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HUMAN:SPDEF

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) SPDEF (synonyms: PDEF, PSE)
Protein Name(s) SAM pointed domain-containing Ets transcription factor

Prostate epithelium-specific Ets transcription factor Prostate-specific Ets Prostate-derived Ets factor

External Links
UniProt O95238
EMBL AB031549
AF071538
AK301543
BX255971
AL157372
BX255972
BX255973
BC021299
CCDS CCDS4794.1
CCDS59013.1
RefSeq NP_001239223.1
NP_036523.1
XP_005249045.1
XP_006715111.1
UniGene Hs.485158
PDB 1YO5
2DKX
PDBsum 1YO5
2DKX
ProteinModelPortal O95238
SMR O95238
BioGrid 117335
STRING 9606.ENSP00000363149
PhosphoSite O95238
MaxQB O95238
PaxDb O95238
PRIDE O95238
DNASU 25803
Ensembl ENST00000374037
ENST00000544425
GeneID 25803
KEGG hsa:25803
UCSC uc003ojq.2
CTD 25803
GeneCards GC06M034505
HGNC HGNC:17257
HPA HPA055707
MIM 608144
neXtProt NX_O95238
PharmGKB PA134993886
eggNOG NOG243414
GeneTree ENSGT00760000118996
HOGENOM HOG000237327
HOVERGEN HBG080776
InParanoid O95238
KO K09442
OMA YPEDSSW
OrthoDB EOG76X60D
PhylomeDB O95238
TreeFam TF318679
EvolutionaryTrace O95238
GeneWiki SPDEF
GenomeRNAi 25803
NextBio 47011
PRO PR:O95238
Proteomes UP000005640
Bgee O95238
CleanEx HS_SPDEF
Genevestigator O95238
GO GO:0005634
GO:0043565
GO:0000981
GO:0030154
GO:0060576
GO:0060480
GO:0007275
GO:0010454
GO:0000122
GO:0043065
GO:0010455
GO:0045944
GO:0006366
Gene3D 1.10.10.10
1.10.150.50
InterPro IPR000418
IPR003118
IPR013761
IPR011991
Pfam PF00178
PF02198
PRINTS PR00454
SMART SM00413
SM00251
SUPFAM SSF47769
PROSITE PS00345
PS00346
PS50061
PS51433

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0060770

negative regulation of epithelial cell proliferation involved in prostate gland development

PMID:21229552[1]

ECO:0000314

P

Fig 1:Western blot and one step RT-PCR showing expression of PDEF in normal and prostate lesions and cell lines.

complete

GO:0043065

positive regulation of apoptosis

PMID:21229552[1]

ECO:0000314

P

Fig 2: Immunohistochemistry shows down regulation and loss of PDEF in prostate cancer tissues compared to normal tissues.

complete

GO:0043065

positive regulation of apoptosis

PMID:21229552[1]

ECO:0000314

P

Fig 3: Immunohistochemisty staining is used to show the reducing levels of PDEF, the later stages of cancer. Confirming that PDEF has a role in prostate cancer development.

complete

GO:0008634

negative regulation of survival gene product expression

PMID:21229552[1]

ECO:0000314

P

Figure 4: Re-expression of PDEF inhibits cell growth, positively regulates apoptosis and down regulates survivin gene expression in invasive PC-3 cancer cell lines.

complete

GO:0008634

negative regulation of survival gene product expression

PMID:21229552[1]

ECO:0000314

P

Figure 7: Induction of apoptosis using MSeA causes an upregulation of PDEF and a down regulation of survivin.

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[2]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[2]

ECO:0000255

match to sequence model evidence used in manual assertion

InterPro:IPR000418

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000113

ECO:0005556

multiple sequence alignment evidence used in manual assertion

UniProtKB:Q8R4Z4

F

Seeded From UniProt

complete

enables

GO:0001227

DNA-binding transcription repressor activity, RNA polymerase II-specific

GO_REF:0000036

ECO:0000305

curator inference used in manual assertion

GO:0000122,GO:0043565

F

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

PMID:23332764[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0043065

positive regulation of apoptotic process

PMID:21656828[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:21656828[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:109336
PANTHER:PTN000218930

P

Seeded From UniProt

complete

involved_in

GO:0006357

regulation of transcription by RNA polymerase II

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95455
MGI:MGI:95610
MGI:MGI:98282
PANTHER:PTN000218930
UniProtKB:Q15723

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000097
FB:FBgn0000567
FB:FBgn0003118
MGI:MGI:101762
MGI:MGI:107180
MGI:MGI:109637
MGI:MGI:1335079
MGI:MGI:1353422
MGI:MGI:2449712
MGI:MGI:95455
MGI:MGI:95554
MGI:MGI:95610
MGI:MGI:98282
MGI:MGI:99423
PANTHER:PTN000218930
RGD:1359607
RGD:1598663
RGD:2583
UniProtKB:P14921
UniProtKB:P17947
UniProtKB:P19419
UniProtKB:P32519
UniProtKB:P41161
UniProtKB:Q01543
UniProtKB:Q06546
WB:WBGene00002990
WB:WBGene00017687

C

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000218930
UniProtKB:Q15723

F

Seeded From UniProt

complete

involved_in

GO:0010455

positive regulation of cell fate commitment

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9WTP3
ensembl:ENSMUSP00000025054

P

Seeded From UniProt

complete

involved_in

GO:0010454

negative regulation of cell fate commitment

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9WTP3
ensembl:ENSMUSP00000025054

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9WTP3
ensembl:ENSMUSP00000025054

C

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9WTP3
ensembl:ENSMUSP00000025054

P

Seeded From UniProt

complete

involved_in

GO:0060576

intestinal epithelial cell development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9WTP3
ensembl:ENSMUSP00000025054

P

Seeded From UniProt

complete

involved_in

GO:0060480

lung goblet cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9WTP3
ensembl:ENSMUSP00000025054

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9WTP3
ensembl:ENSMUSP00000025054

P

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000418

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003118

C

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000418

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000418
InterPro:IPR003118

F

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

PMID:10625666[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 () PubMed GONUTS page
  2. ↑ 2.0 2.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
  3. ↑ Jolma, A et al. (2013) DNA-binding specificities of human transcription factors. Cell 152 327-39 PubMed GONUTS page
  4. ↑ 4.0 4.1 Ghadersohi, A et al. (2011) Prostate-derived Ets transcription factor (PDEF) is a potential prognostic marker in patients with prostate cancer. Prostate 71 1178-88 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  6. ↑ Oettgen, P et al. (2000) PDEF, a novel prostate epithelium-specific ets transcription factor, interacts with the androgen receptor and activates prostate-specific antigen gene expression. J. Biol. Chem. 275 1216-25 PubMed GONUTS page
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