé, P et al. (2004) The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs. Nucleic Acids Res. 32 2411-20 PubMed GONUTS page
↑ Kopeikina, KJ et al. (2011) Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer's disease brain. Am. J. Pathol. 179 2071-82 PubMed GONUTS page
↑ ^28.0 ^28.1 Gómez-Ramos, A et al. (2008) Extracellular tau promotes intracellular calcium increase through M1 and M3 muscarinic receptors in neuronal cells. Mol. Cell. Neurosci. 37 673-81 PubMed GONUTS page
↑ Yoshiyama, Y et al. (2007) Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron 53 337-51 PubMed GONUTS page
↑ Luo, W et al. (2007) Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies. Proc. Natl. Acad. Sci. U.S.A. 104 9511-6 PubMed GONUTS page
↑ ^31.00 ^31.01 ^31.02 ^31.03 ^31.04 ^31.05 ^31.06 ^31.07 ^31.08 ^31.09 ^31.10 ^31.11 ^31.12 ^31.13 ^31.14 ^31.15 Zhang, CC et al. (2016) The Role of MAPT in Neurodegenerative Diseases: Genetics, Mechanisms and Therapy. Mol. Neurobiol. 53 4893-904 PubMed GONUTS page
↑ Huang, DY et al. (1995) ApoE3 binding to tau tandem repeat I is abolished by tau serine262 phosphorylation. Neurosci. Lett. 192 209-12 PubMed GONUTS page
↑ Strittmatter, WJ et al. (1994) Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease. Proc. Natl. Acad. Sci. U.S.A. 91 11183-6 PubMed GONUTS page
↑ ^34.0 ^34.1 Brandt, R et al. (1995) Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain. J. Cell Biol. 131 1327-40 PubMed GONUTS page
↑ Caceres, A et al. (1992) Suppression of MAP2 in cultured cerebellar macroneurons inhibits minor neurite formation. Neuron 9 607-18 PubMed GONUTS page
↑ ^36.0 ^36.1 ^36.2 Black, MM et al. (1996) Tau is enriched on dynamic microtubules in the distal region of growing axons. J. Neurosci. 16 3601-19 PubMed GONUTS page
↑ Dinh, K et al. (2009) Fluorescence microscopy and 3D image reconstruction of cytokine initiated disruption of the Parkinson disease associated proteins alpha-synuclein, tau and ubiquitin in cultured glial cells. Cytokine 45 179-83 PubMed GONUTS page
↑ Drechsel, DN et al. (1992) Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau. Mol. Biol. Cell 3 1141-54 PubMed GONUTS page
↑ Chambraud, B et al. (2010) A role for FKBP52 in Tau protein function. Proc. Natl. Acad. Sci. U.S.A. 107 2658-63 PubMed GONUTS page
↑ ^40.0 ^40.1 ^40.2 ^40.3 Gamblin, TC et al. (2003) Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease. Proc. Natl. Acad. Sci. U.S.A. 100 10032-7 PubMed GONUTS page
↑ Canu, N et al. (1998) Tau cleavage and dephosphorylation in cerebellar granule neurons undergoing apoptosis. J. Neurosci. 18 7061-74 PubMed GONUTS page
↑ ^42.0 ^42.1 Lee, G et al. (1998) Tau interacts with src-family non-receptor tyrosine kinases. J. Cell. Sci. 111 ( Pt 21) 3167-77 PubMed GONUTS page
↑ Butner, KA & Kirschner, MW (1991) Tau protein binds to microtubules through a flexible array of distributed weak sites. J. Cell Biol. 115 717-30 PubMed GONUTS page
↑ ^44.0 ^44.1 ^44.2 ^44.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Pacheco, CD et al. (2009) Tau deletion exacerbates the phenotype of Niemann-Pick type C mice and implicates autophagy in pathogenesis. Hum. Mol. Genet. 18 956-65 PubMed GONUTS page
↑ Falcon, B et al. (2018) Structures of filaments from Pick's disease reveal a novel tau protein fold. Nature 561 137-140 PubMed GONUTS page
↑ Guo, JP et al. (2006) Abeta and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer's disease. Proc. Natl. Acad. Sci. U.S.A. 103 1953-8 PubMed GONUTS page
↑ ^48.0 ^48.1 ^48.2 Kutter, S et al. (2016) Regulation of Microtubule Assembly by Tau and not by Pin1. J. Mol. Biol. 428 1742-59 PubMed GONUTS page
↑ ^49.0 ^49.1 ^49.2 Kim, Y et al. (2016) Caspase-cleaved tau exhibits rapid memory impairment associated with tau oligomers in a transgenic mouse model. Neurobiol. Dis. 87 19-28 PubMed GONUTS page
↑ Poepsel, S et al. (2015) Determinants of amyloid fibril degradation by the PDZ protease HTRA1. Nat. Chem. Biol. 11 862-9 PubMed GONUTS page
↑ Wang, YP et al. (2007) Stepwise proteolysis liberates tau fragments that nucleate the Alzheimer-like aggregation of full-length tau in a neuronal cell model. Proc. Natl. Acad. Sci. U.S.A. 104 10252-7 PubMed GONUTS page
↑ ^52.0 ^52.1 Takei, Y et al. (2015) Defects in Synaptic Plasticity, Reduced NMDA-Receptor Transport, and Instability of Postsynaptic Density Proteins in Mice Lacking Microtubule-Associated Protein 1A. J. Neurosci. 35 15539-54 PubMed GONUTS page
↑ Gong, CX et al. (2000) Regulation of phosphorylation of neuronal microtubule-associated proteins MAP1b and MAP2 by protein phosphatase-2A and -2B in rat brain. Brain Res. 853 299-309 PubMed GONUTS page
↑ Bodea, LG et al. (2016) Tau physiology and pathomechanisms in frontotemporal lobar degeneration. J. Neurochem. 138 Suppl 1 71-94 PubMed GONUTS page

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[PMID:26436840-50] Poepsel, S et al. (2015) Determinants of amyloid fibril degradation by the PDZ protease HTRA1. Nat. Chem. Biol. 11 862-9 PubMed GONUTS page

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