HUMAN:SQSTM

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SQSTM1 (synonyms: ORCA, OSIL)
Protein Name(s)	Sequestosome-1 EBI3-associated protein of 60 kDa EBIAP p60 Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa Ubiquitin-binding protein p62
External Links
UniProt	Q13501
EMBL	U41806 U46751 AK098077 AK312451 AC008393 BC000951 BC001874 BC003139 BC017222 BC019111 AF060494
CCDS	CCDS34317.1 CCDS47355.1
RefSeq	NP_001135770.1 NP_001135771.1 NP_003891.1
UniGene	Hs.724025
PDB	1Q02 2JY7 2JY8 2K0B 2KNV 4MJS
PDBsum	1Q02 2JY7 2JY8 2K0B 2KNV 4MJS
ProteinModelPortal	Q13501
SMR	Q13501
BioGrid	114397
DIP	DIP-34443N
IntAct	Q13501
MINT	MINT-269914
STRING	9606.ENSP00000374455
PhosphoSite	Q13501
DMDM	74735628
MaxQB	Q13501
PaxDb	Q13501
PRIDE	Q13501
DNASU	8878
Ensembl	ENST00000360718 ENST00000389805
GeneID	8878
KEGG	hsa:8878
UCSC	uc003mkw.4
CTD	8878
GeneCards	GC05P179234
HGNC	HGNC:11280
HPA	CAB004587
MIM	601530 602080
neXtProt	NX_Q13501
Orphanet	803 280110
PharmGKB	PA36109
eggNOG	NOG278569
GeneTree	ENSGT00390000002781
HOVERGEN	HBG052750
InParanoid	Q13501
KO	K14381
OMA	SVCPNYD
PhylomeDB	Q13501
TreeFam	TF328470
Reactome	REACT_13415 REACT_13643 REACT_13696 REACT_22442
SignaLink	Q13501
ChiTaRS	SQSTM1
EvolutionaryTrace	Q13501
GeneWiki	Sequestosome_1
GenomeRNAi	8878
NextBio	33335
PRO	PR:Q13501
Proteomes	UP000005640
Bgee	Q13501
CleanEx	HS_SQSTM1
ExpressionAtlas	Q13501
Genevestigator	Q13501
GO	GO:0016235 GO:0005776 GO:0005737 GO:0000932 GO:0031410 GO:0005829 GO:0005783 GO:0070062 GO:0016234 GO:0005770 GO:0005764 GO:0005654 GO:0016605 GO:0000407 GO:0042802 GO:0019901 GO:0005080 GO:0004674 GO:0030971 GO:0042169 GO:0043130 GO:0008270 GO:0097190 GO:0006914 GO:0030154 GO:0016197 GO:0002376 GO:0035556 GO:0016236 GO:0043066 GO:0048011 GO:0043065 GO:0016239 GO:0001934 GO:0045944 GO:0051291 GO:0008104 GO:0006468 GO:0043122 GO:0046578 GO:0006950 GO:0006511
InterPro	IPR000270 IPR009060 IPR015940 IPR000433
Pfam	PF00564 PF00569
SMART	SM00666 SM00165 SM00291
SUPFAM	SSF46934
PROSITE	PS50030 PS01357 PS50135

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0061912	selective autophagy	PMID:22622177^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005776	autophagosome	PMID:22948227^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:27368102^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9BY78	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:27368102^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9Y4E8	F		Seeded From UniProt	complete
involved_in	GO:1905719	protein localization to perinuclear region of cytoplasm	PMID:27368102^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:27368102^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007032	endosome organization	PMID:27368102^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035973	aggrephagy	PMID:28404643^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q562E7	P		Seeded From UniProt	complete
part_of	GO:0005776	autophagosome	PMID:19640926^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0044753	amphisome	PMID:19640926^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0044754	autolysosome	PMID:19640926^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	PMID:28404643^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0061635	regulation of protein complex stability	PMID:25127057^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q9C035) has_regulation_target:(UniProtKB:Q9GZQ8)	Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:25127057^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9C035	F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:25127057^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9BYV6	F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:25127057^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P0CI25	F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:25127057^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8IYM9	F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:25127057^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9Y577	F		Seeded From UniProt	complete
involved_in	GO:0010821	regulation of mitochondrion organization	PMID:20890124^[7]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000422	autophagy of mitochondrion	PMID:20098416^[8]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000423	mitophagy	PMID:20457763^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9JK66	P	part_of:(GO:0098780)	Seeded From UniProt	complete
involved_in	GO:0098780	response to mitochondrial depolarisation	PMID:20457763^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9JK66	P		Seeded From UniProt	complete
part_of	GO:0005776	autophagosome	PMID:20168092^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016236	macroautophagy	PMID:20168092^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016605	PML body	PMID:20168092^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:20168092^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016234	inclusion body	PMID:20168092^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[11]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
enables	GO:0035255	ionotropic glutamate receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q64337	F		Seeded From UniProt	complete
involved_in	GO:1903078	positive regulation of protein localization to plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q64337	P	has_regulation_target:(UniProtKB:P42261)	Seeded From UniProt	complete
involved_in	GO:1900273	positive regulation of long-term synaptic potentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q64337	P		Seeded From UniProt	complete
involved_in	GO:0046578	regulation of Ras protein signal transduction	PMID:8618896^[12]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043130	ubiquitin binding	PMID:12857745^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	PMID:12857745^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042169	SH2 domain binding	PMID:8650207^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:8650207^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0016236	macroautophagy	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q14596	P		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	PMID:17580304^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005776	autophagosome	PMID:17580304^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005080	protein kinase C binding	PMID:14676191^[16]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P41743	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:8618896^[12]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000932	P-body	PMID:20357094^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107931 PANTHER:PTN000387090 UniProtKB:Q13501	F		Seeded From UniProt	complete
part_of	GO:0044753	amphisome	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000387090 UniProtKB:Q13501	C		Seeded From UniProt	complete
involved_in	GO:0035973	aggrephagy	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000387090 UniProtKB:Q13501	P		Seeded From UniProt	complete
part_of	GO:0016235	aggresome	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107931 PANTHER:PTN000387090	C		Seeded From UniProt	complete
involved_in	GO:0007032	endosome organization	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000387090 UniProtKB:Q13501	P		Seeded From UniProt	complete
involved_in	GO:0007005	mitochondrion organization	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003231 PANTHER:PTN000387090	P		Seeded From UniProt	complete
part_of	GO:0005776	autophagosome	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003231 MGI:MGI:107931 PANTHER:PTN000387090 UniProtKB:Q13501	C		Seeded From UniProt	complete
enables	GO:0005080	protein kinase C binding	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000387090 RGD:69287 UniProtKB:Q13501	F		Seeded From UniProt	complete
involved_in	GO:0000423	mitophagy	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000387090 UniProtKB:Q13501	P		Seeded From UniProt	complete
part_of	GO:0005776	autophagosome	PMID:24954904^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:25686248^[20]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13501	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:25416956^[21]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13501	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21900206^[22]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13501	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:20562859^[23]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13501	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:16169070^[24]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13501	F		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004674	P		Seeded From UniProt	complete
part_of	GO:0097413	Lewy body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08623 ensembl:ENSRNOP00000056021	C		Seeded From UniProt	complete
involved_in	GO:0051291	protein heterooligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08623 ensembl:ENSRNOP00000056021	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08623 ensembl:ENSRNOP00000056021	F		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08623 ensembl:ENSRNOP00000056021	C		Seeded From UniProt	complete
enables	GO:0005080	protein kinase C binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08623 ensembl:ENSRNOP00000056021	F		Seeded From UniProt	complete
involved_in	GO:0002931	response to ischemia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08623 ensembl:ENSRNOP00000056021	P		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08623 ensembl:ENSRNOP00000056021	P		Seeded From UniProt	complete
involved_in	GO:1903078	positive regulation of protein localization to plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64337 ensembl:ENSMUSP00000099835	P		Seeded From UniProt	complete
involved_in	GO:1900273	positive regulation of long-term synaptic potentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64337 ensembl:ENSMUSP00000099835	P		Seeded From UniProt	complete
part_of	GO:0097225	sperm midpiece	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64337 ensembl:ENSMUSP00000099835	C		Seeded From UniProt	complete
enables	GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64337 ensembl:ENSMUSP00000099835	F		Seeded From UniProt	complete
part_of	GO:0044754	autolysosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64337 ensembl:ENSMUSP00000099835	C		Seeded From UniProt	complete
involved_in	GO:0044130	negative regulation of growth of symbiont in host	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64337 ensembl:ENSMUSP00000099835	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64337 ensembl:ENSMUSP00000099835	F		Seeded From UniProt	complete
enables	GO:0035255	ionotropic glutamate receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64337 ensembl:ENSMUSP00000099835	F		Seeded From UniProt	complete
part_of	GO:0016235	aggresome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64337 ensembl:ENSMUSP00000099835	C		Seeded From UniProt	complete
part_of	GO:0005776	autophagosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64337 ensembl:ENSMUSP00000099835	C		Seeded From UniProt	complete
part_of	GO:0000407	phagophore assembly site	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64337 ensembl:ENSMUSP00000099835	C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64337 ensembl:ENSMUSP00000099835	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000433	F		Seeded From UniProt	complete
enables	GO:0030971	receptor tyrosine kinase binding	PMID:8650207^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:8702753^[25]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	PMID:19816510^[26]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:12857745^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:8650207^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016197	endosomal transport	PMID:12857745^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008104	protein localization	PMID:8650207^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:8650207^[14] Reactome:R-HSA-5205673 Reactome:R-HSA-5205663 Reactome:R-HSA-5205649 Reactome:R-HSA-507719 Reactome:R-HSA-209566 Reactome:R-HSA-205008 Reactome:R-HSA-204947 Reactome:R-HSA-193705 Reactome:R-HSA-193703 Reactome:R-HSA-193694 Reactome:R-HSA-193684 Reactome:R-HSA-193641	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0070498	interleukin-1-mediated signaling pathway	Reactome:R-HSA-9020702	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043130	ubiquitin binding	Reactome:R-HSA-205008	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	Reactome:R-HSA-193639	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	Reactome:R-HSA-205043	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016236	macroautophagy	Reactome:R-HSA-5205685	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-204947	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256 UniProtKB-SubCell:SL-0095	C		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0458 UniProtKB-SubCell:SL-0158	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0072	P		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
part_of	GO:0005776	autophagosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0023	C		Seeded From UniProt	complete
part_of	GO:0030017	sarcomere	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0313	C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0152	C		Seeded From UniProt	complete
part_of	GO:0016605	PML body	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0465	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Taillebourg, E et al. (2012) The deubiquitinating enzyme USP36 controls selective autophagy activation by ubiquitinated proteins. Autophagy 8 767-79 PubMed GONUTS page
↑ Colecchia, D et al. (2012) MAPK15/ERK8 stimulates autophagy by interacting with LC3 and GABARAP proteins. Autophagy 8 1724-40 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Jongsma, ML et al. (2016) An ER-Associated Pathway Defines Endosomal Architecture for Controlled Cargo Transport. Cell 166 152-66 PubMed GONUTS page
↑ ^4.0 ^4.1 Liu, X et al. (2017) The BEACH-containing protein WDR81 coordinates p62 and LC3C to promote aggrephagy. J. Cell Biol. 216 1301-1320 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Alegre-Abarrategui, J et al. (2009) LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model. Hum. Mol. Genet. 18 4022-34 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Mandell, MA et al. (2014) TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition. Dev. Cell 30 394-409 PubMed GONUTS page
↑ Narendra, D et al. (2010) p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both. Autophagy 6 1090-106 PubMed GONUTS page
↑ Geisler, S et al. (2010) PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat. Cell Biol. 12 119-31 PubMed GONUTS page
↑ ^9.0 ^9.1 Lee, JY et al. (2010) Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy. J. Cell Biol. 189 671-9 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 Clausen, TH et al. (2010) p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy. Autophagy 6 330-44 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ ^12.0 ^12.1 Park, I et al. (1995) Phosphotyrosine-independent binding of a 62-kDa protein to the src homology 2 (SH2) domain of p56lck and its regulation by phosphorylation of Ser-59 in the lck unique N-terminal region. Proc. Natl. Acad. Sci. U.S.A. 92 12338-42 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 Ciani, B et al. (2003) Structure of the ubiquitin-associated domain of p62 (SQSTM1) and implications for mutations that cause Paget's disease of bone. J. Biol. Chem. 278 37409-12 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 Joung, I et al. (1996) Molecular cloning of a phosphotyrosine-independent ligand of the p56lck SH2 domain. Proc. Natl. Acad. Sci. U.S.A. 93 5991-5 PubMed GONUTS page
↑ ^15.0 ^15.1 Pankiv, S et al. (2007) p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J. Biol. Chem. 282 24131-45 PubMed GONUTS page
↑ Brajenovic, M et al. (2004) Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network. J. Biol. Chem. 279 12804-11 PubMed GONUTS page
↑ O'Connor, C et al. (2010) p62/sequestosome-1 associates with and sustains the expression of retroviral restriction factor TRIM5alpha. J. Virol. 84 5997-6006 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 ^18.4 ^18.5 ^18.6 ^18.7 ^18.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Dooley, HC et al. (2014) WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1. Mol. Cell 55 238-52 PubMed GONUTS page
↑ Rui, YN et al. (2015) Huntingtin functions as a scaffold for selective macroautophagy. Nat. Cell Biol. 17 262-75 PubMed GONUTS page
↑ Rolland, T et al. (2014) A proteome-scale map of the human interactome network. Cell 159 1212-26 PubMed GONUTS page
↑ Vinayagam, A et al. (2011) A directed protein interaction network for investigating intracellular signal transduction. Sci Signal 4 rs8 PubMed GONUTS page
↑ Behrends, C et al. (2010) Network organization of the human autophagy system. Nature 466 68-76 PubMed GONUTS page
↑ Stelzl, U et al. (2005) A human protein-protein interaction network: a resource for annotating the proteome. Cell 122 957-68 PubMed GONUTS page
↑ Vadlamudi, RK et al. (1996) p62, a phosphotyrosine-independent ligand of the SH2 domain of p56lck, belongs to a new class of ubiquitin-binding proteins. J. Biol. Chem. 271 20235-7 PubMed GONUTS page
↑ Wang, M et al. (2010) Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis. Cell Death Differ. 17 488-98 PubMed GONUTS page

[PMID:22622177-1] Taillebourg, E et al. (2012) The deubiquitinating enzyme USP36 controls selective autophagy activation by ubiquitinated proteins. Autophagy 8 767-79 PubMed GONUTS page

[PMID:22948227-2] Colecchia, D et al. (2012) MAPK15/ERK8 stimulates autophagy by interacting with LC3 and GABARAP proteins. Autophagy 8 1724-40 PubMed GONUTS page

[PMID:27368102-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Jongsma, ML et al. (2016) An ER-Associated Pathway Defines Endosomal Architecture for Controlled Cargo Transport. Cell 166 152-66 PubMed GONUTS page

[PMID:28404643-4] 4.0 ^4.1 Liu, X et al. (2017) The BEACH-containing protein WDR81 coordinates p62 and LC3C to promote aggrephagy. J. Cell Biol. 216 1301-1320 PubMed GONUTS page

[PMID:19640926-5] 5.0 ^5.1 ^5.2 Alegre-Abarrategui, J et al. (2009) LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model. Hum. Mol. Genet. 18 4022-34 PubMed GONUTS page

[PMID:25127057-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Mandell, MA et al. (2014) TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition. Dev. Cell 30 394-409 PubMed GONUTS page

[PMID:20890124-7] Narendra, D et al. (2010) p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both. Autophagy 6 1090-106 PubMed GONUTS page

[PMID:20098416-8] Geisler, S et al. (2010) PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat. Cell Biol. 12 119-31 PubMed GONUTS page

[PMID:20457763-9] 9.0 ^9.1 Lee, JY et al. (2010) Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy. J. Cell Biol. 189 671-9 PubMed GONUTS page

[PMID:20168092-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 Clausen, TH et al. (2010) p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy. Autophagy 6 330-44 PubMed GONUTS page

[PMID:19056867-11] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:8618896-12] 12.0 ^12.1 Park, I et al. (1995) Phosphotyrosine-independent binding of a 62-kDa protein to the src homology 2 (SH2) domain of p56lck and its regulation by phosphorylation of Ser-59 in the lck unique N-terminal region. Proc. Natl. Acad. Sci. U.S.A. 92 12338-42 PubMed GONUTS page

[PMID:12857745-13] 13.0 ^13.1 ^13.2 ^13.3 Ciani, B et al. (2003) Structure of the ubiquitin-associated domain of p62 (SQSTM1) and implications for mutations that cause Paget's disease of bone. J. Biol. Chem. 278 37409-12 PubMed GONUTS page

[PMID:8650207-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 Joung, I et al. (1996) Molecular cloning of a phosphotyrosine-independent ligand of the p56lck SH2 domain. Proc. Natl. Acad. Sci. U.S.A. 93 5991-5 PubMed GONUTS page

[PMID:17580304-15] 15.0 ^15.1 Pankiv, S et al. (2007) p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J. Biol. Chem. 282 24131-45 PubMed GONUTS page

[PMID:14676191-16] Brajenovic, M et al. (2004) Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network. J. Biol. Chem. 279 12804-11 PubMed GONUTS page

[PMID:20357094-17] O'Connor, C et al. (2010) p62/sequestosome-1 associates with and sustains the expression of retroviral restriction factor TRIM5alpha. J. Virol. 84 5997-6006 PubMed GONUTS page

[PMID:21873635-18] 18.0 ^18.1 ^18.2 ^18.3 ^18.4 ^18.5 ^18.6 ^18.7 ^18.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:24954904-19] Dooley, HC et al. (2014) WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1. Mol. Cell 55 238-52 PubMed GONUTS page

[PMID:25686248-20] Rui, YN et al. (2015) Huntingtin functions as a scaffold for selective macroautophagy. Nat. Cell Biol. 17 262-75 PubMed GONUTS page

[PMID:25416956-21] Rolland, T et al. (2014) A proteome-scale map of the human interactome network. Cell 159 1212-26 PubMed GONUTS page

[PMID:21900206-22] Vinayagam, A et al. (2011) A directed protein interaction network for investigating intracellular signal transduction. Sci Signal 4 rs8 PubMed GONUTS page

[PMID:20562859-23] Behrends, C et al. (2010) Network organization of the human autophagy system. Nature 466 68-76 PubMed GONUTS page

[PMID:16169070-24] Stelzl, U et al. (2005) A human protein-protein interaction network: a resource for annotating the proteome. Cell 122 957-68 PubMed GONUTS page

[PMID:8702753-25] Vadlamudi, RK et al. (1996) p62, a phosphotyrosine-independent ligand of the SH2 domain of p56lck, belongs to a new class of ubiquitin-binding proteins. J. Biol. Chem. 271 20235-7 PubMed GONUTS page

[PMID:19816510-26] Wang, M et al. (2010) Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis. Cell Death Differ. 17 488-98 PubMed GONUTS page

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